1.A Comparison of Level of the Injury, Sacral Cord Sign and Urodynamic Testing in the Evaluation of the Patients with Spinal Cord Injury.
Byoung Kyu JEON ; Jeong Gu LEE
Korean Journal of Urology 1996;37(9):996-1002
To define if the signs of sacral cord involvement have any predictive values in the behavior of bladder and sphincter function after spinal cord injury, we analysed results of neurologic signs and urodynamic studies from 45 patients with spinal cord injuries. Patients were classified based on the anatomical level (suprasacral vs. infrasacral), and the presence or absence of sacral cord sign (SCS) (bulbocavemous reflex latency time, perineal sense, anal sphincter tone). Urodynamic findings were classified as either detrusor hyperreflexia (DH), detrusor sphincter dyssynergia (DSD), detrusor areflexia (DA) or normal. Results were as follows; 1) Of the 15 suprasacral cord lesioned patients 6 (40%) had DA, of the 30 infrasacral cord lesioned patients 9 (20%) had either DA or DH with DSD. 2) SCS was positive in 16 out of 30 infrasacral, and in 3 out of 15 suprasacral cord lesioned patients. Of the 26 SCS negative patients, suprasacral cord lesioned patients comprised 46%. 3) Of the 30 infrasacral lesioned patients, 21 had DA and 16 had positive SCS. Incidence of positive SCS in the patients with DA was 72%. 4) Incidence of negative SCS with DH or DH+DSD was 100% in suprasacral lesion. But of the 15 suprasacral lesioned patients, 6 had DA and 3 had positive SCS. 5) In all levels of the injury, positive predictive value for the DA in positive SCS was 95%. However, negative predictive value for DA or DA+DSD in negative SCS was only 62%. These results indicate that there were poor correlation between the level of the cord injury and types of urodynamic abnormalities. Also, the correlation of the SCS with anatomical level of the injury was relatively poor. Correlation of the Positive SCS with DA was very significant for both levels of the cord injury; whereas there were poor correlation of the negative SCS with DH or DH+DSD. In conclusion, the positive SCS in itself are thought to be valuable tool in predicting infrasacral lesion and/or detrusor areflexia However, the results of negative SCS may not exclude infrasacral lesion or detrusor areflexia completely. Thus, combination of the sacral cord sign and results of urodynamic evaluation will provide a more precise diagnosis and treatment plan for the patients of spinal cord lesions.
Anal Canal
;
Ataxia
;
Diagnosis
;
Humans
;
Incidence
;
Neurologic Manifestations
;
Reflex
;
Reflex, Abnormal
;
Spinal Cord Injuries*
;
Spinal Cord*
;
Urinary Bladder
;
Urodynamics*
2.Effective Treatment of Suspicious Riehl's Melanosis Using Low Fluence 1,064 nm Q-switched Nd:YAG Laser and 595 nm Pulsed Dye Laser.
Sung Kyu JUNG ; Jae Beom PARK ; Byoung Joon SO ; Jie Hyun JEON ; Hwa Jung RYU ; Il Hwan KIM
Korean Journal of Dermatology 2014;52(8):589-590
No abstract available.
Lasers, Dye*
;
Melanosis*
3.Effect of Steroid on the Development of Cerebral Edema in Experimental Intracerebral Hemorrhage.
Byoung Kon KIM ; Byung Woo YOON ; Beom Seok JEON ; Sang Bok LEE ; Jae Kyu ROH
Journal of the Korean Neurological Association 1999;17(2):279-284
BACKGROUND: Although steroid is one of the most widely used therapeutic measures for brain edema, its effect on brain edema after intracerebral hemorrhage (ICH) remains to be clarified. We performed this study to evaluate the efficacy of high dose methylprednisolone and conventional dose dexamethasone on the development of brain edema after experimental ICH. METHODS: Fifty-four male Sprague-Dawley rats, weighing 350-450 g, were used. ICH was made by stereotaxic injection of autologous arterial blood (0.13ml) into the right caudatoputamen. The animals were divided into three groups (n = 18 each). Group A received intraperitoneal(IP) injection of normal saline at 8-hour interval. Group B received dexamethasone (0.2mg/kg IP 30minutes after blood injection and 0.1mg/kg IP every 8h thereafter). Group C received methylprednisolone (30 mg/kg IP 30 minutes after ICH, 15mg/kg IP at 2 h after initial dose, and every 8h thereafter). We sacrificed the rat after 3 days and the development of brain edema was determined by measuring brain water content. We compared brain water content in each group. RESULTS: Water content of the right hemisphere was slightly lower in the methylprednisolone-treated rats than other groups; mean + S.D. in group A, B, and C was 80.94 + 0.66%, 80.56 + 0.70%, and 80.42 + 0.91%, respectively. However, there was no statistical significance ( p > 0.1) by the ANOVA test. The difference of the mean water contents between the two hemispheres was slightly higher in the saline-treated group than other groups, but without statistical significance ( p > 0.1). CONCLUSION: We could not find any significant reduction of the brain water content in the groups treated with steroid regardless of the doses. Our results do not warrant the popular steroid therapy in patients with ICH.
