Background: The prescription of Shar gaa made from the Curcuma longa L., Tribulus terrestris L., Cortex Phellodendri L., Gardenia jasminoides L. By reviewing a lot of relative research papers and the pharmacological dictionaries, we summarized the conclusion that the efficiency components of the Shar gaa extract is effective to control the infection of bacteria and the fungi, to relieve skin inflammation and pain.Aim:We conducted the control experiment to discuss thecontrol effect of the Shar gaa extract to the fungi and the bacteria. Materials and methods:We carried out susceptibility test to fungus and bacterium using medicine dilution method and cup-plate method on the sand clan proof agar culture and nutrient agar culture. The fungi inhibition results show that the Shar gaa extract has the significant restrain effects to all of experimental fungi. It has the better effects to the Microsporum lanosum M.grpseum、T.rubrum、M. canis、C.albicans、Pityrosporum than the 20% Ethanol control group (P<0.05). Meanwhile, it has the same affects with the CAILE extract (P>0.05). In addition, the Shar gaa extract of high concentration has no significant difference with the one of the low concentration. This phenomenon demonstrated the truth that the Shar gaa extract has no concentration diversity to inhibit the fungi (P>0.05). On the other hand, the bacterium inhibition results demonstrate that the weak restrain effects of the Shar gaa extract. Regard to the gram positive bacteria (mainly including the S.aureas, Bacillus anthraci, Staphylococcus), the Shar gaa extract has the less effect to control the bacteria than the Penicillin group (P<0.05) and to the gram negative bacteria (the Pseudomonas) the Shar gaa extract has the less effect to control the bacteria than the Gentamicin group (P<0.05). Invalid of the drug-resistant E. coli and the P.mirabilis the Shar gaa extract group. The 20% Ethanol on bacterial group had no inhibitory effect. Conclusion: The Shar gaa extract possessed favourable inhibitory effect to frequent fungus and relative weak inhibitory effect to general bacterium in clinic. The research achievement not only expanded the new type of the Shar gaa -4 tan, but also developed the new usage of the Shar gaa-4 tan. It is to have the potential guide significance to clinical application.