A 28-year-old woman had a 13-month history of skin-colored, well-circumscribed, hyperkeratotic plaques on both heels. Histological examination showed hyperkeratosis and acanthosis in the epidermis. Special stain for elastic tissue revealed marked fragmentation, diminution and thickening of elastic fibers in the dermis. We report a rare case with the lesions of acrokeratoelastoidosis on both heels.
Adult ; Dermis ; Elastic Tissue ; Epidermis ; Female ; Heel ; Humans

No abstract available.
Ankle* ; Dislocations* ; Tendons*

BACKGROUND: Squamous cell carcinoma(SCC) on sun-damaged skin is a malignant neoplasm that evolves from its inception as squamous cell carcinoma in situ, which is commonly referred to as an actinic keratosis(AK) or Bowen's disease(BD). OBJECTIVE: The purpose of this study was to determine whether there is a significant association between cutaneous SCC on sun-damaged skin and AK or BD in Korean. METHODS: A total of 50 Korean patients with SCC on sun-damaged skin was enrolled in this study. The hospital charts and histopathological slides of the patients with SCC on sun-damaged skin diagnosed at Chungbuk National University Hospital from July 1, 1991 to March 1, 2001 were reviewed. We investigated the incidence of actinic keratosis and Bowen's disease and histopathological characteristics of actinic keratosis at the periphery or within the confines of cutaneous SCC. RESULTS: Of the 50 cutaneous SCC cases on sun-damaged skin reviewed, 96.0% (48 out of 50) were found to have concomitant AK or BD at the periphery or within the confines of cutaneous SCC. The most common histopathological subtype of accompanying AK in the cutaneous SCC was the hypertrophic type. CONCLUSION: The 96.0% prevalence of concomitant AK or BD and SCC in our biopsy population suggests a strong correlation between these lesions.
Actins* ; Biopsy ; Bowen's Disease* ; Carcinoma, Squamous Cell* ; Chungcheongbuk-do ; Humans ; Incidence ; Keratosis, Actinic* ; Prevalence ; Skin

A healthy 18-year-old woman presented with an asymptomatic tiny papular eruption on the hands, forearms, legs and trunk. A skin biopsy from the left forearm revealed a typical lichen nitidus lesion associated with an adjacent transepidermal perforating lesion. We report a case of perforating lichen nitidus, and briefly review the relevant literature of perforating lichen nitidus.
Adolescent ; Biopsy ; Female ; Forearm ; Hand ; Humans ; Leg ; Lichen Nitidus* ; Lichens* ; Skin

BACKGROUND: The prevalence of ovat hyperthyroidism ar hypothyroidism has been estimated up to 5% in the general populatian. Subclinical hyperthyroidism and subclinical hypothyroidism have pevalences of approximately 1% and 6%, ectively. The prevalence of hypothyroidism may be associated with excessive intake of iodine in iodine sufficient areas. Therefore, we assumed the prevalence of thyroid dysfunction in Karea might be different from those af Western cauntries. However, thete have been no surveys to examine the prevalence of thyroid dysfunction in Karea. We performed the study to investigate the prevalence of thyrotoxicosis and hypothyroidism in Korean adults. METHODS: This study was performed in 15019 subjects (8275 men, 6744 women; between 17 and 87 years of age) visited in health promotion center of Samsung Medical Center for 12 months in 1996. Serum T3, T4, and TSH concentrations were measured with RIA or IRMA using commercial kits. History of thyroid dysfunction and current medication were obtained from medical records. The criteria for thyrotoxicosis were TSH level below than 0.30 mU/L and increased T3 or T4 levels (T3 > 3.1 nmol/L or T4 > 152 nmol/L). Patients who had TSH level above than 5.0 mU/L and T4 level below than 77 nmol/L met the criteria for hypothyroidism. RESULTS: The prevalence of thyrotoxicosis was 5.5/1000 population (men 3.6/1000, women 7.7/1000) with peak prevalence in fifth decade. The prevalence of previously undiagnosed thyrotoxicosis was 4.0/1000 (men 2.9/1000, women 5.3/1000). The prevalence of hypothyroidism was 2.8/1000 population (men 1.1/1000, women 4.9/1000) with peak prevalence in seventh decade. The prevalence of previously undiagnosed hypothyroidism was 1.6/1000 (men 0.6/1000, women 2.S/1000). The prevalence of subclinical thyrotoxicosis was 12.4/1000 population (men 11.8/1000, women 13.0/1000). The prevalence of subclinical hypothyroidism was 18.2/1000 population (men 11.2/1000, women 26.7/1000) which frequency was increased with age. CONCLUSION: Although the prevalence of thyrotoxicosis and hypothyroidism was not significantly different from those of other countries, it was lower than expected and female preponderance is not significant. The prevalence of subclinical thyrotoxicosis and subclinical hypothyroidism was lower than those of other countries. The prevalence of subclinical hypothyroidism was higher in women and old ages. (J Kor Soc Endecrinol 14:301~313, 1999)
Adult ; Female ; Health Promotion ; Humans ; Hyperthyroidism ; Hypothyroidism* ; Iodine ; Male ; Medical Records ; Prevalence* ; Thyroid Gland ; Thyrotoxicosis*