Animals
;
Brain
;
Brain Edema*
;
Cerebral Hemorrhage*
;
Dexamethasone
;
Humans
;
Male
;
Methylprednisolone
;
Rats
;
Rats, Sprague-Dawley
4.An Immunohistochemical Study on the Human Synoviocytes and Synovial Sarcoma.
Jae Won YOU ; Sang Ho HA ; Sang Hong LEE ; Dong Min SHIN ; Young Bae PYO ; Byoung Ho LEE ; Sang Kyu KIM ; Ho Jong JEON
The Journal of the Korean Orthopaedic Association 1998;33(4):1206-1216
The synovium is lined by a layer of intimal cells which have been classified on ultrastructural criteria into type A and B synoviocytes. The functionally important lining cells of the synovium(type A and B synoviocytes) are the subjects of many study but have presented problems with their characterization and microscopical identification. Synovial sarcoma is a distinct and generally recognized soft tissue tumor that its origin still raises controversy. In this study, 12 cases of nonspecifically proliferative and resting human synoviocytes have been obtained from the synovium of knee and hip joints, and 3 cases of synovial sarcoma which have arisen in the left thigh, left buttock and right inguinal region were examined with light microscopy, immunohistochemical observation, and electron microscopy. In light microscopic level, it was difficult to differentiate the type A synoviocytes from type B synoviocytes morphologically. The reactive type B synoviocytes were positive for the protein of cytoskeleton such as pancytokeratin, CK1, CK8, CEA, and vimentin. The resting type B synoviocytes showed positive reactions for pancytokeratin, CK1, and CK8. The markers for the monocytes/histiocytes(CD15, CD68, lysozyme, Al-AT, Al-ACT) were reactive in resting and reactive type A synoviocytes. Also, MHC class II antigen was reactive in type A synoviocytes. Three cases of primary synovial sarcoma were 2 fibrous monophasic and 1 biphasic. Spindle-shaped cell in fibrous monophasic synovial sarcoma showed reactivity for CK7 and pancytokeratin, and epithelial cells (lining the glands) in biphasic synovial sarcoma were reactive for CK 7, pancytokeratin, EMA, and focally CEA, but only spindle cells reactive for vimentin, By electron microscopy, fibrous monophasic synovial sarcoma showed pseudogland formation with intercellular junctions of paired subplasmalemmal density and discontinuous basal lamina. These results suggest that the reactive type B synoviocytes and synovial sarcoma show an aberrant expression of the vimentin and CEA. The expression of CK on the resting and reactive type B synoviocytes and fibrous monophasic and biphasic synovial sarcomas are different. Type A synoviocytes expressing the MHC class II molecule and monocyte/histiocyte markers suggest a member of the mononuclear phagocytic system. The reasons of the aberrant expression of the intermediate filament, vimentin and oncofetal antigen, and CEA in reactively proliferative type B synoviocytes and synovial sarcoma and the different expression of cytokeratin on the resting, reactive type B synoviocyte and synovial sarcoma should be further evaluated.
