The clinicopathological study was performed on 80 patients with urinary bladder tumor between 1973 and 1983. The histopathological survey was carried out using preserved tumor specimen slide on the retrospective fashion, that included the growth pattern and vessel invasion. The results were as follows : 1. The tumor histology were papillary and nonpapillary in 70 %, and 30 %, respectively in growth pattern and 74 transitional cell carcinoma(TCC), 3 squamous cell carcinoma(SCC), 2 adenocarcinoma (AC) and 1 mucoepithermoid carcinoma in cell type. 2. The Fade of TCC, Go, G1. G2 and G3 were 1.4%, 36.5%, 39.2% and 22.9% respectively, and the stage of those, in which superficial tumors(pTis-pT1) and invasive tumors( pT2-pT4) were 57.0% and 30.8% respectively. The histopathological mode of local spread was to have strands, nests and individual cells in about one sixth, lymphatic invasion in about one third and venous invasion in about one fifth. 3. The intramural hispathological mode of local spread (INF alpha,beta, and alpha), lymphatic invasion ( lyo, 1 and 2) and venous invasion were highly significant with respect to the hispathological grade and stage, and also within mutual relationship on the other hand.
Adenocarcinoma ; Hand ; Humans ; Retrospective Studies ; Urinary Bladder Neoplasms ; Urinary Bladder*

To determine the concentration and the physiologic role of metal components in blood plasma and seminal plasma in relation to male infertility, the concentrations of twelve metal components in blood plasma and seminal plasma including Na, Mg, K, Ca, Cr, Mn, Fe, Cu, Zn, Se, Cd and Pb were measured by atomic absorbance spectrophotometery or ion selective electrode analysis. Semen and blood samples were obtained from a total of 110 men including 70 male infertility patients, 20 vasectomized persons and 20 fertility proven volunteers visited to the Male Infertility Clinic of Pusan National University Hospital. The concentrations of Ca, Zn, Mg, Cr and Cd in control group were higher in seminal plasma than in blood plasma, and additionally Pb were higher in infertility group. The concentrations of all metal components revealed no significant difference according to patients' age, resident, occupation, sperm density, motility and hormone level in blood plasma, but some metal components including Ca, Mg, Cu, Mn, Cd and Pb revealed a significant difference according to each these parameters except patient's age in seminal plasma. The concentrations of Mn, Cd and Pb in the vasectomy persons were higher than in the infertility group III including testicular and epididymal factors, but not in blood plasma. We conclude that the quantitative changes of metal components in the seminal plasma may have effects on not only spermatogenesis and sperm function, but also contribute to diagnostic parameter according to organ specificity of the metal in the male reproduction.
Busan ; Electrodes ; Fertility ; Humans ; Infertility ; Infertility, Male ; Male* ; Occupations ; Organ Specificity ; Plasma ; Reproduction ; Semen* ; Spermatogenesis ; Spermatozoa ; Vasectomy ; Volunteers

Female pseudohermaphrodities are 46XX genetic females with normal Mullerian derivatives, but have various degrees of ambiguous external genitalia. While most of them are commonly associated with adrenogenital syndrome, some of them have been occasionally associated with maternal ingestion of testosterone or synthetic progestational agent, maternal virilizing tumor or rarely idiopathic. Herein, we present three cases of female pseudohermaphroditism which is unrelated with adrenogenital syndrome. One case is resulted from maternal ingestion of progestational agent during the first trimester of pregnancy, and the other idiopathic.
46, XX Disorders of Sex Development* ; Adrenogenital Syndrome ; Eating ; Female* ; Genitalia ; Humans ; Pregnancy ; Pregnancy Trimester, First ; Testosterone

