Purpose: This study investigated patient safety management activities among general hospital nurses and aimed to identify the factors influencing patient safety management activities. Methods: A cross-sectional descriptive design included 159 ward nurses working at two tertiary hospitals located in Busan city. Data were collected with self-reported questionnaires from April 8 to April 20, 2024 and were analyzed using descriptive statistics, the t-test, analysis of variance, Pearson correlation coefficients, and multiple regression in SPSS 29.0. Results: Factors significantly influencing patient safety management activities in nurses were perceptions of patient safety culture (β = .47, p < .001) and perceptions of patient rounding (β = .31, p < .001). The explanatory power of these variables was 43%. Conclusion This study found that perceptions of patient safety culture and perceptions of patient rounding had significant effects on nurses’ patient safety management activities. Thus, it is necessary to promote patient safety management activities among nurses through the development of intervention programs to improve perceptions of patient safety culture and perceptions of patient rounding.

Purpose: This study investigated patient safety management activities among general hospital nurses and aimed to identify the factors influencing patient safety management activities. Methods: A cross-sectional descriptive design included 159 ward nurses working at two tertiary hospitals located in Busan city. Data were collected with self-reported questionnaires from April 8 to April 20, 2024 and were analyzed using descriptive statistics, the t-test, analysis of variance, Pearson correlation coefficients, and multiple regression in SPSS 29.0. Results: Factors significantly influencing patient safety management activities in nurses were perceptions of patient safety culture (β = .47, p < .001) and perceptions of patient rounding (β = .31, p < .001). The explanatory power of these variables was 43%. Conclusion This study found that perceptions of patient safety culture and perceptions of patient rounding had significant effects on nurses’ patient safety management activities. Thus, it is necessary to promote patient safety management activities among nurses through the development of intervention programs to improve perceptions of patient safety culture and perceptions of patient rounding.

Purpose: This study investigated patient safety management activities among general hospital nurses and aimed to identify the factors influencing patient safety management activities. Methods: A cross-sectional descriptive design included 159 ward nurses working at two tertiary hospitals located in Busan city. Data were collected with self-reported questionnaires from April 8 to April 20, 2024 and were analyzed using descriptive statistics, the t-test, analysis of variance, Pearson correlation coefficients, and multiple regression in SPSS 29.0. Results: Factors significantly influencing patient safety management activities in nurses were perceptions of patient safety culture (β = .47, p < .001) and perceptions of patient rounding (β = .31, p < .001). The explanatory power of these variables was 43%. Conclusion This study found that perceptions of patient safety culture and perceptions of patient rounding had significant effects on nurses’ patient safety management activities. Thus, it is necessary to promote patient safety management activities among nurses through the development of intervention programs to improve perceptions of patient safety culture and perceptions of patient rounding.

Purpose: This study investigated patient safety management activities among general hospital nurses and aimed to identify the factors influencing patient safety management activities. Methods: A cross-sectional descriptive design included 159 ward nurses working at two tertiary hospitals located in Busan city. Data were collected with self-reported questionnaires from April 8 to April 20, 2024 and were analyzed using descriptive statistics, the t-test, analysis of variance, Pearson correlation coefficients, and multiple regression in SPSS 29.0. Results: Factors significantly influencing patient safety management activities in nurses were perceptions of patient safety culture (β = .47, p < .001) and perceptions of patient rounding (β = .31, p < .001). The explanatory power of these variables was 43%. Conclusion This study found that perceptions of patient safety culture and perceptions of patient rounding had significant effects on nurses’ patient safety management activities. Thus, it is necessary to promote patient safety management activities among nurses through the development of intervention programs to improve perceptions of patient safety culture and perceptions of patient rounding.

PURPOSE: Several studies have proven that EGCG, the primary green tea catechin, and glucosamine-6-phosphate (PGlc) reduce triglyceride contents in 3T3-L1 adipocytes. The objective of this study is to evaluate the combination effect of EGCG and PGlc on decline of accumulated fat in differentiated 3T3-L1 adipocytes. METHODS: EGCG and PGlc were administered for 6 day for differentiation of 3T3-L1 adipocytes. Cell viability was measured using the CCK assay kit. In addition, TG accumulation in culture 3T3-L1 adipocytes was investigated by Oil Red O staining. We examined the expression level of several genes and proteins associated with adipogenesis and lipolysis using real-time RT-PCR and Western blot analysis. A flow cytometer Calibar was used to assess the effect of EGCG and PGluco on cell-cycle progression of differentiating 3T3-L1 cells. RESULTS: Intracelluar lipid accumulation was significantly decreased by combination treatment with EGCG 60 microM and PGlc 200 microg/m compared with control and EGCG treatment alone. In addition, use of combination treatment resulted in directly decreased expression of PPARgamma, C/EBPalpha, and SREBP1. In addition, it inhibited adipocyte differentiation and adipogenesis through downstream regulation of adipogenic target genes such as FAS, ACSL1, and LPL, and the inhibitory action of EGCG and PGlc was found to inhibit the mitotic clonal expansion (MCE) process as evidenced by impaired cell cycle entry into S phase and the S to G2/M phase transition of confluent cells and levels of cell cycle regulating proteins such as cyclin A and CDK2. CONCLUSION: Combination treatment of EGCG and PGlc inhibit-ed adipocyte differentiation through decreased expression of genes related to adipogenesis and adipogenic and cell cycle arrest in early stage of adipocyte differentiation.
3T3-L1 Cells ; Adipocytes* ; Adipogenesis* ; Blotting, Western ; Catechin ; Cell Cycle Checkpoints* ; Cell Cycle* ; Cell Survival ; Cyclin A ; Lipolysis ; Phase Transition ; PPAR gamma ; S Phase ; Tea ; Triglycerides

