1.The Operative Treatment of the Resistant clubfoot: Comparative study between modified Turco's Operation and combining calcaneocuboid release
Sung Joon KIM ; Kuhn Sung WHANG ; Young Hwan KIM ; Byeong Goo LIM
The Journal of the Korean Orthopaedic Association 1995;30(3):551-561
The 17 patients with 22 resistant clubfeet were treated with modified Turco's operation with or without combining release of calcaneocuboid joint at Department of Orthopaedic Surgery, Hanyang University School of Medicine between 1896 and 1991. They were analysed preoperatively and postoperatively with chinical and radiological methods. In patients who were treated with combined procedures, the latetal talocalcaneal angle and anteroposterior talo-first metatarsal angle in radiological findings were showed better improvement(p < 0.05), and anteroposterior talocalcaneal angle was also showed better improvement but not significant statistically, than those who were treated with modified Turco's operation alone. The final results of combined procedures were better than that of modified Turco's operation. And the most common characteristic physical findings in resistant clubfoot were small heel, deep longitudinal crease on the medial aspect of midfoot area and a single transverse crease on the posterior heel just proximal to the insertion of the tendocalcaneus. So we suggest these physical findings may be expectance for the resistance of the congenital clubfoot to conservative treatment, but it need further comparative study.
Clubfoot
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Heel
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Humans
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Joints
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Metatarsal Bones
2.Diagnostic Signification of Antiperinuclear Factor(APF) in Rheumatoid Arthritis
Il Yong CHOI ; Kwang Hyun LEE ; Shin Kyoo KIM ; Byeong Goo LIM
The Journal of the Korean Orthopaedic Association 1995;30(6):1558-1563
In systemic rheumatic disease, marker antibodies such as anti-Sm, anti Scl-70 and anti Jo-1 are helpful in the diagnosis of disease, but in rheumatoid arthritis, the diagnosis is difficult due to the low sensitivity and specificity of the rheumatoid factor(RF). So, a new maker antibody with high sensitivity and specificity was needed. Recently, the antiperi- nuclear factor(APF) has gained particular attention. The results of the APF and RF test in 165 patients with rheumatoid arthritis, 77 patients with osteoarthritis, and 109 normal healthy persons, which were taken between January, 1994 through December 1994 were as follows; 1. The sensitivity, specificity, and predictive value of positivity of the RF test in patients with rheumatoid arthritis were 58.2%, 93.5%, and 95.0%, and that of the APF test were 72.1%, 94.6% and 92.2%, respectively. 2. The sensitivity, specificity and predictive value of positivity when combining the APF with the RF were 83.0%, 85.7%, and 92.6%, respectively. 3. The disease status of the patients correlated with intensity of the APF test, that is, the more severe the disease status, the higher intensity. In conclusion, the APF was useful in the diagnosis of rheumatoid arthritis, and may be used as an indicator of disease status. When combining test the APF with RF, the incidence of sero-negative rheumatoid arthritis decreased.
Antibodies
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Arthritis, Rheumatoid
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Diagnosis
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Humans
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Incidence
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Osteoarthritis
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Rheumatic Diseases
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Sensitivity and Specificity
3.Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis.
Chae Jin LIM ; Yong Moon LEE ; Seung Goo KANG ; Hyung W LIM ; Kyong Oh SHIN ; Se Kyoo JEONG ; Yang Hoon HUH ; Suin CHOI ; Myungho KOR ; Ho Seong SEO ; Byeong Deog PARK ; Keedon PARK ; Jeong Keun AHN ; Yoshikazu UCHIDA ; Kyungho PARK
Biomolecules & Therapeutics 2017;25(5):511-518
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses the UVB irradiation-induced skin aging. Treatment with Aquatide directly activates SIRT1 and stimulates autophagy induction in cultured human dermal fibroblasts. Next, we found that Aquatide-mediated activation of SIRT1 increases autophagy induction via deacetylation of forkhead box class O (FOXO) 1. Finally, UVB irradiation-induced cellular senescence measured by SA-β-gal staining was significantly decreased in cells treated with Aquatide in parallel to occurring SIRT1 activation-dependent autophagy. Together, Aquatide modulates autophagy through SIRT1 activation, contributing to suppression of skin aging caused by UV irradiation.
