1.Diagnostic Value of Adenosine Deaminase Activity in Tuberculous Pericardial Effusion.
Keum Soo PARK ; Chul Han KIM ; Byoung Chul MIN ; Kyung Hoon CHOE
Korean Circulation Journal 1990;20(1):141-147
Adenosine deaminase(ADA) is an enzyme capable of catalysing the pathway from adenosine to inosine. Previous studies have shown that this enzyme may be useful in recognition of a tubeculous etiology of pleural, peritoneal, or meningeal effusions. ADA activity was studied in 42 patients with large amount of pericardial effusion. Patients were subdivided into the following four group : (A) 15 cases of tuberculous effusions : (B) 4 with pyogenic effusions : (C) 15 with idiopathic effusions : (D) 9 with malignant effusions. The results were as follows ; 1) The mean ADA activities assessed in pericardial effusions were 134.0+/-77.6U/L in group A : 93.8+/-43.8 in group B : 38.3+/-23.2 in group C : 27.3+/-20.8 in group D. Comparing the level achieved in group A with all others, the difference is significant at the P<0.001 level. 2) The mean ADA activities assessed in sera were 50.7+/-57.2 U/L in group A : 63.5+/-24.1 in group B : 25.9+/-12.0 in group C : 14.0+/-7.5 in group D. Comparing the level achieved in group A with all others, there is no significant difference. 3) Specificity(0.87) and sensitivity(0.93) of the test for the differential diagnosis of patients with tuberculous effusion from those with idiopathic effusion is high, when a value of more than 50 U/L is considered. In conclusion, the assessment of ADA in pericardial effusions is of great value in the diagnosis of tuberculous pericarditis.
Adenosine Deaminase*
;
Adenosine*
;
Diagnosis
;
Diagnosis, Differential
;
Humans
;
Inosine
;
Pericardial Effusion*
;
Pericarditis, Tuberculous
2.Survey of experience rate of allergic disease of elementary school children in a large city.
Byoung Jo MIN ; Sun Young MIN ; Chul Gab LEE
Journal of the Korean Academy of Family Medicine 2001;22(8):1262-1270
BACKGROUND: Recently, the apartment complex is rapidly increasing as a new type of housing in a large city. So the purpose of the this survey is to research the experience rate of young children's allergic disease in an area of the apartment complex of a large city and to help the family medical doctor to diagnose and treat the young patients. METHODS: The experience rate of atopic dermatitis, bronchial asthma, allergic rhinitis, allergic conjunctivitis, food allergy was surveyed on June 1999 at an elementary school in a large apartment complex in Kwang ju. The survey group were 832 students attending elementary school from the second to sixth grade. Also this survey was used to elicit information about the relationship between allergic disease and factors such as age, sex, birth history, family history, and home environment. For analysis of our finding, we have been used chi square test. RESULTS: The survey shows that the experience rate of allergic disease is 40.4%. The experience rate of allergic disease was not related with sex, but the more ages the less experience rate. Allergic disease was not related with birth weight, gestational age, feeding method, use of carpet, breeding of pet, smoker in home, and the previous housing type. But experience rate of allergic disease was increased with positive family history. CONCLUSION: General facts of allergic disease in elementary school children had no differentiation between large city and the other region. The experience rate of allergic disease is 40.4%.
Asthma
;
Birth Weight
;
Breeding
;
Child*
;
Conjunctivitis, Allergic
;
Dermatitis, Atopic
;
Feeding Methods
;
Floors and Floorcoverings
;
Food Hypersensitivity
;
Gestational Age
;
Gwangju
;
Housing
;
Humans
;
Reproductive History
;
Rhinitis
3.Leiomyoma of the stomach, report of 3 cases.
Byoung Yoon RYU ; Young Joo LEE ; Hong Ki KIM ; Min Chul LEE ; Chang Sig CHOI
Journal of the Korean Surgical Society 1991;40(5):677-683
No abstract available.