Basement Membrane
;
Buttocks
;
Cytoskeleton
;
Epithelial Cells
;
Hip Joint
;
Histocompatibility Antigens Class II
;
Humans*
;
Immunohistochemistry
;
Intercellular Junctions
;
Intermediate Filaments
;
Keratins
;
Knee
;
Microscopy
;
Microscopy, Electron
;
Muramidase
;
Sarcoma, Synovial*
;
Synovial Membrane
;
Thigh
;
Vimentin
5.Erratum: Correction of Acknowledgements
Se Jeong KIM ; Hyo Jeong AHN ; Jung Yeon PARK ; Byoung Jae KIM ; Kyu Ri HWANG ; Taek Sang LEE ; Hye Won JEON ; Sun Min KIM
Obstetrics & Gynecology Science 2018;61(1):175-175
The Acknowledgements was published incorrectly. The authors apologize for any inconvenience that it may have caused.
6.A Clinicopathologic Characteristics and Survival Analysis of 217 Cases of Epithelial Ovarian Cancer.
Eul Ju MOON ; Woo Jin JEON ; Jae Kyu LEE ; Byoung Sun YOUN ; Sang Young RYU ; Jong Hoon KIM ; Byoung Gie KIM ; Sang Yoon PARK ; Eui Don LEE ; Kyung Hee KIM
Korean Journal of Obstetrics and Gynecology 2000;43(9):1604-1610
No abstract available.
Ovarian Neoplasms*
;
Survival Analysis*
7.Decrease in acceptance of genetic amniocentesis after alteration of social conditions toward pregnancy termination.
Byoung Jae KIM ; Kyu Ri HWANG ; Taek Sang LEE ; Hye Won JEON ; Kwang Bum BAI
Korean Journal of Obstetrics and Gynecology 2010;53(12):1085-1091
OBJECTIVE: To investigate the effect of alteration of social conditions towards pregnancy termination on the acceptance of genetic amniocentesis. METHODS: Retrospective review of medical records was conducted for women (<20 weeks' gestation, singleton pregnancy) who visited our outpatient department between February 1, 2009 and August 31, 2010. Acceptance of genetic amniocentesis was compared between two groups of women: one from February 1, 2009 to November 30, 2009 (2009 group) and the other from December 1, 2009 to August 31, 2010 (2010 group) after strict regulation of pregnancy termination. The acceptance rate of those who were referred to our center for genetic amniocentesis in same time period was also evaluated. RESULTS: Overall, 19 of 101 (19%) women in the 2009 group and 10 of 93 (11%) in the 2010 group, opted for invasive diagnostic methods (P=0.16). Women > 35 years in the 2010 group (5/30, 17%) were less likely to accept genetic amniocentesis than 2009 group (15/30, 50%; P=0.01). Similar results were observed in those who were indicated for genetic amniocentesis. (9/35, 26% vs 19/34, 56%; P=0.02). Acceptance rate of genetic amniocentesis was increased for those who were referred from private clinic, but without statistical significance (15/21, 71% vs 13/14, 93%; P=0.20). CONCLUSION: After strict regulation of pregnancy termination, acceptance rate of genetic amniocentesis was significantly decreased among women who had increased risk for chromosomal abnormalities or neural tube defect at our center. Whereas, there were no significant change in acceptance rate for those who were referred for amniocentesis from private clinic.
Abortion, Therapeutic
;
Amniocentesis
;
Chromosome Aberrations
;
Female
;
Humans
;
Medical Records
;
Neural Tube Defects
;
Outpatients
;
Pregnancy
;
Prenatal Diagnosis
;
Retrospective Studies
;
Social Conditions
8.Clinicopathologic Characteristics and Prognosis of Endometrial Cancer : A Study of 100 Cases.
Woo Jin JEON ; Eul Ju MOON ; Sang Young RYU ; Jong Hoon KIM ; Byoung Gie KIM ; Sang Yoon PARK ; Jae Kyu LEE ; Eui Don LEE ; Jong Sung LEE ; Kyung Hee LEE
Korean Journal of Obstetrics and Gynecology 2000;43(9):1616-1623
No abstract available.
Endometrial Neoplasms*
;
Female
;
Prognosis*
9.Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus.
