1.A Case of Juvenile Chronic Myelogenous Leukemia Presented as Recurrent Erythema Nodosum-Like Lesions.
Ji Hwan HWANG ; Kyu Han KIM ; Byoung Kook KIM ; Hyeong Don BANG ; Kyoung Chan PARK
Annals of Dermatology 1996;8(2):125-128
No abstract available.
Erythema*
;
Leukemia, Myelomonocytic, Juvenile*
2.Acanthosis Nigricans Associated with Vitiligo.
Do Youn CHO ; Sung Han KIM ; Kyu Cherl CHOI ; Byoung Soo CHUNG
Annals of Dermatology 2005;17(1):9-12
No abstract available.
Acanthosis Nigricans*
;
Vitiligo*
3.A Case of Malignant Histiocytosis Showing Papulosquamous Skin Lesions and Fever as Initial Manifestations.
Ji Hwan HWANG ; Kyu Han KIM ; Byoung Kook KIM ; Hyeong Don BANG ; Kyoung Chan PARK
Annals of Dermatology 1996;8(2):117-120
We report a case of malignant histiocytosis which began with intermittent fever and scaly skin lesions. A 3-year-old girl presented with erythematous scaly papules on the face and the trunk, and high fever for 3 months. The cutaneous lesions consisted of widespread coin-sized erythematous scaly papules with marginal brownish pigmentation. She was anemic and thrombocytopenic and had impairment of the liver function. Histopathologic study of the skin lesions showed non-specfic findings except for hyperkeratosis. However, bone marrow examination revealed an increased number of histiocytes, mostly immature with active phagocytosis of erythroid cells, myeloid cells, and platelets. She was diagnosed as having malignant histiocytosis and treated with cyclophosphamide and vincristine. She died the next day after the treatment had begun.
Bone Marrow Examination
;
Child, Preschool
;
Cyclophosphamide
;
Erythroid Cells
;
Female
;
Fever*
;
Histiocytes
;
Histiocytic Sarcoma*
;
Humans
;
Liver
;
Myeloid Cells
;
Phagocytosis
;
Pigmentation
;
Skin*
;
Vincristine
4.The Immunohistochemical Study of MAPKs Expression in Psoriatic Epidermis.
Sung Han KIM ; Jung Hun KO ; Kyu Cherl CHOI ; Byoung Soo CHUNG
Annals of Dermatology 2004;16(3):99-104
No abstract available.
Epidermis*
;
Psoriasis
5.The Natural History of Simple Renal Cysts in Adults.
Byoung Kyu HAN ; Doo Sang KIM ; Nam Kyu LEE
Korean Journal of Urology 2006;47(1):80-84
PURPOSE: Simple renal cysts are common in older patients and they are usually left untreated, yet only a few studies have been done on the natural history of simple renal cysts. We investigated the sequential changes in their size and number in 103 patients. MATERIALS AND METHODS: From January 1993 to August 2003, we followed 103 patients who were suffering with simple renal cysts. Their mean age was 55.8+/-18.72 years old (M:F=58:51). Using Abdominal USG and CT, the annual changes in renal cysts were analyzed through the follow-up period, and the mean follow-up period was 52.3+/-17.58 months. The values of the parameters were compared with using a 2-tailed Student's t-test, multivariate logistic regression analysis and the chi-square test. RESULTS: At the time of diagnosis, the mean number and size of simple renal cyst were 1.5+/-1.31 cysts per each kidney and 25.3+/-12.42mm, respectively. On the consecutive imaging study, the size of the renal cysts was increased 4.4+/-1.54mm per year. The average size increase was significantly greater in the individuals younger than 50 versus the patients 50 years or older (5.7+/-2.14mm/year vs 3.7+/-1.45mm/year, respectively). The multiple cysts showed a significantly larger size increase than did the single cysts (8.1+/-3.27mm/year vs 3.6+/-1.64mm/year, respectively). The size increase of the bilateral renal cysts was significantly larger than that of the unilateral renal cysts (5.6+/-1.48mm/year vs 4.1+/-1.02mm/year, respectively). No significant difference was observed for the average size increase with regard to gender or the initial cyst size. Only the number of cysts was a significant predictor of aggressiveness on the multivariate logistic regression analysis. CONCLUSIONS: The simple renal cysts progress in size and they appear to grow with aging. They seem to grow more rapidly in patients with a younger age, and for multiple and bilateral renal cysts.
