In spite of the long history of notice, research on the pharmacotherapy of body dysmorphic disorder is limited. No placebo-controlled, continuation, maintenance, or discontinuation studies have been published. But accumulated data and experiences in recent days enable us even roughly to set up a pharmacological treatment step for body dysmorphic disorder. In addition to the clinical aspect of body dysmorphic disorder and its relation to obsessive-compulsive disorder, this article reviewed recent researches and clinical experiences about the pharmacotheray issues like SRI treatment, augmented treatment strategy using buspirone or neuroleptics or others, clomipramine pulse-loaded intravenous therapy, and other treatment methods including ECT and brain surgery, mainly for the purpose of making helpful guidelines for the clinicians. Some tips about cognitive-behavior therapy and future research directions were also added.
Antipsychotic Agents ; Body Dysmorphic Disorders* ; Brain ; Buspirone ; Clomipramine ; Drug Therapy ; Obsessive-Compulsive Disorder

It was not above two or three decades from the changes began that regarding nicotine dependence as a kind of addictive disorder and a therapeutic target. Despite the short period of history, lots of medications were developed and showing significant clinical outcomes. In this review, we introduce the both of medications available at this time and in the status of developing for nicotine dependence. The clinical efficacies, practical ways of prescription, and common adverse events of the medications currently available are described through the survey of literatures. The novel medications in the process of developing are arranged by the proposed mechanism of action and summarized the phases of clinical trials at present. Among the diverse pharmacological tools now available, nicotine replacement and bupropion could be the first-line recommendation drugs and nortriptyline and clonidine could be the second-line recommendation drugs. Other medications like several antidepressants (e.g., moclobemide), buspirone, and naltrexone may be helpful in some specific population. Most of medications currently available have uncertainties in the aspects of their mechanisms of action except nicotine replacement materials; however, medications in developing have clearer neurobiological basis in their applications. Therefore, we can expect higher treatment outcomes by new products. Additionally, introduction of nicotine vaccines for high-risk group is drawing near. It could be possible for the individualizing for strategies of smoking cessation according to the patients' specific situation in a future.
Antidepressive Agents ; Bupropion ; Buspirone ; Clonidine ; Naltrexone ; Nicotine* ; Nortriptyline ; Prescriptions ; Smoking Cessation ; Tobacco Use Disorder* ; Vaccines

To provide a recent knowledge about pharmacological treatment of anxiety disorders in elderly, the author reviewed the articles and books for the treatment of elderly anxiety patients. Anxiety is the one of the most prevalent psychiatric symptoms in the elderly. Many psychological and physical causes including used drugs can induce the anxiety symptoms in elderly. However, it is often unrecognized and inadequately treated. The pharcokinetics and pharmacodynamic changes, con-comittent illnesses, compliance problems, and increased sensitivity to drugs in elderly have to be considered. Various pharmacological treatments (e.g benzodiazepines, buspirone, antidepressnats, beta-blockers, antihistamines, neuroleptics)were reported as having therapeutic effects for the treatment of geriatric anxiety disorders patients. They have their own advantages and disadvantages. However, anxiety in elderly have received little focus to date. The study results often depend on the studies from adult samples. A comprehensive, flexible, integrated, and specific treatment approaches should be applied to elderly anxious patients. The more systematized studies are needed to broaden the knowledge of the pharmacological treatment of anxiety disorders in the elderly.
Adult ; Aged* ; Anxiety ; Anxiety Disorders ; Benzodiazepines ; Buspirone ; Compliance ; Drug Therapy* ; Histamine Antagonists ; Humans

Anxiety disorders are common psychiatric illnesses in the elderly. However, anxiety disorders in older people have not drawn much attention from researchers and clinicians alike, compared with late-life depression or dementia. The author searched for articles published from 1986 to 2006 using the key words including "anxiety", "elderly", "aged", and "pharmacological" therapy in the MEDLINE, PsychINFO, and KMbase in order to clarify effective pharmacological therapy in the elderly with anxiety disorders. Well designed studies for pharmacologic intervention in late-life anxiety disorders were rarely found. Nonetheless, studies on young adults demonstrated a number of pharmacological treatment options that can be applied to these patients. Pharmacologic treatments for the elderly include therapies using antideprssants, especially SSRI or SNRI, buspirone, or benzodiazepines. The latter requires special caution in the administration in the elderly because it can lead to adverse events. Therefore, well designed clinical trials are further needed to obtain optimal pharmacological intervention for the elderly with anxiety disorders.
Aged ; Anxiety Disorders* ; Anxiety* ; Benzodiazepines ; Buspirone ; Dementia ; Depression ; Drug Therapy* ; Humans ; Young Adult