Shin Hee KIM ; In Ah JUNG ; Yeon Jin JEON ; Won Kyoung CHO ; Kyoung Soon CHO ; So Hyun PARK ; Min Ho JUNG ; Byoung Kyu SUH
Annals of Pediatric Endocrinology & Metabolism 2014;19(4):191-196
PURPOSE: We aimed to investigate serum lipid profiles and glycemic control in adolescents and young adults with type 1diabetes mellitus (T1DM). METHODS: This cross-sectional study included 29 Korean young adults and adolescents with T1DM. The median age was 17 years (range, 10-25 years) and 18 (62.1%) were female. We compared the lipid profiles of patients with dyslipidemia and those without dyslipidemia. Correlations between glycosylated hemoglobin (HbA1c) and lipid profiles (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglyceride [TG]) were determined by linear regression analysis. RESULTS: Of the 29 patients with T1DM, 11 (37.9%) were classified as having dyslipidemia due to the following lipid abnormality: TC> or =200 mg/dL in 8 patients, LDL-C> or =130 mg/dL in 4 patients, TG> or =150 mg/dL in 2 patients, and HDL-C< or =35 mg/dL in 2 patients. Compared to patients without dyslipidemia, patients with dyslipidemia were more likely to have higher values of HbA1c (median, 10.6%; range, 7.5%-12.3% vs. median, 8.0%; range, 6.6%-10.0%; P=0.002) and a higher body mass index z score (median, 0.7; range, -0.57 to 2.6 vs. median, -0.4; range, -2.5 to 2.2; P=0.02). HbA1c levels were positively correlated with TC (P=0.03, R2=0.156) and TG (P=0.005, R2=0.261). CONCLUSION: A substantial proportion of adolescents and young adults with T1DM had dyslipidemia. We found a correlation between poor glycemic control and poor lipid profiles in those patients.
Adolescent*
;
Body Mass Index
;
Cholesterol
;
Cross-Sectional Studies
;
Diabetes Mellitus
;
Diabetes Mellitus, Type 1*
;
Dyslipidemias
;
Female
;
Glycemic Index
;
Hemoglobin A, Glycosylated
;
Humans
;
Linear Models
;
Lipoproteins
;
Prevalence
;
Triglycerides
;
Young Adult*
10.Gestational Age-specific Cut-off Values Are Needed for Diagnosis of Subclinical Hypothyroidism in Early Pregnancy.
Hye Sung KIM ; Byoung Jae KIM ; Sohee OH ; Da Young LEE ; Kyu Ri HWANG ; Hye Won JEON ; Seung Mi LEE
Journal of Korean Medical Science 2015;30(9):1308-1312
During the first trimester of pregnancy, thyroid-stimulating hormone (TSH) >2.5 mIU/L has been suggested as the universal criterion for subclinical hypothyroidism. However, TSH levels change continuously during pregnancy, even in the first trimester. Therefore the use of a fixed cut-off value for TSH may result in a different diagnosis rate of subclinical hypothyroidism according to gestational age. The objective of this study was to obtain the normal reference range of TSH during the first trimester in Korean gravida and to determine the diagnosis rate of subclinical hypothyroidism using the fixed cut-off value (TSH >2.5 mIU/L). The study population consisted of pregnant women who were measured for TSH during the first trimester of pregnancy (n=492) and nonpregnant women (n=984). Median concentration of TSH in pregnant women was lower than in non-pregnant women. There was a continuous decrease of median TSH concentration during the first trimester of pregnancy (median TSH concentration: 1.82 mIU/L for 3+0 to 6+6 weeks; 1.53 mIU/L for 7+0 to 7+6 weeks; and 1.05 mIU/L for 8+0 to 13+6 weeks). Using the fixed cut-off value of TSH >2.5 mIU/L, the diagnosis rate of subclinical hypothyroidism decreased significantly according to the gestational age (GA) at TSH (25% in 3+0 to 6+6 weeks, 13% in 7+0 to 7+6 weeks, and 9% for 8+0 to 13+6 weeks, P<0.001), whereas the diagnosis rate was 5% in all GA with the use of a GA-specific cut-off value (P=0.995). Therefore, GA-specific criteria might be more appropriate for the diagnosis of subclinical hypothyroidism.
Adult
;
*Algorithms
;
Biomarkers/blood
;
Diagnosis, Computer-Assisted/*methods
;
*Diagnostic Techniques, Obstetrical and Gynecological
;
Female
;
*Gestational Age
;
Humans
;
Hypothyroidism/blood/*diagnosis
;
Pregnancy
;
Pregnancy Complications/blood/*diagnosis
;
Reproducibility of Results
;
Republic of Korea
;
Sensitivity and Specificity
;
Thyrotropin/*blood