A congenital neoplasm arising in the central nervous system is rarely encountered, and the majority of case reports that have dealt with intracranial tumors have been divided almost equally between teratomas and various gliomas. We experienced a rare case of congenital glioblastoma multiforme encountered in a three day-old male infant who presented with hydrocephalus since birth. Post-mortem examination revealed that the tumor seemed to have originated from the right thalamic region extending centrifugally to the cerebral cortex and through the brain-stem down to the cerebellum.
Autopsy ; Brain Neoplasms/*congenital/pathology ; Glioblastoma/*congenital/pathology ; Humans ; Hydrocephalus/*etiology/pathology ; Infant, Newborn ; Male ; Neoplasm Invasiveness

A case of congenital tectal lipoma found incidentally at an autopsy is reported. This female fetus was a product of pregnancy termination at 24 weeks of gestational age after sonographic detection of hydrocephalus. Autopsy revealed a small mass in the periaqueductal portion. The mass was composed of adipose tissue, cartilage, and mature bony tissue with hematopoiesis. The resultant diagnosis was tectal lipoma with osteocartilagenous element. It is uncertain whether the lesion represents a teratoma or hamartoma or mesenchymal metaplasia. The osteocartilagenous component suggests the latter.
Adult ; Autopsy ; Bone and Bones/pathology ; Brain Neoplasms/*congenital/pathology ; Cartilage/pathology ; Case Report ; *Corpora Quadrigemina/pathology ; Female ; Human ; Infant, Newborn ; Lipoma/*congenital/pathology ; Pregnancy

The results of Brain CT in 93 children with seizure and or other neurologic problems are evaluated in relation to the age of onset, patients' history, final diagnosis & EEG. The overall incidence of abnormal scans were 78.5% in our series. Analysis of CT results showed that the incidence of abnormal scan was closely related to the following criteria. 1. Patients with onset of neurologic problems during the age of 1 year, have a higher incidence of abnormal CT scans(87.5%), particularly if the onset was below 1 month of age. (93.8%), Also the results of CT were markedly different between the age under the 6 years and the age above the 6 years. In the former group of paients, brain atrophy and hydrocephalus were the most common cause of abnormal findings and in the latter group, brain tumor and vascular lesions. 2. Patients with a first attack of seizure have a higher incidence of abnormal scans than that of recurrent attacks(87%, 75%). 3. CT was particularly valuable for the diagnosis of tumor, complicated with meningitis, congenital hydrocephalus, vascular lesions, tuberous sclerosis, infarction, abscess, congenital toxoplasmosis & skull fracture. 4. Patients with focal slowing or focal spike with focal slowing on EEG findings manifested significant positive results on CT scan.(93.4%, 100%). 5. The number of patients who revealed abnormalities on contrast enhancement were 13 patients Among those 13 patients, 4 patients were with tuberculous meningitis and these all 4 patients showed characteristic findings of hydrocephalus with prominent basal and Sylvian fissure enhancement after injection of intravenous contrast media. 6. No. particular correlationship was noticed between simple skull roentgenorraphy and brain CT scan in the diagnosis of intracranial pathology except in the detection of skull fracture & large calcification.
Abscess ; Age of Onset ; Atrophy ; Brain Neoplasms ; Brain* ; Child ; Contrast Media ; Diagnosis ; Electroencephalography ; Humans ; Hydrocephalus ; Incidence ; Infarction ; Meningitis ; Pathology ; Pediatrics* ; Seizures ; Skull ; Skull Fractures ; Tomography, X-Ray Computed ; Toxoplasmosis, Congenital ; Tuberculosis, Meningeal ; Tuberous Sclerosis