The optimal management of hepatic metastases in colorectal carcinoma patients has become increasingly complex with the myriad of available treatment options. Because the timing of any therapy has become integral to the success of the treatment, a collaborative approach involving multiple specialties is needed for achieving the best patient outcome. Surgical resection is the most effective therapy for metastatic colorectal cancer isolated to the liver. Liver resection of colorectal metastases is associated with three- and five-year survival rates close to 40~60% and 30~50%, respectively. Because the technique for hepatic resection has improved, patients with multiple, biloba, and huge metastases can undergo resection. Every liver resection should be planned after intraoperative ultrasonography, and an anatomical surgical procedure should be preferred instead of wedge resection. Since some of patients diagnosed with metastatic colorectal disease are initially classified as unresectable, neoadjuvant chemotherapy is being increasingly employed to downsize colorectal metastasis. The greatest benefit of the preoperative approach is the potential to convert patients with initially unresectable metastatic disease to a resectable state. Although various prognostic risk factors have been identified, there has been no dependable staging or prognostic scoring system for metastatic hepatic tumor. As surgeons become more proficient in the technical aspects of resection, the patient selection criteria as based on the biologic determinants of the outcome are becoming increasingly important. The goal of this review is to provide the optimal management, treatment and follow-up for patients with colorectal metastasis to the liver.
Colorectal Neoplasms ; Drug Therapy ; Follow-Up Studies ; Humans ; Liver* ; Neoplasm Metastasis* ; Patient Selection ; Risk Factors ; Survival Rate ; Ultrasonography

Cholangiocarcinomas originate from the bile duct mucosa and can occur at any level of the biliary tract. Approximately 40 to 60% of cases are found at the hilar level.-Currently, a curative surgical resection is the only treatment method. The surgical treatments of a hilar cholangiocarcinoma are challenging but the diagnostic accuracy has improved with the better preoperative imaging and noninvasive diagnostic techniques. Using the percutaneous transhepatic choledochoscope,-direct visualization of the extent and possible invasion of the tumor is possible, which provides information for determining the extent of the resection. During an endoscopic examination, it is also possible to-pathologically confirm a carcinoma and drain biliary system to relieve an obstruction. Portal vein embolization to increase the volume of the future remaining liver has been attempted in steps of-accomplishing an extended surgical resection of hilar cholangiocarcinoma.- The 5-year survival of hilar cholangiocarcinoma is still poor, ranging from 20~40% after a curative resection with-a median survival of 12-16 months. A R0 resection is the most important prognostic factor that affects the survival significantly . The choice of surgical procedure is determined by the location of the tumor. In general, unilobar involvement even with ipsilateral encasement of the hepatic artery or portal vein branch, and/or ipsilateral secondary biliary radicals with associated lobar atrophy are considered resectable. In carefully selected candidates,-an extended hepatic resection with a concomitant en bloc resection of the vascular structures and accompanied by a reconstruction along with a biliary excision has been advocated for complex hilar tumors to attain some survival benefit through a R0 resection. We review the recent trends in various diagnostic methods and surgical treatments for hilar cholangiocarcinoma.
Atrophy ; Bile Ducts ; Biliary Tract ; Cholangiocarcinoma* ; Hepatic Artery ; Liver ; Mucous Membrane ; Portal Vein ; Prognosis

Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by thunderclap headache with reversible vasoconstriction of the cerebral arteries. RCVS has been reported to occur in various clinical settings. However, RCVS triggered by blood transfusion is rare. A 50-year-old woman had severe anemia and received multiple blood transfusions. She developed thunderclap headache after transfusion. Cerebral artery vasoconstrictions were demonstrated by magnetic resonance angiography and transfemoral cerebral angiography. RCVS might be triggered by red blood cell transfusion in patients with severe anemia.

No abstract available.
Leg* ; Osteomyelitis*