1.Clinicopathological correlation in endometrial carcinoma.
Byung Soo HAN ; Hak Hee LEE ; Joon SONG ; Chan Yong PARK
Korean Journal of Obstetrics and Gynecology 1992;35(4):562-570
No abstract available.
Endometrial Neoplasms*
;
Female
2.Change of Serum IGF-I and IGFBP-3 Concentration During Induction Chemotherapy in Children with Acute Lymphocytic Leukemia.
Jee Yeon SONG ; Bin CHO ; Hak Ki KIM ; Byung Churl LEE
Journal of Korean Society of Pediatric Endocrinology 1997;2(1):53-59
PURPOSE:The most important regulatory factor for IGF-I and IGFBP-3 known so far GH and food intake. Poor nutrition in children with acute lymphocytic leukemia(ALL) increase morbidity during treatment. The aim of this study was to assess the changes of serum IGF-I and IGFBP-3 concentration during induction chemotherapy in 13 children with acute lymphocytic leukemia. METHODS:13 children aged between 1.6 and 13.5 years with ALL were studied the changes of serum IGF-I and IGFBP-3 concentration before, at 2 and 4 weeks after induction chemotherapy. Serum IGF-I and IGFBP-3 were measured using radioimmunoassay. Results : 1) Mean serum IGF-I and IGFBP-3 concentration before induction chemotherapy in ALL patient was significantly lower than the those of normal control(p<0.05). 2) Mean serum IGF-I and IGFBP-3 concentration at 2 weeks of induction chemotherapy were significantly higher than the those of the basal levels (p<0.05). 3) Mean serum IGF-I and IGFBP-3 concentration at 4 weeks after induction chemotherapy were significantly higher than the those of the basal levels (p<0.05). Conclusion : Concentration of serum IGF-I and IGFBP-3 in patients with ALL were significantly increased during induction chemotherapy. These results are probably related to improvement of nutritional status following induction chemotherapy.
Child*
;
Eating
;
Humans
;
Induction Chemotherapy*
;
Insulin-Like Growth Factor Binding Protein 3*
;
Insulin-Like Growth Factor I*
;
Nutritional Status
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
;
Radioimmunoassay
3.Immunohistochemical Study on Proliferating Cells in Alopecia using Proliferating Cell Nuclear Antigen.
Hak Kyu LEE ; Yoon Whoa CHO ; Byung In RO ; Kye Yong SONG
Korean Journal of Dermatology 1994;32(3):391-398
Backgroud : The number of proliferating cell populations in the hair is follicles is closely related to the regulation of hair growth. Destruction of hair germ cells and the loss of proliferating cells have been suggested to be of major pathogenetic significance in alopecia areata OBJECTIVE: The purpose of this study is to compare the growth frrections in proliferating cells of normal hair follicles with those in alopecia. METHODS: An immunohiatochemical study was done to detect the proliferating cells in hair follicles using a monoclonal antibody against proliferating cell nuclear antigen(PCNA) in the scalp biopsy of an alopecia patient on the peraffin embedded sections. RESULTS: A significant decrease of the labelling indeces of PCNA were observed in the hair follicles of alopecia compared with normal condition. But we could not find significant differences of labelling index in the clinical types of alopecia, responses to treatment, anc systemic immunologic state. CONCLUSIONS : Whole the above results confirmed that significant decreases of proliferating cells in the hair follicle could explain the part of the pathogenetic mechanism in alopecia, its direct cause which inhibit the proliferation of cells is not clear.
Alopecia Areata
;
Alopecia*
;
Biopsy
;
Germ Cells
;
Hair
;
Hair Follicle
;
Humans
;
Proliferating Cell Nuclear Antigen*
;
Scalp
4.Effect of Cyclic GMP on Human Cytomegalovirus Gene Expression.
Joo Hyun YOON ; Gyu Cheol LEE ; Byung Hak SONG ; Young Jin KIM ; Chan Hee LEE
Journal of the Korean Society of Virology 1999;29(4):261-269
No abstract available.
Cyclic GMP*
;
Cytomegalovirus*
;
Gene Expression*
;
Humans*
5.Primary Cutaneous B Cell Lymphoma.
Hak Kyu LEE ; Yoon Whoa CHO ; Kye Yong SONG ; Byoung Hoon YOO ; Byung In RO
Annals of Dermatology 1995;7(1):58-61
A 7-year-old girl had a 7 × 6cm sized dark red colored tumor on the left elbow and several erythematous macules on the face, right upper arm, and both thighs. Her general health was good and all laboratory findings were within normal limit. Histopathologic examination revealed an infiltration of atypical mononuclear cells in the dermis and subcutis. L26 and leukocyte common antigen were positively stained in an immunohistochemical study. According to clinical, histological and immunohistochemical findings, we diagnosed the disease as primary cutaneous B cell lymphoma. The patient's skin lesions markedly improved after a surgical excision and chemotherapy.
