No abstract available.
Animals ; Female* ; Gonadotropin-Releasing Hormone* ; Haloperidol* ; Humans ; Rats*

We described here a case of hyperkeratosis of the nipple and areola. A 23-year- old woman had a verrucous thickening and brownish discoloration on her right nipple and areola that had been present for 4 yeare. The only symptom was an intermittent mild itching sensation. The patient had no other additioa.al hyperkeratotic conditians. She was not married and had never had a pregnancy. Riopsy spccimen showed papillomatous elongation of the epidermis and edema, of the underlying papillary eonnective tissue. The epidermis was parakeratotic and hyperpigmented, and showed focal intercellular and intracellular edema. The present case seems to be the nevoid form by the Levy-Franckel classification. The world literature was briefly reviewed.
Classification ; Edema ; Epidermis ; Female ; Humans ; Nipples* ; Pregnancy ; Pruritus ; Sensation

A characteristic dermatosis of infancy and childhood has recently been reported as many names, called juvenile plsntar dermatoais, recurrent juvenile eezema of hands and feet, and atopic winter feet in children. However, the clinicsl and epidemiological features of the published cases are strikingly the same The etiology of the diseaee remains unclear. The role of atopy appears to be highly controversial. We have observed 11 patients with juvenile plantar dermatosis and sumrnarized the results as followa: 1. The disease was found mainly in female children (3 boys, 8 girls) between 1 and 18 years old. Duration of the disease ranged from 1 month to 10 years. 2. The lesions occured or were exacerbated dunng the winter in 9 of them. 3. The disease affected symmetrically on the pressure areas of the feet, mainly the forefeet and toes, the lateral margins of the soles, and the heels. Five of our patients also showed the lesions on the hands simultaneously. 4. We have found a high incidence of atopy among the patients or close relative. Nine patients had a personal history of atopy and 5 gatients also had a history of atopy in the first degree relatives. 5. The serum IgE value increased in one of 6 patients determined. From the above clinical findinge, it is evident that juvenile plantar dermatosis is a true localized atopic dermatitis but also a primary irritant contact derrnatitis to which atopics are prone but which may occur in susceptible non-atopics.
Adolescent ; Child ; Dermatitis, Atopic ; Female ; Foot ; Hand ; Heel ; Humans ; Immunoglobulin E ; Incidence ; Skin Diseases* ; Toes

A case of hereditary papulotranslucent acrokeratoderma, a variant of familiaI punctate keratoderma, is presented. A 20-year-old female patient had a five-year history of persistent, asymptomatic, yellowish-white translucent papules and plaques on the thenar and hypothenar eminences and knuckles of both hands, and on the dorsa of proximal interphalangeal joints of both feet. She also had a vitiligo lesion on the left side of the face of 1.5 years duration. Her elder brother also had similar papular skin lesions on both hands and feet. Histologic section of a papule from the right thenar eminence showed marked hyperkeratosis, hypergranulosis, and acanthosis of the epidermis.
Female ; Humans

Trichorrhexis nodosa is a distinctive response of the hair shaft to physical or chemical trauma, characterized by the development of node-like swelling, through which the shaft readily fractures. We have described here a case of trichorrhexis nodosa with scanning electron microscopic findings. Nodular swelling of the affected hair showed longitudinal fissures and fractures in the cortex with loss of cuticular scales. At the site of fracture, a paintbrush-like effect was seen.
Hair ; Weights and Measures

Superoxide dismutase(SOD), catalase and glutathione peroxidase and the levels of lipid peroxide were assayed in erythrocytes and synovial fluid isolated from 17 patients with osteoarthritis of the knee joints and 7 with healthy knee joints as a control groups. In the erythrocytes, SOD, catalase and glutathione peroxidase activities were significantly increased in osteoarthritis compared with normal control groups, but the changes of malonyldialdehyde level was not significant. The activity of SOD in synovial fluid was significantly decreased in osteoarthritis compared with normal control groups, but catalase activity was significantly increased in synovial fluid of osteoarthritis. This result suggested that the increament of antioxidant enzymes in erythrocytes were probably due to increased production of oxygen radicals in osteoarthritis. In osteoarthritis, knee joints might be injured more easily by oxygen radicals because of decreased activity of SOD in synovial fluid of osteoarthritis.
Catalase ; Erythrocytes ; Glutathione Peroxidase ; Glutathione ; Humans ; Joints ; Knee Joint ; Knee ; Malondialdehyde ; Osteoarthritis ; Osteoarthritis, Knee ; Reactive Oxygen Species ; Superoxide Dismutase ; Superoxides ; Synovial Fluid

No abstract available.
Animals ; Histamine Release* ; Histamine* ; Mast Cells* ; Rats*

No abstract available.
Animals ; Rats*

No abstract available.
Progeria*

It is generally accepted that ectopic bone should be removed after full maturation. Removal of immature ectopic bone was attempted combined with immidiate postoperative irradiation to suppress its recurrence. The authors report two cases immature heterotropic bone resection around elbow joint followed by 2000 Rad midplane irradiation given in ten fractions over fourteen days. The results obtained are as follows: 1. There was no evidence of recurrence after removal of immature ectopic bone. 2. Improved range of joint motion was observed during 3 months and 6 months posteroperatively.
Elbow Joint ; Joints ; Osteogenesis ; Recurrence