Multiple endocrine neoplasia (MEN) Ila is an inherited disease characterized by the development of medullary thyroid carcinoma, pheochromocytoma and hyperparathyroidism. It has been shown to be associated with germ-line mutatians in the RET proto-oncogene. Presymptomatic screening of medullary thyroid carcinoma in MEN IIa families enables the early diagnosis of this tumor with its significant morbidity, We describe a 19-year-old woman fmm a MEN IIa family who was founded by DNA analysis to be a gene carrier of MEN IIa and then was diagnosed, using a pentagastrin stimulation test, as having presymptomatie medullary thyroid carcinoma She underwent thyroidectomy and histologic examination confirmed medullary thyroid carcinoma. It is cancluded that direct genetic analysis for mutations in the RET proto-oncogene should be the diagnstlc test of choice for identifying family members at risk for MEN IIa and thyroidectomy on the basis of genetic analysis is a rational course of action.
DNA ; Early Diagnosis ; Female ; Genes, vif ; Humans ; Hyperparathyroidism ; Male ; Mass Screening* ; Multiple Endocrine Neoplasia ; Multiple Endocrine Neoplasia Type 2a* ; Pentagastrin ; Pheochromocytoma ; Proto-Oncogenes ; Thyroid Gland* ; Thyroid Neoplasms* ; Thyroidectomy ; Young Adult

BACKGROUND: Waist circumference is one of the key components of metabolic syndrome. Recent studies demonstrated that the reproductive profile was associated with metabolic syndrome in postmenopausal women. This study focused on the association between central obesity and age at first childbirth. It also considered other factors associated with central obesity in postmenopausal women. METHODS: This study was based on the 2013–2015 Korean National Health and Nutrition Examination Survey and involved 3,143 naturally postmenopausal women. These women were divided into three groups according to their age at first childbirth: 19 years or younger (n=252), 20–29 years (n=2,695), and 30 years or older (n=196). Multivariate analysis using logistic regression was performed to evaluate the effects of various reproductive factors, including other confounding factors. RESULTS: During adjustment for confounding factors, in the early age at first childbirth group, odds ratios (95% confidence intervals) for central obesity decreased. In the final model, younger age at first childbirth was not significantly related to central obesity (waist circumference more than 85 cm) in naturally postmenopausal women after adjusting for other confounding factors. CONCLUSION: Younger age at first childbirth was not significantly associated with central obesity after adjustment for confounding factors.
Female ; Humans ; Logistic Models ; Menopause ; Multivariate Analysis ; Nutrition Surveys* ; Obesity, Abdominal* ; Odds Ratio ; Parturition* ; Waist Circumference

Retroperitoneal Schwannoma is relatively rare and benign tumor originating from Schwann cell. Schwannomas arising in the retroperitoneum are infrequently reported. The majority of Schwannoma is found incidentally and misdiagnosed for other benign conditions both clinically and radiologically. We report a case of a benign retroperitoneal pelvic Schwannoma which was preoperatively misdiagnosed as an ovarian tumor with brief review of literatures.
Neurilemmoma*

This paper reports a case of malignant histiocytic lymphoma mainly in the frontal region with intracranial extradural extension. Operation was performed to remove the mass but the tumor began to recur rapidly. And so under the condition that the operative wound was not fully healed, the patient received radiotheray and chemotherapy postoperatively, with remarkable regession of the tumor.
Drug Therapy ; Humans ; Lymphoma ; Lymphoma, Large B-Cell, Diffuse* ; Scalp* ; Wounds and Injuries

PURPOSE: To evaluate risk factors of falls and related injuries for home-staying elderly people in a rural community, and to provide basic data to minimize injuries after falls. MATERIALS AND METHODS: We surveyed for 479 subjects aged 65 or more in the region of two cites of Kyungbuk, and analyzed risk factors of falls, which more divided into intrinsic and extrinsic variables. RESULTS: Of the participants, 219 (45.7%) fell during past year. Most falls occurred during walking (50.2%), on the road (28.8%), at sunset (36.1%), and in winter (44.7%). Of 219 people, 72.6% were injured in falls, 31.5% sustained serious injuries including fractures (14.6%). The lower extremities (35.2%) were most frequently injuried. 14.6% were admitted to hospital. 76.6% who experienced falls were afraid of recurrence, and 39.7% reduced physical activity after falls. CONCLUSION: Up to these days, we have only treated patients who visited hospital, but from now on we must make effort for preventive activity. We suggest that more systemic prevention and study for intrinsic and extrinsic factors of falls are needed to minimize a degree of injury after falls in elderly people.
Aged ; Humans ; Lower Extremity ; Motor Activity ; Recurrence ; Risk Factors ; Rural Population ; Walking