OBJECTIVES: Since the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) was developed in 2002, the fourth revision of KMAP-BP was completed in 2018 in order to reflect the recent rapid research and development into bipolar disorder and psychopharmacology.METHODS: According to the methodology of previous versions, KMAP-BP 2018 was revised using a questionnaire consisting of 10 questions. Among eighty-four experts of the review committee, sixty-one completed the survey.RESULTS: The first-line pharmacotherapeutic strategy for acute bipolar depressive episode with moderate, non-psychotic severe and psychotic severe episode was mood stabilizer (MS) combined with atypical antipsychotic (AAP) or AAP with lamotrigine. Switching or adding AAP, lamotrigine, or MS as 2nd strategies and clozapine or augmentation of buspirone, stimulant, or thyroid hormone as 3rd strategies were recommended. Compared to the previous KMAP-BP series, preference of AAP and lamotrigine has increased in the treatment of bipolar depressive episode in KMAP-BP 2018. Among the AAPs, olanzapine, quetiapine, and aripiprazole were preferred.CONCLUSION: Compared with the previous versions, we found that more active pharmacological strategies using AAP and lamotrigine as initial and next treatment strategies, respectively, were preferred, although few drugs were approved for bipolar depression.
Advisory Committees ; Aripiprazole ; Bipolar Disorder ; Buspirone ; Clozapine ; Drug Therapy ; Psychopharmacology ; Quetiapine Fumarate ; Thyroid Gland

OBJECTIVES: The purpose of this study was to evaluate the prolactin and cortisol responses to 5-HT 1A receptor activation by buspirone in alcoholics. METHODS: The subjects were twenty two male alcoholic patients meeting the DSM-IV criteria for alcohol dependency and abstaining for more than 3 months. Patients were free from overt anxiety and depressive symptoms. Controls were fifteen male normal volunteers, with no psychiatric and medical illness. Blood samples for the measurement of serum cortisol and prolactin levels were drawn 0, 30, 60, 90, 120, 150 minutes after oral administration of 30mg buspirone hydrochloride at 9:00 a.m. RESULTS: The baseline cortisol levels were not significantly different between alcoholics and controls. Serum cortisol levels of controls after buspirone administration were significantly increased over time(p<0.01), but those of alcoholics did not increased. After 60 minutes following buspirone administration, cortisol levels were significantly lower in alcoholics than in controls(p<0.05). Prolactin responses to buspirone were not significantly different between the two groups. CONCLULSION: Our results suggested that 5-HT 1A receptor function is decreased in alcoholic patients.
Administration, Oral ; Alcoholics ; Alcoholism* ; Anxiety ; Buspirone* ; Depression ; Diagnostic and Statistical Manual of Mental Disorders ; Healthy Volunteers ; Humans ; Hydrocortisone* ; Male ; Prolactin* ; Serotonin

Generalized anxiety disorder (GAD) is highly prevalent psychiatric disorder in primary care population and is a source of major morbidity. However, the underawareness and undertreatment of GAD, which is due to insufficient knowledge about the disorder, often hinder the proper management of this chronic condition. Other characteristic features such as chronic course of GAD, frequent comorbidity with other anxiety and depressive disorders, and the controversy regarding the best diagnostic criteria should be fully discussed. First of all, proper and accurate diagnosis is crucial for an appropriate management. Primary care management of GAD and associated comorbidities includes education about the nature of GAD and counseling about treatment alternatives and coping strategies is an important first step. The most effective treatment of GAD is combined psychotherapeutic and pharmacotherapeutic approach. The major psychotherapeutic approaches to GAD are cognitive-behavioral therapy with relaxation techniques. Pharmacological treatment for GAD includes benzodiazepine, buspirone, and antidepressants. In this review, these combined treatment at the view point of primary practitioners was described.
Antidepressive Agents ; Anxiety Disorders* ; Anxiety* ; Benzodiazepines ; Buspirone ; Comorbidity ; Counseling ; Depressive Disorder ; Diagnosis* ; Education ; Primary Health Care ; Relaxation Therapy

