1.A five year study of patch test reactions in the Dermatology Department of the Jose R. Reyes Memorial Medical Center, Philippines.
Bunagan Mary Jo Kristine S. ; Villafuerte Lillian L.
Journal of the Philippine Dermatological Society 2005;14(1):45-48
A total of 336 patients suspected of having allergic contact dermatitis underwent patch testing at our institution from August 2000 to February 2005 using the European Standard Series by Chemotechnique Diagnostics composed of 25 allergens. The cutaneous lesions were located on the hands (46.2 percent), feet (29.1 percent), arms (25.5 percent), legs (21.0 percent) and trunk (15.9 percent). Patch test results showed that 303 (90 percent) had one or more positive patch test reaction. The most frequent positive reactions were to nickel sulfate (42 percent), potassium dichromate (30.7 percent), cobalt chloride (25.5 percent), parabens (22.5 percent) and fragrance mix (18.65 percent) while the least frequent were Tixocortil-21-pivalate (33 percent), Quarternium -15 1.0 percent pet (3 percent), Budesonide (2.7 percent) and Quinolone mix 6.0 percent pet (2.7 percent). In this study the most frequent relevant sources for nickel sulfate were keys/keychains, costume jewelry, coins and watches. For potassium dichromate the top sources were adhesives, detergents and leather. The most common sources for cobalt chloride were zippers/buttons and jewelry. For parabens the relevant sources were food products and cosmetics while for fragrance mix these were cosmetics and fragrances.
Human ; Male ; Female ; Aged ; Middle Aged ; Adult ; Adolescent ; Child ; Child Preschool ; Allergens ; Budesonide ; Cobalt ; Dermatitis, Allergic Contact ; Patch Tests ; Quinolones
2.A critical appraisal of an article on therapy: Efficacy of topical applications of human breast milk on atopic eczema healing among infants: A randomized clinical trial.
Ng Janice Natasha C. ; Bunagan Mary Jo kristine S.
Journal of the Philippine Dermatological Society 2016;25(1):63-66
Human
;
Male
;
Female
;
Infant
;
Breast Feeding
;
Dermatitis, Atopic
;
Milk, Human
;
Wound Healing
;
Eczema
3.A critical appraisal of an article on therapy: Safety and efficacy of oral fusidic acid as a steroid-sparing agent in the treatment of lepra reactions: An assessor-blinded, randomized controlled clinical trial
Maria Vinna N. Crisostomo, ; Mary Jo Kristine S. Bunagan
Journal of the Philippine Dermatological Society 2018;27(1):87-89
5.Pigmented extramammary Paget’s disease: A potential pitfall of misdiagnosis
Kristy Lydia S. Bunagan ; Janice Natasha C. Ng ; Maricarr Pamela M. Lacuesta ; Mary Jo Kristine S. Bunagan
Journal of the Philippine Dermatological Society 2019;28(2):50-54
Introduction:
Extramammary Paget’s disease (EMPD) is a rare cutaneous slow growing tumor seen in areas rich in
apocrine glands such as the anogenital region while ectopic EMPD is defined as EMPD arising on non-apocrine areas.
The pigmented variant of EMPD is a very rare finding, with only a few reported cases, and can be misdiagnosed as
melanoma.
Case report:
We report a case of a 74-year-old woman who presented with a four-year history of pruritic, non-
healing erythematous plaques located on the right axilla and left lower abdomen. Histopathology revealed
acanthotic epidermis with atypical keratinocytes that was negative for anti S-100 and Melan-A and was positive
for carcinoembryonic antigen (CEA), cytokeratin (CK), CK 7 and epithelial membrane antigen (EMA). Patient was
managed as pigmented and ectopic variant of extramammary Paget’s disease. Several tests and imaging were
done to rule out malignancy. Wide excision with axillary node dissection, bilateral inguinal node dissection, frozen
section biopsy and reconstruction using right pectoralis major musculocutaneous flap, split thickness skin graft with
left inguinohypogastric drain were done by reconstructive surgery. Frozen section biopsy was negative for S-100,
MELAN-A and HMB-45, ruling out malignant melanoma. Patient followed up every month for 6 months after the
procedure with no recurrence and lymphadenopathy.
Conclusion
This case emphasizes that extramammary Paget’s disease is not a preventable disease and early diagnosis
is the key to a favorable diagnosis. Any unilateral eczematous lesion that does not respond to an appropriate course
of topical treatment warrants a skin biopsy.
Melanoma
;
Immunohistochemistry
6.A randomized, comparative study on the efficacy and safety of mangosteen 1% extract gel versus benzoyl peroxide 5% gel in the treatment of mild to moderate acne vulgaris
Janice Natasha C. Ng ; Maria Vinna N. Crisostomo ; Margaret Stephanie L. Jimenez ; Mary Jo Kristine S. Bunagan
Journal of the Philippine Dermatological Society 2021;30(2):15-23
Introduction:
Acne vulgaris is a common dermatologic disorder caused by follicular epidermal hyperproliferation, excess se-
bum production, inflammation, and Cutibacterium acnes (C. acnes). The mangosteen fruit rind contains large amount of xantho-
nes, which has high antimicrobial activity against C. acnes.
Objectives:
To compare the efficacy and safety of mangosteen 1% extract gel versus benzoyl peroxide (BPO) 5% gel in the treat-
ment of mild to moderate acne vulgaris.
Methods
A total of 60 participants with mild to moderate acne or a rating of 2 or 3 in the Investigator’s Global Assessment (IGA)
for acne were randomized to receive either mangosteen 1% extract gel or BPO 5% gel applied on the face twice daily over an
8-week period. Primary outcomes measured in the study were clinical remission graded as “clear” or “almost clear” (rating of 0 or
1) based on the IGA and any adverse reaction.
Acne Vulgaris
;
Benzoyl Peroxide