Adult*
;
Aging
;
Diagnosis
;
Follow-Up Studies
;
Humans
;
Kidney
;
Logistic Models
;
Natural History*
6.Identification of Streptococcus viridans group Isolated from the Blood of Patients.
Jongyoun YI ; Byoung Wook SONG ; Kyu LEE ; Kyu Sub HAN ; Myoung Hee PARK ; Eui Chong KIM
Korean Journal of Clinical Microbiology 2003;6(1):12-17
BACKGROUND: Streptococcus viridans group (SVG) is the normal flora of the upper respiratory tract, skin and genitourinary tract, and is the major causative agent isolated in 30-40% of bacterial endocarditis patients. However, SVG has not been properly identified to the species level for lack of diagnostic system which enables the accurate identification of SVG. Poyart et al. have recently described the identification of SVG to the species level by DNA sequencing of superoxide dismutase gene (sodAint). Using this method, we report here the identification of SVG isolated from the patients in Seoul National University Hospital within recent 2 years. METHODS: According to the method by Poyart et al., a set of two oligonucleotides, D1 (5 '-CCI TAY ICI TAY GAY GCI YTI GAR CC-3 ') and D2 (5 '-ARR TAR TAI GCR TGY TCC CAI ACR TC-3 ') were used as PCR primers, and PCR products of 480-bp size were obtained. The PCR products purified by MicroSpin S-400 HR Column were sequenced using ABI-PRISM 3700 Sequence Analyzer. D1 and D2 were used as sequencing primers. The clinical isolates were respectively identified as the species showing the greatest sequence homology which was demonstrated by the BLAST program provided by NCBI(USA). RESULTS: Clinical strains isolated from 26 patients who had shown two or more positive blood cultures were analyzed by DNA sequencing of superoxide dismutase gene, which showed 6 strains of S. salivarius, five S. oralis, four S. sanguis, three S. pasteuri, three S. equisimilis, two S. gordonii, one S. constellatus, one S. luteciae, and one S. mitis. S. salivarius and S. sanguis were clearly discriminated, while S. equisimilis and S. pyogenes were not. Species identification results by conventional method seldom corresponded to those by DNA sequencing. Among 7 patients suspected to have bacterial endocarditis, S. sanguis were isolated in 4 patients, and S. gordonii, S. oralis, S. pasteuri in one, respectively. Among 17 patients with liver cirrhosis or cancer, S. salivarius were isolated in 6 patients, and S. oralis in four. CONCLUSIONS: In this study, we could identify the species of SVG isolated from the patients with bacteremia; S. sanguis were frequently isolated from patients with bacterial endocarditis, while S. salivarius from ones with malignancy. These results imply that a different group of underlying diseases could show correspondingly different group of SVG species which cause bacteremia, and we suggest that further pathophysiological study on the correlations between underlying disease and the species of SVG be performed.
Bacteremia
;
Endocarditis, Bacterial
;
Homosexuality, Male
;
Humans
;
Liver Cirrhosis
;
Male
;
Oligonucleotides
;
Polymerase Chain Reaction
;
Respiratory System
;
Seoul
;
Sequence Analysis
;
Sequence Analysis, DNA
;
Sequence Homology
;
Skin
;
Streptococcus*
;
Superoxide Dismutase
;
Viridans Streptococci*
7.Prognostic Significance of the Tumor Volume and Tumor Percentage for Localized Prostate Cancer.
Jae Seung CHUNG ; Byoung Kyu HAN ; Seong Jin JEONG ; Sung Kyu HONG ; Seok Soo BYUN ; Gheeyoung CHOE ; Sang Eun LEE
Korean Journal of Urology 2008;49(12):1074-1080
PURPOSE: Tumor volume has been thought to be an important predictive factor for significant prostate cancer. We assessed the impact of the tumor volume(TV) and the tumor percentage(TP) of radical prostatectomy specimens on the pathological variables and the oncological outcome. MARERIALS AND METHODS: The tumor percentage and tumor volume were calculated for 525 cases by a single pathologist who determined the volume based on the surface area of the slides involved by tumor of the prostate. Univariate and multivariate logistic regression analyses were used to characterize the association of TP categories(<5%, 5-10%, 11-20% and >20%) and TV(<1.8cc, 1.8-3.7cc, 3.8-7.5cc, >7.5cc) with the clinicopathological variables. Biochemical recurrence(BCR) was estimated using Kaplan-Meier analysis and Cox's hazard regression model. RESULTS: The mean prostate cancer volume was 6.5+/-8.5cc(median: 3.8, range: 0.04-73.8) and the mean percent tumor composition was 0.17+/-0.19 (median: 0.1, range: 0.01-0.95). A higher tumor volume and a higher tumor percentage were associated with extra-capsular extension(ECE), a positive surgical margin(PSM), a higher pT stage and a higher prostate-specific antigen(PSA) Gleason score(all p<0.05). In addition, TP was the independent predictor of ECE(adjusted odds ratio(OR): 22.66, 95% confidence interval(CI): 1.801-285.079, p=0.016), but the tumor volume was not associated with ECE on the multivariate logistic analyses. On the Kaplan-Meier analysis, but not on the Cox-hazard analyses, the TP did demonstrate a significant association with biochemical recurrence(p=0.035), yet the TV did not reach statistical significance(p=0.190). CONCLUSIONS: Our data indicates that the tumor percentage had a significant effect on the BCR on the Kaplan-Meier analysis. The tumor percentage rather than the tumor volume might be more useful to predict the prognosis of prostate cancer.
