No abstract available.

No abstract available.

No abstract available.
Eustachian Tube*

OBJECTIVE: This study was to evaluate the prevalence rate of group B streptococcal infection in pregnant women after 35th gestational week and the relationship between group B streptococcal infection and the prognosis of pregnant women and their neonates. METHODS: From January 1, 2000 to June 30, 2001, the medical records of 204 pregnant women who had visited department of Ob and Gyn, Inha Hospital for antenatal care were reviewed. The specimen were obtained from lower vaginal wall and perineum, and were inoculated on selective media to isolate group B streptococci. The relationship between group B streptococcal infection in those pregnant women and the prognosis of them and their neonates peripartum were evaluated. RESULTS: The prevalence of group B streptococci in pregnant women was 1.96% (4/204). No group B streptococcal infection was found in their neonates (0/4). There is no significant statistical differences in prognosis between the pregnant women with group B streptococci and those without group B streptococi. CONCLUSION: This study was revealed that the prevalence rate of group B streptococci in pregnant women was very low and the screening test for group B streptococcal infection in pregnant women might be regarded as meaningless. However, group B streptococcus has been known to cause many complications in pregnant women and their neonates. Further studies are needed for the significance of group B streptococcal infection in pregnant women and their neonates.
Female ; Humans ; Infant, Newborn ; Mass Screening ; Medical Records ; Perineum ; Peripartum Period ; Pregnant Women* ; Prevalence ; Prognosis ; Streptococcal Infections* ; Streptococcus

PURPOSE: Few studies have reported ovarian cancer risks in Korean patients with the BRCA1/2 mutation. We investigated the prevalence of ovarian cancer in Korean women at high risk for hereditary breast-ovarian cancer (HBOC) syndrome and reviewed the clinicopathological factors of ovarian cancer. METHODS: Female subjects who were enrolled in the Korean Hereditary Breast Cancer study were included. The questionnaire included a personal and family history of cancer. The BRCA1/2 mutation and CA-125 level were tested at the time of enrollment. A transvaginal ultrasonogram (TVUS) was recommended for subjects with an elevated CA-125 level. RESULTS: A total of 1,689 patients were included. No ovarian cancer was newly diagnosed by CA-125 level or TVUS during the enrollment. The prevalence of ovarian cancer was 1.71% in BRCA1/2 mutation carriers and 0.39% in non-carriers. Among 11 patients with ovarian cancer, five had the BRCA1 mutation and one had the BRCA2 mutation. The most common histopathological type was serous cystadenocarcinoma. No difference in clinicopathological findings between BRCA1/2 mutation carriers and non-carriers was observed. CONCLUSION: The prevalence of ovarian cancer was 58-fold elevated in women at high-risk for HBOC syndrome and 146-fold elevated in the BRCA1 subgroup, compared with the Korean general population. Further investigation with a long-term follow-up is required to evaluate BRCA1/2 gene penetrance.
Female ; Humans ; Breast Neoplasms ; Ovarian Neoplasms