Infectious mononucleosis is an acute infectious disease occurring predominantly in older children and young adults due to primary Epstein-Barr virus infection. The clinical picture is extremely variable in both severity and duration. The disease in children is generally mild. It is characterized clinically by fever, exudative or membranous pharyngitis, generalized lymphadenopathy, and splenomegaly. Rarely, it complicates neurologic involvement such as cranial nerve palsy, meningoencephalitis, and transverse myelitis, hematologic involvement such as hemolytic anemia, immune thrombocytopenic purpura, and aplastic anemia, rupture of spleen, myocarditis, interstitial pneumonia, and orchitis, etc. We experienced a case of infectious mononucleosis with pleural effusion and ascites in a 5-year-old male with the chief complaint of fever, sore throat and vomiting 3 days prior to admission. The diagnosis was made on the clinical findings, immunologic findings and the typical findings of peripheral blood smear. On peripheral blood smear, leukocytosis with atypical lymphocytosis were seen. On immunologic study, anti-VCA IgM and IgG were positive by ELISA method. We reported this case and reviewed related literatures briefly.
Anemia, Aplastic ; Anemia, Hemolytic ; Ascites* ; Child ; Child, Preschool ; Communicable Diseases ; Cranial Nerve Diseases ; Diagnosis ; Enzyme-Linked Immunosorbent Assay ; Fever ; Herpesvirus 4, Human ; Humans ; Immunoglobulin G ; Immunoglobulin M ; Infectious Mononucleosis* ; Leukocytosis ; Lung Diseases, Interstitial ; Lymphatic Diseases ; Lymphocytosis ; Male ; Meningoencephalitis ; Myelitis, Transverse ; Myocarditis ; Orchitis ; Pharyngitis ; Pleural Effusion* ; Purpura, Thrombocytopenic, Idiopathic ; Rupture ; Spleen ; Splenomegaly ; Vomiting ; Young Adult

We report a case of a 5-year-old girl who developed left hemiparesis and left facial palsy, 6 days after the initiation of fever and respiratory symptoms due to pneumonia. Chest radiography, conducted upon admission, showed pneumonic infiltration and pleural effusion in the left lung field. Brain magnetic resonance imaging showed acute ischemic infarction in the right middle cerebral artery territory. Brain magnetic resonance angiography and transfemoral cerebral angiography revealed complete occlusion of the right middle cerebral artery. Mycoplasma pneumoniae infection was identified by a 4-fold increase in IgG antibodies to M. pneumoniae between acute and convalescent sera by enzyme-linked immunosorbent assay. Fibrinogen and D-dimer levels were elevated, while laboratory exams in order to identify other predisposing factors of pediatric stroke were all negative. This is the first reported pediatric case in English literature of a M. pneumoniae-associated cerebral infarction involving complete occlusion of the right middle cerebral artery.
Antibodies ; Brain ; Causality ; Cerebral Angiography ; Cerebral Infarction ; Child, Preschool ; Enzyme-Linked Immunosorbent Assay ; Facial Paralysis ; Female ; Fever ; Fibrinogen ; Humans ; Immunoglobulin G ; Infarction ; Infarction, Middle Cerebral Artery ; Lung ; Magnetic Resonance Angiography ; Magnetic Resonance Imaging ; Middle Cerebral Artery* ; Mycoplasma pneumoniae* ; Mycoplasma* ; Paresis ; Pleural Effusion ; Pneumonia* ; Pneumonia, Mycoplasma* ; Radiography ; Stroke ; Thorax

