No abstract available.
Chimerism* ; Stem Cell Transplantation* ; Stem Cells*

BACKGROUND: The xenon arc solar simulator is the most commonly used light source in studies on immediate tanning, but there has been no report on the immediate tanning response in Korean skin induced by UVA from that source. OBJECTIVE: This study was conducted to measure the minimal immediate tanning dose(MITD) for UVA in Korean, brown skin. Methods: UVA irradiation was performed on normal back skin of twenty-six healthy Korean young adults, with increasing doses from 0.5J/cm2 to 4.5J/cm2 using xenon arc solar simulator equipped with appropriate filters. Visual assessment of MITD was done by two investigators. Results: The mean and standard deviations of MITD were 2.38+/- 0.65J/cm2 in 26 subjects. MITDs distributed from 1.0J/cm2 to 3.5J/cm2. There were no significant differences of MITD between skin type III and IV. Conclusion: Conclusively, we obtained the data on the MITD in Korean skin induced by UVA from the solar simulator. The results of this study may be valuable for the research into photomedicine and useful data for evaluating sunscreens.
Humans ; Research Personnel ; Skin ; Sunscreening Agents ; Tanning* ; Triacetoneamine-N-Oxyl* ; Xenon ; Young Adult*

Generalized pustular psoriasis is a rare disease, even psoriasis involving oral mucosa is very rare. There are many reports of tongue lesions in patients with psoriasis that are clinically and histologically indistinguishable from geographic tongue, and there are many reports of fissured tongue in association with psoriasis. It has been debated whether oral psoriasis exists or not, or occurs as part of generalized pustular psoriasis. We experienced two cases of combined geographic tongue and fissured tongue in patient with generalized pustular psoriasis, and report these cases with review of the literature about the oral lesions in psoriasis, geographic tongue, and fissured tongue.
Glossitis, Benign Migratory* ; Humans ; Mouth Mucosa ; Psoriasis* ; Rare Diseases ; Tongue ; Tongue, Fissured*

No abstract available.
Dermatitis, Allergic Contact*

Peripheral blood stem cells(PBSC) were collected for autologous transplantation for the first time in Korea wish Fenwal CS-3000 Plus blood cell separator. Twenty-nine procedures were performed for 7 patients without any incidents. GM-CSF(400ug) was administered daily for 5 days before PBSC collection and the collections were performed 3-6 successive days. A total of 3.5-11.4 x 109 mononuclear cells(MNCs) were collected from 7,000mL blood processed per procedure. The number of MNCs collected was mainly dependent on the concentration of MNCs in patient's blood(r = 0.68, p<0.01). We concluded that the PBSC trans plantation program could be set up without difficulty in Korea since the Fenwal CS-3000 Plus blood cell separator is already available in many institutions and the procedure used in this study is easy to follow.
Autografts ; Blood Cells* ; Humans ; Korea ; Stem Cells* ; Transplantation, Autologous

No abstract available.
Adult* ; Humans ; Purpura, Thrombocytopenic, Idiopathic*

No abstract available.
Adult* ; Humans ; Purpura, Thrombocytopenic, Idiopathic*

No abstract available.
Blood Platelets* ; Humans* ; Membranes* ; Plasminogen*

BACKGROUND: Angiogenesis is crucial for many biological processes such as embryogenesis, cyclic changes in the endometrium and wound healing. It is also critical for the growth, invasion and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) acts as a mitogen for endothelial cells and is expressed by the presence of various tumor cells. The objective of this study is to evaluate if angiogenesis is involved in the mouse skin carcinogenesis and if VEGF is related to angiogenesis. METHODS: We induced premalignant and malignant lesions on mouse (BALB/c) skin using the two stage chemical carcinogenesis moedl, DMBA (7,12-dimethylbenzanthracene) initiation and TPA (tetra decanoyl-phorbol-acetate) promotion. And we analysed the microvessel densities (MVD) and expression of VEGF in various stages of premalignant and malignant lesions by immunohistochemical studies. RESULTS: Squamous papillomas, keratoacanthoma, dermatofibroma, and squamous cell carcinomas were developed in 20 weeks. There were no differences in the incidence of benign and malignant tumors between 10-week and 20-week promotion groups. There were significant increases in MVD from normal and hyperplastic skin through premalignant lesion to invasive squamous cell carcinoma (p<0.0005). But the degree of VEGF expression neither correlated with neither MVD nor the tumor groups. CONCLUSIONS: Increased angiogenesis begins from the hyperplastic stage. VEGF produced by tumor cells may not play major roles in the angiogenesis in the two stage chemical carcinogenesis model of the mouse skin.
9,10-Dimethyl-1,2-benzanthracene ; Animals ; Biological Processes ; Carcinogenesis* ; Carcinoma, Squamous Cell ; Embryonic Development ; Endometrium ; Endothelial Cells ; Female ; Histiocytoma, Benign Fibrous ; Incidence ; Keratoacanthoma ; Mice* ; Microvessels ; Neoplasm Metastasis ; Papilloma ; Pregnancy ; Skin* ; Vascular Endothelial Growth Factor A* ; Wound Healing

No abstract available.
Diagnosis* ; Hemoglobinuria*