1.Optimization of the Extraction Process for Bioactive Compounds from the Root Barks of Moringa oleifera
Do Hoang GIANG ; Tran Van HIEN ; Nguyen Thi THU MINH ; Nguyen Thu UYEN ; Hoang Thuy DUONG ; Bui Thi NHAT LE ; Mai Thi THU HA ; Nguyen Tien DAT
Natural Product Sciences 2023;29(4):281-286
The optimal condition for Moringa oleifera root barks extraction was determined using response surface methodology and Box-Behnken Design. The actual optimal condition of the factors was 65 o C, ethanol 60%, 40 (mL/g) liquid-to-solid ratio with 240 minutes extraction time. The enrichment of phenolic compounds sharply affected the antioxidant, and inhibitions of α-amylase enzyme, as well as, the anti-inflammatory effect of the extract from M. oleifera root barks. The extract in the optimal condition exhibited better 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and α-amylase inhibitory activities than those of positive controls.Also, the extract showed weak hydroxyl free radical scavenging and nitric oxide (NO) production inhibitory effects. These revealed a simple and promising method for the preparation of bioactive products from the root bark of M. oleifera.
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