No abstract available.
Infant, Newborn ; Humans

No abstract available.
Brain* ; Epilepsy*

No abstract availalbe.
Carcinoma, Hepatocellular* ; Fibrosis* ; Humans ; Prospective Studies*

BACKGROUND: Fulminant hepatic failure is a devastating process associated with high mortality, but no sequele after recovep. At the moment, there are no specific therapeutic modalities except for the orthotopic liver transplantation(OLT) which is limited to a small number of patients due to a lack of donor organ. Recently, several nonsurgical managements have been investigated to overcome the donor shortage and to bridge patients to OLT. These include artificial hepatic support systems, hepatocyte transplantation and extracorporeal liver support. Xenotransplantation is also being investigated to circumbent the donor shortage. Hepatocyte transplantation:The application of liver cell transplantation has been envisioned for temporary metabolic support during liver failure, provision of specific liver functions in inherited metabolic diseases of the liver and as a vehicle for ex vivo gene therapy. Potential advantages over OLT are that the procedure is simple, hepatoyctes can be cryopreserved for immediate use in need, the cost is less expensive and abrogation of allograft rejection may be easier by the modification of antigenicity during culture. Moreover, donor shortage can be overcome by the use of fetal hepatocytes, conditionally immortalized hepatocytes and possibly liver progenitor cells. However, the optimum route and the method are still being investigated. Recently, biodegradable matrix or cotransplantation with non-parencymal liver cells is used to improve and prolong the survival of transplanted hepatocytes in the peritoneum, and injection of donor type splenocytes into the thymus along with ablation of the peripheral lymphocytes with antilymphocyte globulin is adopted to tolerize the recipient to allogeneic hepatocytes. BioartiTicial liver:Presently, several bioartificial liver systems use mammalian hepatocytes held within cartridges, mostly hollow- fiber bioreactor perfused by plasma or whole blood. Plasma is separated from patient blood using Background:Fulminant hepatic failure is a devastating process associated with high mortality, but no sequele after recovep. At the moment, there are no specific therapeutic modalities except for the orthotopic liver transplantation(OLT) which is limited to a small number of patients due to a lack of donor organ. Recently, several nonsurgical managements have been investigated to overcome the donor shortage and to bridge patients to OLT. These include artificial hepatic support systems, hepatocyte transplantation and extracorporeal liver support. Xenotransplantation is also being investigated to circumbent the donor shortage. Hepatocyte transplantation:The application of liver cell transplantation has been envisioned for temporary metabolic support during liver failure, provision of specific liver functions in inherited metabolic diseases of the liver and as a vehicle for ex vivo gene therapy. Potential advantages over OLT are that the procedure is simple, hepatoyctes can be cryopreserved for immediate use in need, the cost is less expensive and abrogation of allograft rejection may be easier by the modification of antigenicity during culture. Moreover, donor shortage can be overcome by the use of fetal hepatocytes, conditionally immortalized hepatocytes and possibly liver progenitor cells. However, the optimum route and the method are still being investigated. Recently, biodegradable matrix or cotransplantation with non-parencymal liver cells is used to improve and prolong the survival of transplanted hepatocytes in the peritoneum, and injection of donor type splenocytes into the thymus along with ablation of the peripheral lymphocytes with antilymphocyte globulin is adopted to tolerize the recipient to allogeneic hepatocytes. BioartiTicial liver:Presently, several bioartificial liver systems use mammalian hepatocytes held within cartridges, mostly hollow- fiber bioreactor perfused by plasma or whole blood. Plasma is separated from patient blood using
Allografts ; Antilymphocyte Serum ; Bioreactors ; Cell Transplantation ; Genetic Therapy ; Hepatocytes* ; Humans ; Liver ; Liver Failure* ; Liver Failure, Acute ; Liver, Artificial* ; Lymphocytes ; Metabolic Diseases ; Mortality ; Peritoneum ; Plasma ; Stem Cells ; Thymus Gland ; Tissue Donors ; Transplantation, Heterologous ; Transplants

