Background: Our research team aimed at determining the prevalence of depression and mutual interaction of other diseases among elderly in today’s changing period of morbidity of population due to social and economic transition.Goal: To determine the correlation between depression and other diseases among elderlyObjectives:1. To determine the prevalence of depression among elderly2. To find out the correlation between depression and other diseasesMaterials and method: The research was carried out by cross sectional method. In the research was involved 1207 elderly, who are retired, of which 60 and over for male and 55 and over for female from one cluster of each economic and geographic regions of Mongolia. The depression was evaluated by using Geriatric Depression Scale.Results: In the research was involved 392 (32.5 percent) men, 675 (67.5 percent) women and their mean age was 68.1±8.1 (68.9±6.5 in male and 65.7±8.5 in female) from 4 economic and geographic regions of Mongolia. Among survey involved elderly, 16.5 (199) percent of them were found to have depression. Out of survey involved depressed elderly, 27.6 percent were male and 72.3 percent female. The mean age of depressed elderly was 67.9, in which 67.1 in women and 70.2 in men. Due to depression status among survey involved elderly, the share of elderly, who inclined to affect by depression was 158 (13.1%). Furthermore, 169 (14%) of them were affected by slight depression, while 30 (2.5%) of them were with severe depression.Among survey involved elderly, 24.5 percent of elderly with anxiety were inclined to be affected by depression and 29.2 percent of them were with mildly depression. However, 5.6 percent of elderly with severely level of anxiety were affected by severe depression. It was not found severe depressed elderly among elderly, who did not have anxiety. The depression of elderly and their morbidity has direct correlation. Elderly depression and anxiety has direct medium correlation.Conclusions:1. The prevalence of depression among Mongolian elderly refers 16.5 percent.2. Depression among Mongolian elderly has direct correlation to some investigated somatic diseases.

Background: In our country, the survey on mental condition of Mongolian elderly, in particularly on assessing the cognitive status has not provided yet. Goal: To determine the cognitive status of elderly and find out some factors which affect on it. Objectives:1. Determine the cognitive ability of Mongolian elderly2. Find out some factors which affect the cognitive ability of elderlyMaterials and Methods: In this cross sectional study, we had chosen randomizily 1 cluster from each 4 economic and geographic regions of Mongolia and Ulaanbaatar city, and totally comprised of 1207 elderly, of which 60 and over for male and 55 and over for female. The cognitive status of survey involved elderly was evaluated by mini mental examination test (MMET).Results: The mean age of survey involved elderly was 68.1±8.1 (68.9±6.5 in male and 65.7±8.5 in female). While 60.3(728) percent of elderly people were normal, 39.7(479) percent of them estimated to have cognitive decline. Out of elderly with cognitive decline, 59.5 percent had slight cognitive impairment, 35.1 percent moderate cognitive impairment and rest 5.4 percent had severe cognitive impairment. The cognitive impairment predominantly revealed in female and prevailed more in elderly who live in countryside compared to elderly who live in the city (P<0.001). The cognitive impairment was related to educational background of elderly who had cognitive decline. Along the decline of education estimated higher level of cognitive impairment, as well as 47.5 percent of male and 53.8 percent of female, who had lower education, shared most percentage of cognitive impairment, compared to other educational levels.The cognitive impairment is directly correlated to decline of Activity of daily living and Instrumental activity of daily living of elderly (p<0,0001).Conclusions:1. The decline of cognitive status of elderly is correlated to gender. The educational background, income and family are related to their cognitive impairment.2. Activity of daily living and Instrumental activity of daily living have direct correlation to cognitive impairment of elderly.

