1.The evaluation of the endometrial curettage in patients of ectopic pregnancy.
Young Mi SUNG ; Yoon Ho JO ; Byoung Sun KIM ; Keun Young PARK ; Seo Yoo HONG
Korean Journal of Obstetrics and Gynecology 1993;36(7):1261-1267
No abstract available.
Curettage*
;
Female
;
Humans
;
Pregnancy
;
Pregnancy, Ectopic*
2.A Case of Prostatic Adenocarcinoma Confirmed by Immunoperoxidase Technique.
Ju Tae SEO ; Byoung Jo KWON ; Young Yo PARK ; Sung Won KWON
Korean Journal of Urology 1988;29(4):629-631
Recently, the use of immunoperoxidase technique for the location of prostatic acid phosphatase is well established. We experienced 67 year-old male patient who taken TUR due to mass on bladder neck. Previously he had received Rt. radical nephrectomy due to renal cell carcinoma 6 years ago and TUR due to metastatic urethral adenocarcinoma from renal cell carcinoma origin 3 years ago. The Pathologic report represented that the mass was malignant adenocarcinoma. To confirm the origin of adenocarcinoma, we performed immunoperoxidase technique and the adenocarcinoma was originated from the prostate.
Acid Phosphatase
;
Adenocarcinoma*
;
Aged
;
Carcinoma, Renal Cell
;
Humans
;
Immunoenzyme Techniques*
;
Male
;
Neck
;
Nephrectomy
;
Prostate
;
Urinary Bladder
3.Analysis of Prognostic Factors in 1,435 Surgically Treated Patients with Gastric Cancer.
Won Hong SEO ; Byoung Jo SEO ; Hang Jong YU ; Woo Yong LEE ; Hea Kyoung LEE
Journal of the Korean Gastric Cancer Association 2009;9(3):143-151
PURPOSE: Gastric cancer is prevalent in Korea, therefore the purpose of this study was to determine the clinicopathologic characteristics, 5-year survival rate, and prognostic factors for gastric patients who underwent gastrectomy by a single surgeon. MATERIALS AND METHODS: A total of 1,435 patients diagnosed with gastric cancer who underwent gastrectomy in the Department of Korean Gastric Cancer Center at Seoul Paik Hospital between September 1998 and August 2003, and the gender, age, location and size of the tumor, visual and histologic analysis, depth of invasion, lymph node metastasis, invasion (perineural, venous, and lymphatic), and surgical method were examined retrospectively. RESULTS: The ratio between males and females was 2.29:1, and the average age was 56.7 years. Based on the UICC TNM classification, the patients were distributed as follows: IA 35.4%, IB 14.1%, II 12.6%, IIIA 12.3%, IIIB 8.3% and IV 17.3%. The 5-year survival rate was 69.6%. The results of univariate analysis showed that there were significant differences in the survival rate by age, location and size of tumor, Borrmann type, level of differentiation, Lauren's classification, depth of invasion, metastasis in lymph nodes, UICC TNM stage, invasion (perineural, venous, and lymphatic), and surgical method. Based on multivariate analysis, only the depth of invasion and lymph node metastasis were independent prognostic factors. CONCLUSION: Although various clinicopathologic characteristics affect the prognostic factors of the patients with gastric cancer, the results of this study showed that the stage of disease, such as depth of invasion and metastasis in lymph nodes, are the most critical factors. There is a need to establish the diagnosis of gastric cancer early and to study and develop various treatment methods based on the diagnostic factors in order to improve the survival of patients with gastric cancer.
Female
;
Gastrectomy
;
Humans
;
Korea
;
Lymph Nodes
;
Male
;
Multivariate Analysis
;
Neoplasm Metastasis
;
Retrospective Studies
;
Stomach Neoplasms
;
Survival Rate
4.A Case of Systemic Lupus Erythematosus Presented with Streptococcal Myositis.