Leiomyoma*
;
Stomach*
4.A Study of Antibiotic Susceptibility of Staphylococcus aureus in Bacterial Skin Infections.
Min Sung KIM ; Byoung Soo CHUNG ; Kyu Chul CHOI
Korean Journal of Dermatology 2006;44(7):805-810
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is an important nosocomial pathogen. It can also cause community-acquired infection. However, there are few reports on MRSA in community-acquired infections. OBJECTIVE: To evaluate the prevalence and antibiotic susceptibility of Staphylococcus aureus (S. aureus) in community-acquired bacterial skin infections. METHODS: Bacterial cultures and antimicrobial susceptibility tests were performed on out-patients with bacterial skin infection from January 2004 to October 2005. RESULTS: Of 252 pyoderma cases, bacteria were cultured from 145 (57.5%) cases. Among them, S. aureus was isolated from 85 (33.7%) patients. Eight (9.4%) S. aureus isolates were MRSA. The others were coagulase-negative Streptococcus (10.3%), Streptococcus (5.6%) and gram-negative bacilli (12.3%). The resistant rates of S. aureus against antibiotics were as follows: penicilin 97.6%, tetracycline 29.7%, gentamycin 23.5%, tobramycin 16.2%, fusidic acid 13.5%, oxacillin 9.4%, erythromycin 8.1%, aberkacin 5%, ciprofloxacin 4.7%, rifampin 2.7%, clindamycin 2.4%, trimethoprim/sulfameth-oxazole 2.4%, amoxicillin/clavulanic acid 0%, teicoplanin 0% and vancomycin 0%. The effective antibiotics for the treatment of MRSA were amoxicillin/clavulanic acid (0%), teicoplanin (0%) and vancomycin (0%). CONCLUSION: S. aureus was the most predominent pathogen in community-acquired pyoderma, and was sensitive to oxacillin, erythromycin, aberkacin, ciprofloxacin, rifampin, clindamycin, trimethoprim/sulfametho-xazole, amoxicillin/clavulanic acid, teicoplanin and vancomycin. Among these, amoxicillin/clavulanic acid, teicoplanin and vancomycin were also effective in the treatment of MRSA.
Anti-Bacterial Agents
;
Bacteria
;
Ciprofloxacin
;
Clindamycin
;
Community-Acquired Infections
;
Erythromycin
;
Fusidic Acid
;
Gentamicins
;
Humans
;
Methicillin-Resistant Staphylococcus aureus
;
Outpatients
;
Oxacillin
;
Prevalence
;
Pyoderma
;
Rifampin
;
Skin*
;
Staphylococcus aureus*
;
Staphylococcus*
;
Streptococcus
;
Teicoplanin
;
Tetracycline
;
Tobramycin
;
Vancomycin
5.Results of 6 month short course chemotherapy for pulmonary tubercul-osis with 2SHRZ/4HR.
Hyong Ju LEE ; Chul Hong MIN ; Sun Woo LEE ; In Won PARK ; Byoung Whui CHOI ; Sung Ho HUE
Tuberculosis and Respiratory Diseases 1991;38(2):93-98
No abstract available.
Drug Therapy*
6.A Case of Primary Laryngeal Aspergillosis Confused with Vocal Cyst.
Young In KIM ; Byoung Chul PARK ; Jang Su LEE ; Han Ki MIN
Korean Journal of Otolaryngology - Head and Neck Surgery 2010;53(11):726-728
With a surge in the population of immunocompromised patients, the incidence of laryngeal fungal infection has also been increased. Infection by aspergillus, which is a kind of mold, or a filamentous fungus, occurs rarely in larynx. Furthermore, most aspergillosis of the upper airway is an extension of the pulmonary or systemic aspergillosis in the immunocompromised host. So, the primary laryngeal aspergillosis that occurrs as an isolated laryngeal infection of aspergillus without other aerodigestive tract extension is very rarely encountered. We present a case of primary laryngeal aspergillosis misconceived as a vocal cord cyst in a 24-year-old female who had no past history of immune deficiency, voice abuse or steroid use.
