1.A Case of Primary Hepatic Burkitt's Lymphoma.
Seung Hyun LEE ; Hyung Joon KIM ; Jang Sik MUN ; Hyoung Chul OH ; Hyun Woong LEE ; Chang Hwan CHOI ; Jeong Wook KIM ; Jae Hyuk DO ; Jae Gyu KIM ; Sae Kyung CHANG ; Mi Kyung KIM
The Korean Journal of Gastroenterology 2008;51(4):259-264
Burkitt's lymphoma is a rare disease that belongs to the aggressive non-Hodgkin's lymphoma. Herein, we report a case of primary hepatic Burkitt's lymphoma. A 19-year-old man visited the hospital for right upper quadrant pain. He felt fatigue for two months. Physical examination revealed hepatomegaly and no palpable lymph node. He had no fever, weight loss, or night sweating. Laboratory finding showed mild anemia (hemoglobin, 12.4 g/dL), mild elevated transaminase (ALT, 52 IU/L), elevated lactate dehydrogenase (LDH, 437 IU/L), and alkaline phosphatase (ALP, 129 IU/L). The viral marker was positive for HBsAg, HBeAg, anti-HBs, and anti-HBc (IgG), and negative for anti-HBe, anti-HCV, and anti-HIV. CEA, AFP, and CA19-9 levels were within normal ranges. The HBV DNA quantitation was 1.3x10(9) copies/ml. Abdominal-Pelvis CT scan and abdominal MRI finding were compatable with malignant lymphoma. Liver biopsy examination confirmed Burkitt's lymphoma. No metastasis was detected in the thoracic cavity, bone marrow, and spinal fluid. The patient was treated with the combination regimen of cyclophosphamide, doxorubicin, vincristine, prednisone and high dose methotrexate. Cytosine arabinoside and methotrexate were added for CNS prophylaxis by intrathecal installation. Chemotherapy was administered every 3 weeks for fifteen cycles. Serial follow-up CT scan showed a marked decrease in the size of hepatic lesions. Follow-up CT scan and PET-CT scan were perfomed 4 weeks after the final cycle disclosed no definite residual or active lesion confirming the state of complete remission.
Antimetabolites, Antineoplastic/therapeutic use
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Burkitt Lymphoma/*diagnosis/drug therapy/pathology
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Combined Modality Therapy
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Cytarabine/therapeutic use
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Diagnosis, Differential
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Humans
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Liver Neoplasms/*diagnosis/drug therapy/pathology
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Male
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Methotrexate/therapeutic use
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Tomography, X-Ray Computed
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Young Adult
2.Human immunodeficiency virus/acquired immunodeficiency syndrome-related Burkitt's lymphoma: report of two cases.
Ze-tao SHAO ; Yun PAN ; Zheng-jin LI ; Lin-bo TIAN ; Min WANG ; Lei BI ; Yue-kang LI
Chinese Journal of Pathology 2012;41(6):408-410
Acquired Immunodeficiency Syndrome
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drug therapy
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genetics
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surgery
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Adult
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Burkitt Lymphoma
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drug therapy
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genetics
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surgery
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virology
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Diagnosis, Differential
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Female
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Genes, myc
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HIV
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isolation & purification
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HIV Infections
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Herpesvirus 4, Human
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genetics
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Humans
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Immunohistochemistry
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Lymphoma, AIDS-Related
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drug therapy
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genetics
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surgery
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virology
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Lymphoma, B-Cell
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pathology
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Lymphoma, Mantle-Cell
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pathology
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Male
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Middle Aged
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RNA, Viral
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analysis
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Sarcoma, Myeloid
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pathology
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Translocation, Genetic
3.Clinicopathologic features of granulocytic sarcoma: a study of 38 cases.
Hai-yan LIU ; Hong-lin YIN ; Jun DU ; Ying CAI ; Zhen-feng LU ; Hang-bo ZHOU ; Xiao-jun ZHOU
Chinese Journal of Pathology 2010;39(3):172-176
OBJECTIVETo study the clinicopathologic features of granulocytic sarcoma.
