A 46-year-old male patient had recurrent episodes of generalized pruritic wheals during hemodialysis. He has experienced urticaria during hemodialysis whenever he used a capillary dialyser sterilized by ethylene oxide(EO, Polysulfone-) gas which is used to sterilize hemodialysers and other medical equipment. On the other hand, capillary dialyser sterilized by Gamma ray (Hemophad) has not evoked urticaria. Although the presence of EO-specific antibodies was not detected, urticarial rash never developed when the equipment was switched to a gamma-sterilized one. We herein report a case referred to ethylene oxide induced cutaneous hypersensitivity during hemodialysis.
Antibodies ; Capillaries ; Ethylene Oxide ; Exanthema ; Gamma Rays ; Hand ; Humans ; Hypersensitivity* ; Kidneys, Artificial ; Male ; Middle Aged ; Renal Dialysis* ; Urticaria

BACKGROUND: The human sebaceous glands have long been known to change their activity with aging. Downing and his co-workers state that the ratio of wax ester/cholesterol+cholesterol ester in the skin surface lipids might be a good index for sebaceous gland acti ity. OBJECTIVE: Our purpose was to evaluate the effects of aging on the sebaceous gland activity and relative skin surface lipid composition by using thin layer chromatography. METHOD: Skin surface lipids of anterior chest from 65 healthy Korean indivisuals were collected by using the cup method. Skin surface lipid were separated and meaurd by thin layer chromatographic analysis. RESULTS: The sebaceous gland activity, vrhich was expressed by tlie ratio wax ester/[cholesterol+cholesterol ester] showed a ilistinct change from infancy to senescenc. The curve of the ratio makes a peak in the third decade and decreases with advancing age. CONCLUSION: This result disclosed that sebaceous gland activity iaifected by advancing age in Koreans and can be used as one of the biologic markers of aging.
Aging* ; Biomarkers ; Chromatography, Thin Layer ; Humans ; Sebaceous Glands* ; Skin* ; Thorax

Erythroplasia of Queyrat is an uncommon form of carcinoma in situ involving the glans penis and adjacent mucosal structures. Treatment modalities of Erythroplasia of Queyrat vary widely and topical 5-fluorouracil treatment is very effective and regarded as the choice of t eatment. This article reports a case of erythroplasia of Queyrat involving the perimeatal region of the glans penis and identifies the difficulty of effectively treating erythroplasia of Queyrat which is adjaer to the urethral meatus with 5-fluorouracil and usefulness of electron beam irradiation therapy.
Carcinoma in Situ ; Erythroplasia* ; Fluorouracil ; Male ; Penis*

Idiopathic midline destructive disease(IMDD) is a subgroup of midline granuloma syndrome, which is a clinical entity characterized by a relentless uilcer ation of the upper air way involving the nose, the palate, and the face, with a fatal outcorne. A 32 year-old male had symptoms of nasal obstruct.ion and rhinorrhea for about 4 months prior to visiting the hospital ad was referred to our Department for evaluation of a verely destruct.ive skin lesions on his face. The patient, revealed unique clinopatholcgic featurs compat with IMDD. These were : 1) prescence of locally destructive lesion which were restricted to the upper respiratory tract. 2) abscence of systemic disease durin the follow up peroid, 3) The histologic features consisted of acute and chronic inflarnmation with a variable dearel of necrosis on the examination of repeated biopsy specimens, 4) inabiliy to demonst rate an infectious causative organisms on repeated laboratory tests.
Adult ; Biopsy ; Follow-Up Studies ; Granuloma* ; Humans ; Male ; Necrosis ; Nose ; Palate ; Respiratory System ; Skin

The malignant fibrous histiocytoma is a predominantly pleomorphic arcoma usually occuring in the deep soft tissue of adults. Because of its highly variable morphologic pattern, this tumor has often been confused with other sarcomas such as pleomorphic rhabdomyosarcoma and liposarcoma. Although the histogenesis of this neoplasm remains controversial, it is best regarded as a primitive and pleomorphic nature reflected by collagen production and occasional phagocytosis. As report a case of malignant fibrous histiocytoma occurring in a 54-year-old female who presented with 4.5 x 5 x 0.5cm sized mass on the right thigh and metastasis later. Histopathologic findings shows plamp spindle cells appearing in a storiform-pleomorphic pattern around slitlike vessels. Immunohistochemical staining and electron microscopic findings led to the final diagnosis as malignant fibrous histiocytoma. The treatment was surgical excision.
Adult ; Collagen ; Diagnosis ; Female ; Histiocytoma, Malignant Fibrous* ; Humans ; Liposarcoma ; Middle Aged ; Neoplasm Metastasis ; Phagocytosis ; Rhabdomyosarcoma ; Sarcoma ; Thigh

