No abstract available.
Osteotomy* ; Prognathism* ; Recurrence*

No abstract available.
Mandible* ; Osteoblastoma*

No abstract available.
Mandible* ; Osteoblastoma*

PURPOSE: Fibrous dysplasia (FD) is a fibro-osseous disease associated with activating missense mutations of the gene encoding the alpha-subunit of stimulatory G protein. FD may affect a single bone (called monostotic form) or multiple bones (called polyostotic form). The extent of lesions reflects the onset time of mutation. In this study, cells from monostotic FD in maxilla of a patient were isolated and cultured in vitro for characterization. MATERIALS AND METHODS: The single cells were released from FD lesion which was surgical specimen from 15 years-old boy. These isolated cells were cultured in vitro and tested their proliferation activity with MTT assay. In osteogenic media, these cells underwent differentiation process comparing with its normal counterpart i.e. bone marrow stromal cells. The proliferated FD cells were detached and transplanted into the dordsal pocket of nude mouse and harvested in 6 weeks and 12 weeks. RESULTS AND SUMMARY: FD cells have an increased proliferation rate and poor differentiation. As a result, cells isolated from FD lesion decreased differentiation into osteoblast and increased proliferation capacity. MTT assay presented that proliferation rate of FD cells were higher than control. However, the mineral induction capacity of FD was lesser than that of control. Monostotic FD cells make fewer amounts of bone ossicles and most of them are woven bone rather than lamellar bone in vivo transplantation. In transplanted FD cells, hematopoietic marrow were not seen in the marrow space and filled with the organized fibrous tissue. Therefore, they were recapitulated to the original histological features of FD lesion. Collectively, these results indicated that the FD cells were shown that the increased proliferation and decreased differentiation potential. These in vitro and in vivo system can be useful to test FD cell's fate and possible
Animals ; Bone Marrow ; Durapatite ; GTP-Binding Proteins ; Humans ; Maxilla ; Mesenchymal Stromal Cells ; Mice ; Mice, Nude ; Mutation, Missense ; Osteoblasts ; Transplants

PURPOSE: Fibrous dysplasia (FD) is a fibro-osseous disease associated with activating missense mutations of the gene encoding the alpha-subunit of stimulatory G protein. FD may affect a single bone (called monostotic form) or multiple bones (called polyostotic form). The extent of lesions reflects the onset time of mutation. In this study, cells from monostotic FD in maxilla of a patient were isolated and cultured in vitro for characterization. MATERIALS AND METHODS: The single cells were released from FD lesion which was surgical specimen from 15 years-old boy. These isolated cells were cultured in vitro and tested their proliferation activity with MTT assay. In osteogenic media, these cells underwent differentiation process comparing with its normal counterpart i.e. bone marrow stromal cells. The proliferated FD cells were detached and transplanted into the dordsal pocket of nude mouse and harvested in 6 weeks and 12 weeks. RESULTS AND SUMMARY: FD cells have an increased proliferation rate and poor differentiation. As a result, cells isolated from FD lesion decreased differentiation into osteoblast and increased proliferation capacity. MTT assay presented that proliferation rate of FD cells were higher than control. However, the mineral induction capacity of FD was lesser than that of control. Monostotic FD cells make fewer amounts of bone ossicles and most of them are woven bone rather than lamellar bone in vivo transplantation. In transplanted FD cells, hematopoietic marrow were not seen in the marrow space and filled with the organized fibrous tissue. Therefore, they were recapitulated to the original histological features of FD lesion. Collectively, these results indicated that the FD cells were shown that the increased proliferation and decreased differentiation potential. These in vitro and in vivo system can be useful to test FD cell's fate and possible
Animals ; Bone Marrow ; Durapatite ; GTP-Binding Proteins ; Humans ; Maxilla ; Mesenchymal Stromal Cells ; Mice ; Mice, Nude ; Mutation, Missense ; Osteoblasts ; Transplants

The factors influencing the relapse and recurrence of skeletal deformity after the orthognathic surgery include various factors such as condylar deviation, the amount of mandibular set-back, stretching force by the soft tissues and muscles around the facial skeleton. The purpose of this report is to recognize and analyze the possible factors of reoperation after orthognathic surgery, due to early relapses. Six patients underwent reoperation after the orthognathic surgeries out of 110 patients from 2006 to 2009 were included in this study. In most cases, clincal signs of the insufficient occlusal stability, anterior open bite, and unilateral shifting of the mandible were founded within 2 weeks postoperatively. Although elastic traction was initiated in every case, inadequate correction made reoperation for these cases inevitable. The chief complaints of five cases were the protruded mandible combined with some degree of asymmetric face and in the other one case, it was asymmetric face only. Various factors were considered as a major cause of post-operative instability such as condylar sagging, counter-clockwise rotation of the mandibular segment, soft tissue tension related with asymmetrical mandibular set-back, preoperatively existing temporomandibular disorder (TMD), poor fabrication of the final wafer, and dual bite tendency of the patients.
Bites and Stings ; Congenital Abnormalities ; Humans ; Mandible ; Muscles ; Open Bite ; Orthognathic Surgery ; Recurrence ; Reoperation ; Skeleton ; Temporomandibular Joint Disorders ; Traction

