Objective To investigate the clinical condition of incompatibility of common intravenous drug use,investigate variation of drug compatibility and promote rational drug use,reduce nurse-patient disputes and adverse drug reactions occurrence,ensure patient medication safety.Methods To search articles about drug incompatibility by retrieving the Articles Database such as Chinese Journal of Nursing,Chinese Journal of Modern Nursing,Chinese Journal of Practical Nursingfrom 2000 to 2013.The reported clinical drug incompatibility in the literature,involving the number of periodicals dealt with incompatibility,the type of drug compatibility,change of compatibility type,and other circumstances affecting patients were analyzed.Results In a total of 925 issued periodicals,688 articles reported incompatibility,which involved 700 types of drugs,compatibility of drug B involving 824 kinds.The common reported drugs were sodium fusidate,ambroxol injection,pantoprazole sodium omeprazole sodium,vinpocetine.The major compatibility changes were color reaction,turbidity,there-floe or precipitate,bubbles,etc.The incompatibility did not affect the patients generally.Conclusions The incompatibility of many drugs showed certain regular pattern.We should pay attention to the rational confect and clinical use.Nurses should master related knowledge and compatibility variation of the drugs,take effective measures to avoid the occurrence of changes in physical and chemical properties,and effectively promote clinical safety.