Sang Jae LEE ; Chan Hee SEO ; Byeong Il JANG ; Soo Jin JUN ; Sang Jo MIN ; Dong Kyu KIM ; Byoung Moon CHOI ; Choong Won LEE
The Journal of the Korean Rheumatism Association 2003;10(4):446-450
Streptococcal myositis is an extremely uncommon infectious disease caused by Group A streptococcus (GAS). GAS infection spreads rapidly and diffusely through the muscle, resulting in edema and necrosis. Consequently, it results in streptococcal toxic shock syndrome having extremely high mortality. We report a 42 year-old female patient with systemic lupus erythematosus accompanying with streptococcal myositis who initially presented with fever, severe pain, and tenderness on the calf. Her systemic toxic symptoms were aggravated and finally she died of the disease in spite of aggressive management.
Adult
;
Communicable Diseases
;
Edema
;
Female
;
Fever
;
Humans
;
Lupus Erythematosus, Systemic*
;
Mortality
;
Myositis*
;
Necrosis
;
Shock, Septic
;
Streptococcus
5.Both Carotid Endarterectomy in Obstrution of Carotid Arteries and Bypass Graft with Kidney Preservation in Obstrution of Abdominal Aorta: A Report of Case.
Byoung Chul KIM ; Seung Hwan PYUN ; Jung Wook SEO ; Joo Yeon KIM ; Pill Jo CHOI ; Jong Su LEE ; Si Chan SUNG ; Jong Soo WOO
The Korean Journal of Thoracic and Cardiovascular Surgery 1997;30(6):625-630
A 56 years old male patient admitted to our neurology department because of repeated tingling sensation in right 3, 4, 5th. fingers and weakness on grasping, which were progressively developed recently. At this time, he had also suffered from claudication in both lower extremities. Carotid angiogram showed that right internal carotid artery was obstructed completely, and both common, both external and left internal carotid arteries had significant stenosis, Concommitantly, aortogram suggested complete obstruction just below the renal arteries. We planned staged operation for two separated arterial lesions. Both carotid endarterectomy was performed. and we used carotid shunt for left side during operation. Abdominal aortic lesion was operated 2 weeks later. We obligately clamped aorta just below the celiac artery and infused kidney perservation solution to pertect kidney during ischemia. Reversed Y bypass graft and kidney perservation was successful despite of 40 minute ischemia. Postoperative coure was uneventful and patient was discharged without any specific problem.
Aorta
;
Aorta, Abdominal*
;
Carotid Arteries*
;
Carotid Artery, Internal
;
Carotid Stenosis
;
Celiac Artery
;
Constriction, Pathologic
;
Endarterectomy, Carotid*
;
Fingers
;
Hand Strength
;
Humans
;
Ischemia
;
Kidney*
;
Lower Extremity
;
Male
;
Middle Aged
;
Neurology
;
Organ Preservation
;
Renal Artery
;
Sensation
;
Transplants*
6.Epidemiologic Study of Human Epidermal Growth Factor Receptor 2 Expression in Advanced/Metastatic Gastric Cancer: an Assessment of Human Epidermal Growth Factor Receptor 2 Status in Tumor Tissue Samples of Gastric and Gastro-Esophageal Junction Cancer.