PURPOSE: The purpose of this paper was to evaluate the treatment results according to bone union, union time, and complications, including infection of unreamed nailing of tibial fractures between closed and open fractures. MATERIALS AND METHODS: We reviewed 64 tibial shaft fractures that were treated with unreamed tibial nail. These included 42 closed fractures and 22 open fractures. RESULTS: Average union time of closed fractures was 19.8 weeks and that of open fractures was 20.2 weeks, nonunion rate were 4/42 and 3/22 in closed and open fractures. Average union time were 19.2, 20.4, 21.3 weeks in open grade I, II, llla fractures. According to the type of fractures, average union time were 18.5, 20.2, 24.6 weeks and nonunion rate were 2/29, 3/26, 2/9 in type A, B, C fractures. According to the level of fractures, average union time were 20.0, 20.3, 19.4 weeks and nonunion rate were 1/5, 4/37, 2/22 in proximal, middle, and distal fractures. There was no significant differences in average period of radiologic union, infection rate and nonunion rate between closed and open fracture group, but longer union time and higher nonunion rate in complex and comminuted fractures (P<0.05). CONCLUSIONS: We consider unreamed intramedullary nailing in the tibial shaft fractures as a good treatment modality for closed and open grade I, II, IIIa fractures
Fracture Fixation, Intramedullary ; Fractures, Closed ; Fractures, Comminuted ; Fractures, Open ; Tibial Fractures*

Hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber disease, is an autosomal dominant hereditary disorder leading to easily bleeding telangiectases on skin and mucosal surfaces, and it is associated with the presence of arteriovenous malformations in multiple organ systems. It is usually recognized as classic triad of telangiectasia, recurrent epistaxis and a family history of the disorder. We report herein a case of hereditary hemorrhagic telangiectasia in a 12-year-old male who had episodes of recurrent epistaxis and compatible telangiectatic skin lesion. And his grandfather, father, uncle and cousin also had similar punctiform, linear and spider-like telangiectatic lesions.
Arteriovenous Malformations ; Child ; Epistaxis ; Fathers ; Hemorrhage ; Humans ; Male ; Skin ; Telangiectasia, Hereditary Hemorrhagic* ; Telangiectasis

A 7-year-old female was presentd with two black papules and linear pigmentation between papules on the vulva. No other abnormalities were found in her personal and family history. Histopathological examination was consistent with the apocrine hidrocystoma and the pigment in the luminal cells was iron negative and Fontana Masson positive, confirming its melanin nature. We herein report a 7-year-old female patient with pigmented apocrine hidrocystoma occuring on the vulva with the evidence of melanin as the underlying mechanism of the pigmentation.
Child ; Female ; Hidrocystoma* ; Humans ; Iron ; Melanins ; Phenobarbital ; Pigmentation ; Vulva*

Pemphigus foliaceus is a rare, relatively mild and chronic variety of pemphigus which is characterized by superficial flaccid bullae which show acantholytic changes in the upper part of the epidermis histopathologically. Present case is a 40-year-old female with a 2 month history of yellowish colored verrucous plaques on the whole scalp. 6 years ago, she had been admitted to our hospital because of nearly generalized erythematous eroded patches, crusted plaques and bullae and diagnosed as pemphigus foliaceus and treated with corticosteroid and methotrexate. 2 months ago, an additional lesion was found on the scalp, where yellowish colored, verrucous surfaced plaques were observed. Histologic examination on the verrucous plaque showed hyperkeratosis, acanthosis and papillomatosis with acantholysis in the granular layer, leading to a subcorneal blister and dyskeratotic granular keratinocytes were seen within the blister. On the basis of clinicopathologic examination we diagnosed as pemphigus foliaceus and then we treated her with prednisolone and the skin lesion had subsided 7 months later. We report a patient of pemphigus foliaceus who was presented with verrucous surfaced plaque, which clinically mimicked pemphigus vegetans.
Acantholysis ; Adult ; Blister ; Cytochrome P-450 CYP1A1 ; Epidermis ; Female ; Humans ; Keratinocytes ; Methotrexate ; Papilloma ; Pemphigus* ; Prednisolone ; Scalp ; Skin

Neurofibromatosis(NF) is a heterogeneous disorder clinically characterized by the presence of neurofibromas, multiple caf au lait spots, intertriginous freckles and Lisch nodules. It is usually expressed as a generalized form, but is rarely localized in a limited part of the body as a segmental form. In 1982, Riccardi classified NF into 8 types and in a segmental NF(type V) the cutaneous lesions are limited to a single body segment, often in a unilateral, dermatomal disposition. We report a 45-year-old Korean woman who presented with several grouped soft, fresh red colored papules and nodules on the left side of the neck(left C2, C3 dermatomes). There were no caf -au-lait spots, axillary freckles, Lisch nodules or family history. A biopsy specimen of cutaneou nodules showed circumscribed non-encapsulated tumor of the dermis was composed of loosely spaced spindle cells with elongated, wavy nuclei and thin, wavy collagenous strands. On the basis of clinicopathologic examination we diagnosed as segmental NF.
Biopsy ; Collagen ; Dermis ; Female ; Humans ; Melanosis ; Middle Aged ; Neurofibromatoses*