METHODSThe clinical and pathologic findings of 38 cases of granulocytic sarcoma were retrospectively analyzed. Immunohistochemical study was performed and the literature was reviewed.
RESULTSThe age of patients ranged from 2 to 77 years (mean = 43.3 years). The male-to-female ratio was 1.5:1. Major clinical presentations included superficial lymph node enlargement and painful soft tissue mass. Follow-up data were available in 18 patients; and 14 of them died of tumor-related diseases. The average duration of survival of the patients was 16.9 months. Histologically, the tumor cells were relatively uniform in appearance and small to medium in size. The cytoplasm was scanty and pale in color. The nuclei were round or focally irregular, with fine chromatin and inconspicuous nucleoli. Mitosis figures were readily identified. Scattered immature eosinophilic myelocytes were seen. Immunohistochemical study showed that the tumor cells in all cases expressed MPO and CD43. Most cases were also positive for CD68, lysozyme, CD99 and TdT. The staining for CD3, CD20, CD79a, pan-cytokeratin and PLAP were negative.
CONCLUSIONSGranulocytic sarcoma is a known histologic mimicker of non-Hodgkin lymphoma, Ewing sarcoma/PNET and embryonal rhabdomyosarcoma. Detailed morphologic examination, when coupled with immunohistochemical study, is useful in arriving at a correct diagnosis.
Adolescent ; Adult ; Aged ; Burkitt Lymphoma ; metabolism ; pathology ; Child ; Child, Preschool ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Humans ; Leukosialin ; metabolism ; Lymph Nodes ; pathology ; Male ; Middle Aged ; Muscle Neoplasms ; drug therapy ; metabolism ; pathology ; surgery ; Ovarian Neoplasms ; drug therapy ; metabolism ; pathology ; surgery ; Peroxidase ; metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; metabolism ; pathology ; Retrospective Studies ; Sarcoma, Ewing ; metabolism ; pathology ; Sarcoma, Myeloid ; drug therapy ; metabolism ; pathology ; surgery ; Skin Neoplasms ; drug therapy ; metabolism ; pathology ; surgery ; Survival Rate ; Young Adult
4.Primary cutaneous follicle centre lymphoma: report of a case.
Yin-fang RONG ; Lin-ming HE ; Yong-sheng ZHANG ; Yi-zhong FENG
Chinese Journal of Pathology 2013;42(11):769-770
Antigens, CD20
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metabolism
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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Burkitt Lymphoma
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metabolism
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pathology
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CD79 Antigens
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metabolism
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Cyclophosphamide
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therapeutic use
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DNA-Binding Proteins
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metabolism
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Diagnosis, Differential
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Doxorubicin
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therapeutic use
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Humans
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Lymphoma, B-Cell
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pathology
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Lymphoma, Follicular
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drug therapy
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metabolism
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pathology
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Lymphoma, Large B-Cell, Diffuse
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metabolism
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pathology
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Male
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Middle Aged
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Prednisone
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therapeutic use
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Proto-Oncogene Proteins c-bcl-6
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Skin Neoplasms
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drug therapy
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metabolism
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pathology
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Vincristine
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therapeutic use
5.Pediatric B-cell Lymphoma, Unclassifiable, With Intermediate Features Between Those of Diffuse Large B-cell Lymphoma and Burkitt Lymphoma: A Report of Two Cases.
Shanxiang ZHANG ; David WILSON ; Magdalena CZADER
Annals of Laboratory Medicine 2015;35(2):254-256
No abstract available.
Adolescent
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Antineoplastic Combined Chemotherapy Protocols/therapeutic use
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Burkitt Lymphoma/*pathology
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Child, Preschool
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Cyclophosphamide/therapeutic use
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Doxorubicin/therapeutic use
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Female
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Gene Rearrangement
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Herpesvirus 4, Human/metabolism
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Humans
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Immunohistochemistry
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Lymphoma, B-Cell/*diagnosis/drug therapy
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Lymphoma, Large B-Cell, Diffuse/*pathology
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Male
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Prednisone/therapeutic use
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Proto-Oncogene Proteins c-myc/genetics
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Tomography, X-Ray Computed
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Vincristine/therapeutic use
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Viral Matrix Proteins/immunology/metabolism