Kyung Won SEO ; Taeyong JEON ; Sewon KIM ; Sung Soo KIM ; Kwanghee KIM ; Byoung Jo SUH ; Sunhwi HWANG ; SeongHee CHOI ; Seungwan RYU ; Jae Seok MIN ; Young Joon LEE ; Ye Seob JEE ; Hyeondong CHAE ; Doo Hyun YANG ; Sang Ho LEE
Journal of Gastric Cancer 2017;17(1):52-62
PURPOSE: The Trastuzumab for gastric cancer (GC) trial identified human epidermal growth factor receptor 2 (HER2) as a predictor of successful treatment with trastuzumab (HER2 receptor targeting agent) among patients with advanced/metastatic GC. To date, the prevalence of HER2 overexpression in the Korean population is unknown. The present study aimed to assess the incidence of HER2 positivity among GC and gastroesophageal (GE) junction cancer samples and the relationship between HER2 overexpression and clinicopathological characteristics in Korean patients. MATERIALS AND METHODS: Tumor samples collected from 1,695 patients with histologically proven GC or GE junction enrolled at 14 different hospitals in Korea were examined. After gathering clinicopathological data of all patients, HER2 status was assessed by immunohistochemistry (IHC) at each hospital, and IHC 2+ cases were subjected to silver-enhanced in situ hybridization at 3 central laboratories. RESULTS: A total of 182 specimens tested positive for HER2, whereas 1,505 tested negative. Therefore, the overall HER2-positive rate in this study was 10.8% (95% confidence interval: 9.3%–12.3%). The HER2-positive rate was higher among intestinal-type cases (17.6%) than among other types, and was higher among patients older than 70 years and 50 years of age, compared to other age groups. CONCLUSIONS: Our evaluation of the HER2 positivity rate (10.8%) among Korean patients with GC and GE junction indicated the necessity of epidemiological data when conducting studies related to HER2 expression in GC and GE junction.
Epidemiologic Studies*
;
Epidermal Growth Factor*
;
Humans*
;
Immunohistochemistry
;
In Situ Hybridization
;
Incidence
;
Korea
;
Prevalence
;
Receptor, Epidermal Growth Factor*
;
Receptor, ErbB-2
;
Stomach Neoplasms*
;
Trastuzumab
7.Gastroprotective Effect of Cochinchina momordica Seed Extract in Nonsteroidal Anti-Inflammatory Drug-Induced Acute Gastric Damage in a Rat Model.
Ji Hwan LIM ; Joo Hyun KIM ; Nayoung KIM ; Byoung Hwan LEE ; Pyoung Ju SEO ; Jung Mook KANG ; So Young JO ; Ji Hyun PARK ; Ryoung Hee NAM ; Hyun CHANG ; Jin Won KWON ; Dong Ho LEE
Gut and Liver 2014;8(1):49-57
BACKGROUND/AIMS: The major compounds of Cochinchina momordica seed extract (SK-MS10) include momordica saponins. We report that the gastroprotective effect of SK-MS10 in an ethanol-induced gastric damage rat model is mediated by suppressing proinflammatory cytokines and downregulating cytosolic phospholipase A2 (cPLA2), 5-lipoxygenase (5-LOX), and the activation of calcitonin gene-related peptide. In this study, we evaluated the gastroprotective effects of SK-MS10 in the nonsteroidal anti-inflammatory drug (NSAID)-induced gastric damage rat model. METHODS: The pretreatment effect of SK-MS10 was evaluated in the NSAID-induced gastric damage rat model using aspirin, indomethacin, and diclofenac in 7-week-old rats. Gastric damage was evaluated based on the gross ulcer index by gastroenterologists, and the damage area (%) was measured using the MetaMorph 7.0 video image analysis system. Myeloperoxidase (MPO) was measured by enzyme-linked immunosorbent assay, and Western blotting was used to analyze the levels of cyclooxygenase (COX)-1, COX-2, cPLA2, and 5-LOX. RESULTS: All NSAIDs induced gastric damage based on the gross ulcer index and damage area (p<0.05). Gastric damage was significantly attenuated by SK-MS10 pretreatment compared with NSAID treatment alone (p<0.05). The SK-MS10 pretreatment group exhibited lower MPO levels than the diclofenac group. The expression of cPLA2 and 5-LOX was decreased by SK-MS10 pretreatment in each of the three NSAID treatment groups. CONCLUSIONS: SK-MS10 exhibited a gastroprotective effect against NSAID-induced acute gastric damage in rats. However, its protective mechanism may be different across the three types of NSAID-induced gastric damage models in rats.