Background: Surgical ciliated cysts, also known as postoperative maxillary cysts or implantation cysts, occur mainly in the posterior maxilla after radical maxillary sinus surgery; they rarely develop in the mandible. They are thought to occur when the sinonasal epithelium is infiltrated by a surgical instrument during surgery or as a result of transplantation of bone or cartilage with respiratory epithelium attached.Case presentationWe report a case in which a surgical ciliated cyst developed in the anterior part of the mandible, presumably as a result of bimaxillary orthognathic surgery and genioplasty performed 24 years earlier. We then review the few similar cases reported in the literature. Conclusion Surgical ciliated cysts in the mandible are extremely rare, but they could occur after simultaneous surgery on the maxilla and mandible, even decades later. To prevent surgical ciliated cysts in the mandible, we recommend that the surgical instruments, especially the saw blade used during bimaxillary surgery, be new or cleaned and that previously placed plates and screws be removed at an appropriate time.

Objectives: To evaluate changes in bone volume induced by absorbable collagen sponge (ACS) use during maxillary sinus floor elevation and to identify associated factors. Patients and Methods: After elevating the sinus membrane through a crestal approach (CA) or lateral approach (LA), ACS (AteloPlug; Bioland) was inserted, and dental implants were placed simultaneously. Changes in bone volume at 12 months were evaluated by three-dimensional (3D) analyses of cone-beam computed tomography images. Factors including age, sex, smoking status, span, number of ACSs, and perforation were assessed for associations with changes in sinus bone volume using uni- and multivariable analyses based on the generalized estimating equation. Results: Medical records of 108 patients were collected and retrospectively evaluated, with 135 regions of interest defined (CA, 45; LA, 90). The changes in bone volume at the sinus floor were 159.38±134.52 mm 3 and 486.83±253.14 mm 3 in the CA and LA groups, respectively. Bone volume changes in the CA group were significantly affected by the number of ACSs (P<0.001) and perforation of the sinus membrane (P<0.001), whereas bone volume changes in the LA group were significantly affected by the number of ACSs (P=0.001). Conclusion Use of ACS for maxillary sinus elevation resulted in detection of new bone formation in 3D analysis. Clinicians can ensure stable amounts of bone formation by inserting an adequate number of ACSs.

Xanthomas are benign lesions characterized by the aggregation of lipid-laden histiocytes and foamy cells within tissues. Intraosseous xanthomas (IOXs), especially those in the jaw bone, are rare, with only around 50 cases documented. This case report describes an IOX located at an osteotomy site in the mandible during sagittal split ramus osteotomy (SSRO). Preoperative radiographs revealed a heterogenic radiolucent-radiopaque lesion in the right ramus. After meticulous curettage of the lesion, proximal and distal segments were fixed in the semi-rigid plates and screws. At the one-year followup, radiographs showed excellent bony union between proximal and distal segments, with no significant interval change. IOXs rarely occur in the jaw.However, their predilection for the posterior mandible suggests that such lesions can be encountered during orthognathic surgery. This report demonstrates the feasibility of performing SSRO directly through the lesion with concurrent curettage without compromising surgical outcomes. This case will contribute to the limited literature on IOX of the jaw bone and its treatment via SSRO as a feasible surgical option in concomitant orthognathic surgery.

Objectives: To evaluate changes in bone volume induced by absorbable collagen sponge (ACS) use during maxillary sinus floor elevation and to identify associated factors. Patients and Methods: After elevating the sinus membrane through a crestal approach (CA) or lateral approach (LA), ACS (AteloPlug; Bioland) was inserted, and dental implants were placed simultaneously. Changes in bone volume at 12 months were evaluated by three-dimensional (3D) analyses of cone-beam computed tomography images. Factors including age, sex, smoking status, span, number of ACSs, and perforation were assessed for associations with changes in sinus bone volume using uni- and multivariable analyses based on the generalized estimating equation. Results: Medical records of 108 patients were collected and retrospectively evaluated, with 135 regions of interest defined (CA, 45; LA, 90). The changes in bone volume at the sinus floor were 159.38±134.52 mm 3 and 486.83±253.14 mm 3 in the CA and LA groups, respectively. Bone volume changes in the CA group were significantly affected by the number of ACSs (P<0.001) and perforation of the sinus membrane (P<0.001), whereas bone volume changes in the LA group were significantly affected by the number of ACSs (P=0.001). Conclusion Use of ACS for maxillary sinus elevation resulted in detection of new bone formation in 3D analysis. Clinicians can ensure stable amounts of bone formation by inserting an adequate number of ACSs.