1.Burkitt Lymphoma.
Journal of the Korean Pediatric Society 1981;24(7):705-708
No abstract available.
Burkitt Lymphoma*
2.The next step for Burkitt lymphoma.
Korean Journal of Hematology 2011;46(2):60-61
No abstract available.
Burkitt Lymphoma
3.A Case of Burkitt's Lymphoma Involving Skin.
Kwang Hee WON ; Ji Su HAN ; Woo Jin LEE ; Chong Hyun WON ; Sung Eun CHANG ; Jee Ho CHOI ; Kee Chan MOON ; Mi Woo LEE
Korean Journal of Dermatology 2014;52(12):919-920
No abstract available.
Burkitt Lymphoma*
;
Skin*
4.Burkitt Lymphoma in Children.
Soo Jong HONG ; Dong Kyu JIN ; Hee Young SHIN ; Hyo Seop AHN ; Chang Yee HONG ; Je G CHI
Journal of the Korean Pediatric Society 1988;31(4):482-491
No abstract available.
Burkitt Lymphoma*
;
Child*
;
Humans
5.Burkitt Lymphoma of the Right Ovary.
Journal of the Korean Pediatric Society 1983;26(8):840-842
No abstract available.
Burkitt Lymphoma*
;
Female
;
Ovary*
6.Acute Tumor Lysis Syndrome in Burkitt Lymphoma.
Dong Kyu JIN ; Soo Jong HONG ; Il Soo HA ; Hyo Seop AHN ; Yong CHOI ; Chang Yee HONG
Journal of the Korean Pediatric Society 1988;31(3):362-369
No abstract available.
Burkitt Lymphoma*
;
Tumor Lysis Syndrome*
7.Fungemia due to Trichosporon dermatis in a patient with refractory Burkitt's leukemia.
Satoshi HASHINO ; Shojiro TAKAHASHI ; Rena MORITA ; Hiroe KANAMORI ; Masahiro ONOZAWA ; Takahito KAWAMURA ; Kaoru KAHATA ; Takeshi KONDO ; Issei TOKIMATSU ; Takashi SUGITA ; Koji AKIZAWA ; Masahiro ASAKA
Blood Research 2013;48(2):154-156
No abstract available.
Burkitt Lymphoma
;
Fungemia
;
Humans
;
Trichosporon
8.Therapy-related Acute Myeloid Leukemia Following Treatment for Burkitt's Lymphoma
Chonnam Medical Journal 2017;53(3):229-230
No abstract available.
Burkitt Lymphoma
;
Leukemia, Myeloid, Acute
10.Effect of Baicalin Derivative 02-036 on Burkitt Lymphoma Cell Line CA46 and Its Related Mechanisms.
Zhong-Yang HUANG ; Dong-Hui GAN ; Ying-Yu CHEN ; Hai-Jun CHEN ; Min-Hui LIN ; Shimuye Kalayu YIRGA ; Jian-Da HU
Journal of Experimental Hematology 2019;27(5):1497-1503
OBJECTIVE:
To investigate the effect of baicalin derivative 02-036 on proliferation and apoptosis human Burkitt lymphoma cell line CA46 and its related mechanisms.
METHODS:
The MTT assay and cell colony formation assay were used to measure the growth inhibition of CA46 cells after 02-036 treatment. The flow cytometry with AnnexinV-FITC/PI double staining was employed to detect the apoptosis induction effect of 02-036 on CA46 cells. Cell cycle distribution of CA46 cells was estimeted by using DNA ploid analysis. Western blot was used to determine the changes of apoptosis-related proteins, including C-MYC, BCL-2, Procaspase-9, Procaspase-3, PARP and Cleaved-PARP.
RESULTS:
Baicalin derivative 02-036 obviously inhibited the proliferation of CA46 cells, with dose- and time-dependent manner (r=0.963, r=0.992). The averaged IC value of CA46 cells was (6.04±0.11) μmol/L after 48-hour treatment. Low concentration of 02-036 could significantly inhibit the colony formation of CA46 cells. Flow cytometry analysis confirmed that 02-036 could effectively induce CA46 cell apoptosis. The apoptosis rate correlated with drug concentrations (r=0.959). Also, DNA ploid analysis showed that the cell cycle of CA46 was arrested in the S phase. The expression levels of BCL-2, Pro-caspase-9, Pro-caspase-3, PARP and C-MYC proteins decreased with a 02-036-dose dependent manner (r values were -0.990, -0.939, -0.971 and -0.967, respectively). In contrast, the expression level of cleaved-PARP increased with the same manner (r=0.920).
CONCLUSION
Baicalin derivative 02-036 can effectively inhibit the proliferation and induce apoptosis of CA46 cells, and its related mechanisms may be correlated with the down-regulation of apoptosis-related molecule expression levels, such as BCL-2, Pro-caspase-9, Pro-caspase-3, PARP and C-MYC.
Apoptosis
;
Burkitt Lymphoma
;
Cell Line, Tumor
;
Cell Proliferation
;
Flavonoids
;
Humans
Result Analysis
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