1.Association of HLA Class II and Non-HLA Gene Polymorphisms with Disease Susceptibility in Korean Children with Type 1 Diabetes Mellitus.
Min Ho JUNG ; Byung Kyu SUH ; Tai Gyu KIM ; Choong Ho SHIN ; Byung Churl LEE
Journal of Korean Society of Pediatric Endocrinology 2004;9(2):136-144
Purpose : The main genetic contribution to type 1 diabetes susceptibility is the human leukocyte antigen (HLA) class II gene. Several non-HLA chromosomal regions are also known to be involved. We studied the association of HLA class II and non-HLA candidate genes, which are cytotoxic T lymphocyte antigen-4 (CTLA4), tumor necrosis factor (TNF), lymphotoxin-alpha(LT-alpha, and vitamin D receptor (VDR) gene, polymorphisms with disease susceptibility in Korean children with type 1 diabetes.Methods : Fifty Korean children with type 1 diabetes (29 girls and 21 boys) and 166 healthy Koreans were investigated in this study. HLA class II alleles were determined by PCR-SSP (sequence-specific primer) and PCR-SSOP (sequence specific oliogonucleotide probe) method. CTLA4 exon 1 polymor phism was analyzed by PCR-SSCP (single strand conformation polymorphism), and TNF promotor and LT-alphagene polymorphism by PCR-RFLP (restriction fragment length polymorphism), respectively. VDR gene polymorphisms were analyzed by PCR-RFLP using restriction enzyme FokI, ApaI, TaqI, and BsmI. Results : The frequencies of HLA-DRB1*04, DRB1*09, and DQB1*04 were significantly increased and those of HLA-DRB1*14, DRB1*15, DQB1*05 and DQB1*06 were significantly decreased in the patients with type 1 diabetes compared with the control subjects. No significant differences in the distribution of CTLA4 exon 1, TNF promotor, LT-alpha and VDR gene polymorphisms were observed between the patients with type 1 diabetes and the control subjects. Conclusion : These data suggest that HLA-DRB1*04, DRB1*09, and DQB1*04 are susceptible genes for type 1 diabetes, whereas HLA-DRB1*14, DRB1*15, DQB1*05, and DQB1*06 are protective genes in Korean children. CTLA4 exon 1, TNF promotor, LT-alpha and VDR gene polymorphisms are not associated with susceptibility to type 1 diabetes in Korean children.
Alleles
;
Child*
;
Diabetes Mellitus, Type 1*
;
Disease Susceptibility*
;
Exons
;
Female
;
Genes, MHC Class II
;
Humans
;
Leukocytes
;
Lymphocytes
;
Receptors, Calcitriol
;
Tumor Necrosis Factor-alpha
2.Induction chemotherapy in locally advanced cervical cancer.
Yong Hak KIM ; Byung Gyu YOO ; Ki Tae KIM ; Hyun Chan KIM
Korean Journal of Obstetrics and Gynecology 1992;35(9):1288-1299
No abstract available.
Induction Chemotherapy*
;
Uterine Cervical Neoplasms*
3.A Case of Insulinoma Localized by Percutaneous Tracshepatic Portal Catheterization with Insulin Hormone Assay
Byung Jin KIM ; Jun Sang LEE ; Kyung Seuk LEE ; Byung Gyu PARK ; In Joo KIM ; Yong Ki KIM
Journal of Korean Society of Endocrinology 1996;11(3):355-361
The diagnosis of insulinoma is made primarily by the detection of an inappropriately elevated serum insulin level in the presence of a low blood glucose level. The successful resection of insulin-secreting islet cell turnors is greatly facilitated by accurate preoperative localization. But, the modalities of ultrasonography, computer tomography, magnetic resonance imaging and selective arteriography often fail to detect insulinoma smaller than 1.5 cm in diameter. In this report, we describe a patient with an insulinoma successfully localized by percutaneous transhepatic portal vein sampling but not by abdominal ultrasonography, computer tomography and selective arteriography. Percutaneous transhepatic portal vein catheterization with insulin sampling showed sudden step-up of insulin concentrations near 6 cm from distal splenic vein. During operation, a 1×1.3cm sized tumor was found at the junction of body and tail of pancreas, so distal pancreatectomy was performed, We propose that preoperative percutaneous transhepatic portal vein catheterization with measurement of radioimmunoactive insulin concentration is a safe and reliable method and plays an important role to localize insulinoma that are considered occult after conventional diagnostic studies have been negative.
Angiography
;
Blood Glucose
;
Catheterization
;
Catheters
;
Diagnosis
;
Humans
;
Insulin
;
Insulinoma
;
Islets of Langerhans
;
Magnetic Resonance Imaging
;
Methods
;
Pancreas
;
Pancreatectomy
;
Portal Vein
;
Splenic Vein
;
Tail
;
Ultrasonography
4.Rectal carcinoma presenting with a solitary brain metastasis.
Byung Sik KIM ; Jin Cheon KIM ; Kun Choon PARK ; Moon Gyu LEE ; In Cheol LEE ; Yang GWON
Journal of the Korean Society of Coloproctology 1992;8(2):181-186
No abstract available.