We report a case of a 5-year-old girl who developed left hemiparesis and left facial palsy, 6 days after the initiation of fever and respiratory symptoms due to pneumonia. Chest radiography, conducted upon admission, showed pneumonic infiltration and pleural effusion in the left lung field. Brain magnetic resonance imaging showed acute ischemic infarction in the right middle cerebral artery territory. Brain magnetic resonance angiography and transfemoral cerebral angiography revealed complete occlusion of the right middle cerebral artery. Mycoplasma pneumoniae infection was identified by a 4-fold increase in IgG antibodies to M. pneumoniae between acute and convalescent sera by enzyme-linked immunosorbent assay. Fibrinogen and D-dimer levels were elevated, while laboratory exams in order to identify other predisposing factors of pediatric stroke were all negative. This is the first reported pediatric case in English literature of a M. pneumoniae-associated cerebral infarction involving complete occlusion of the right middle cerebral artery.
Antibodies ; Brain ; Causality ; Cerebral Angiography ; Cerebral Infarction ; Child, Preschool ; Enzyme-Linked Immunosorbent Assay ; Facial Paralysis ; Female ; Fever ; Fibrinogen ; Humans ; Immunoglobulin G ; Infarction ; Infarction, Middle Cerebral Artery ; Lung ; Magnetic Resonance Angiography ; Magnetic Resonance Imaging ; Middle Cerebral Artery* ; Mycoplasma pneumoniae* ; Mycoplasma* ; Paresis ; Pleural Effusion ; Pneumonia* ; Pneumonia, Mycoplasma* ; Radiography ; Stroke ; Thorax

PURPOSE: This study was designed to evaluate the incidence of complication in severely obese children and to determine whether the difference of Lp (a) between severely obese children and normal control group exists. METHODS: Body weight, height and obesity index were measured in 5885 (M:F= 3089:2796) elementary school children. Eight eight (M:F=63:25) were selected as severely obese children. Of the 88 children, 74 agreed to venous puncture for the measurement of serum glucose, total cholesterol, AST, ALT, HDL-cholesterol, apo A1, apo B and Lp (a). Blood pressure and atherogenic index were also checked. Twenty nine children were selected for the control group. RESULTS: The prevalence of severe obesity in elementary school children was 1.5%. Of 74 severely obese children, serum total cholesterol was over 200mg/dl in 16.2%, and HDL cholesterol below 40mg/dl in 47.3%. Atherogenic index was over 3 in 60.8%. The incidence of hypertension and fatty liver was 6.8% and 13.5%, respectively. DM was not found. The levels of total cholesterol, ALT, HDL cholesterol and atherogenic index in severely obese group differed significantly from those of control group. There were no significant differences in apolipoprotein levels between severely obese and control group. CONCLUSIONS: The incidence of complication in severely obese children is considerably high. We need systemic program about obesity prevention and management, and individualized approaches to prevention have to be applied. It seems that severe obesity doesn't directly influence on the levels of Lp (a) and apolipoproteins.
Apolipoprotein A-I ; Apolipoproteins B ; Apolipoproteins* ; Blood Glucose ; Blood Pressure ; Body Weight ; Child* ; Cholesterol ; Cholesterol, HDL ; Fatty Liver ; Humans ; Hypertension ; Incheon* ; Incidence ; Lipoprotein(a)* ; Lipoproteins* ; Obesity ; Obesity, Morbid ; Prevalence ; Punctures

Multicentric reticulohistiocytosis(MR) is a rare systemic disease of unknown etiology, characterized by destructive polyarthritis and mucocutaneous eruptions in various locations. In most cases rapidly progressive destructive polyarthritis is the presenting symptom, followed by typical skin eruptions. Skin lesions are characterized clinically by erythematous to brownish nodular lesions on the face, periungual areas and the trunk. The biopsy demonstrating the characteristic granulomatous infiltration of multinucleated giant cells and histiocytes with a ground-glass appearance is diagnostic. We report a case of multicentric reticulohistiocytosis in a 57-year-old female patient, who had skin lesions with polyarthritis and cardiac problem. To our knowledge, this is the first case report in Korea.
Arthritis ; Biopsy ; Female ; Giant Cells ; Histiocytes ; Humans ; Korea ; Middle Aged ; Skin