Introduction: The issue of meeting need of rehabilitation care service required to elders is one of determinants which influences in enabling quality of life of elderly people. In our country, we lack of survey on determining current need of long term care and one of its form rehabilitation care service for the elderly, so it became the background of the research. Goal: Reveal some needs of rehabilitation care service through determining the Activities of daily living and Instrumental Activities of daily living of Mongolian elderly people Materials and Method: The research was carried out by cross sectional method. In the research was involved 1207 elderly, who are retired, of which 60 and over for male and 55 and over for female from one cluster of each economic and geographic regions of Mongolia. The research was conducted by using ADL and IADL tests as well as questionnaire to determine the needs of rehabilitation care service. Results: Out of survey involved 1207 elderly, 32.5 percent (392) referred to men, 67.5 percent (815) to women, and their mean age was 68.1±8.1 (68.9±6.5 in male and 65.7±8.5 in female). While 473 elderly were from Ulaanbaatar city, 734 of them were from 4 regions of countryside. Among survey involved elderly, the mean of ADL ability was 87.4 percent, of which, the following abilities were better such as: continence (92.5%), toileting (91.3%), dressing (87.9%), while bathing ability was impaired mostly or 18.2 percent. Subsequently, the mean of IADL ability among survey involved elderly was found to be 29.9 percent. The health needs of elderly were differed. Due to extensive indicator, 24.8 percent of elderly wanted to admit in a hospital, 20.8 percent - home nursing care and 32.6 percent -involvement in rehabilitation care service. In terms of amount, the maximum needs were eight, while most of elderly requested 1-3 kinds of needs. Conclusions: 1. The impairment of Activity of Daily Living was found to be approximately 22.6 percent, while Instrumental Activity of Daily Living was 29.9 percent among Mongolian elderly people. 2. The impairment level of Activities of Daily Living and Instrumental Activities of Daily Living indicated the requirement of occupational and physical therapy in health care service for the elderly.

Introduction: The mental and behavioral diseases affect in loneliness and discrimination of elderly people and mostly reduce the quality of life of elderly people compared to injury and accidence. Wulf Rossler, Switzerland mentioned that all kinds of mental diseases require long term care, especially rehabilitation. In our country, we lack of survey on determining psychosocial rehabilitation needs for the elderly, therefore it became the background of the research. Goal: Determine the psychosocial rehabilitation needs of Mongolian elderly people Method and materials: The research was carried out by cross sectional method. In the research was involved 1207 elderly, who are retired, of which 60 and over for male and 55 and over for female from one cluster of each economic and geographic regions of Mongolia. The research was conducted by using Geriatric depression test, Spielberg Hanin test to reveal anxiety, Mini mental examination test to assess the cognitive status and AUDIT test to evaluate the alcohol usage. The diagnoses were put according to ICD-10 based on geriatric examination. Results: Out of survey involved 1207 elderly, 32.5 percent (392) referred to men, 67.5 percent (815) to women, and their mean age was 68.1±8.1 (68.9±6.5 in male and 65.7±8.5 in female). While 473 elderly were from Ulaanbaatar city, 734 of them were from 4 regions of countryside. In terms of mental and behavioral diseases, anxiety and depression were prevailing among Mongolian elderly. Thirty eight point five percent of survey involved elderly investigated to have depression and 44 percent - anxiety. Moreover, dementia was found 36 and sleep disorder 28 per 1000 elders. Twenty three point six percent of elderly had slight cognitive impairment, 13.9 percent moderate cognitive impairment, while 2.1 percent had severe cognitive impairment. The cognitive impairment is differed in terms of region. The moderate cognitive impairment predominantly revealed in mountainous and eastern regions, while the severe cognitive impairment was prevailing in central and eastern regions. Due to classification of needs of elderly into medical, financial and other needs, found that, 37 percent of elderly required medical, 33 percent financial and 37 percent other needs. In terms of psychosocial needs, 30.4 percent wanted to have a place for spending free time, 23.9 percent to make new friends and 6.1 percent to hire a job. Also 4.4 percent of elderly had a need of having a caregiver. Conclusions: 1. Out of mental and behavioral diseases, anxiety (38.5 percent) and depression (44 percent) were prevailing among elderly. 2. Each Mongolian elderly had need of 1-2 psychosocial needs. 3. All kinds of psychosocial rehabilitation including the medical, adaptation enhancing and social rehabilitation are equally required for the elderly people.

Introduction. Stigma and discrimination against patients with mental illness is very common amongst the society. Therefore, this study aims to study the knowledge and understanding of mental illness and attitudes to patient with mental illness, among the general population.Goal. To assess the knowledge and understanding of mental illness and attitude to patient with mental illness among population of Ulaanbaatar city and compare its results with a similar research in carried out in 2002.Methods. The study was conducted in Ulaanbaatar city from February to April, 2008 and included 991 people aged over 18 years. The sample was selected from 30 micro districts of Ulaanbaatar city, The method of sampling was using primary dot in first step, sampling households in mid step and selecting people by using method of Sweden key from household in final step. The study used 30 item standardized questionnaires. Also there were 2 extra cards to read for respondents.Result. Among the respondents, 45% were males and 55 % females. Average age was 37 years. In view of identifying negative attitude of patient with schizophrenia, majority of respondents answered as “loony person” (n=136) and “mad person” (n=83). Conclusion. Although there was stigma amongst the study population, 66% of subjects who were involved in study could give right diagnosis in non professional level and were able to identify symptoms of mental illness suggesting that more than half of the sample studied had some knowledge of mental illness.

