The study was done to evaluate disturbances in blood gases and acid-base balance in 140 patients with chronic renal failure at the end stage (108 patients with hemodialysis, 32 patients without hemodialysis). The primarily results showed that: 33.3% arterial hypoxemia, 35.1% disturbances in PaCO2, 31.48% SaO2 decreased, 93.5% disturbances in AaDO2, 6.48% chronic respiratory failure with 71.49% type I and 28.51% type II. 77.8% pH decreased, 96.3% BE decreased, 94.45% HCO3 decreased, 92.56% TCO2 decreased. Disturbances in PaO2, PaCO2, AaDO2 of chronic renal failure with hemodialysis were lower than chronic renal failure without hemodialysis.
Kidney Failure, Chronic ; Gases

Studying features on the standard chest radiography and CT in 118 patients with chronic renal failure with peritoneal hemodialysis showed that: 61.29-83.29% patients have high density of lung hila, vascular syndrome, enlarged heart size, lung calcifications on the standard chest radiography, and CT. The ratio of finding pleural effusion, pleural thickening, Pneumonia of CT is higher than standard chest radiography (p<0.05).
Kidney Failure, Chronic ; ventilation

This study was performed on 38 patients with chronic renal failure with intermittent dialysis. The results showed that changes of the blood gas: intermittent dialysis lessen PaO2¬ from 95.27 mmHg before dialysis to 89.39 mmHg after dialysis (p<0.01), PaCO2 increased from 31.34 to 34.24 mmHg (P<0.01), and SaO2 increased from 93.78 to 95.64% (p<0.001). However, those changes were in the allowable limit. Balance of acid-base: Disordered balance of acid-base in chronic renal failure patients at the end-stage has been metabolic acidosis. Intermittent dialysis method improved the situation of the disorder; blood pH and HCO3- were recovered (p<0.001).
Kidney Failure, Chronic ; ventilation ; gases

270 patients with chronic renal failure and 40 healthy controls were studied. The results suggested that the serum calcium concentration decreased in the first stage, normalized in stages I and II and increased at the end-stage of chronic renal failure. Urine calcium level decreased through 4 stages in the patients with chronic glomerulonephritis-related renal failure. In the patients with urinary calculus-related chronic renal failure, urine calcium concentration decreased during stages I and II but normalized during stages III and IV. Urine calcium level of the patients with urinary calculus-related chronic renal failure was higher than that of those with chronic-glomerulonephritis-related renal failure who were in the same stage of renal failure.
Kidney Failure, Chronic ; calcium

In vitro study on effects of methamidophos (MAP) on antioxidant enzymes, total antioxidant status (TAS) and lipid peroxidation of human erythrocytes have shown: human plasma total antioxidant status (TAS) and enzym cholinesterase (ChE) activity were significantly decreased by increasing MAP concentrations (from 5 to 10 mM) and incubation period. Human erythrocyte superoxi.
Refuse Disposal ; Hygiene

(MAP) on O2 uptake, CO2 production and rate of methemoglobin of human erythrocytes. The in vitro effects of methamidophos (MAP) on O2 uptake, CO2 production and rate of methemoglolin of human erythrocytes were studied: (1) after exposure of human erythrocytes to MAP at the concentrations from 1 to 10mM, only at concentration higher than 100mM of MAP in 37oC for 3 hours, the hemolysis was significantly induced. (2) at MAP concentrations between 1 and 10 mM, the significant increase of oxygen uptake and carbonic productions in human erythrocytes was seen. (3) At MAP concentrations between 1 and 10 mM, rate of methemoglobin in erythrocytes was increased significantly. These findings suggest that MAP act as oxidative chemical
methamidophos ; In Vitro

The workers in insecticide factory generally are exposed to organophosphate insecticide chemicals while working in the plants. We have investigated the effects of organophosphate insecticides on the activities of some erythrocyte antioxidant enzymes, total antioxidant status and lipid peroxidation in the blood of the insecticide producing workers. The results: (1) erythrocyte superoxide dismutase (SOD) and glutathione reductase (GR) activities were significantly depressed by 37.64% and 28.55%, respectively while serum cholinesterase (ChE) activity was only depressed by 13.47% as compared with an unexposed group; (2) erythrocyte glutathione peroxidase (GPx) was increased significantly; (3) serum total antioxidant status (TAS) was depressed by 9.86% (p>0.05). This preliminary study suggests that erythrocyte SOD may be a sensitive indicator of exposure to organophosphate insecticides.
Phosphoric Acid Esters ; Insecticides ; Erythrocytes ; Antioxidants

The study was performed on 80 chronic renal failure(CRF) subjects. Initial results: Clinical respiratory manifestation: The main respiratory symptom in CRF: chest pain 60,49%, cough 46,25%. There is not significant difference in respiratory symptoms between CRF with intermittent dialysis (P>0.05). Physical symptoms: Crepitating 48,75%, rough vesicular breathing 37,5%. Vesicular breathing and crackle in CRF with intermittent dialysis were significantly higher (P<0,01). Lung radiographic features: There are 8 lesions on lung X-ray, main lesions: lung calcification 80%, large-lung hilar syndrome 71%, lung manifestation in hyperuremia 32,5%, pleural effusion 26,25%. Lung calcification and large lung hilar-syndrom in CRF with ID were higher (P<0,01). There is a relationship between the lesions on chest X-ray and hyperuremia level.
Kidney Failure ; Lung ; Signs and Symptoms, Respiratory

16 adult healthy rabbits aged 12 months were divided into 2 groups. All of them were intoxicated acutely by methamidophos and the one used BELAF sulution, the other group was intoxicated by NaCl 0.9% solution. Results showed that a simple dose of methamidophos could reduce the antioxidant capacity, especially with the activity of red blood cell superocid dismutase and the concentration of reducing total antioxidation of rabbit plasma. However, these changes were recovered after 48 hours of the experiments. The recovered effect of BELAF was not manifested fully.
Antioxidants ; Pharmaceutical Preparations ; Rabbits ; Organothiophosphorus Compounds

43 people in 30 days before and after oral use of BELAF were studied. Results: blood red cell superocid dismistase (SOD) activation increased (691.7106.46 versus 984.23102.98 U/g Hb), white blood red cell glutathion peroxidase (GPx) and glutathion reductase (GR) had not any change obviously. The plasma total antioxidant state enhanced, MDA level decreased, ChE activetion enhanced. The study showed that BELAF could help to improve the state of antioxidation in blood red cell and in plasma of workers of chemical production
Pesticides ; Therapeutics ; drugs ; Lipid Peroxidation