1.Thalamic Ataxia in the Elderly.
Byeong Chul OH ; Man Wook SEO ; Yun Jeong YANG
Journal of the Korean Geriatrics Society 1999;3(2):96-101
Ataxia is one of the most serious neurological symptoms in elderly The clarification of the related anatomical structures are necessary for the understanding of pathophysiologic mechanisms of ataxia. We have recently experienced a case of thalamic infarct in the territory of thalamogeniculate artery. The localization of lesion was based on CT and MR imaging. At first time, right hemiparesis and ataxia were prominent. Hemiparesis was transient but ataxia had been persistent for several months. It has been suspected that thalamus could be the part of neural circuits in balancing. Our case support this suggestion clinically. Based on clinical observations, a plausible extrapolation can be made to thalamic ataxia. It maybe related with dysfunction of dentatorubrothalamic and corticopontine pathway. Thus our case led us to conclude that thalamus could be engaged in balance control of human body.
Aged*
;
Arteries
;
Ataxia*
;
Human Body
;
Humans
;
Magnetic Resonance Imaging
;
Paresis
;
Thalamus
2.Giant cell tumor in cervical spine: a report of two cases.
Byeong Mun PARK ; Yeo Hon YUN ; Ick Hwan YANG
The Journal of the Korean Orthopaedic Association 1991;26(3):1010-1015
No abstract available.
Giant Cell Tumors*
;
Giant Cells*
;
Spine*
3.Two Cases of Marchiafava-Bignami Disease.
Byeong Cheol OH ; Yun Jeong YANG ; Young Hyun KIM
Journal of the Korean Neurological Association 1999;17(5):764-766
We described 2 patients with Marchiafava-Bignami disease, a neurological disorder associated with chronic alcohol consumption. Patient 1 expressed general weakness and confusion, while patient 2 expressed dysphagia and seizures. Lesions involving the corpus callosum were identified with T2 weighted MR imaging in which there was a hyperintensity in the splenium of patient 1 and in the entire corpus callosum of patient 2. While the conditions of both patients were improved by with nutritional support, they were left with cognitive impairment.
Alcohol Drinking
;
Corpus Callosum
;
Deglutition Disorders
;
Demyelinating Diseases
;
Humans
;
Magnetic Resonance Imaging
;
Marchiafava-Bignami Disease*
;
Nervous System Diseases
;
Nutritional Support
;
Seizures
4.'Rescue Therapy' with Mycophenolate Mofetil in Non-transplant Renal Disease Patients Experienced Conventional Immunosuppressive Treatments : Clinical Observation.
Byeong Yun YANG ; Jin KANG ; Sang Heon SONG ; Dong Won LEE ; Ihm Soo KWAK
Korean Journal of Nephrology 2008;27(1):110-116
PURPOSE: Mycophenolate mofetil (MMF) is thought to have not only low frequency of adverse side effects but also have equal efficacy to other conventional immunosuppressants (CIS). But It's hard to conclude that CIS may be replaceable with MMF. So we inquired into another aspect of MMF as 'Rescue therapy' in non-transplant renal diseases. METHODS: Twenty nine patients with non-transplant renal diseases received MMF therapy between January 2000 and April 2007. Eighteen patients who had received MMF more than 6 months were included. Sixteen of the 18 patients included were resistant to CIS and two were patients who maintained complete remission (CR) with MMF because of the adverse side effects of CIS. Treatment outcome was evaluated by dip-stick urine test. CR was defined by negative or trace, partial remission (PR) by 1 positive and treatment failure (TF) by more than 1 positive. RESULTS: Eleven of the resistant 16 patients had shown CR (69%) and maintained CR. Two of maintenance therapy with MMF had kept CR more than 12 months. The proportions of the patients who had shown decreased proteinuria in each treatment duration were 69% for 3 months (p=0.005), 81% for 6 months (p=0.001), 86% for 9 months (p=0.002) and 91% for 12 months (p=0.004), respectively. There were few adverse effects. CONCLUSION: We observed the efficacy of MMF in decreasing proteinuria and maintaining CR as 'Rescue therapy' for previously treated non-transplant renal disease patients with CIS. Large controlled clinical trials are expected for defining this effect.