Background: Nucleic acid sequencing is a multi-step process taken place in medical research or diagnostic laboratories. Since the emerge of second generation sequencing technology generally referred as next generation sequencing (NGS), the mass parallel reads covering human genome or transcriptome is achieved by cost cut down over thousand folds. Though the technology made tremendous push forward to various applications, its data analysis time and effort still takes worrisome time and human effort, bringing the emerge of next-step demand: targeted mass sequencing of only desired part from human genome or transcriptome with lower material cost and labor. By targeted sequencing, both run cost and data analysis process can be further cut down, and the read results are more reliable on changes such as determining varied number of repeats, heterozygote alleles, deletions, chromosomal scale abnormality and more. Objective: In this study, we explored the utilization of biotinylated RNA baits on captured sequencing of cancer marker genes functional regions. Method: Targeted NGS was achieved by capturing desired genomic regions using preparatory nucleic acid probes. RNA bait capturing of desired genomic regions has shown to have high specificity and quality.
The study was carried out with informed consent obtained from patients, with the approval №53 in 2018.03.15 by Medical Ethics committee, Ministry of Health, Mongolia. Result: By preparing library of biotinylated RNA baits with 75000 unique sequences, we achieved mass parallel sequencing of human 410 cancer-marker-genes’ exons and UTRs with average read depth ~760, and covered thousands of SNPs on 5 genomic DNA samples. Tissue samples derived from breast cancer and ovary cancer had SNP and deletion on 7 marker genes (BRCA1, BRCA2, ATM, BRIP1, PTEN, TP53, RAD51C) not registered in database. Conclusion Experiments showed RNA baits with up to 117 nucleotide length, produced from ssDNA oligonucleotide stock, can be utilized to capture desired regions of human genome, and bring the cost of captured mass sequencing to 1500 USD, with 93.14-93.33% of Q30 read quality.

Introduction: Khuumii (throat singing) is a unique form of art derived from the nomadic population of Central Asia, producing two or more “simultaneous” sounds and melodies through the organ of speech. Material and Methods: The aim of the study is to identify the anatomical structures involved in the formation of khuumii and the features and patterns of their functions and compare each type of khuumii as performed by Mongolian people. A total of 60 participants aged 18-60 years (54 men and 6 women) were selected by non-random sampling method using cross-sectional study. Statistical analysis was performed using SPSS 23 software using questionnaires, X-ray, endoscopy, sound research method, and general blood tests. Results: 90.7% of the khuumii singers were male and 9.3% were female. The average height of the participants was 172.91±0.93 cm (arithmetic mean and mean error), average body weight was 77.53±2.46 kg, and body mass index was 25.93±5.31 respectively. Heart rate was 92.19±20.71 per minute prior to khuumii while 133.19±19.09 after performing khuumii and 85.81-98.56 at 95% confidence interval. In terms of ethnicity (ethnographically), the Khalkh were the largest ethnic group (72.1%), followed by Bayad, Buryatia, Darkhad, Torguud, and Oirat (2.3%), respectively. 60.5% of the participants were professional khuumii singers who graduated from relevant universities and colleges. The process of Khuumii was recorded by X-ray examination, and laryngeal endoscopy evaluated the movement of true and false vocal chords, interstitial volume, movements of epiglottis and arytenoid cartilage, and mucosa. Khuumii increases the workload of the cardiovascular system by 70-80%. Furthermore, the sound frequency is 2-4 times higher than that of normal speech, and sound volume is 0.5-1 times higher. 95.3% of throat singers did not have a sore throat, 88.4% did not experience heavy breathing, and 74.1% had no hoarseness. During the formation of khuumii sound, thoracic cavity, diaphragm, and lungs regulate the intensity of the air reaching the vocal folds, exert pressure on the airways and vibrate the sound waves through air flows passing through the larynx and vocal folds. Mouth-nose cavity as well as pharynx are responsible for echoing the sound. Conclusion It is appropriate to divide khuumii into two main types according to structural and functional changes in the organs involved; shakhaa and kharkhiraa. Khuumii, the “Human music” originating from the people of Altai Khangai basin by imitating the sounds of nature with their own voice in ancient times, spread all over the world from Mongolia and it is proposed to classify khuumii into two main types of shakhaa and kharkhiraa in terms of structural involvement and functionality.