2.Acute Spontaneous Spinal Epidural Hemorrhage.
Bo Seung KANG ; Jeong Hoon LEE ; Hyung Kon SONG ; Keun Jung SONG ; Yeon Kwon JEONG ; Byoung Cheol KIM
Journal of the Korean Society of Emergency Medicine 2000;11(2):248-254
Spontaneous spinal epidural hemorrhage(SSEH) represent 0.3%~0.9% of spinal epidural-space-occupying lesions. The therapeutic outcome seems to be determined by the accuracy of the diagnosis and by the time interval between the onset of symptom and surgical decompression. Thus, SSEH is a rare spinal emergency and a diagnostic challenge. We experienced two such cases. In one case, the symptoms were confused with those for a ureter stone, aortic aneurysm, spinal cord infarction. That patient completely recovered spontaneously within 2 hours. In the other case, which was initially diagnosed incorrectly as a cerebral infarction, surgical decompression was performed. That patient recovered completely within 1 month.
Aortic Aneurysm
;
Cerebral Infarction
;
Decompression, Surgical
;
Diagnosis
;
Emergencies
;
Hematoma, Epidural, Spinal*
;
Humans
;
Infarction
;
Spinal Cord
;
Ureter
3.A Case of Meconium Pseudocyst which was Prenatally Diagnosed.
Cheol Gyu KANG ; Sug Young KIM ; Gyoung Hoon LEE ; Byoung Cheol CHOI ; Young Su NOH ; Kyoung Cheol SONG ; Ki Nam EOM ; Seung Ug IM
Korean Journal of Obstetrics and Gynecology 2001;44(7):1345-1349
Prenatal Ultrasonographic findings of meconium peritonitis show calcificalion, and abdominal echogenic masses such as pseudocyst. Also, we can find availability of 3 dimensional ultrasonography above these descriptions. We present a case of meconium peritonitis in uterus which was diagnosed by means of prenatal 2D & 3D ultrasonography with brief review of literatures.
Meconium*
;
Peritonitis
;
Ultrasonography
;
Uterus
4.A case of primary malignant fibrous histiocytoma of the lung.
In Cheol SHIN ; Sun Woo LEE ; Moon Jun NO ; In Won PARK ; Byoung Whui CHOI ; Sung Ho HUE ; Mi Kyoung KIM ; Kye Yong SONG ; Dong Suep SOHN ; Ki Min YANG
Tuberculosis and Respiratory Diseases 1991;38(3):309-316
No abstract available.
Histiocytoma, Malignant Fibrous*
;
Lung*
5.Treatment of Tibial Fractures with the Ilizarov Method
Hae Ryong SONG ; Se Hyun CHO ; Kyung Hoi KOO ; Hyung Bin PARK ; Yeon Cheon JUNG ; Sun Cheol HWANG ; Jai Soo KIM ; Byoung Suck KIM ; Ye Soo PARK
The Journal of the Korean Orthopaedic Association 1994;29(2):655-664
Between 1987 and 1992, 86 tibial fractures were treated with the Ilizarov external fixator at Gyeong-Sang National University Hospital and Okpo Hospital. The mean follow-up period was 31.4 months. Sixty-six were open fractures and twenty were closed fractures with severe comminution. In 66 open fractures, there were 9 Gustilo type I, 10 type II, and 47 type III fractures. Of 66 open fractures, 22 had bone defects ranged from 2cm to 17cm and 16 had extensive loss of soft tissue. Twenty-two bone defects were treated with cancellous bone grafts in 8 cases, bifocal osteosynthesis with bone graft in 12 cases, and trifocal osteosynthesis with bone graft in 2 cases. Thirty-four extensive soft tissue defects were treated with split-thickness skin graft, musculocutaneous flap, soft tissue transportation with ring used in bifocal, trifocal osteosynthesis, and acute shortening of fracture site. Of 20 closed fractures, 14 were treated with cancellous bone graft for decreasing union time and 6 were treated with monofocal compression without bone graft. The mean time to union was 20.5 weeks in closed fractures, and 35.4 weeks in open fractures. Of 40 complications, 12 were knee and ankle joint contractures, 12 were soft tissue and bone infections of pin tract, 5 were refracture, 5 were angular deformities of 10 degree or more, 5 were delayed union, and 2 were nonunion. According to Tucker's classification, the results were graded as excellent in 31, good in 38, fair in 12, and poor in 5 cases. Primary or secondary bone graft is necessary for early bony union and anatomical reduction combined with bone graft could prevent the complications of delayed union and nonunion.