Brain*
;
Neoplasm Metastasis*
5.Computed tomographic findings of traumatic intracranial lesions
Seong Wook JEONG ; Il Young KIM ; Byung Ho LEE ; Ki Jeong KIM ; Il Gyu YOON
Journal of the Korean Radiological Society 1985;21(5):689-698
Traumatic intracranial lesion has been one of the most frequent and serous problem in neurosurgical pathology. CT made it possible to get prompt diagnosis and surgical intervention of intracranial lesions by its safety, fastiness and accuracy. Computed tomographic scan was carried out on 1309 cases at Soonchunhyang Chunan Hospitalfor 15 months from Oct. 1983 to Dec. 1984. We have reviewed the computed tomographic scans of 264 patients whichshowed traumatic intracranial lesion. The results were as follows: 1. Head trauma was the most frequentlydiagnosed disase using computed tomographic scans(57.8%), and among 264 cases the most frequent mode of injury wastraffic accident (73.9%). 2. Skull fracture was accompained in frequency of 69.7% and it was detected in CT in38.6%: depression fractue was more easily detected in 81%. 3. Countercoup lesion(9.5%) was usually accompained with temporal and occipital fracture, and it appeared in lower incidence among pediatric group. 4. Intracranial lesions of all 264 cases were generalized cerebral swelling(24.6%), subdural hematoma(22.3%), epiduralhematoma(20.8%), intracerebral hematoma(6.1%), and subarachnoid hemorrhage(3.0%). 5. The shape of hematoma wasusually biconvex(92.7%) in acute epidural hematoma and cresentic(100%) in acute subdural hematoma, but the morechronic the cases became, they showed planoconvex and biconvex shapes. 6. Extra-axial hematoma was getting decreased in density as time gone by. 7. Hematoma density was not in direct proportion to serum hemoglobin levelas single factor.
Chungcheongnam-do
;
Craniocerebral Trauma
;
Depression
;
Diagnosis
;
Hematoma
;
Hematoma, Subdural, Acute
;
Humans
;
Incidence
;
Pathology
;
Skull Fractures
6.A Case of Multiple Skeletal Tuberculosis with Spina Ventosa: A Case Report
Byung Duk PARK ; Dong Hae KIM ; Hyun Gyu KIM ; Kyung Soo YOO
The Journal of the Korean Orthopaedic Association 1976;11(2):220-224
A case of multiple skeletal tuberculosis with spina ventosa proved by radiological and pathologicaI methods in 3 year old Korean male child is reported. It was treated with antituberculous chemotherapy (triple method of PAS, INAH, streptomycin). At follow up check within 2 years, we obtained good healing process without other complication.
Child
;
Drug Therapy
;
Follow-Up Studies
;
Humans
;
Male
;
Methods
;
Tuberculosis
7.Antitumor and Immunomodulatory Activities of Mushroom ( Phellinus linteus ) Cultured on Oak and Mulberry.
Young Sub KIM ; Byung Eui LEE ; Gyu Bong JO ; Yeon Tae LEE ; Dae Jin LEE
Korean Journal of Immunology 2000;22(3):165-171
No abstract available.
Agaricales*
;
Morus*
8.Clinical evaluation of the Port-A-Cath implantation.
Jin Kyung LEE ; Sung Gyu LEE ; Byung Sik KIM ; Tae Won KWON ; Pyung Chul MIN
Journal of the Korean Cancer Association 1992;24(3):450-455
No abstract available.
Vascular Access Devices*
9.Effect of Cyclic GMP on Human Cytomegalovirus Gene Expression.
Joo Hyun YOON ; Gyu Cheol LEE ; Byung Hak SONG ; Young Jin KIM ; Chan Hee LEE
Journal of the Korean Society of Virology 1999;29(4):261-269
No abstract available.
Cyclic GMP*
;
Cytomegalovirus*
;
Gene Expression*
;
Humans*
10.Two Cases of Leber's Hereditary Optic Atrophy Occurred in Mother and Son.
Byung Gyu PARK ; Kwang Soo KIM
Journal of the Korean Ophthalmological Society 1982;23(3):867-871
Leber's hereditary optic atrophy is characterized by sudden loss of central vision occuringin the second and third decade of life and nondirect transmission with male preponderance, Leber disease affecting both eyes in different degree and not simultaneouly, showing in its. early stage hyperemia of optic disc followes by a secondary atrophy, which involves a serious permanent impairment of central vision. Recently, the auther have been experienced Leber hereditary optic atrophy in 30 years old mother and 12 years old son, with severe impaiarment of visual acuity and central scotoma in both eyes and had pallor on the discs. Clinical ophthalmoscopic, perimetric, color vision test and neurologic examination were performed in two persons.
Adult
;
Atrophy
;
Child
;
Color Vision
;
Humans
;
Hyperemia
;
Male
;
Mothers*
;
Neurologic Examination
;
Optic Atrophy, Hereditary, Leber*
;
Pallor
;
Scotoma
;
Visual Acuity