Autophagy
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Cell Aging*
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Fibroblasts
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Humans
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Skin
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Skin Aging
4.Clinical Practice Guideline for Cardiac Rehabilitation in Korea Online only
Chul KIM ; Jidong SUNG ; Jong Hwa LEE ; Won Seok KIM ; Goo Joo LEE ; Sungju JEE ; Il Young JUNG ; Ueon Woo RAH ; Byung Ok KIM ; Kyoung Hyo CHOI ; Bum Sun KWON ; Seung Don YOO ; Heui Je BANG ; Hyung Ik SHIN ; Yong Wook KIM ; Heeyoune JUNG ; Eung Ju KIM ; Jung Hwan LEE ; In Hyun JUNG ; Jae Seung JUNG ; Jong Young LEE ; Jae Young HAN ; Eun Young HAN ; Yu Hui WON ; Woosik HAN ; Sora BAEK ; Kyung Lim JOA ; Sook Joung LEE ; Ae Ryoung KIM ; So Young LEE ; Jihee KIM ; Hee Eun CHOI ; Byeong Ju LEE ; Soon KIM
Annals of Rehabilitation Medicine 2019;43(3):355-356
OBJECTIVE: Though clinical practice guidelines (CPGs) for cardiac rehabilitation (CR) are an effective and widely used treatment method worldwide, they are as yet not widely accepted in Korea. Given that cardiovascular disease is the second leading cause of death in Korea, it is urgent that CR programs be developed. In 2008, the Government of Korea implemented CR programs at 11 university hospitals as part of its Regional Cardio-Cerebrovascular Center Project, and three additional medical facilities will be added in 2019. In addition, owing to the promotion of CR nationwide and the introduction of CR insurance benefits, 40 medical institutions nationwide have begun CR programs even as a growing number of medical institutions are preparing to offer CR. The purpose of this research was to develop evidence-based CPGs to support CR implementation in Korea. METHODS: This study is based on an analysis of CPGs elsewhere in the world, an extensive literature search, a systematic analysis of multiple randomized control trials, and a CPG management, development, and assessment committee comprised of 33 authors—primarily rehabilitation specialists, cardiologists, and thoracic surgeons in 21 university hospitals and two general hospitals. Twelve consultants, primarily rehabilitation, sports medicine, and preventive medicine specialists, CPG experts, nurses, physical therapists, clinical nutritionists, and library and information experts participated in the research and development of these CPGs. After the draft guidelines were developed, three rounds of public hearings were held with staff members from relevant academic societies and stakeholders, after which the guidelines were further reviewed and modified. PRINCIPAL CONCLUSIONS: CR involves a more cost-effective use of healthcare resources relative to that of general treatments, and the exercise component of CR lowers cardiovascular mortality and readmission rates, regardless of the type of coronary heart disease and type and setting of CR. Individualized CR programs should be considered together with various factors, including differences in heart function and lifestyle, and doing so will boost participation and adherence with the CR program, ultimately meeting the final goals of the program, namely reducing the recurrence of myocardial infarction and mortality rates.