Animals
;
Anti-Inflammatory Agents, Non-Steroidal/adverse effects
;
Arachidonate 5-Lipoxygenase/drug effects
;
Calcitonin Gene-Related Peptide/drug effects
;
Cyclooxygenase 1/drug effects
;
Cyclooxygenase 2/drug effects
;
Disease Models, Animal
;
Gastric Mucosa/chemistry/drug effects
;
Group IV Phospholipases A2/drug effects
;
Male
;
Momordica/*chemistry
;
Peroxidase/drug effects
;
Plant Extracts/*pharmacology
;
Rats
;
Rats, Sprague-Dawley
;
Seeds/*chemistry
;
Stomach Ulcer/chemically induced/*prevention & control
;
Treatment Outcome
8.Roles of Sphingosine-1 Phosaphate During Pathogenesis of Bone Destruction and Inflammation in Rheumatoid Arthritis Mice Model.
Han Bok KWAK ; Deok Su KWON ; Sung Jo JANG ; Eun Yong CHOI ; Eun Gyeong LEE ; Byoung Hyun PARK ; Hyun Dai KIM ; Phil Seung SEO ; Jeong Joong KIM ; Min Kyu CHOI ; Hae Joong CHO ; Jeong Woo KIM ; Hun Soo KIM ; Myeung Su LEE ; Churl Hong CHUN ; Jae Min OH
Korean Journal of Anatomy 2007;40(4):277-286
Sphingosine 1-phosphate (S1P) is a bioactive lipid molecule that mediates cell proliferation, differentiation, migration, and angiogenesis in vivo. However, the roles of S1P on pathogenesis of arthritis have been not completely understood. This study was designed to determine the effects of S1P modulation on collageninduced arthritis (CIA) model. DBA/1J mice were injected with collagen into the tail for induction of CIA model. S1P was administered into the peritoneal cavity every other days from day 1 to day 42 after collagen injection. To determine the degree of damage in CIA, we examined macroscopic findings of CIA. The inflammation and bone destruction of CIA mice were evaluated by histo-patholigy and radiography (CT and microradiography). The expressions of TNF-alpha, IL-6, and RANKL which have important roles in pathogenesis of rheumatoid arthritis and bone destruction were observed by immuno-histochemical staining. After injection with collagen in the DBA/1J mice, CIA was induced by swelling in the knee and ankle joint. Administration of S1P suppressed damages and incidence of arthritis elicited by collagen. In histologic and radiographic studies, S1P strongly suppressed the infiltration of inflammatory cells, the swelling of synovial membrane, erosion, and the destruction of bone on CIA mice. Injection of S1P resulted in down-regulation of the expression of the pro-inflammatory and bone destruction mediators such as TNF-alpha, IL-6, and RANKL on CIA mice. Furthermore, S1P suppressed the differentiation of bone marrow cells into osteoclasts by RANKL. In conclusion, this study suggest that S1P has protective effects on inflammation and bone destruction during pathogenesis of CIA, which indicates S1P can be a new possible therapeutic strategy for rheumatoid arthritis
Animals
;
Ankle Joint
;
Arthritis
;
Arthritis, Rheumatoid*
;
Bone Marrow Cells
;
Cell Proliferation
;
Collagen
;
Down-Regulation
;
Incidence
;
Inflammation*
;
Interleukin-6
;
Knee
;
Mice*
;
Osteoclasts
;
Peritoneal Cavity
;
Radiography
;
Sphingosine
;
Synovial Membrane
;
Tail
;
Tumor Necrosis Factor-alpha
9.2014–2017 Nationwide Bariatric and Metabolic Surgery Report in Korea