Humans
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Immunosuppressive Agents
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Kidney Diseases
;
Mycophenolic Acid
;
Proteinuria
;
Treatment Failure
;
Treatment Outcome
5.Pediatric Fetal Rhabdomyoma Representing as Acute Mastoiditis: A Case Report and Literature Review
Byeong Jin KIM ; Yun Na YANG ; Chan Mi LEE ; Eun Jung LEE
Korean Journal of Otolaryngology - Head and Neck Surgery 2022;65(5):283-287
Rhabdomyomas are rare benign tumors. Most extracardiac rhabdomyomas are found in the head and neck region, especially in the pharynx and larynx. Herein, we have described the case of a 1-year-old boy presenting with recurrent otorrhea and postauricular swelling. His symptoms were due to a mass that was histologically diagnosed as fetal rhabdomyoma (FR). Here, we report the first case of FR in the postauricular area. Clinicians should keep in mind the possibility of FR if a child presents with external auditory canal mass associated with recurrent otorrhea and signs of mastoiditis.
6.Primary copper-associated chronic hepatitis without copper metabolism domain containing 1 mutation in a Dalmatian: a case report
Sumin YUN ; Dohee LEE ; Jimin OH ; Yeon CHAE ; Taesik YUN ; Yoonhoi KOO ; Mhan-Pyo YANG ; Byeong-Teck KANG ; Hakhyun KIM
Korean Journal of Veterinary Research 2022;62(4):e31-
A 12-year-old intact male Dalmatian dog presented hyporexia and vomiting for 1 week. Blood analysis revealed increased liver enzyme activity. Histopathological examination of the liver confirmed chronic hepatitis with fibrosis and necrosis. Copper staining revealed marked copper accumulation (2,770 ppm; normal range, 200 to 400 ppm), prominent in the centrilobular region, and compatible with copper-associated chronic hepatitis. However, copper metabolism domain containing 1 (COMMD1) mutation predisposing to copper accumulation in the liver tissue was not identified. The dog received medications but died 1 month after first visit. This is the first case of primary copper-associated hepatitis without COMMD1 mutation in a Dalmatian dog in South Korea.
7.The Result of Evaluation According to Radioactivity of Sequential Sentinel Nodes Biopsy in Breast cancer.
Jae Won OH ; So Young JUNG ; Ho HUR ; Jan Di LEE ; Seung Il KIM ; Se Hoon KIM ; Woo Ick YANG ; Mi Jin YUN ; Byeong Woo PARK
Journal of Breast Cancer 2006;9(3):235-240
PURPOSE: Radio-guided sentinel node biopsy has become a standard method for evaluating the axillary status. However, there is no guideline for the optimum extent of sentinel lymphadenectomy. The object of this study was to assess the probability of metastases according to the sequence of radioactivity in the sentinel nodes and to determine the accuracy of the methods for evaluating metastases. METHODS: 80 consenting patients underwent sentinel lymph node biopsy using 99mTc-phytate. All the lymph nodes that showed radioactivity higher than surroundings were excised and labeled as SN1 to SN5 according to the sequential radioactivity. All the excised sentinel nodes were evaluated by frozen sectioning (FS) and permanent sectioning (PS). The sensitivity, specificity, negative predictive value and accuracy of the procedure were then analyzed according to the evaluation method. RESULTS: All 80 patients showed a variable number of axillary sentinel node sites (SN1-SN5) and 19 patients (23.8%) had three or more sentinel node sites, with an average number of 1.98. The sensitivity, specificity, NPV and accuracy were higher on PS (94.4%, 100%, 98.4% and 98.8% respectively) than on FS (88.9%, 100%, 96.9% and 97.5% respectively). 20 patients were found to have metastatic breast cancer within the sentinel lymph nodes by IHC, but one case of a metastatic, non-sentinel node was found in the 60 patients with negative sentinel nodes, so that the final false negative rate was 4.8%. In 18 of the 20 sentinel node-positive patients(90.0%), the most radioactive lymph node (SN1) was a positive node. The removal of the most radioactive sentinel node and the 2nd most radioactive sentinel node accurately staged all 20 sentinel node-positive patients. CONCLUSION: Careful evaluation of the sentinel nodes with FS, PS and IHC study is essential to reduce the false negative results. In addition, excision of the highest and the 2nd highest lymph nodes is essential and the excision of the 3rd highest node if any, should also be considered for obtaining a better treatment results.
Biopsy*
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Breast Neoplasms*
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Breast*
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Humans
;
Lymph Node Excision
;
Lymph Nodes
;
Neoplasm Metastasis
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Radioactivity*
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Sensitivity and Specificity
;
Sentinel Lymph Node Biopsy
8.Factors determining renal function in Korean patients with autosomal dominant polycystic kidney disease.