Acute Coronary Syndrome
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Cardiovascular Diseases
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Cause of Death
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Consultants
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Coronary Disease
;
Delivery of Health Care
;
Heart
;
Hospitals, General
;
Hospitals, University
;
Humans
;
Insurance Benefits
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Korea
;
Life Style
;
Methods
;
Mortality
;
Myocardial Infarction
;
Nutritionists
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Physical Therapists
;
Preventive Medicine
;
Recurrence
;
Rehabilitation
;
Secondary Prevention
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Specialization
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Sports Medicine
;
Surgeons
5.Clinical Practice Guideline for Cardiac Rehabilitation in Korea: Recommendations for Cardiac Rehabilitation and Secondary Prevention after Acute Coronary Syndrome
Chul KIM ; Jidong SUNG ; Jong Hwa LEE ; Won Seok KIM ; Goo Joo LEE ; Sungju JEE ; Il Young JUNG ; Ueon Woo RAH ; Byung Ok KIM ; Kyoung Hyo CHOI ; Bum Sun KWON ; Seung Don YOO ; Heui Je BANG ; Hyung Ik SHIN ; Yong Wook KIM ; Heeyoune JUNG ; Eung Ju KIM ; Jung Hwan LEE ; In Hyun JUNG ; Jae Seung JUNG ; Jong Young LEE ; Jae Young HAN ; Eun Young HAN ; Yu Hui WON ; Woosik HAN ; Sora BAEK ; Kyung Lim JOA ; Sook Joung LEE ; Ae Ryoung KIM ; So Young LEE ; Jihee KIM ; Hee Eun CHOI ; Byeong Ju LEE ; Soon KIM
Korean Circulation Journal 2019;49(11):1066-1111
Though clinical practice guidelines (CPGs) for cardiac rehabilitation (CR) are an effective and widely used treatment method worldwide, they are as yet not widely accepted in Korea. Given that cardiovascular (CV) disease is the second leading cause of death in Korea, it is urgent that CR programs be developed. In 2008, the Government of Korea implemented CR programs at 11 university hospitals as part of its Regional Cardio-Cerebrovascular Center Project, and 3 additional medical facilities will be added in 2019. In addition, owing to the promotion of CR nationwide and the introduction of CR insurance benefits, 40 medical institutions nationwide have begun CR programs even as a growing number of medical institutions are preparing to offer CR. The purpose of this research was to develop evidence-based CPGs to support CR implementation in Korea. This study is based on an analysis of CPGs elsewhere in the world, an extensive literature search, a systematic analysis of multiple randomized control trials, and a CPG management, development, and assessment committee comprised of thirty-three authors—primarily rehabilitation specialists, cardiologists, and thoracic surgeons in 21 university hospitals and 2 general hospitals. Twelve consultants, primarily rehabilitation, sports medicine, and preventive medicine specialists, CPG experts, nurses, physical therapists, clinical nutritionists, and library and information experts participated in the research and development of these CPGs. After the draft guidelines were developed, 3 rounds of public hearings were held with staff members from relevant academic societies and stakeholders, after which the guidelines were further reviewed and modified. CR involves a more cost-effective use of healthcare resources relative to that of general treatments, and the exercise component of CR lowers CV mortality and readmission rates, regardless of the type of coronary heart disease and type and setting of CR. Individualized CR programs should be considered together with various factors, including differences in heart function and lifestyle, and doing so will boost participation and adherence with the CR program, ultimately meeting the final goals of the program, namely reducing the recurrence of myocardial infarction and mortality rates.
Acute Coronary Syndrome
;
Cause of Death
;
Consultants
;
Coronary Disease
;
Delivery of Health Care
;
Heart
;
Hospitals, General
;
Hospitals, University
;
Humans
;
Insurance Benefits
;
Korea
;
Life Style
;
Methods
;
Mortality
;
Myocardial Infarction
;
Nutritionists
;
Physical Therapists
;
Preventive Medicine
;
Recurrence
;
Rehabilitation
;
Secondary Prevention
;
Specialization
;
Sports Medicine
;
Surgeons
6.Clinical Practice Guideline for Cardiac Rehabilitation in Korea
Chul KIM ; Jidong SUNG ; Jong Hwa LEE ; Won Seok KIM ; Goo Joo LEE ; Sungju JEE ; Il Young JUNG ; Ueon Woo RAH ; Byung Ok KIM ; Kyoung Hyo CHOI ; Bum Sun KWON ; Seung Don YOO ; Heui Je BANG ; Hyung Ik SHIN ; Yong Wook KIM ; Heeyoune JUNG ; Eung Ju KIM ; Jung Hwan LEE ; In Hyun JUNG ; Jae Seung JUNG ; Jong Young LEE ; Jae Young HAN ; Eun Young HAN ; Yu Hui WON ; Woosik HAN ; Sora BAEK ; Kyung Lim JOA ; Sook Joung LEE ; Ae Ryoung KIM ; So Young LEE ; Jihee KIM ; Hee Eun CHOI ; Byeong Ju LEE ; Soon KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 2019;52(4):248-285