BACKGROUND: Iron deficiency anemia frequently occurs in adolescence because of accelerated physical growth in both boys and girls, and because of menstrual iron loss and dieting to avoid obesity in female teenagers. As little is known about iron deficiency in adolescents in Korea, this study was aimed at assessing the prevalence of iron deficiency and iron deficiency anemia (IDA) in apparently healthy Korean adolescents in relation to gender, physical development, and dietary habit. METHODS: With a questionnaire regarding their demographic characteristics, blood samples were obtained from apparently healthy students aged 10~18 years by venipuncture at Sept. and Oct. 1996. Hemoglobin (Hb), hematocrit, RBC indices, serum ferritin levels, iron and total iron-binding capacity (TIBC) were measured. RESULTS: A total of 1,164 students (M:F = 610:554) aged 10~18 years were included in this study. In boys, the mean Hb concentration increased with age from 13.3g/dL in the 10~12 years group to 15.3g/dL in the 17~18 years group. In girls, the mean Hb concentration was 13.2g/dL in the 10~12 years group, and 12.7g/dL in the 15~16 years group. In boys, iron deficiency prevalence was 5.6% in the 10~12 years group, 10.6% in the 13~16 years. In girls, the prevalence of anemia increased with age: 0.8% in the 10~12 years group; 5.5% in the 13~14 years group; 16.9% in the 15~16 years group; 19.7% in the 17~18 years group. Iron deficiency prevalence in girls was 9.2% in the 10~12 years group, 14.1%in the 13~14 years group, 22.6% in the 15~16 years group, and 30.7% in the 17~18 years group. The prevalence of IDA in girls was 0.8% in the 10~12 years group, 4.3% in the 13~14 years group, 7.3% in the 15~16 years group, and 13.1% in the 17~18 years group. On questionnaire, 19.5% of males and 40.0% of females usually missed one meal a day. The proportion of missed meals in girls increased with age. The proportions of Hb<12g/dL and ferritin<10ng/dL were significantly high in boys aged 10~14 years with vegetarian parents. The prevalence of anemia and iron deficiency in the students with menstruation was 14.9% and 21.6%, which was higher than the prevalence of 3.3% and 13.2% in those who did not have the menarche (P<0.001 and P<0.05, respectively). CONCLUSION: As the prevalence of iron deficiency and IDA were substantially greater than expected, studies of iron state in adolescent girls, especially middle to high school age, should be undertaken to assess iron deficiency. In addition, nutritional education for adolescents is warranted.
Adolescent* ; Anemia ; Anemia, Iron-Deficiency* ; Diet ; Education ; Female ; Ferritins ; Food Habits ; Hematocrit ; Humans ; Iron* ; Korea ; Male ; Meals ; Menarche ; Menstruation ; Obesity ; Parents ; Phlebotomy ; Prevalence* ; Surveys and Questionnaires

Objective: This study examined whether the preventive effects of the safety belt on traumatic brain injury (TBI) from motor vehicle collisions (MVCs) differ according to the occupants’ age. Methods: This study was a retrospective, observational study. This study evaluated the crash data from 2011 to 2016 obtained from the Emergency Department-based Injury In-depth Surveillance registry. The injured occupants were categorized by age into young adults (age, 18-35 years; n=35,032), middle-aged adults (age, 36-55 years; n=34,507), and older adults (aged older than 55 years, n=21,895). The primary (TBI), secondary (intensive care unit [ICU] admission), and tertiary endpoint (mortality) were set. Multivariate logistic regression analysis was performed, and the adjusted odds ratios (aORs) of subgroups were calculated for study outcomes adjusted for any potential confounders. Results: Among 91,434 patients, 61,205 used seat belts at the time of the crashes. Compared to the unbelted group, the belted group was less likely to have a TBI. A comparison of the aOR of subgroups for TBI revealed the odds ratio reduction to be the highest in young adults (aOR, 0.39; 95% confidence interval [CI], 0.32-0.47), followed by middle-aged adults (aOR, 0.39; 95% CI, 0.33-0.47) and older adults (aOR, 0.49; 95% CI, 0.42-0.56). In addition, seat belt use had a preventive effect on ICU admission and mortality at all subgroups, the effect of which decreased with age. Conclusion The protective effects of seat belts on TBI, ICU admission, and mortality from MVCs were reduced with age.