Antigens, CD45
;
Arm
;
Child
;
Dermis
;
Drug Therapy
;
Elbow
;
Female
;
Humans
;
Lymphoma, B-Cell*
;
Skin
;
Thigh
6.Crush-Cleavage Fracture in Thoracolumbar and Lumbar Spine: Comparative Study with Type B Burst Fracture
Kyung Jin SONG ; Hak Ji KIM ; Ki Young CHANG ; Sang Soon CHOI ; Byung Yun HWANG
The Journal of the Korean Orthopaedic Association 1996;31(4):702-710
We noticed a group of thoracolumbar and lumbar spine fractures showing a unique fracture pattern that consisted of 1) superior disc injury, 2) crush fracture of the upper half of the vertebral body, 3) sagittal fracture of the lower half of the vertebral body, 4) bone fragments in the spinal canal, and 5) lamina fracture. Some of these fracture patterns were present in type B burst fracture of Denis classification. The purpose of this study was to compare the difference between crush-cleavage fracture and type B burst fracture in the viewpoint of neural canal involvement and neurologic status, and functional outcome with surgical treatment. Ten cases were identified as crush-cleavage fractures in 22 type B burst fractures during a 5 year period from Mar. 1989 to Jun. 1993 at the Department of Orthopedic Surgery of Chonbuk National University Hospital. Four out of 10 crush-cleavage fractures and 4 out of 12 type B burst fractures were paraparetic. Crush-cleavage fracture must be an unstable thoracolumbar comminuted fracture, but there were no significant differences in the neural canal involvement, incidence of neurologic deficit, and in the functional outcome, compared with type B burst fracture (P>0.05). It could be classified as a progressed form of type B burst fracture in Denis classification, or as a burst-split fracture in Magerl classification in the anatomical viewpoint. In conclusion, crush-cleavage fracture must be a variant of burst fracture.
Classification
;
Fractures, Comminuted
;
Incidence
;
Jeollabuk-do
;
Neural Tube
;
Neurologic Manifestations
;
Orthopedics
;
Spinal Canal
;
Spine
7.The Studies of Contractile and Relaxing Responses of Abdominal Aorta and Effects of Angiotensin II Blocker(Losartan) in Spontaneously Hypertensive Rats Combined with Renovascular Hypertension.
Hyung Jun LEE ; Byung Keun HAN ; Eun Young LEE ; Jin Soo KIM ; Eung Ho GAL ; Mi Hye KIM ; Jung Min KIM ; Ki Hak SONG ; Seung Ok CHOI
Korean Journal of Nephrology 1999;18(6):887-893
This study was designed to evaluate the contractile and relaxing responses of abdominal aorta in renovascular hypertension accompanied with essential hyper- tension and to examine the effect of angiotensin II receptor blocker(losartan). An experimental renovascular hypertension accompanied with essential hypertension model was established by clipping the left renal artery of spontaneously hypertensive rats(SHR). These rats were then divided into two groups of which one was given losartan during the one week postopertion before being terminated. Ring preparations of the abdominal aorta were obtained one week after the operation. The contraction of abdominal aorta strips were induced by high potassium or norepinephrine, and relaxation produced by acetylcholine or sodium nitroprusside. The contractile and relaxing responses were recorded and compared with data obtained from the control group. In the second experiment, the rats received angiotensin Il blocker(LRAO group), losartan in the drinking water for 7 days after the induction of the renal artery stenosis operation. Then, the contractile and relaxing responses were evaluated by the same method. The following results were obtained; 1) The contractile responses to the high level potassium solution and norepinephrine in renal artery occlusion(RAO) group were significantly increased compared with SHR group(p<0.05). 2) The contractile reponses to the high level norepinephrine in LRAO group were similar to that of SHR control group. However, there was no remarkable differences for high potassium. 3) The relaxing responses to the acetylcholine were significantly reduced in the RAO group compared with the SHR group. However, there was no remarkable differences for sodium nitroprusside. 4) There were no significant differences in the acetylcholine or sodium nitroprusside induced vasodilation response between the LRAO group and SHR group. From the above result, it is suggested that re- novascular hypertension in spontaneously hypertensive rats might induce changes of vascular responses and this effects may be concerned with endothelium-dependant mechanism. And angiotensin II receptor blocker rnay prevent the development of abnormal endothelium-dependent relaxation in renovascular hypertension accompanied with essential hypertension by maintaining endothelial function.
Acetylcholine
;
Angiotensin II*
;
Angiotensins*
;
Animals
;
Aorta, Abdominal*
;
Drinking Water
;
Hypertension
;
Hypertension, Renovascular*
;
Losartan
;
Nitroprusside
;
Norepinephrine
;
Potassium
;
Rats
;
Rats, Inbred SHR*
;
Receptors, Angiotensin
;
Relaxation
;
Renal Artery
;
Renal Artery Obstruction
;
Vasodilation
8.Hypopharyngeal Wall Exposure within the Surgical Field : The Role of Axial Rotation of the Thyroid Cartilage during Anterior Cervical Surgery.