BACKGROUND: Though clinical practice guidelines (CPGs) for cardiac rehabilitation (CR) are an effective and widely used treatment method worldwide, they are as yet not widely accepted in Korea. Given that cardiovascular disease is the second leading cause of death in Korea, it is urgent that CR programs be developed. In 2008, the Government of Korea implemented CR programs at 11 university hospitals as part of its Regional Cardio-Cerebrovascular Center Project, and 3 additional medical facilities will be added in 2019. In addition, owing to the promotion of CR nationwide and the introduction of CR insurance benefits, 40 medical institutions nationwide have begun CR programs even as a growing number of medical institutions are preparing to offer CR. The purpose of this research was to develop evidence-based CPGs to support CR implementation in Korea. METHODS: This study is based on an analysis of CPGs elsewhere in the world, an extensive literature search, a systematic analysis of multiple randomized control trials, and a CPG management, development, and assessment committee comprised of 33 authors—primarily rehabilitation specialists, cardiologists, and thoracic surgeons in 21 university hospitals and 2 general hospitals. Twelve consultants, primarily rehabilitation, sports medicine, and preventive medicine specialists, CPG experts, nurses, physical therapists, clinical nutritionists, and library and information experts participated in the research and development of these CPGs. After the draft guidelines were developed, 3 rounds of public hearings were held with staff members from relevant academic societies and stakeholders, after which the guidelines were further reviewed and modified. RESULTS: CR involves a more cost-effective use of healthcare resources relative to that of general treatments, and the exercise component of CR lowers cardiovascular mortality and readmission rates, regardless of the type of coronary heart disease and type and setting of CR. CONCLUSION: Individualized CR programs should be considered together with various factors, including differences in heart function and lifestyle, and doing so will boost participation and adherence with the CR program, ultimately meeting the final goals of the program, namely reducing the recurrence of myocardial infarction and mortality rates.
Acute Coronary Syndrome
;
Cardiovascular Diseases
;
Cause of Death
;
Consultants
;
Coronary Disease
;
Delivery of Health Care
;
Heart
;
Hospitals, General
;
Hospitals, University
;
Humans
;
Insurance Benefits
;
Korea
;
Life Style
;
Methods
;
Mortality
;
Myocardial Infarction
;
Nutritionists
;
Physical Therapists
;
Preventive Medicine
;
Recurrence
;
Rehabilitation
;
Secondary Prevention
;
Specialization
;
Sports Medicine
;
Surgeons
7.Clinical Practice Guideline for Cardiac Rehabilitation in Korea: Recommendations for Cardiac Rehabilitation and Secondary Prevention after Acute Coronary Syndrome
Chul KIM ; Jidong SUNG ; Jong Hwa LEE ; Won Seok KIM ; Goo Joo LEE ; Sungju JEE ; Il Young JUNG ; Ueon Woo RAH ; Byung Ok KIM ; Kyoung Hyo CHOI ; Bum Sun KWON ; Seung Don YOO ; Heui Je BANG ; Hyung Ik SHIN ; Yong Wook KIM ; Heeyoune JUNG ; Eung Ju KIM ; Jung Hwan LEE ; In Hyun JUNG ; Jae Seung JUNG ; Jong Young LEE ; Jae Young HAN ; Eun Young HAN ; Yu Hui WON ; Woosik HAN ; Sora BAEK ; Kyung Lim JOA ; Sook Joung LEE ; Ae Ryoung KIM ; So Young LEE ; Jihee KIM ; Hee Eun CHOI ; Byeong Ju LEE ; Soon KIM
Korean Circulation Journal 2019;49(11):1066-1111
Though clinical practice guidelines (CPGs) for cardiac rehabilitation (CR) are an effective and widely used treatment method worldwide, they are as yet not widely accepted in Korea. Given that cardiovascular (CV) disease is the second leading cause of death in Korea, it is urgent that CR programs be developed. In 2008, the Government of Korea implemented CR programs at 11 university hospitals as part of its Regional Cardio-Cerebrovascular Center Project, and 3 additional medical facilities will be added in 2019. In addition, owing to the promotion of CR nationwide and the introduction of CR insurance benefits, 40 medical institutions nationwide have begun CR programs even as a growing number of medical institutions are preparing to offer CR. The purpose of this research was to develop evidence-based CPGs to support CR implementation in Korea. This study is based on an analysis of CPGs elsewhere in the world, an extensive literature search, a systematic analysis of multiple randomized control trials, and a CPG management, development, and assessment committee comprised of thirty-three authors—primarily rehabilitation specialists, cardiologists, and thoracic surgeons in 21 university hospitals and 2 general hospitals. Twelve consultants, primarily rehabilitation, sports medicine, and preventive medicine specialists, CPG experts, nurses, physical therapists, clinical nutritionists, and library and information experts participated in the research and development of these CPGs. After the draft guidelines were developed, 3 rounds of public hearings were held with staff members from relevant academic societies and stakeholders, after which the guidelines were further reviewed and modified. CR involves a more cost-effective use of healthcare resources relative to that of general treatments, and the exercise component of CR lowers CV mortality and readmission rates, regardless of the type of coronary heart disease and type and setting of CR. Individualized CR programs should be considered together with various factors, including differences in heart function and lifestyle, and doing so will boost participation and adherence with the CR program, ultimately meeting the final goals of the program, namely reducing the recurrence of myocardial infarction and mortality rates.