In Gyu KWON ; Jong Won KIM ; Gil Ho KANG ; Dong Wook KIM ; Sung Geun KIM ; Seong Min KIM ; Seong Soo KIM ; Yong Jin KIM ; Wook KIM ; Jong Han KIM ; Ji Heon KIM ; Jin Jo KIM ; Ho Goon KIM ; Seung Wan RYU ; Do Joong PARK ; Dong Jin PARK ; Sung Soo PARK ; Yoon Chan PARK ; Joong Min PARK ; Ji Yeon PARK ; Kyung Won SEO ; Byoung Jo SUH ; Soo Min AHN ; Hye Seong AHN ; Moon Won YOO ; Sang Kuon LEE ; Han Hong LEE ; Hyuk Joon LEE ; Kyong Hwa JUN ; Kyung Ook JUNG ; Minyoung CHO ; Seung Ho CHOI ; Man ho HA ; Tae Kyung HA ; Sang Moon HAN ; Sang Uk HAN ; Yoon Seok HEO ; Woo Jin HYUNG ; Joo Ho LEE ;
Journal of Metabolic and Bariatric Surgery 2018;7(2):49-53
PURPOSE: The information committee of the Korean Society for Metabolic and Bariatric Surgery (KSMBS) performed the nationwide survey of bariatric and metabolic operations to report IFSO (International Federation for the Surgery of Obesity and Metabolic Disorders) worldwide survey annually. This study aimed to report the trends of bariatric and metabolic surgery in Korea in 2014–2017. MATERIALS AND METHODS: We analyzed the accumulated nationwide survey data conducted for annual ISFO survey from 2014 to 2017. Trends such as the number of operations by hospital type and the number of operations by surgical method were analyzed. RESULTS: The number of operations has decreased sharply in 2015 comparing to 2014 (913⇒550). The number of operations performed in private hospitals dropped sharply from 529 to 250, 198, and 103 cases. The number of revisional surgeries increased to 223 in 2015. The primary surgery number fell from 757 in 2014 to 327 in 2015. In primary surgery, sleeve gastrectomy was gradually increased from 2014 to 143 (18.9%), 105 (32.1%), 167 (47.2%) and 200 (56.3%) and became the most frequently performed surgery. On the other hand, the incidence of adjustable gastric band decreased gradually from 439 (58.0%) to 117 (35.8%), 112 (31.6%) and 59 (16.6%). CONCLUSION: The overall number of obesity metabolic operations has decreased since 2014, especially the number of adjustable gastric band, and the number of operations in private hospitals declined sharply. On the other hand, the number of operations in university hospitals did not change much, and the number of sleeve gastrectomy increased.
Bariatric Surgery
;
Gastrectomy
;
Hand
;
Hospitals, Private
;
Hospitals, University
;
Incidence
;
Korea
;
Methods
;
Obesity
10.Hereditary Hemolytic Anemia in Korea: a Retrospective Study from 1997 to 2006.
Hee Soon CHO ; Jeong Ok HAH ; Im Ju KANG ; Hyung Jin KANG ; Jae Yong KWAK ; Hong Hoe KOO ; Hoon KOOK ; Byoung Kook KIM ; Soon Ki KIM ; Seung Taik KIM ; Young Dae KIM ; Ji Yoon KIM ; Chul Soo KIM ; Thad GHIM ; Heung Sik KIM ; Sang Gyu PARK ; Seon Yang PARK ; Jun Eun PARK ; Soo Mee BANG ; Jong Jin SEO ; Chang In SUH ; Sang Kyun SOHN ; Ho Jin SHIN ; Hee Young SHIN ; Hyo Sup AHN ; Doyeun OH ; Eun Sun YOO ; Chuhl Joo LYU ; Sung Soo YOON ; Kun Soo LEE ; Kwang Chul LEE ; Kee Hyun LEE ; Soon Yong LEE ; Young Ho LEE ; Jung Ae LEE ; Jong Seok LEE ; Young Tak LIM ; Jae Young LIM ; Ho Joon IM ; Dae Chul JEONG ; So Young CHONG ; Joo Seop CHUNG ; Hye Lim JUNG ; Goon Jae CHO ; Deog Yeon JO ; Jong Youl JIN ; Eun Jin CHOI ; Myung Soo HYUN ; Pyung Han HWANG
Korean Journal of Hematology 2007;42(3):197-205