Ankle Joint
;
Classification
;
Congenital Abnormalities
;
Contracture
;
External Fixators
;
Follow-Up Studies
;
Fractures, Closed
;
Fractures, Open
;
Ilizarov Technique
;
Knee
;
Myocutaneous Flap
;
Skin
;
Tibia
;
Tibial Fractures
;
Transplants
;
Transportation
6.Predictive Factors for Switched EGFR-TKI Retreatment in Patients with EGFR-Mutant Non-Small Cell Lung Cancer.
Byoung Soo KWON ; Ji Hyun PARK ; Woo Sung KIM ; Joon Seon SONG ; Chang Min CHOI ; Jin Kyung RHO ; Jae Cheol LEE
Tuberculosis and Respiratory Diseases 2017;80(2):187-193
BACKGROUND: Third-generation tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR-TKIs) have proved efficacious in treating non-small cell lung cancer (NSCLC) patients with acquired resistance resulting from the T790M mutation. However, since almost 50% patients with the acquired resistance do not harbor the T790M mutation, retreatment with first- or second-generation EGFR-TKIs may be a more viable therapeutic option. Here, we identified positive response predictors to retreatment, in patients who switched to a different EGFR-TKI, following initial treatment failure. METHODS: This study retrospectively reviewed the medical records of 42 NSCLC patients with EGFR mutations, whose cancers had progressed following initial treatment with gefitinib or erlotinib, and who had switched to a different first-generation EGFR-TKI during subsequent retreatment. To identify high response rate predictors in the changed EGFR-TKI retreatment, we analyzed the relationship between clinical and demographic parameters, and positive clinical outcomes, following retreatment with EGFR-TKI. RESULTS: Overall, 30 (71.4%) patients received gefitinib and 12 (28.6%) patients received erlotinib as their first EGFR-TKI treatment. Following retreatment with a different EGFR-TKI, the overall response and disease control rates were 21.4% and 64.3%, respectively. There was no significant association between their overall responses. The median progression-free survival (PFS) after retreatment was 2.0 months. However, PFS was significantly longer in patients whose time to progression was ≥10 months following initial EGFR-TKI treatment, who had a mutation of exon 19, or whose treatment interval was <90 days. CONCLUSION: In patients with acquired resistance to initial EGFR-TKI therapy, switched EGFR-TKI retreatment may be a salvage therapy for individuals possessing positive retreatment response predictors.
Carcinoma, Non-Small-Cell Lung*
;
Disease-Free Survival
;
Erlotinib Hydrochloride
;
Exons
;
Humans
;
Medical Records
;
Protein-Tyrosine Kinases
;
Receptor, Epidermal Growth Factor
;
Retreatment*
;
Retrospective Studies
;
Salvage Therapy
;
Treatment Failure
7.Positive Rate of HLA Class I Antibodies in Multiparous Korean Women.
Eun Young SONG ; Sun Mee KIM ; Byoung Cheol KIM ; Kyou Sup HAN ; Myoung Hee PARK
Korean Journal of Clinical Pathology 2000;20(2):210-214
BACKGROUND: Anti-HLA antibodies are most frequently induced by transfusion or pregnancy, and these anibodies can be used as antisera for HLA typing. However these antibodies may elicit adverse reactions such as transfusion reaction or rejection of transplanted organs. In this study, frequency and specificities of antibodies against HLA class I antigens were determined in multiparous Korean women. METHODS: Sera from 671 multiparous women were tested for anti-HLA antibody screening by standard microlymphocytotoxicity test using 49~50 lymphocyte panels. PRA(panel reactive antibody) values were calculated as percentage of postive panels among total lymphocyte panels tested. HLA antibody specificities and reaction strengths were determined by analysis of serologic reaction patterns. RESULTS: A total of 671 sera were tested and 124 sera(18.5%) were positive for HLA antibodies. Among HLA antibody-positive sera(n=124), 117(94.4%) showed PRA values of < OR = 50% and only 7(5.6%) showed PRA values of >50%. Specificities of HLA antibodies were identified in 51 sera(41.1%) and 18 sera(14.5%) contained reagent quality antibodies(r> or =0.8, SI> or =70%), corresponding to 2.7% of total multiparous women. Among these, 4 sera had monospecific HLA antibodies and 14 sera had HLA antibodies against two or more antigens: 4 sera containing HLA antibodies against 7 CREG(cross reactive group), 5 sera containing antibodies against 5 CREG. CONCLUSION: Through the analysis of frequency and specificity of HLA antibodies in 671 multiparous women, it is concluded that HLA antisera can be obtained from multiparous women as effectively as from pregnant women. The frequency of high level of sensitization(PRA>50%), which can elicit problems in relation to transfusion or organ transplantation, is very low(1.0%).