A group of the 59 patients (64 kidneys) of renal calculi, operated at our hospital in the past a half and four years from 1976 Jun. to 1980 May, was investigated statistically. 1. In the 64 operations there were 2 nephrectomies (3.1per cent), 12 pyelolithotomies (18.8 percent), 4 nephrolithotomies (6.3 per cent), 16 extended pyelolithotomies (25.0 per cent), 19 extended pyelolithotomies combined with local nephrolithotomies (29.7 per cent), 5 partial nephrectomies (7.8 per cent), and 6 lower pole pyelocalycotomies (9.4 per cent). From our experience the choice of surgery staghorn or multiple stone was indicated lower surgery is the treatment of choice most of the patients and nephrectomy was performed only in a small group. 2. In 62 conservative operations for renal calculi, residual calculi were observed in 6 kidneys (9.7 per cent). 3. In postoperative course, hematuria was discontinued within 3 days. Urine leakage also disappeared within 3 days in pyelolithotomy with closure of renal pelvis, but within 5 days in extended pyelolithotomy without closure of renal pelvis. In some cases, postoperative urinary tract infection was perpetuated by residual stone and preoperative infection.
Calculi ; Hematuria ; Humans ; Kidney ; Kidney Calculi* ; Kidney Pelvis ; Nephrectomy ; Urinary Tract Infections

We studied the usefulness of prostate specific antigen (PSA) as well as prostatic acid phosphatase (PAP) as marker of prostatic cancer in twelve cases of advanced prostatic cancer including 4 or stage C and 8 of stage D, 50 cases of benign prostatic hyperplasia (BPH) and 50 cases of nonprostatic diseases as normal control. The positive rates of PSA were 100% for prostatic cancer, 20% for BPH and O% for nonprostatic diseases, and those of PAP were 75% for prostate cancer, 8% for BPH and 2% for nonprostatic diseases. These results indicated hat PSA is more sensitive than PAP but less specific than PAP in diagnosis of prostatic cancer. Serum PSP level was correlated with the weight of prostate in BPH patients. Serum PSA level determined during the follow-up after endocrine therapy for prostatic cancer reflected the clinical course of the patients. Because of its relatively low specificity, PSA alone may not be useful for early diagnosis of prostatic cancer. If in combination with other diagnostic modalities, it may be useful in early diagnosis and therapeutic monitoring of prostatic cancer within restricted limits.
Acid Phosphatase ; Diagnosis ; Early Diagnosis ; Follow-Up Studies ; Humans ; Prostate* ; Prostate-Specific Antigen* ; Prostatic Hyperplasia ; Prostatic Neoplasms ; Sensitivity and Specificity

No abstract available.
Cyclic GMP* ; Cytomegalovirus* ; Gene Expression* ; Humans*

To investigate tumor heterogeneity and the relationship between DNA ploidy and histopathological parameters. flow cytometric assessments were performed on fifteen control bladders and 77 transitional cell carcinomas of bladder confirmed histopathologically. Between August 1984 and July 1990 in Pusan National University Hospital. 31 TUR surgeries and 46 total cystectomies were done and are included in this series. The cystectomized specimens were topographically evaluated with bladder mapping method ; 146 multiple formalin-fixed paraffin-embedded blocks (1-6 blocks with s mean of 3.0) were selected from the histologically different sites including main exophytic mass. concomitant carcinoma in situ. and neighboring normal bladder epithelium. Thirty one TUR blocks (one per case) with histopathological reviews were selected. The results were as follows 1. Flow cytometry positive rates revealed 58.1% in the TUR group and 76.1% in the cystecbmy group 2. Flow cytometry positive rates according to histopathological stage revealed 43.8% and 73.3% of Ta and T1. respectively, in the TUR group, so that in T1 the positive rate is nearly twice that of Ta. Flow cytometry positive rates revealed 100.0%, 70.0%. 100.0%, 66.6% and 77.8% of Tis. T1. T2. T3 and T4, respectively. in the cystectomy group, so that no significant differences were observed between each T-category.3. Flow cytometry positive rates according to histopathological grade revealed 38.5%, 70.6% and 100.0% or grade I, II and III in the TUR group. and O%, 68.0% and 90.0% in the cystectomy group. respectively. So positive rates proportionally increased with up-grading in both TUR end cystectomy groups. 4. Intratumoral ploidy heterogeneity of main exophytic mass in the cystectomy group was in 58.3%, and intertumoral ploidy heterogeneity between main exophytic mass and concomitant carcinoma in situ was 51.7%. 5. DNA ploidy assessment of nontumorous mucosa was thought to provide valuable information for the comprehension of natural history in bladder cancer. 6. DNA ploidy had a significant relationship with the recurrence rates in the TUR group, but was not correlated with the survival rates in contrast to grade and stage in the cystectomy group.According to the above results, we thought that flow cytometric DNA assessment was valuable in evaluating the multicentricity in origin with heterogeneity and to predict the malignant potential as an adjunct of the histopathological factors in bladder cancer.
Busan ; Carcinoma in Situ ; Carcinoma, Transitional Cell ; Comprehension ; Cystectomy ; DNA* ; Epithelium ; Flow Cytometry ; Mucous Membrane ; Natural History ; Ploidies ; Population Characteristics ; Recurrence ; Survival Rate ; Urinary Bladder Neoplasms* ; Urinary Bladder*