We analyze ninty-seven cases of Colles fractures treated with closed reduction and sugar tong splint immobilization and followed for more than 1 year at Seoul National University from January 1981 to Decmber 1985. The results of this study were as follows; l. All of 97 cases were closed fractures and the incidence was high in females who aged over 6th decades. The main cause of this injury was slipping down accident comprising of 68.0%. 2. 63 cases (64.9%) were simple extra-articular fractures, and 34 cases (35.1%) were comminuted intra-articular fractures. 3. In a group of simple extra-articular fracture the functional end result was satisfactory in 88.9%, so closed reduction and sugar tong splint were thought to be a good procedure in this group. 4. In a group of comminuted intra-articular fracture the functional end result was satisfactory in 58.9% only. In the cases which show unacceptable loss of position during first two weeks of routine sugar tong splint immobilization we feel another technique is indicated, such as.pin and plaster immobilization or percutaneous pinning. 5. The main cause of unsatisfactory result was malunion, which was produced by loss of reduction position.
Clinical Study ; Colles' Fracture ; Female ; Fractures, Closed ; Humans ; Immobilization ; Incidence ; Intra-Articular Fractures ; Seoul ; Splints

M. supracostalis anterior is a rare varlation which occurs on the external aspect of the upper thoracic wall. This thin, short-like musc1e lies deep to the pectoralis major and minor muscles, and extends longitudinally over the upper four or five ribs. It is known that the muscle usually occurs bilaterally but sometimes unilaterally. In the present report, a case of unilateral (right) M.supracostalis anterior, observed in a 58-year-old man cadaver, is described. Because the muscle had not been reported in Korea, morphological characteristics and nerve innervation of the muscle were investigated. 1. M. supracostalis anterior, observed only on the right side, extended longitudinally from the first rib to the fourth rib deep to the pectoralis minor. 2. The suprarostalis anterior arose from the antero-inferior surface below the groove for subclavian vein of the first rib. After arising from the first rib, the smaller, more media part of the muscle inserted into the upper border of the fourth rib and the larger, more lateral part inserted into the upper border of the fourth rib. 3. The length of the musce is 9.9cm, and the width is 0.8cm at its origin, 1.7cm at the upper border of the third rib and 2.4cm at the upper border of the fourth rib. 4. It was confirmed, under stereomicroscope, that the muscle was innervated by the terminal branches of the nerve to the first external intercostal muscle deriving from Thl and Th2. Blood supply of the M. supracostalis anterior was provided mainly by the lateral thoracic artery arising from the axillary artery.
Axillary Artery ; Cadaver ; Humans ; Intercostal Muscles ; Korea ; Middle Aged ; Muscles ; Ribs ; Subclavian Vein ; Thoracic Arteries ; Thoracic Wall

A thorough knowledge about the branching variations of the femoral and deep femoral arteries is important in vascular reconstructive surgery of the proximal leg. The present study was done to describe the patterns of origin of the main branches of the femoral and deep femoral arteries in Koreans. The cadavers of 77 Koreans(male, 51 ; female, 26), who were 18-97 years old of time of death, were used in the present investigations and the femoral arteries of 152 sides(right side, 77 ; left side, 75) were observed. The femoral arteries of two left sides were excluded from this study because their branches were not clearly examined during dissection. The results were as follows : 1. Lateral circumflex femoral artery arose from the deep femoral artery in 78.9% and from the femoral artery in 21.1%. Significant differences between the right and left sides were not observed. 2. Medial circumflex femoral artery arose from the deep femoral artery in 77.0% and from the femoral artery in 22.4%. This artery arose more frequently from the femoral artery on the left side, and from the deep femoral artery on the right side in about a 9-10% differential respectively. In one case, the medial circumflex femoral artery arose from the lateral circumflex femoral artery on the left side. 3. The descending branch, which is normally a branch of the lateral circumflex femoral artery, arose from either the femoral or the deep femoral arteries in about 7% of the cases respectively. 4. The patterns of origin of the deep and circumflex femoral group of arteries were classified into 18 types. Each type is represented in three letters by using the initial of the deep femoral artery (D) or femoral artery (F) or lateral circumflex femoral artery (L) in the order of origin of the lateral circumflex femoral artery, medial circumflex femoral artery and descending branch. Types DDL(49.3%), FDL(18.4%) and DFL(15.1%) constituted the three major types on both sides. In addition, seven types (DFD, FFL, DDD, DDF, DFF, DLL and FDF) were found on the left side and three types (DDF, DDD and DFD) on the right side.
Adult* ; Arteries ; Cadaver ; Dichlorodiphenyldichloroethane ; Female ; Femoral Artery* ; Humans ; Leg

