No abstract available.
Prurigo

No abstract available.
Hypopigmentation ; Lichens

The glucose uptake rate by Eurytrema pancreaticum was a mean value of 16.44 +/- 2.42 micro-mole/hr/g, and total CO(2) production rate by the fluke averaged 5.82 +/- 0.97 micro-mole/hr/g. The relative specific activity of respiratory CO(2) showed a mean value of 5.75 +/- 0.84 per cent. The rate of CO(2) production derived from medium C(14)-glucose was a mean of 0.33 +/- 0.10 micor-mole/hr/g. Therefore, the average value of 0.32 +/- 0.04 per cent of glucose utilized by the flukes from the medium C(14)-glucose was oxidized to respiratory CO(2). The tissue concentration of glycogen in E. pancreaticum was a mean of 45.50 +/- 2.18 mg/g or 4.55 +/- 0.22 %/g. But the turnover rate of glycogen pool was a mean of 0.027 +/- 0.003 %/hr or 0.009 +/- 0.002 mg/hr/g. The average value of 0.64 +/- 0.23 percent of glucose utilized by the flukes from the medium C(14)-glucose was incorporated into the glycogen. These data account for that only 1 per cent of the utilized glucose by the flukes participated in furnishing the oxidation into respiratory CO(2) and the synthetic process into glycogen.
parasitology-helminht-trematoda- Eurytrema pancreaticum ; glucose-biochemistry ; autoradiograhy ; glucose ; glycogen ; CO(2)

BACKGROUND/AIMS: To compare treatment outcome of hepatocellular carcinoma(HCC) under the size of 5 cm in relation to underlying liver function and treatment modalities, analysis of data from 145 patients was performed. METHODS: In this study, the records of 145 patients with small HCC (< 5 cm in diameter determined by hepatic angiography) were reviewed. Clinical parameters were analyzed and survival rate, recurrence rate were calculated. RESULTS: There were 107(73.8%) men and 38 women. Mean age at diagnosis was 55.1(range .' 25 83 year-old). HBsAg was detected in 97(66.9%) patients. Seventy two(50.0%) patients showed markedly elevated(>40 ng/mL) serum alpha-fetoprotein(AFP) level. Liver cirrhosis was associated in 109(75.2%) patients. Sixty five(44.8%) patients underwent surge, 63(43.5%) underwent transarterial therapy(TAT), 8(5.5%) underwent other modalities of therapy and the remaining 9(6.2% ) patients did not receive any specific treatment for HCC. In relation to the underlying liver function, 119(82.1% ) patients belonged to the non-cirrhotic or Child-Pugh class A, 20(13.8%) to class B and 6(4.1%) to class C. The median follow-up duration was 21 months. When analyzed with respect to treatment modalities alone, median survival was 43 months for all patients, 60 months for surgery, 29 months for TAT, 20 months for other treatment and 18 months for patients who received no specific treatment. Without considering liver function, cumulative 3 year survival rate was 68.6% for surgery, 43.9% for TAT, 29.2% for other treatment and 0% for no treatment. The survival rate for the patients who underwent surgery was significantly higher than for any other treatment modalities without considering the underlying liver function or in the non-cirrhotic/Child-Pugh class A(p<0.001). In patients whose tumor size was equal to or less than 3 cm, there was no difference in survival rate in relation to the treatment modalities when not considering the underlying liver function of each patient(p>0.05). But in patients classified as the non-cirrhotic/Child-Pugh class A, better survival was observed in the surgep group than the TAT group(p<0.05). The only factor influencing survival was the pre-treatment serum AFP level(p<0.05). The overall recurrence rate was 30.3%. For the entire patients, the factor significantly influencing the recurrence rate was the presence of underlying cirrhosis. When considering only the patients in the surgery group, the different types of surgical procedures significantly influenced the recurrence rate. CONCLUSION: Surgery is the treatment of choice for patients with HCC equal to or smaller than 5 cm. But for those patients whose tumor size is less than 3 cm, TAT may be a reasonable alternative to surgep when the liver function is not adequate for hepatic resection. Because overall recurrence rate exceeded 30% and median time of recurrence was only 9.5 months after definitive treatment, careful follow-up is required for all patients who undergo treatment for small HCC.
Carcinoma, Hepatocellular* ; Diagnosis ; Female ; Fibrosis ; Follow-Up Studies ; Hepatitis B Surface Antigens ; Humans ; Liver Cirrhosis ; Liver* ; Male ; Recurrence ; Survival Rate ; Treatment Outcome*