BACKGROUND: The aim of this study was to investigate the prevalence, clinical and laboratory findings of hereditary hemolytic anemia (HHA) in Korea from 1997 to 2006 and to develop the appropriate diagnostic approach for HHA. METHODS: By the use of questionnaires, information on the clinical and laboratory findings ofHHA diagnosed from 1997 to 2006 in Korea was collected and analyzed retrospectively. A total of 431 cases were enrolled in this study from 46 departments of 35 hospitals. RESULTS: The overall frequency of HHA did not change through the 10-year period for pediatrics but did show an increasing tendency for internal medicine. The overall male to female sex ratio did not show sex predominance (1.17:1), but a significant male predominance with a ratio of 1.49:1 was seen for pediatrics while a significant female predominance with a ratio of 1:1.97 was seen forinternal medicine. Of the total cases, 74.2% (282/431) were diagnosed before the age of 15 years. The etiologies of HHA were classified as red cell membrane defects, hemoglobinopathies, red cell enzyme deficiencies and unknown causes. There were 382 cases (88.6%) of red cell membrane defects with 376 cases (87.2%) of hereditary spherocytosis and 6 cases (1.4%) of hereditary elliptocytosis, 20 cases (4.6%) of hemoglobinopathies with 18 cases (4.2%) of beta-thalassemia, a case (0.2%) of alpha-thalassemia and a case (0.2%) of Hemoglobin Madrid, 7 cases (1.6%) of red cell enzyme deficiencies with 5 cases (1.2%) of glucose-6- phosphate dehydrogenase (G-6-PD) deficiency, a case (0.2%) of pyruvate kinase (PK) deficiency and a case (0.2%) of enolase deficiency, and 22 cases (5.1%) of unknown causes. The most common chief complaint in pediatric patients was pallor and that in adult patients was jaundice. In the red cell membrane defect group of patients, the level of hemoglobin was significantly higher than in adult patients. The mean corpuscular volume, mean corpuscular hemoglobin, corrected reticulocyte count, total and indirect bilirubin level and lactate dehydrogenase levels in the hemoglobinopathy group of patients were significantly lower than the values in the red cell membrane defect group of patients. The mean concentration of G-6-PD was 0.8+/-0.7U/1012RBC in the G-6-PD deficient patients, PK was 1.7U/1010 RBC in the PK deficient patient, and the level of enolase was 0.04U/g of Hb in the enolase deficient patient. CONCLUSION: The most prevalent cause of HHA in Korea during 1997 to 2006 was hereditary spherocytosis, but HHA by other causes such as hemoglobinopathy and red cell enzyme deficiency gradually increased with the development of molecular diagnostic methods and increasing general interest. However, the etiologies of HHA need to be pursued further in 5.1% of the patients. An systematic standard diagnostic approach is needed in a nationwide prospective study for correct diagnoses and appropriate management of HHA.
Adult
;
alpha-Thalassemia
;
Anemia, Hemolytic, Congenital*
;
beta-Thalassemia
;
Bilirubin
;
Cell Membrane
;
Diagnosis
;
Elliptocytosis, Hereditary
;
Erythrocyte Indices
;
Female
;
Hemoglobinopathies
;
Humans
;
Internal Medicine
;
Jaundice
;
Korea*
;
L-Lactate Dehydrogenase
;
Male
;
Oxidoreductases
;
Pallor
;
Pathology, Molecular
;
Pediatrics
;
Phosphopyruvate Hydratase
;
Prevalence
;
Pyruvate Kinase
;
Reticulocyte Count
;
Retrospective Studies*
;
Sex Ratio
;
Surveys and Questionnaires