Testicular biopsy to have been utilized as a diagnostic tool in male infertility were underwent experimentally to observe the effects on the morphology and the physiology of post-biopsied testis of 17 male rabbits. Bilateral orchiectomy was done at third day, 1st week, 2nd week and 4th week after open testicular biopsy, and biopsied testes were compared with contralateral control in histopathological views. The results were summarized as follows : 1. In seminiferous tubules of sham-operated tests, there was no significant pathologic changes. 2. The inflammatory reaction was most severe at third day after biopsy and completely disappeared at 4th week. 3. Increased thickness of tunica albuginea and fibrotic reaction were observed near the biopsy site. 4. Spermatogenesis did not only decrease near the biopsy site with atrophy of the seminiferous tubules but also mildly decreased on the far area, that all began to recover at 4th week. 5. No evidence of immunologic reaction and hyperplasia of Leydig cell were demonstrated. It was suggested that testicular injury after biopsy was developed by interference of local blood flow, obstruction of seminiferous tubules and inflammatory reaction, so that could be minimized by application of open testicular biopsy only to definitively indicated cases.
Atrophy ; Biopsy* ; Humans ; Hyperplasia ; Infertility, Male ; Male ; Orchiectomy ; Physiology ; Rabbits ; Seminiferous Tubules ; Spermatogenesis ; Testis*

No abstract available.
Guillain-Barre Syndrome* ; Pregnancy*

Successful removal of staghorn and multiple renal calculi has been one of the mist difficult tasks that confront the urologists. The operative method for removal of the renal calculi was selected according to the size, number, location and anatomic features of the renal collecting system. We utilized the coagulum to improve the success of the stone removal for last five months. The coagulum material were mixed in a ratio of 5ml cryoprecipitate or 4% fibrinogen: 1ml 20 unit /ml human thrombin:0.2ml 10% calcium chloride. The results were as follows. 1. The patients were provided by 3 coagulum pyelolithotomy and 6 coagulum nephrolithotomy, of which utilized cryoprecipitate in 7 cases and 4% fibrinogen in 2 for the fibrinogen source. 2. The seven of nine cases(78.2%) were successfully removed without residual stone, but incompletely in two cases(22.2%). 3. Nondemonstrable stone of the preliminary film were removed additionally in one cases(11.1%). 4. As to the complication, meaningless wound infection and dehiscence was observed in only one case. On basis of our experiences, present here a histologic perspectives, methods, cases and its results, in dication and contraindication for coagulum pyelolithotomy and nephrolithotomy.
Calcium Chloride ; Fibrinogen ; Humans ; Kidney Calculi ; Wound Infection