No abstract available.
Female ; Fetal Heart* ; Fetal Movement* ; Heart Rate, Fetal* ; Music* ; Pregnancy

No abstract available.
Child* ; Epilepsy* ; Humans

PURPOSE: Acute administration of non-selective serotonin (5-HT) reuptake inhibitor such as imipramine and selective 5-HT reuptake inhibitor, like fluoxetine leads, to an increase of extracellular 5-HT concentration in the brain. We sought to determine the average time spent asleep, the frequency of REM sleep, and the percent of REM and NREM sleep in the total sleep time in saline (sham-treated control) (n=6), imipramine (n=8), or fluoxetine (n=6)-treated animals. METHODS: Right and left cortical and hippocampal electrodes were placed in 10-15 day old Sprague-Dawley rats. The following day 2 hour video EEG recordings were done to monitor sleep induced by intraperitoneal injection of saline, imipramine (10mg/kg), or fluoxetine (10mg/kg) after getting a baseline EEG during 30 minutes. And data were analyzed using t-test. RESULTS: 1) Following intraperitoneal injection of saline, imipramine, or fluoxetine, there were no epileptiform features or changes in the EEG except for a difference in sleep cycling. 2) The percent of average time spent asleep was significantly greater for control (87.8%) and fluoxetine-treated animals (92%) compared to imipramine-treated animals (66.1 %) (p<0.005). 3) The average frequency of REM sleep was 11.2 in control, 0.1 in imipramine-treated animals, and 8.7 in fluoxetine-treated animals, respectively during the 2 hours. And the frequency of REM sleep was significantly less for imipramine-treated animals compared to control (p<0.002). 4) Control animals (41.2%) spent significantly less time in NREM sleep compared to imipramine (98.8%)- and fluoxetine (93%)-treated animals (p<0.0001) and significantly more time (58.8%) in REM sleep compared to both imipramine (1.2%)- and fluoxetine (7%) treated animals (p<0.0001). CONCLUSION: We confirmed that postnatal 10-15 day old rats spent more time in REM sleep than NREM sleep, and acute administration of imipramine or fluoxetine increased NREM sleep by decreasing the frequency and the duration of REM sleep by 5-HT reuptake inhibition in the brain.
Animals ; Brain ; Electrodes ; Electroencephalography ; Fluoxetine* ; Imipramine* ; Injections, Intraperitoneal ; Rats* ; Rats, Sprague-Dawley ; Serotonin ; Sleep, REM

PURPOSE: Febrile convulsion is a common clinical problem affecting 2-4 percent of children. The recurrence rate of FC is a approximately 33-50%. To identify factors influencing the recurrences of febrile convulsions, we investigated the risk factors, especially the relationship between the degree of pyrexia at the initial febrile seizure and the likelihood of subsequent febrile fits. METHODS: During the 24 months, we reviewed the children who presented their first febrile convulsion. All were admitted to the hospital for investigation and treatment. The study group compromised 136 children. A febrile convulsion was defined as a generalized convulsion that occurred within 15 minutes in a child aged 6 months to 5 years who had no pre-existing evidence of neurological abnormalities. The children were divided into three groups according to the severity of the fever recorded on presentation to hospital. Group I had temperatures higher than 39.5degrees C, group II, 38.5-39.4degrees C, and group III lower than 38.4degrees C. RESULTS: 1) 17 (40.5%) children had recurrences with a positive family history in first-degree relatives, 12 (60.0%) of febrile convulsions, 3 (42.9%) of epilepsy and 2 (66.7%) of febrile convulsions and epilepsy.2) In group I, three (15.8%) infants aged 6-18 months and two (13.3%) aged 19-30 months had recurrences of febrile convulsions. In group II, 13 (36.1%) infants aged 6-18 months and 5 (23.8%) aged 19-30 months had recurrences of febrile convulsions. In group III, 10 (41.7%) infants aged 6-18 months and 6 (46.2%) aged 19-30 months had recurrences of febrile convulsions.3) The overall recurrence after the initial febrile convulsion was 22 (52.4%) children by 6 months, 34 (81.0%) children by 12 months, 39 (92.9%) children by 18 months, and 42(100%) by 24 months.4) Fifteen (42.9%) had the recurrences between 6 and 12 months of age at initial febrile convulsion, 21(27.6%) between 13 and 24 months, and 4 (18.2%) between 25 and 36 months. CONCLUSION: Early age at onset of first febrile convulsion, a history of febrile convulsions in first-degree relatives were associated with an increased risk of recurrent febrile convulsions. Especially children with the lower degree of pyrexia at the time of the initial convulsion were more susceptible to recurrent convulsions than those with higher levels of pyrexia.
Child ; Epilepsy ; Fever* ; Humans ; Infant ; Recurrence* ; Risk Factors ; Seizures ; Seizures, Febrile*

