1.F-18 Fluorodeoxyglucose PET/CT and Post Hoc PET/MRI in a Case of Primary Meningeal Melanomatosis.
Hong Je LEE ; Byeong Cheol AHN ; Seong Wook HWANG ; Suk Kyong CHO ; Hae Won KIM ; Sang Woo LEE ; Jeong Hyun HWANG ; Jaetae LEE
Korean Journal of Radiology 2013;14(2):343-349
Primary meningeal melanomatosis is a rare, aggressive variant of primary malignant melanoma of the central nervous system, which arises from melanocytes within the leptomeninges and carries a poor prognosis. We report a case of primary meningeal melanomatosis in a 17-year-old man, which was diagnosed with 18F-fluorodeoxyglucose (F-18 FDG) PET/CT, and post hoc F-18 FDG PET/MRI fusion images. Whole-body F-18 FDG PET/CT was helpful in ruling out the extracranial origin of melanoma lesions, and in assessing the therapeutic response. Post hoc PET/MRI fusion images facilitated the correlation between PET and MRI images and demonstrated the hypermetabolic lesions more accurately than the unenhanced PET/CT images. Whole body F-18 FDG PET/CT and post hoc PET/MRI images might help clinicians determine the best therapeutic strategy for patients with primary meningeal melanomatosis.
Adolescent
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Brain Neoplasms/*diagnosis/radionuclide imaging
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Fluorodeoxyglucose F18/diagnostic use
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Humans
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*Magnetic Resonance Imaging
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Male
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Melanoma/*diagnosis/radionuclide imaging
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Meningeal Neoplasms/*diagnosis/radionuclide imaging
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*Positron-Emission Tomography and Computed Tomography
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Radiopharmaceuticals/diagnostic use
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Whole Body Imaging
2.A Rare Case of Primary Hyperparathyroidism Associated with Primary Aldosteronism, Hurthle Cell Thyroid Cancer and Meningioma.
You Lim KIM ; Young Woo JANG ; Jin Taek KIM ; Su Ah SUNG ; Tae Seok LEE ; Won Mi LEE ; Hyo Jeong KIM
Journal of Korean Medical Science 2012;27(5):560-564
Multiple endocrine neoplasia type 1 (MEN1) syndrome includes varying combinations of endocrine and non-endocrine tumors. There are also a considerable number of atypical MEN1 syndrome. In this case, a 68-yr-old woman was referred to the Department of Endocrinology for hypercalcemia. Five years ago, she had diagnosed as primary hyperaldosteronism and now newly diagnosed as parathyroid hyperplasia with laboratory and pathologic findings. Hurthle-cell thyroid cancer was also resected during the parathyroid exploration and small meningioma was found on brain MRI. Her general condition has markedly improved and her adrenal mass and meningioma are being closely observed now. We could find the loss of heterozygosity of the MEN1 locus in parathyroid glands, suggesting a MEN1-related tumor, but not a germline mutation. Considering a variety of phenotypic expression and a limitation of current molecular analysis, periodic follow up will be needed in patients with a MEN1-like phenotype.
Aged
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Base Sequence
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Brain/radionuclide imaging
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Female
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Humans
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Hyperaldosteronism/complications/*diagnosis
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Hyperparathyroidism, Primary/*diagnosis/etiology/pathology
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Loss of Heterozygosity
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Magnetic Resonance Imaging
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Meningeal Neoplasms/complications/*diagnosis/radionuclide imaging
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Meningioma/complications/*diagnosis/radionuclide imaging
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Mutation
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Parathyroid Glands/pathology
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Proto-Oncogene Proteins/genetics/metabolism
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Sequence Analysis, DNA
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Thyroid Neoplasms/complications/*diagnosis/pathology
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Tomography, X-Ray Computed
3.Bromocriptine for Control of Hyperthermia in a Patient with Mixed Autonomic Hyperactivity after Neurosurgery: A Case Report.
Seong Hee KANG ; Min Ja KIM ; Il Young SHIN ; Dae Won PARK ; Jang Wook SOHN ; Young Kyung YOON
Journal of Korean Medical Science 2012;27(8):965-968
Mixed autonomic hyperactivity disorder (MAHD) among patients with acquired brain injury can be rare. A delayed diagnosis of MAHD might exacerbate the clinical outcome and increase healthcare expenses with unnecessary testing. However, MAHD is still an underrecognized and evolving disease entity. A 25-yr-old woman was admitted the clinic due to craniopharyngioma. After an extensive tumor resection, she complained of sustained fever, papillary contraction, hiccup, lacrimation, and sighing. An extensive evaluation of the sustained fever was conducted. Finally, the cause for MAHD was suspected, and the patient was successfully treated with bromocriptine for a month.
Adult
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Brain/radionuclide imaging
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Bromocriptine/*therapeutic use
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Craniopharyngioma/complications/diagnosis/surgery
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Female
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Fever/complications/*drug therapy
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Hormone Antagonists/*therapeutic use
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Humans
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Hyperkinesis/complications/*diagnosis
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Magnetic Resonance Imaging
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Neurosurgical Procedures/*adverse effects
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Pituitary Neoplasms/complications/diagnosis/surgery
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Tomography, X-Ray Computed
4.Magnetoencephalography in Pediatric Lesional Epilepsy Surgery.
Hunmin KIM ; Byung Chan LIM ; Woorim JEONG ; June Sic KIM ; Jong Hee CHAE ; Ki Joong KIM ; Chun Kee CHUNG ; Yong Seung HWANG ; Hee HWANG
Journal of Korean Medical Science 2012;27(6):668-673
This study was performed to assess the usefulness of magnetoencephalography (MEG) as a presurgical evaluation modality in Korean pediatric patients with lesional localization-related epilepsy. The medical records and MEG findings of 13 pediatric patients (6 boys and 7 girls) with localization-related epilepsy, who underwent epilepsy surgery at Seoul National University Children's Hospital, were retrospectively reviewed. The hemispheric concordance rate was 100% (13/13 patients). The lobar or regional concordance rate was 77% (10/13 patients). In most cases, the MEG spike sources were clustered in the proximity of the lesion, either at one side of the margin (nine patients) or around the lesion (one patient); clustered spike sources were distant from the lesion in one patient. Among the patients with clustered spike sources near the lesion, further extensions (three patients) and distal scatters (three patients) were also observed. MEG spike sources were well lateralized and localized even in two patients without focal epileptiform discharges in the interictal scalp electroencephalography. Ten patients (77%) achieved Engel class I postsurgical seizure outcome. It is suggested that MEG is a safe and useful presurgical evaluation modality in pediatric patients with lesion localization-related epilepsy.
Adolescent
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Brain/radionuclide imaging
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Brain Diseases/pathology
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Child
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Child, Preschool
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Epilepsies, Partial/pathology/*surgery
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Female
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Ganglioglioma/pathology
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Humans
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Infant
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Magnetic Resonance Imaging
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*Magnetoencephalography
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Male
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Malformations of Cortical Development/pathology
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Neoplasms, Neuroepithelial/pathology
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Positron-Emission Tomography
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Retrospective Studies
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Seizures/diagnosis