Vascular dementia is defined as a clinical syndrome of acquired intellectual impairment resulting from a brain injury due to a cerebrovascular disorder. It incorporates various vascular pathophysiological mechanisms and changes in the brain, and has diverse cause and clinical manifestations. The main suptypes of vascular dementia include 1) multi-infarct dementia, 2) strategic infarct dementia, and 3) subcortical vascular dementia. Both multi-infarct dementia and strategic infarct dementia show heterogeneity in etiologies, changes of the brain, as well as clinical manifestations. On the contrary, subcortical vascular dementia is suggested to be a more homogenous group. To better understand the clinical features of vascular dementia, cases corresponding to each subtype of vascular dementia are briefly discussed this review.
Brain ; Brain Injuries ; Cerebrovascular Disorders ; Dementia ; Dementia, Multi-Infarct ; Dementia, Vascular* ; Population Characteristics

A particular problem associated with osseointegrated implants is the fact that the implants lack a periodontal ligament. Thereby, marginal inflammation around an implant may cause more serious bone loss than does marginal inflammation around teeth with a periodontal ligament. In addition, osseointegrated implants are ankylosed and do not haute the same mobility as natural teeth with a periodontal ligament. Implants with a periodontal ligament would eliminate these problems. In order to explore the possibility of producing a periodontal ligament around titanium dental implants, a study of the attachment of cultured periodontal ligament cells to titanium was carried out. Periodontal ligament cells obtained from premolar teeth of individuals undergoing tooth extraction for orthodontic reasons were cultured on titanium-coated epon blocks. Sections of the blocks were cut perpendicular to the surface of the cell layer. Transmission electron microscopy of the periodntal ligament cells/titanium interface showed that there was no evidence of attachment at the cultured periodontal ligament cells titanium interface. The microfilaments, commonly located adjacent to the titanium surface, run mostly parallel to the titanium surface. The study showed that cultured periodontal ligament cells did not create an attachment structure on a titanium surface similar to that of natural teeth.
Actin Cytoskeleton ; Bicuspid ; Dental Implants ; Inflammation ; Ligaments ; Microscopy, Electron, Transmission ; Periodontal Ligament* ; Titanium* ; Tooth ; Tooth Extraction

This study was performed to investigate the prevalence of theileriosis and to compare the prevalence of this disease in Korean native cattle reared under different environmental conditions, namely, in a grazing area and a non-grazing area by polymerase chain reaction. Three hundred and one Korean native cattle (276 cows and 25 bulls) that had not received prior treatment or been vaccinated to prevent theileriosis were examined by PCR for Theileria sergenti infection from 2001 to 2002. In our study, the parasitemia range in T. sergenti-positive cattle by microscopy were from 0.1 to 3% (mean 0.8%). In terms of mean prevalence, 204 of the 301 Korean native cattle (67.8%) were positive reaction by PCR. Our results also revealed that the infection rate among cows (70.3%) was significantly higher than that among bulls (40.0%) (p < 0.01). T. sergenti infection among the over 3 year-old-group (75%) had a significant higher prevalence than that among the less than 3 year-old-group (61.8%) (p < 0.05). Our data also showed that grazing areas (76.1%) had the significant higher prevalence than non-grazing areas (51%) (p < 0.001). In conclusion, this study demonstrates that the prevalence of T. sergenti infection is high and that its prevalence in grazing cattle is higher than that in non-grazing cattle. Therefore, life-long treatment and the development of an optimal vaccine are needed to reduce the numbers of bovine theileriosis in both grazing and non-grazing areas.
Animals ; Cattle ; Cattle Diseases/diagnosis/*epidemiology/parasitology ; DNA, Protozoan/*analysis ; Female ; Korea/epidemiology ; Male ; Poaceae ; Polymerase Chain Reaction/methods/veterinary ; Prevalence ; Sex Factors ; Theileria/genetics/*isolation & purification ; Theileriasis/diagnosis/*epidemiology/parasitology