PURPOSE: In order to elucidate the actual mechanism and the optimal concentration of Lamotrigine(LTG) that suppresses epileptiform discharges, we observed epileptiform discharges from hippocampal slices of immature rat in 4-aminopyridine(4-AP) added Mg2+ - free medium of artificial cerebrospinal fluid(aCSF) with various LTG concentrations. METHODS: We divided 19-23 day-old Sprague-Dawley rats into 4 groups; control group(n=12) and 3 LTG groups depending on the concentrations of LTG such as 400 (n=9), 800(n=7), and 1,000(n=8) microM. The rats were anesthetized and their brains were taken, soaked in aCSF(NaCl 125 mM, KCl 2.5 mM, NaH2PO4 2 mM, MgSO4 1.25 mM NaHCO3 25 mM, CaCl2 2 mM, Glucose 10 mM, pH 7.3-7.4). And then the brains were cut into 400 microm hippocampal slices by a vibratome. The slices of control group were soaked in 200 microM 4-AP added Mg2+ -free medium of aCSF for 1 hour, and then extracellular recordings were performed in hippocampal CA1 pyramidal region. The slices of LTG groups were soaked in the solution containing 400, 800, and 1,000 microM LTG, then extracellular recordings were performed. RESULTS: Interictal discharges were observed in all the control and the LTG groups. The latency to the first interictal discharges after 4-AP addition was 52.7+/-26.9 sec in control group, but was 225.0+/-28.2 sec in 800 microM and 322.1+/-116.4 sec in 1,000 microM group of LTG(P<0.05). The duration of interictal discharges was 64.6+/-35.6 sec in control group, but was the shortest in 800 microM group of LTG at 39.3+/-12.6 sec. Ictal discharges were observed in all of control and 400 microM group, but the frequency was decreased as the concentration of LTG increases, 57.1% in 800 microM, 12.5% in 1,000 microM group. The latency to ictal discharge after 4-AP addition was 142.1+/-52.6 sec in control group, but increased as the concentration of LTG increases, 304.4+/-84.5 sec in 400 microM group and 689.8+/-213.1 sec in 800 microM group(P<0.05). The duration of ictal discharges was 1,534.7/-339.3 sec in control group, but decreased as the concentration of LTG increases, it was 126.5+/-76.1 sec in 800 microM group(P <0.05) and 42 sec in 1,000 microM group. CONCLUSION: The antiepileptic effects of LTG were most significant when the concentration, inhibiting epileptiform discharges induced by 4-AP and Mg2+ -free medium in hippocampal slices of immature rats, was 800 microM or higher. Although the basic pharmacologic mechanism of LTG is the inhibition of sodium channel, it may also work on potassium channel at higher concentrations.
4-Aminopyridine* ; Animals ; Brain ; Glucose ; Hydrogen-Ion Concentration ; Potassium Channels ; Rats* ; Rats, Sprague-Dawley ; Sodium Channels

Segmental Spinal Instrumentation is effective operative procedure in unstable fracture and fracture-dislocation of the thoracolumbar spine, providing rigid spinal stability and reduces needs of external support and complications. Fifty nine patients with unstable fracture and fracture-dislocation of thoracolumbar spine were treated with Harrington rod instrumentation and sublaminar wiring(31 patients) and Luque rod instrumentation with sublaminar wiring(28 patients) in Hyun Dai Hae Seong Hospital, Ulsan, Paik Hospital, Pusan from Dec. 1983 to April 1986. We have analyzed the results of treatment about two type of S.S.I. and obtained following conclusions; l. In 59 patients, T12 level injury was 17 cases, Ll level was 25 cases and so T12 and Ll involvement were 71%. 2. By Francis Denis classification, 28 cases were burst type fracture, 20 cases were fracture-dislocation type, 6 cases were seat belt type and 5 cases were wedge compression type. 3. In Harrington rod with S.S.I., initial kyphotic angle was 22.4° and postoperative angle was 7.4° and correction rate was 66.9%; in Luque rod with S.S.I., preoperative kyphotic angle was 21.7° and postoperative angle was 6.5° and correction rate 69.6%. So there was no difference of correction rate in two type of S.S.I. 4. In Harrington rod with S.S.I., the loss of reduction was 1.2° and the loss was 7%; in Luque rod with S.S.I., the loss of reduction was 7.2° and the loss rate was 48%. So the loss of reduction of Luque rod with S.S.I. was greater than that of Harrington rod with S.S.I. 5. After removal of implants, Luque rod with S.S.I. patients have better range of motion than Harrington rod with S.S.I. patients clinically, but it needs more follow-up because of a few cases(18 cases).
Busan ; Classification ; Follow-Up Studies ; Humans ; Range of Motion, Articular ; Seat Belts ; Spine ; Surgical Procedures, Operative ; Ulsan