Byung Kwan CHOI ; Won Ho CHO ; Chang Hwa CHOI ; Geun Sung SONG ; Choongrak KIM ; Hak Jin KIM
Journal of Korean Neurosurgical Society 2010;48(5):406-411
OBJECTIVE: Esophageal/hypopharyngeal injury can be a disastrous complication of anterior cervical surgery. The amount of hypopharyngeal wall exposure within the surgical field has not been studied. The objective of this study is to evaluate the chance of hypopharyngeal wall exposure by measuring the amount of axial rotation of the thyroid cartilage (ARTC) and posterior projection of the hypopharynx (PPH). METHODS: The study was prospectively designed using intraoperative ultrasonography. We measured the amount of ARTC in 27 cases. The amount of posterior projection of the hypopharynx (PPH) also was measured on pre-operative CT and compared at three different levels; the superior border of the thyroid cartilage (SBTC), cricoarytenoid joint and tip of inferior horn of the thyroid cartilage (TIHTC). The presence of air density was also checked on the same levels. RESULTS: The angle of ARTC ranged from -6.9degrees to 29.7degrees, with no statistical difference between the upper and lower cervical group. The amount of PPH was increased caudally. Air densities were observed in 26 cases at the SBTC, but none at the TIHTC. CONCLUSION: Within the confines of the thyroid cartilage, surgeons are required to pay more attention to the status of hypopharynx/esophagus near the inferior horn of the thyroid cartilage. The hypopharynx/esophagus at the TIHTC is more likely to be exposed than at the upper and middle part of the thyroid cartilage, which may increase the risk of injury by pressure. Surgeons should be aware of the fact that the visceral component at C6-T1 surgeries also rotates as much as when the thyroid cartilage is engaged with a retractor. The esophagus at lower cervical levels warrants more careful retraction because it is not protected by the thyroid cartilage.
Animals
;
Esophagus
;
Horns
;
Hypopharynx
;
Joints
;
Prospective Studies
;
Thyroid Cartilage
;
Thyroid Gland
9.CT Demonstration of the Extensive Extension of the Emphysematous Gangrene of the Lower Extremity Extending tothe Body: A Case Report.
Hak Soo LEE ; Hyun Chul RHIM ; Yong Soo KIM ; Soon Young SONG ; Byung Hee KOH ; On Koo CHO ; Kyung Bin JOO
Journal of the Korean Radiological Society 1996;35(2):241-244
Emphysematous gangrene of the lower extremity in a diabetic patient due to minor trauma is being presented. The gas originating from the extremity extended along to fascial planes into the pelvic cavity, scrotal region, retroperitoneal space, and abdominal wall. CT demonstrated the pathways of upward extension of emphysematousgangrene. Anatomic pathways of the spread of the disease are insertions of the iliopsoas, piriformis and obturator internus muscles, and their fascial investments, and the endopelvic fascia. Anatomic pathways on CT and the roleof CT are discussed.
Abdominal Wall
;
Extremities
;
Fascia
;
Gangrene*
;
Humans
;
Investments
;
Lower Extremity*
;
Muscles
10.Clinical Manifestations of Chemical Eye Injury.
Sung Kwon SONG ; Hyung Min KIM ; Won Jung JEONG ; Byung Hak SO ; Seung Pill CHOI
Journal of the Korean Society of Emergency Medicine 2013;24(3):302-308
PURPOSE: The purpose of this study is to investigate the clinical characteristics of patients admitted to emergency rooms with ocular chemical injuries, the substances responsible for such injuries, in order to improve their prevention and treatment. METHODS: The subjects of this study were 73 patients admitted to the hospital with ocular chemical injuries from January 1, 2009 to December 31, 2010. The subjects were divided into groups based on the PSS (poisoning severity score) grade of their injuries, where grades 0 and 1 were classified as the low group (low PSS) and grades 2 and 3 were classified as the high group (high PSS). There were 28 subjects in the low PSS group (38.3%) and 45 subjects in the high PSS group (61.6%). The results were retrospectively reviewed by examining the medical records of the patients. RESULTS: Upon their arrival to the hospital, the most common symptoms were red eye (50.7%), pain (39.7%), and eye irritation (39.7%). Red eyes were more frequently observed from 27 persons (60%) in the high PSS group (p=0.04). The most common causative substances were chemicals and adhesives/glues for both groups (21 cases each). Among the 15 patients exposed to acids or alkalis, 13 patients belonged to the high PSS group. Only two patients visited the hospital after having washed their eyes. CONCLUSION: Worse damage was observed from work-related exposure (including alkali or acid exposure), causing red eye and ocular chemical injuries. Onsite first aid was lacking.
Alkalies
;
Burns, Chemical
;
Emergency Service, Hospital
;
Eye Injuries*
;
First Aid
;
Humans
;
Medical Records
;
Occupational Exposure
;
Poisoning
;
Retrospective Studies
;
Therapeutic Irrigation