Objective: This study examined whether the preventive effects of the safety belt on traumatic brain injury (TBI) from motor vehicle collisions (MVCs) differ according to the occupants’ age. Methods: This study was a retrospective, observational study. This study evaluated the crash data from 2011 to 2016 obtained from the Emergency Department-based Injury In-depth Surveillance registry. The injured occupants were categorized by age into young adults (age, 18-35 years; n=35,032), middle-aged adults (age, 36-55 years; n=34,507), and older adults (aged older than 55 years, n=21,895). The primary (TBI), secondary (intensive care unit [ICU] admission), and tertiary endpoint (mortality) were set. Multivariate logistic regression analysis was performed, and the adjusted odds ratios (aORs) of subgroups were calculated for study outcomes adjusted for any potential confounders. Results: Among 91,434 patients, 61,205 used seat belts at the time of the crashes. Compared to the unbelted group, the belted group was less likely to have a TBI. A comparison of the aOR of subgroups for TBI revealed the odds ratio reduction to be the highest in young adults (aOR, 0.39; 95% confidence interval [CI], 0.32-0.47), followed by middle-aged adults (aOR, 0.39; 95% CI, 0.33-0.47) and older adults (aOR, 0.49; 95% CI, 0.42-0.56). In addition, seat belt use had a preventive effect on ICU admission and mortality at all subgroups, the effect of which decreased with age. Conclusion The protective effects of seat belts on TBI, ICU admission, and mortality from MVCs were reduced with age.

BACKGROUND/AIMS: Accurately diagnosing inflammatory bowel disease (IBD) remains a challenge, but is crucial for providing proper management for affected patients. The aim of the present study was to evaluate the frequency of change in diagnosis in Korean patients who were referred to our institution with a diagnosis of IBD. METHODS: We enrolled 1,444 patients diagnosed with ulcerative colitis (UC) and 1,452 diagnosed with Crohn's disease (CD), who had been referred to the Asan Medical Center between January 2010 and December 2014. These patients were assessed and subsequently classified as having UC, CD, indeterminate colitis, possible IBD, or non-IBD. RESULTS: During a median follow-up of 15.9 months, 400 of the 2,896 patients (13.8%) analyzed in this study experienced a change in diagnosis. A change in diagnosis from UC to CD, or vice-versa, was made in 24 of 1,444 patients (1.7%) and 23 of 1,452 patients (1.6%), respectively. A change to a non-IBD diagnosis was the most common modification; 7.5% (108 of 1444) and 12.7% (184 of 1452) of the patients with a referral diagnosis of UC and CD, respectively, were reclassified as having non-IBD. Among the 292 patients who were ultimately determined not to have IBD, 135 (55 UC and 80 CD cases) had received IBD-related medication. CONCLUSIONS: There are diagnostic uncertainties and difficulties in relation to IBD. Therefore, precise assessment and systematic follow-up are essential in the management of this condition.
Chungcheongnam-do ; Cohort Studies* ; Colitis ; Colitis, Ulcerative ; Crohn Disease ; Diagnosis* ; Follow-Up Studies ; Humans ; Inflammatory Bowel Diseases* ; Korea* ; Referral and Consultation

We report a Korean patient with glycogen storage disease type 1b (GSD-1b) whose diagnosis was confirmed by liver biopsy and laboratory results. The patient presented with delay of puberty and short stature on admission and had typical clinical symptoms of GSD as well as chronic neutropenia and inflammatory bowel disease. Mutation analysis of the glucose 6-phosphate translocase 6-phosphate translocase (SLC37A4) gene revealed that the patient was a compound heterozygote of two different mutations including a deletion mutation (c.1042_1043delCT; L348fs) and a missense mutation (A148V). The L348fs mutation was inherited from the patient's father and has been reported in an Italian family with GSD-1b, while the A148V mutation was transmitted from the patient's mother and was a novel mutation. To the best of our knowledge, this is the first report of genetically confirmed case of GSD-1b in Korean.
Base Sequence ; DNA/chemistry/genetics ; DNA Mutational Analysis ; Glycogen Storage Disease Type I/enzymology/*genetics ; Humans ; Korea ; *Mutation, Missense ; Phosphotransferases/*genetics ; Research Support, Non-U.S. Gov't