Aspergillosis
;
Aspergillus
;
Female
;
Fungi
;
Humans
;
Immunocompromised Host
;
Incidence
;
Larynx
;
Vocal Cords
;
Voice
;
Young Adult
7.Lazertinib: on the Way to Its Throne
Jiyun LEE ; Min Hee HONG ; Byoung Chul CHO
Yonsei Medical Journal 2022;63(9):799-805
Lazertinib is an oral, irreversible, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that forms an irreversible covalent bond to the Cys797 residue in the ATP-binding site of the EGFR kinase domain and exhibits a high selectivity for sensitizing and T790M EGFR mutations. In January 2021, it was first approved for the treatment of advanced or metastatic non-small cell lung cancer (NSCLC) patients with EGFR T790M who had previously received EGFR TKI therapy based on LASER201, a phase I/II trial. At a recommended dose of 240 mg, lazertinib achieved an encouraging anti-tumor activity in both extra- and intracranial lesions. With a high half-maximal inhibitory concentration for EGFR wildtype tumors, it is anticipated to pose a lower risk of skin and cardiac adverse events compared to osimertinib. Lazertinib is currently being investigated as a monotherapy in first-line treatment and in combination with amivantamab under various settings. In this review, we systematically summarize the preclinical and clinical data of lazertinib and discuss future perspectives on the treatment of EGFR-mutant NSCLC.
8.Pseudomyxoma peritonei originated from the vermiform appendix.
Byoung Yoon RYU ; Min Jae SUNG ; Dong Kun KIM ; Young Joo LEE ; Hong Ki KIM ; Min Chul LEE ; Chang Sig CHOI
Journal of the Korean Surgical Society 1992;42(5):722-728
No abstract available.
Appendix*
;
Pseudomyxoma Peritonei*
9.Mesenteric cysts: collective review of 31 cases.
Dong Kun KIM ; Sang Oh LEE ; Byoung Yoon RYU ; Young Joo LEE ; Min Chul LEE ; Hong Ki KIM ; Chang Sig CHOI
Journal of the Korean Surgical Society 1991;41(4):458-466
No abstract available.
Mesenteric Cyst*
10.Allogeneic Bone Marrow Transplantation in Shwachman-Diamond Syndrome with Malignant Myeloid Transformation: A Case Report.
So Young PARK ; Min Byoung CHAE ; Yee Gyung KWACK ; Moon Hee LEE ; In Ho KIM ; Young Soo KIM ; Chul Soo KIM
The Korean Journal of Internal Medicine 2002;17(3):204-206
Shwachman-Diamond syndrome (SDS) is a rare genetic disorder of unknown pathogenesis involving exocrine pancreatic insufficiency and hematological and skeletal abnormalities. About 25% of patients develop hematopoietic malignancies. We report on a case of acute myeloid leukemia (M2) in a 21-year-old woman affected by SDS. She was treated with conventional chemotherapy (idarubicin plus cytarabine) and reached complete remission of leukemia. After induction chemotherapy, she underwent allogeneic bone marrow transplantation (BMT). The BMT preparative regimen consisted of total body irradation (TBI) followed by cyclophosphamide. Cyclosporin A and short term methotrexate were used for graft-versus-host disease prophylaxis. After a follow-up of 12 months, she is alive leukemia free off any immunosuppressive agent. Although experience in this field is scarce, we speculate that bone marrow failure in SDS is an indication for BMT which is the only curative trentment option.
Adult
;
*Bone Marrow Transplantation
;
Case Report
;
*Cell Transformation, Neoplastic
;
Female
;
Human
;
Leukemia, Myelocytic, Acute/*pathology/*therapy
;
Myelodysplastic Syndromes/*complications/*therapy
;
Pancreatic Insufficiency/complications/therapy
;
Syndrome
;
Transplantation, Homologous