BACKGROUND: The histologic distinction of dermatofibrosarcoma protuberans (DFSP) and dermatofibroma (DF) may be difficult, especially in the case of DF extending into the subcutaneous fat. CD34 and Factor XIIIa stains are commonly used in distinguishing the DF from DFSP, but is not always helpful. There are no studies regarding the clinicopathologic comparison of DF and DFSP. OBJECTIVE: The aim of our study was to evaluate the clinicopathologic characteristics and differences between the DF and DFSP. METHODS: Retrospective analysis was performed by reviewing the clinicopatholgic records of 40 patients who were diagnosed with DF, and 11 patients who were diagnosed with DFSP, from 1998 to 2012 in Hallym University Medical Center. RESULTS: The ratio of male to female patients in DF and DFSP were 1:2.1 and 1:1.8, respectively. Disease onset ages were 32.6 years and 34.4 years, respectively. The average size was 0.8 cm and 2.0 cm, respectively. The most frequent location was the lower extremity and the trunk, respectively. No symptom was most common subjective symptom in both DF and DFSP. Most of DF presented as brown colored papules and the lesions of DFSP were reported mainly as brown plaques. Histopathologically, the 40 cases of DF were classified as 24 fibrous types, 12 cellular types and 4 aneurysmal types. Of the 11 DFSP, two cases were classified as myxoid type, one case as pigmented lesion (Bednar tumors) and one case as fibrosarcomatous type. Histopathologic findings of the DF showed more significant epidermal hyperplasia, basal hyperpigmentation and collagen trapping, compared to that of the DFSP. The subcutaneous extension and honeycomb pattern were significantly more present in DFSP than in DF. The immunoreactivity of CD34 in DFSP was generally strong and diffuse, in contrast to absent or focal staining seen in DF. CONCLUSION: We conclude that several cilinicopathologic features, including size, location, epidermal and tumoral component, and immunostaining, for CD34 can be used to distinguish DF from DFSP. Further research regarding the characteristics and differences between DF and DFSP should be performed on larger number of cases.
Aneurysm ; Collagen ; Coloring Agents ; Dermatofibrosarcoma ; Factor XIIIa ; Female ; Histiocytoma, Benign Fibrous ; Humans ; Hyperpigmentation ; Hyperplasia ; Lower Extremity ; Male ; Retrospective Studies ; Subcutaneous Fat

Fluoroscopy-induced chronic radiation dermatitis (FICRD) is a cutaneous disorder that results from prolonged exposure to ionizing radiation during interventional procedures. With the expanded use of interventional procedures, there is increased fluoroscopic exposure. However, diagnosis and treatment of such disorder remain difficult. Herein, we report on a case of FICRD that occurred in the right subscapular area.
Angioplasty, Balloon, Coronary ; Dermatitis ; Radiation, Ionizing

Balloon cell melanoma, an uncommon histopathological variant of malignant melanoma, was first described by Gardner and Vazquez in 1970. This condition is histopathologically characterized by the presence of balloon cells with varying sizes and atypical nuclei. An 84-year-old woman presented with a solitary, dome-shaped, walnut-sized, brownish nodule on the posterior aspect of the left ear with bleeding, having only detected the nodule 2 weeks prior. Histopathologically, the lobulated tumor mass revealed copious melanin pigment and many balloon cells with clear cytoplasm, atypical nuclei, and variable size. Immunohistochemically, the tumor mass showed positive reaction to S-100 protein and HMB 45 staining. We herein report a typical case of balloon cell melanoma, which developed primarily on the skin.
Aged, 80 and over ; Cytoplasm ; Ear ; Female ; Hemorrhage ; Humans ; Melanins ; Melanoma ; S100 Proteins ; Skin