Byeong Yun YANG ; Naria LEE ; Jung Min SON ; Jin KANG ; Eun Young SUNG ; Sang Heon SONG ; Dong Won LEE ; Soo Bong LEE ; Ihm Soo KWAK
Korean Journal of Medicine 2010;78(2):207-214
BACKGROUND/AIMS: Previous studies of autosomal dominant polycystic kidney disease (ADPKD) in Koreans have been predominantly cross-sectional and insufficient to elucidate factors determining renal function. METHODS: We retrospectively reviewed the medical records of 60 patients who were diagnosed with ADPKD in our hospital from 1995 to 2005. We surveyed the basal characteristics, symptoms, signs, blood and urine laboratory findings, radiologic extrarenal abnormalities, and kidney length through ultrasonography, and these measures were analyzed to identify their relationship to decreased renal function. RESULTS: The clinical characteristics, such as symptoms and signs, were similar to those reported previously. Following t-tests and simple regression analyses, the statistically significant variables related to renal function deterioration were as follows: hypertension (with decreased renal function, 2.5 mL/min/1.73 m2/year more rapidly than the no-hypertension group, p=0.006), hypercholesterolemia (p=0.007), hypernatremia (p=0.011), mean kidney length (beta=0.378, p=0.029), and albumin (beta=-2.067, p=0.003). The multiple regression analysis revealed that the significant factors were hypertension (beta=0.261, p=0.016), mean kidney length (beta =0.211, p=0.047), and hypernatremia (beta=0.244, p=0.024). CONCLUSIONS: The independent risk factors for deteriorating renal function in Korean patients with ADPKD were hypertension, hypernatremia, and mean kidney length.
Humans
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Hypercholesterolemia
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Hypernatremia
;
Hypertension
;
Kidney
;
Medical Records
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Polycystic Kidney, Autosomal Dominant
;
Renal Insufficiency
;
Retrospective Studies
;
Risk Factors
9.A Case of Metastatic Gastric Calcification in Acute Renal Failure.
Won LIM ; Sang Heon SONG ; Jungmin SON ; Jin KANG ; Byeong Yun YANG ; Eun Young SEONG ; Gwang Ha KIM ; Dong Won LEE ; Ihm Soo KWAK
Korean Journal of Nephrology 2009;28(1):53-57
In end stage renal disease, the precise mechanism of metastatic calcification remains unclear, except that it occurs with hyperphosphatemia, increased Ca x P product, and secondary hyperparathyroidism. It involves various organs such as lung, eye, stomach, kidney, and so on. A 62-year-old male patient, who had acute renal failure (ARF), developed gastric calcification in our institution. The ARF had been result of membranoproliferative glomerulonephritis (MPGN), and the metastatic calcification seemed to be caused by increased Ca x P product and hyperphosphatemia. This case shows that metastatic calcification could arise even in ARF.
Acute Kidney Injury
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Eye
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Glomerulonephritis, Membranoproliferative
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Humans
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Hyperparathyroidism, Secondary
;
Hyperphosphatemia
;
Kidney
;
Kidney Failure, Chronic
;
Lung
;
Male
;
Middle Aged
;
Stomach
10.Pyeloduodenal Fistula Successfully Treated By Endoscopic Ligation without Surgical Nephrectomy: Case Report.
Kyung Nam LEE ; In Hye HWANG ; Min Ji SHIN ; Soo Bong LEE ; Il Young KIM ; Dong Won LEE ; Harin RHEE ; Byeong Yun YANG ; Eun Young SEONG ; Ihm Soo KWAK
Journal of Korean Medical Science 2014;29(1):141-144
A 74-yr-old woman presented with fever and abdominal discomfort. She was in a septic condition caused by urinary tract infection. Her computed tomogram of the abdomen revealed features of hydronephrosis with ureteral stones in both kidneys. During percutaneous nephrostomies, right pyeloduodenal fistula (PDF) was diagnosed. Elective surgery was originally planned but the patient was in a poor condition to undergo surgery. Instead, 2 times endoscopic clipping and ligation by endoloop were applied with parenteral antibiotics for the fistula lesion. On admission day 30, she was discharged from the hospital after confirmation of no more contrast leakage on fistulography. We reviewed the literature and discuss the etiologies, clinical presentations, diagnosis, and treatment of PDF.
Aged
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Duodenal Diseases/complications/radiography/*surgery
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Female
;
Humans
;
Hydronephrosis/complications/radiography
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Intestinal Fistula/complications/radiography/*surgery
;
Kidney/radiography/surgery
;
Kidney Calculi/complications/radiography
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Kidney Diseases/complications/radiography/*surgery
;
Ligation
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Urethral Obstruction/complications/radiography
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Urinary Fistula/complications/radiography/*surgery
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Urinary Tract Infections/complications/radiography