Abstract: Nitraria Sibirica Pall (NSP) is an annual plant of the family Zygophyllaceae that has been used for many diseases. The fruits of NSP have been used as a folk medicine for thousands of years in Mongolia and China. Numerous bioactive phytochemicals, such as flavonoids, alkaloids and glycosides, have been isolated and identified from NSP that are responsible alone or in combination for various pharmacological activities. However, to date, anti-nephrotoxicity effects of NSP on Gentamcin-induced animal models have not been investigated. Method: In the experimental design, 24 Wistar rats were randomly isolated into three groups such as control, gentamicin and NSP. The renal injury was modeled by intramuscular injection of Gentamicin for 5 consecutive days (150 mg/kg). The doses of 25 mg/kg of aqueous extract of NSP were administrated by oral gavages for 14 consecutive days in rats. At 14 days for the rest of them, serum samples were collected for renal function biochemical tests (Blood urea nitrogen, creatinine, creatinine clearance and glomerular filtration rate). Result: We demonstrated that treatment of NSP aqueous extract significantly reduced blood urea nitrogen (BUN), serum creatinine (Cr) levels and increased creatinine clearance, glomerular filtration rate (GFR) levels in Gentamicin-administrated rats. Conclusion These data suggested that NSP shown good effect for anti-inflammatory of kidney.