PURPOSE: A prospective study was performed to evaluate the efficacies of two different dosages of aspirin(ASA) in treating Kawasaki disease(KD). METHODS: Thirty-nine children with KD were admitted to this hospital from July, 1992 to May, 1993, and were assigned randomly into 2 groups. Group A(medium-dose group, 20 patients) was given 50mg/kg/d(# 4), and group B(high-dose gorup, 19 patients) was given 100mg/kg/d(# 4) of ASA. Intravenous gammaglobulin(2g/kg) was given to all patients. RESULTS: 1) There were no significant differences in ages, sex ratios, durations of fever before treatment, and laboratory findings on admission between two groups. 2) The durations of ASA administration were similar in 2 groups(group A, 10.1+/-2.77 ; group B, 10.6+/-3.37 days ;?p>0.1). 3) The durations of fever after onset of treatment were not different significantly (group A, 2.65+/-3.28 ; group B, 1.74+/-1.52 days ; p>0.1). 4) There were no significant differences in laboratory findings after treatment between two groups, except hemoglobin(Hgb) and ESR examined in the 3 rd week of illness (Hgb: group A (N=15), 10.1+/-1.24 ; group B(n=14), 11.1+/-0.92g/dl ; p<0.05) (ESR: group A(n=14), 47.7+/-13.0 ; group B(n=14), 37.1+/-13.6mm/hr ; p<0.05). 5) Serum concentrations of ASA were examined 3 to 5 days after onset of treatment in 31 patients(group A, 17 ; group B, 14). Mean concentrations before the lst dose of the day were 3.28+/-3.01mg/dl in group A and 12.6+/-6.22mg/dl in group B(p<0.001). Mean concentrations before the 3 rd dose of the day were 3.58+/-2.36mg/dl in group A and 13.7+/-6.32mg/dl in group B(p<0.001). 6) EKG was examined 2 and 4 weeks after onset of illness. There were no abnormalities in EKG except sinus tachycardia in both groups. 7) Echocardiography was done 2 and 4 weeks after onset of illness. Coronary artery dilatation was observed in 40% of group A (8/20) and 31.6% of group B(6/19) at the lst examination (p>0.1), and in 25% of group A(5/20) and 10.5% of group B(2/19) at the 2 nd examination (p>0.1). In long-term follow-up, only 1 patient in each group showed coronary aneurysm respectively. CONCLUSIONS: Although serum concentrations of ASA were different significantly, there were no significant differences in recovery from KD and incidences of coronary artery lesions between two grous. So we think medium-dose aspirin therapy is safe and effective in the treatment of Kawasaki disease.
Aspirin* ; Child ; Coronary Aneurysm ; Coronary Vessels ; Dilatation ; Echocardiography ; Electrocardiography ; Fever ; Follow-Up Studies ; Humans ; Incidence ; Mucocutaneous Lymph Node Syndrome* ; Prospective Studies ; Sex Ratio ; Tachycardia, Sinus

Chronic mucocutaneous candidiasis is a rare syndrome characterized by persistent and refractory infection of the skin, nail and mucosal tissue by yeasts of the genus Candida. A 70-year-old woman presented with the following skin lesions: ill-defined annular shaped whitish macules on the upper and lower lips accompanying dryness, pain and burning sensation, and yellowish discoloration with onycholysis of the right 4th finger nail. The upper lip lesion showed histopathologic feature of band-like infiltration of lymphocytes in the upper dermis, consistent with lichen planus. But, systemic glucocorticoid was not effective in treating erosive lip lesions. KOH examination and fungal culture of specimens from the upper lip showed hyphal elements and growth of Candida albicans, respectively. Antifungal agent was administered. After the oral medication, skin lesions were improved but there was repeated recurrence. We report a case of chronic mucocutaneous candidiasis misdiagnosed as lichen planus.
Burns ; Candida ; Candida albicans ; Candidiasis, Chronic Mucocutaneous ; Dermis ; Female ; Fingers ; Humans ; Lichen Planus ; Lichens ; Lip ; Lymphocytes ; Mucous Membrane ; Nails ; Onycholysis ; Recurrence ; Sensation ; Skin ; Yeasts

Sinusoidal hemangioma is a distinctive subset of a group of lesions known collectively as cavernous hemangiomas. Clinically, it develops in adults, predominantly females, and presents as a solitary, painless, bluish, deep dermal or subcutaneous nodule. Lipoma is the most common benign soft tissue tumor. Lipoma is distinguished from sinusoidal hemangioma on both clinical and histological grounds. Several studies have suggested that adipocytes originate from perivascular cells during adipogenesis. Angiogenic cytokines released by adipocytes play a role in the vasoproliferative response. The rearrangement or loss of chromosome 13 can also be associated with hemangioma. However, no previous cases of sinusoidal hemangioma have been associated with benign tumors like lipoma. Here, we describe an unusual case of sinusoidal hemangioma that occurred together with a lipoma on the right upper arm of a 43-year-old male.
Adipocytes ; Adipogenesis ; Adult ; Arm ; Chromosomes, Human, Pair 13 ; Cytokines ; Female ; Hemangioma ; Hemangioma, Cavernous ; Humans ; Lipoma ; Male