Kaplan-Meier Estimate
;
Logistic Models
;
Prognosis
;
Prostate
;
Prostatectomy
;
Prostatic Neoplasms
;
Recurrence
;
Tumor Burden
8.Anterior Sagittal Transrectal Approach (ASTRA) for Urethrovaginal Fistula after Total Repair of Persistent Cloaca: 1 Case Report.
Seong Min KIM ; Chang Woo KIM ; Byoung Kyu KIM ; Jung Tak OH ; Seok Joo HAN
Journal of the Korean Association of Pediatric Surgeons 2007;13(1):76-80
The authors applied anterior sagittal transrectal apporach (ASTRA) for the repair of urethrovaginal fistula which developed after total repair of persistent cloaca. The patient had been diagnosed to have persistent cloaca, double uterus and double vagina, and received PSARP, excision of right-side uterus and vagina, and left vaginal switch operation at 22 months old. After operation, the patient admitted several times due to frequent urinary tract infection and ectopic stone formation in bladder and neovagina. Urethro-neovaginal fistula was confirmed by cystoscopy and corrected with ASTRA. Postoperative voiding cystourethrogram showed no fistula tract. ASTRA showed improved surgical field, minimized ureterocystic damage, and preserved perirectal nerve due to limited incision of rectum.
Cloaca*
;
Cystoscopy
;
Fistula*
;
Humans
;
Infant
;
Rectum
;
Urinary Bladder
;
Urinary Tract Infections
;
Uterus
;
Vagina
9.Two Cases with Bilateral Adie's Pupils.
Byoung Joon KIM ; Sang Kun LEE ; Won Yong LEE ; Jae Kyu ROH ; Sang Bok LEE ; Hojin MYUNG ; Seoul Heui HAN
Journal of the Korean Neurological Association 1990;8(1):92-97
Adie's tonic pupil usually consists of mydriasis, defect in accommodation. Poor or absent light reflex, and tonic near reflex, It is usually unilateral, but rarelY observed bilaterally. The pupillary abnormalities often accompany areflexia, which is called Adie syndrome collechvely, Other autonomic dysfunction especially hypohidrosis. Are rarely reported in association with Adie syndrome. We recently experienced 2 cases of bilateral Adie's pupils in 2 women, one of whom had hypohidrosis, and the other had areflexia. So we report 2 cases with bilateral Adie's pupils with a review of literature.
Adie Syndrome
;
Female
;
Humans
;
Hypohidrosis
;
Mydriasis
;
Reflex
;
Tonic Pupil*
10.An Anthropometric Study of the Head and Face in Uygurs of Xinjiang, China.
Ki Seok KOH ; Young Il HWANG ; Seung Ho HAN ; Byoung Young CHOI ; Kyu Seok LEE ; Hee Jine KIM ; Kyung Hoon LEE ; Min Suk CHUNG
Korean Journal of Physical Anthropology 1994;7(2):187-198
Stature and four cephalometric measurements (head lengh, head breadth, bizygomatic diameter, bigonial diameter) were examined from samples of 461 Uygur in Xinjiang, China. Comparisons of head and facial morphology with geographically adjacent tribes were carried out to characterize Uygur population and to understand racial hybridity. Most of Uygur were hyperbrachycephalic as expressed by cephalic index and had larger lateral facial and smaller antero-posterior dimensions than Western Caucasians. The values of metric traits showed differences between East and West among Uygur populations. The results support the genetic diversity that seems to be caused by genetic hybridity and unequal growth between East and West in Uygur.
China*
;
Genetic Variation
;
Head*
;
Humans
;
Population Groups