8.Clinical Practice Guideline for Cardiac Rehabilitation in Korea
Chul KIM ; Jidong SUNG ; Jong Hwa LEE ; Won Seok KIM ; Goo Joo LEE ; Sungju JEE ; Il Young JUNG ; Ueon Woo RAH ; Byung Ok KIM ; Kyoung Hyo CHOI ; Bum Sun KWON ; Seung Don YOO ; Heui Je BANG ; Hyung Ik SHIN ; Yong Wook KIM ; Heeyoune JUNG ; Eung Ju KIM ; Jung Hwan LEE ; In Hyun JUNG ; Jae Seung JUNG ; Jong Young LEE ; Jae Young HAN ; Eun Young HAN ; Yu Hui WON ; Woosik HAN ; Sora BAEK ; Kyung Lim JOA ; Sook Joung LEE ; Ae Ryoung KIM ; So Young LEE ; Jihee KIM ; Hee Eun CHOI ; Byeong Ju LEE ; Soon KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 2019;52(4):248-285
BACKGROUND:
Though clinical practice guidelines (CPGs) for cardiac rehabilitation (CR) are an effective and widely used treatment method worldwide, they are as yet not widely accepted in Korea. Given that cardiovascular disease is the second leading cause of death in Korea, it is urgent that CR programs be developed. In 2008, the Government of Korea implemented CR programs at 11 university hospitals as part of its Regional Cardio-Cerebrovascular Center Project, and 3 additional medical facilities will be added in 2019. In addition, owing to the promotion of CR nationwide and the introduction of CR insurance benefits, 40 medical institutions nationwide have begun CR programs even as a growing number of medical institutions are preparing to offer CR. The purpose of this research was to develop evidence-based CPGs to support CR implementation in Korea.
METHODS:
This study is based on an analysis of CPGs elsewhere in the world, an extensive literature search, a systematic analysis of multiple randomized control trials, and a CPG management, development, and assessment committee comprised of 33 authors—primarily rehabilitation specialists, cardiologists, and thoracic surgeons in 21 university hospitals and 2 general hospitals. Twelve consultants, primarily rehabilitation, sports medicine, and preventive medicine specialists, CPG experts, nurses, physical therapists, clinical nutritionists, and library and information experts participated in the research and development of these CPGs. After the draft guidelines were developed, 3 rounds of public hearings were held with staff members from relevant academic societies and stakeholders, after which the guidelines were further reviewed and modified.
RESULTS:
CR involves a more cost-effective use of healthcare resources relative to that of general treatments, and the exercise component of CR lowers cardiovascular mortality and readmission rates, regardless of the type of coronary heart disease and type and setting of CR.
CONCLUSION
Individualized CR programs should be considered together with various factors, including differences in heart function and lifestyle, and doing so will boost participation and adherence with the CR program, ultimately meeting the final goals of the program, namely reducing the recurrence of myocardial infarction and mortality rates.