BACKGROUND: Migraine is commonly associated with anxiety disorder. However, whether anxiolytic medicine or changes in anxiety levels affect the migraine attack is unclear. Buspirone, the agonist for 5-HT1A receptor, is effective in treating generalized anxiety disorder. In this study, we attempted to test the efficacy of buspirone for migraine combined with anxiety disorder. METHODS: 111 outpatients aged 20 to 70 years (mean, 46.4; SD, 12.8), were analyzed. The diagnosis of migraine was made according to the HIS (International Headache Society) criteria, and the level of anxiety was rated by the Hamiton Anxiety Rating Scale (HAM-A). The migraineurs were randomly assigned to treatment with either buspirone (15 mg/day) or placebo for 6 weeks. The efficacy variables included changes in headache frequency, headache intensity, Headache Index, Headache Management Self-Efficacy Scale (HMSE), Headache Disability Inventory (HDI), and the Hamilton Anxiety Rating Scale (HAM-A). The correlation between headache improvement and the anxiolytic effect were analyzed. RESULTS: Headache frequency showed a 43.3% reduction (from 6.7/2 weeks to 3.8/2 weeks) in the buspirone-treated group, whereas a 10.3% reduction (from 6.8 to 6.1/2 weeks) in the placebo group. The Headache Index, HDI, and HAM-A were also significantly lowered in buspirone-treated patients than in placebo-treated patients. However, the headache intensity or the HMSE score were not changed. Correlation analysis between the change of Headache Index and that of HAM-A revealed no significant association. CONCLUSIONS: Buspirone is an effective prophylactic agent in migraine combined with anxiety disorder. This prophylactic effect is not secondary to the anxiolytic effect. This suggests that the agonistic action for 5-HT1A is primarily effective in migraine prophylaxis.
Anti-Anxiety Agents ; Anxiety Disorders ; Anxiety* ; Buspirone* ; Diagnosis ; Headache ; Humans ; Migraine Disorders ; Outpatients ; Receptor, Serotonin, 5-HT1A

Triple X syndrome is a relatively rare sex chromosomal anomaly, and its association with psychopathology is not well understood. The authors report one case of obsessive-compulsive disorder(OCD)with karyotype-confirmed triple X syndrome, 47,XXX. She had incomplete sexual development, seconddary amenorrhea and multiple obsessive-compulsive symptoms. Magnetic resonance imaging of the brain revealed left occipital white matter hyperintensity lesion. The patient's multiple obsessive-compulsive symptoms were responded partially with fluoxetine and adjunctive buspirone treatment, however, her overall psychological functions were much improved. With the literature reviews, the authors suggest the possibility that a certain type of sex chromosome aneuploidy might be susceptible to obsessive-compulsive spectrum disorders(OCSDs)or OCD.
Amenorrhea ; Aneuploidy ; Brain ; Buspirone ; Female ; Fluoxetine ; Humans ; Magnetic Resonance Imaging ; Obsessive-Compulsive Disorder* ; Psychopathology ; Sex Chromosomes ; Sexual Development

Generalized anxiety disorder (GAD), that has been introduced into psychiatric nosology in DSM-III, is characterized by chronic worry that may persist for many years. Pharmacological treatment for GAD includes benzodiazepines, buspirone, and antidepressants. Benzodiazepine have commonly been used for treatment of acute anxiety disorders, but they are not ideal in the treatment of chronic generalized anxiety disorder (GAD). Buspirone appears to exert benefit primarily on psychic symptoms of anxiety, but the effect of buspirone is slower in onset, taking at least 2 weeks to become evident. Recently, new antidepressants has opened up a new area of investigation into pharmacotherapy of GAD, with a growing body of evidence supporting the role of therapies such as paroxetine and venlafaxine extended release. At present, some selective serotonin reuptake inhibitors such as paroxetine and venlafaxine are recommended for the best evidence-based approach in the long-term treatment of GAD.
Antidepressive Agents ; Anxiety Disorders* ; Anxiety* ; Benzodiazepines ; Buspirone ; Diagnostic and Statistical Manual of Mental Disorders ; Drug Therapy* ; Paroxetine ; Serotonin Uptake Inhibitors ; Venlafaxine Hydrochloride