Condyloma acuminatum, a benign disease caused by a filtrable virus, occurs predominantly in the perianal andgenital areas. The lesions are noninvasive but are subject to recurrence. In rare instances, a more aggresive formof this disease, known as "giant condlyloma acuminatum" or "Buschke-Lownestein tumor", occures. In this form,infiltration of the lesion into surrounding structures takes place. This tumor has been reported to occurprincipally in the genitourinary tract. The authors experienced a cases of giant condyloma acuminatum originatingfrom rectum in 67 years old male patient which recurred 3 months after electrofulguration.
Buschke-Lowenstein Tumor ; Humans ; Male ; Rectum ; Recurrence

Giant condyloma acuminatum (also known as Buschke-Lowenstein tumor) is a rare disease, for which the treatment of choice is still controversial. In the case described in this report, we used a combination of electrocautery and a surgical scalpel to resect a huge genital wart, followed by long-term local treatment with podophyllin. This procedure was relatively fast, easy to perform, involved minimal bleeding, and did not result in any complications. Moreover, combination therapy enabled us to avoid deep resection of the lesion and consequently, sexual function was preserved completely.
Buschke-Lowenstein Tumor* ; Condylomata Acuminata ; Electrocoagulation* ; Hemorrhage ; Podophyllin* ; Rare Diseases ; Warts

Verrucous carcinoma is a slowly-growing, well-differentiated, low grade squamous cell carcinoma with little tendency to metastasize. There have been several case reports of this tumor but its occurrence at a young age is extremely rare. Herein we report a case of verrucous carcinoma arising on the anogenitalia of a young woman with pancytopenia.
Buschke-Lowenstein Tumor ; Carcinoma, Squamous Cell ; Carcinoma, Verrucous* ; Female ; Humans ; Pancytopenia

Buschke-Lowenstein tumor is a rare disease in the category of designated as verrucous carcinoma characterized by its invasive downward penetration of underlying tissues in the perineum and perianal regions. Viruses, unclean sanitation and cytotoxic immune reaction have been proposed as the etiology of the tumor. However, among all the causes, recent studies have emphasized on the associaton of the tumor and human papilloma virus (HPV). Expecially, HPV also has been discovered in several cutaneous and anogenital lesions of solid organ transplant recipients. We herein report a case of Buschke-Lowenstein tumor in a renal transplant recipient with HPV 6 and 16 coinfection proved by HPV genotyping of DNA extracted from the biopsy specimen of the tumor.
Biopsy ; Buschke-Lowenstein Tumor* ; Carcinoma, Verrucous ; Coinfection ; DNA ; Human papillomavirus 6 ; Humans ; Papilloma ; Perineum ; Rare Diseases ; Sanitation ; Transplantation* ; Transplants

Buschke-Lowenstein (B-L) tumor occurs in penis associated with human papillomavirus (HPV). It appears as a exophytic cauliflower-like mass that may be foul smelling and sometimes ulcerated. B-L tumor is predominantly associated with HPV 6, 11 and rarely 16, 18. Because HPV 6, 11 are usually isolated from benign lesions, it has been hypothesized that other cofactors such as immunosuppression, poor hygiene, lack of circumcision, and chronic irritation may be involved. In addition, genomic alternation or subtle amino-acid changes in the HPV 6 E7 protein may play a role in enhancing oncogenic properties of the low-risk virus, HPV 6. We present a case of B-L tumor with squamous cell carcinoma that showed HPV 6 positive and altered p53.
Buschke-Lowenstein Tumor* ; Carcinoma, Squamous Cell* ; Circumcision, Male ; Female ; Human papillomavirus 6 ; Humans ; Hygiene ; Immunosuppression ; Male ; Penis ; Smell ; Ulcer

Buschke-Lowenstein tumor(BLT) is a rare sexually transmitted disease triggered by human papillomavirus type 6 or 11. It presents as an anogenital exophytic tumor characterized by its size, local infiltration, high recurrence rate and risk of malignant transformation to squamous cell carcinoma. A 45-year-old heterosexual male presented with a 22-year history of slow-growing, multiple, dark brown, verrucous, exophytic nodules and plaques over the trunk, extremities, inguinal and gluteal areas. Two years prior to consult, there was coalescence of lower abdominal plaques with rapid growth of a pinkish cauliflower-like tumor. Pelvic MRI showed that the tumor was limited to the skin. Biopsy of the lower abdominal mass was consistent with BLT and positive for HPV DNA. There was no internal organ involvement or metastasis. Pulsed dye and erbium:YAG lasers were done on the gluteal area test sites followed by wide excision and split-thickness skin graft of the lower abdominal and pubic area.

Human ; Male ; Middle Aged ; Biopsy ; Brassica ; Buschke-lowenstein Tumor ; Carcinoma, Squamous Cell ; Dna ; Erbium ; Heterosexuality ; Human Papillomavirus 6 ; Lasers, Solid-state ; Papillomavirus Infections ; Torso

Anus Neoplasms ; diagnosis ; etiology ; surgery ; Buschke-Lowenstein Tumor ; Carcinoma, Verrucous ; diagnosis ; etiology ; surgery ; Condylomata Acuminata ; etiology ; pathology ; surgery ; Human papillomavirus 16 ; Human papillomavirus 18 ; Humans ; Male ; Middle Aged ; Papillomavirus Infections ; complications ; Penile Neoplasms ; etiology ; pathology ; surgery ; Time Factors