Most obviuos will be the several anatomic differences between the proximal femur of the child and the adult. Fractures of the femoral neck in the children are extremely rsre and usually are the result of severe trauma in 80% of the cases. This accounts for the high frequency of serious associated injuries. In this injury the vascular anatomy changing with age, continuing growth potential and the effect of deforming forces play critical roles in high complication rate and these make treatment difficult. But still any secure guidelines for the treatment of this injury are not established and this is a field which requires more active research and further progress in future. 26 cases treated at Paik Hospital from Jan. 1979 to June 1988 were analyzed in clinical and radiological aspect and the following results were obtained. 1. The commonest type was Cervicotrochanteric fracture in 13 cases(50%),displaced one 21 cases. 2. In Transepiphyseal, Transcervical and Cervicotrochanteric fracture by early reduction and internal fixation, and in Intertrochanteric fracture by conservative treatment we gained satisfactory results. 3. We experienced 2 cases of coxa vara in nonthreaded pin used cases, 4 cases of premature epiphseal closure and 4 cases of avascular necrosis in threaded pin used ones. 4. Complications were developed in 13 cases (50%). These were 5 cases of coxa vara(19.2%) 4 cases of premature epiphyseal closure (15.4%) and 4 cases of avascul necrosis (15.4%). 5. Avascykar necrosis was developed in displaced fracture of Transcervical or Cervico- trochanteric fracture beyond postoperative 1 year. So. we recommend periodic long follow up for evaluation of avascular necrosis.
Adult ; Child ; Clinical Study ; Coxa Vara ; Femur ; Femur Neck ; Follow-Up Studies ; Hip ; Humans ; Necrosis

Flexor tendon grafting is a well-proved procedure for the restoration of tendon defects in the hand. The results are not entirely predictable, it offers a good expectation of successful outcome. Authors have performed the tendon graft in thirteen cases of flexor tendon injury of the hand during the period from September '79 to January '82 and evaluated the results. The followings were the results obtained. 1. Male was eleven, female was two. Age distribution is from 4 to 38 years. 2. Injured fingers were thumb 6, index 2, middle finger 4 and little finger 1 cases. The site of the primary injury was on area of Bunnell's Zone II in all cases. 3. Time interval from tendon injury to flexor tendon graft was 6 weeks to 19 months (average 5.6 months). 4. The results of tendon grafts rated as excellent 2 cases and good 3 cases in preoperative Good group; excellent 1, good 3 and fair 1 in “Scar” group; fair 1 and 1 poor in “Joint” group; fair 1 in “Salvage” group. In the thumbs, the results were better than in the fingers. 5. Degrading the postoperative results were flexion contracture in 3 cases, lack of flexion ROM in 2 cases and bowstringing in 2 cases. 6. Pinch power of the finger where tendon graft was performed was 52% of that of the opposite healthy finger. 7. As complication, bowstringing was observed in 2 cases and recurvatum deformity of the PIP joint in one case.
Age Distribution ; Congenital Abnormalities ; Contracture ; Female ; Fingers ; Hand ; Humans ; Joints ; Male ; Tendon Injuries ; Tendons ; Thumb ; Transplants

Miller-Dieter syndrome consists of severe type I lissencephaly, abnormal facial appearance, and sometimes other birth defects. Lissencephaly is a brain malformation manifested by a smooth cerebral surface, thickened cortical mantle, and microscopic evidence of incomplete neuronal migration. It comprises the agyria-pachygyria spectrum of malformation, thus excluding polymicrogyria and other cortical dysplasia. Type I lissencephaly results from abnormal migration between about 10 and 14 weeks gestaion. The brain is often small, and the ventricle is enlarged posteriorly The corpus callosum may be small or absent. The structural pattern of the cerebral hemispheres and ventricles is distintly immature, reminiscent of fetal brain. The superficial cellular layer resembles an immature cortex, with some separation into zones similar to layers III, V, and VI of normal cortex, although the cell population is decreased. In 1963 Miller described a malformation syndrome in a brother and sister with postnatal growth deficiency, craniofacial defects, and serious abnormalities of neurologic function. Autopsy at 3 and 4month of age, respectively, revealed lissencephaly. Subsequently, Dieker reported four additional patients with this disorder and referred to it as the 'lissencephaly syndrome'. We have experienced a case with this syndrome. Then we report this rare case with brief review of literature.
Autopsy ; Brain ; Cerebrum ; Congenital Abnormalities ; Corpus Callosum ; Humans ; Lissencephaly ; Malformations of Cortical Development ; Neurons ; Siblings

No abstract available.
Fetal Macrosomia*