CT findings of 19 kidneys in 12 patients with renal and perirenal non-Hodgkin's lymphoma were retrospectively reviewed to determine distinguishing characteristic and specific findings. CT manifestation of the renal and perirenal lymphoma included multiple nodules in five kidneys(26.3%), trans-capsular infiltration in three kidneys(15.8%). trans-sinus infiltration in nine kidneys(47.4%) and diffuse infiltration in two kidneys(10.5%0. Perirenal changes were thickening of the renal fascia in ten kidneys(52.6%) and crescentic lesion of low attenuation in the subcapsular area in five kidney(26.3%). Retroperitoneal lymphadenopathy was evident in eleven patient(57.9%). Renal calyceal dilatation without renal pelvic dilatation(selective calcelal dilatation) was noted in three kidneys. Familiarity with these CT findings of renal and perirenal lymphoma may be helpful in the diagnosis and management of patient with non-Hodgkin's lymphoma.
Diagnosis ; Dilatation ; Fascia ; Humans ; Kidney ; Lymphatic Diseases ; Lymphoma ; Lymphoma, Non-Hodgkin* ; Recognition (Psychology) ; Retrospective Studies

Human promyelocytic leukemia cells (HL-60) have been used as a model system in which to study the effects of protein phosphatase inhibitors on NADPH-oxidase activation. Since O2- is generated by NADPH-oxidase, we examined the effect of calyculin A pretreatment on oxidase activation in response to various agonists. When Me2SO-differentiated HL-60 cells were treated with calyculin A prior to the addition of phorbol 12-myristate 13-acetate (PMA), O2- production was inhibited; however, calyculin A enhanced O2- production by N-formyl-methionyl-leucyl-phenylalanine (FMLP). The decreased O2- production seen with calyculin A pretreatment followed by PMA may be due to diminished translocation of the p47-phox and p67-phox, cytosolic components of the oxidase, and inhibition of arachidonic acid release. Interestingly calyculin A pretreatment followed by either agonist significantly enhanced mitogen-activated-protein kinase (MAPK) activity. The differential effects of pretreatment with calyculin A on subsequent oxidase stimulation elicited by FMLP or PMA provide further evidence for substantial heterogeneity in the activation of the respiratory burst.
Arachidonic Acid/metabolism ; Ca(2+)-Calmodulin Dependent Protein Kinase/metabolism ; Cell Differentiation ; Dimethyl Sulfoxide/pharmacology* ; Enzyme Inhibitors/pharmacology* ; HL-60 Cells ; Human ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; NADPH Oxidase/metabolism* ; Neutrophils/metabolism* ; Neutrophils/drug effects ; Oxazoles/pharmacology* ; Oxygen/metabolism ; Phosphoprotein Phosphatase/antagonists & inhibitors ; Phosphoproteins/immunology ; Signal Transduction ; Tetradecanoylphorbol Acetate/pharmacology ; Time Factors