Antibodies*
;
Antibody Specificity
;
Blood Group Incompatibility
;
Female
;
Histocompatibility Antigens Class I
;
Histocompatibility Testing
;
Humans
;
Immune Sera
;
Lymphocytes
;
Mass Screening
;
Organ Transplantation
;
Parity
;
Pregnancy
;
Pregnant Women
;
Sensitivity and Specificity
;
Transplants
8.The effect of magnesium sulfate on postoperative pain in patients undergoing major abdominal surgery under remifentanil-based anesthesia.
Cheol LEE ; Mi Soon JANG ; Yoon Kang SONG ; Seri O ; Seo Young MOON ; Dong Baek KANG ; Byoung Ryun KIM ; Seung Jae BYUN
Korean Journal of Anesthesiology 2008;55(3):286-290
BACKGROUND: Opioid tolerance may involve activation of the N-methyl-D-aspartate (NMDA) system. The possible involvement of the NMDA system suggests that one of the NMDA receptor antagonists, magnesium may be a useful adjunct to opioids for the treatment of postoperative pain following remifentanil infusion. METHODS: For this study, 70 patients scheduled for major abdominal surgery under remifentanil-based anesthesia were randomly allocated into groups that received either magnesium sulfate (group M) or saline (group C) intravenously. The patients in the group M received 25% magnesium sulfate at a dose of 50 mg/kg in 100 ml of saline, and those in the group C received an equal volume of saline prior to the induction of anesthesia. In addition, patients in both groups received 10 mg/kg/h infusion of either magnesium sulfate (group M) or an equal volume of saline (group C) until the end of surgery. Pain was assessed using a visual analog scale at 30 min, and 6, 12, 24, and 36 hours after operation. The time to the first use of postoperative analgesic and cumulative analgesic consumption in both groups were also evaluated. RESULTS: The visual analog scale scores for pain and cumulative analgesic consumption were significantly lower in the group M than in the group C. The time to the first use of postoperative analgesic was significantly shorter in group C than in the group M. CONCLUSIONS: Use of the NMDA-receptor antagonist, magnesium sulfate as an adjuvant analgesic reduced postoperative pain in patients undergoing major abdominal surgery under remifentanil-based anesthesia.
Analgesics, Opioid
;
Anesthesia
;
Humans
;
Magnesium
;
Magnesium Sulfate
;
N-Methylaspartate
;
Pain, Postoperative
;
Piperidines
9.Effect of early oral intake on postoperative bowel function in patients undergoing lower extremities surgery under epidural anesthesia.
Cheol LEE ; Hwa Sung LEE ; Yoon Kang SONG ; Seri O ; Seung Jae BYUN ; Dong Baek KANG ; Ji Hyo HWANG ; Byoung Ryun KIM ; Seo Young MOON ; Dong Youp HAN
Korean Journal of Anesthesiology 2008;55(3):282-285
BACKGROUND: Early oral intake (EOI) associated with early recovery of normal bowel function has been shown to be an important determinant for improving patients' satisfaction. We investigated the tolerability of EOI and its effects on the recovery of bowel function after epidural anesthesia. METHODS: A prospective randomized trial of patients undergoing lower extremities surgery under epidural anesthesia was performed. A liquid drink was given to 150 patients in the EOI group 1 hours after surgery, and to 150 patients in the delayed oral intake (DOI) group 8 hours after surgery. We recorded presence of bowel sounds immediately after operation, symptoms of ileus, time to the first flatus, time to the first defecation, degree of appetite before the first meal, and patients' satisfaction. RESULTS: There was no significant difference in the presence of immediate postoperative bowel sounds, the degree of appetite before the first meal, mild ileus, and severe ileus between groups. Time to the first flatus and time to the first defecation in the EOI group were shorter than those of the DOI group. The patients' satisfaction in the EOI group was higher than that of the DOI group. CONCLUSIONS: For uncomplicated patients undergoing lower extremities under epidural anesthesia, beginning oral hydration as early as 1 hour after the operation is safe and well tolerated and resulting in faster recovery of bowel function and higher patients' satisfaction.
Anesthesia, Epidural
;
Appetite
;
Defecation
;
Flatulence
;
Humans
;
Ileus
;
Lower Extremity
;
Meals
;
Prospective Studies
10.Achilles Tendon Rupture Associated with Ipsilateral Bimalleolar Fracture: A Case Report.
Hyung Jin CHUNG ; Su Young BAE ; Byoung Kwon MIN ; Min Cheol SONG
Journal of Korean Foot and Ankle Society 2011;15(2):107-109
We report here on a case of Achilles tendon rupture associated with ipsilateral bimalleolar fracture that was caused by ski injury. The association of an ankle fracture with rupture of the Achilles tendon is even more infrequent, although both injuries alone are extremely common. We treated as a operation of Achilles tendon repair with Krackow method and open reduction with Tension-band wiring technique for bimalleolar fracture.
Achilles Tendon
;
Animals
;
Ankle
;
Rupture