1.Progress on Post Traumatic Epilepsy and Its Forensic Evaluation.
Yun Ge ZHANG ; Chun Xiao LI ; Guo Fu GUAN ; Ming LÜ ; He Ying CHENG ; Huan CHEN
Journal of Forensic Medicine 2016;32(3):200-203
Post traumatic epilepsy (PTE) refers to the epileptic seizures after traumatic brain injury. Organic damage can be found by imaging examination, and abnormal electroencephalogram can be detected via electroencephalogram examination which has the similar location of the brain injury. PTE has the characteristics of low incidence, absence of case reports, and easy to exaggerate the state of illness, which add difficulties to the forensic identification. This paper reviews the status of epidemiology, pathogenesis, clinical treatment and forensic identification for PTE.
Brain Injuries, Traumatic/physiopathology*
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Electroencephalography
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Epilepsy
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Epilepsy, Post-Traumatic/pathology*
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Forensic Pathology
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Humans
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Incidence
2.Development of a new biomechanical indicator for primary blast-induced brain injury.
Feng ZHU ; Cliff-C CHOU ; King-H YANG ; Albert-I KING
Chinese Journal of Traumatology 2015;18(1):10-12
Primary blast-induced traumatic brain injury (bTBI) has been observed at the boundary of brain tissue and cerebrospinal fluid (CSF). Such injury can hardly be explained by using the theory of compressive wave propagation, since both the solid and fuid materials have similar compressibility and thus the intracranial pressure (ICP) has a continuous distribution across the boundary. Since they have completely different shear properties, it is hypothesized the injury at the interface is caused by shear wave. In the present study, a preliminary combined numerical and theoretical analysis was conducted based on the theory of shear wave propagation/reflection. Simulation results show that higher lateral acceleration of brain tissue particles is concentrated in the boundary region. Based on this fnding, a new biomechanical vector, termed as strain gradient, was suggested for primary bTBI. The subsequent simple theoretical analysis reveals that this parameter is proportional to the value of lateral acceleration. At the boundary of lateral ventricles, high spatial strain gradient implies that the brain tissue in this area (where neuron cells may be contained) undergo significantly different strains and large velocity discontinuity, which may result in mechanical damage of the neuron cells.
Biomechanical Phenomena
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Blast Injuries
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etiology
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physiopathology
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Brain Injuries, Traumatic
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etiology
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physiopathology
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Compressive Strength
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Computer Simulation
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Finite Element Analysis
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Humans
3.Influence of sensorimotor adaptation and learning process for rehabilitation on the functional mobility of a patient with traumatic brain injury: A case report.
Chinese Journal of Traumatology 2018;21(4):246-248
This case report reveals the implementation of sensorimotor adaptation and learning process for rehabilitation in a patient with traumatic brain injury to achieve optimum recovery which is permanent in nature in compliance to the disability rating scale. A twenty two year old gentleman who had a history of fall was diagnosed as having subarachnoid hemorrhage along with diffuse axonal injury of the brain and bilateral lung contusion with pneumothorax. He underwent a total of ten months of sensorimotor adaptation and learning process for rehabilitation, which achieved functional mobility with a walker.
Adult
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Brain Injuries, Traumatic
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physiopathology
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rehabilitation
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Disability Evaluation
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Glasgow Coma Scale
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Humans
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Learning
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Male
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Recovery of Function
4.Impulse Control and ERP Characteristics of Patients with Mental Disorder Caused by Traumatic Brain Injury.
Hong Fei SONG ; Xi DENG ; Ning YANG ; Bo HAO ; Yu Bo HU ; Yan Wei SHI ; Li XUE ; Hu ZHAO
Journal of Forensic Medicine 2020;36(3):326-332
Objective To explore the impulse control and event-related potential (ERP) characteristics of patients with mental disorders caused by traumatic brain injury (TBI) in forensic psychiatry identification and to provide objective auxiliary indicators for forensic psychiatry identification. Methods Thirty patients (TBI group) with mental disorders caused by traumatic brain injury, who were identified as mild psychiatric impairment by judicial psychiatry, including 24 males and 6 females, as well as the thirty people in the control group participated in the study. All the participants completed Barratt Impulsiveness Scale-11 (BIS-11) and ERP induced by Go/NoGo tasks. BIS-11 and ERP data were collected and analyzed. Results The results of the BIS-11 showed that the total score and subscale scores of the TBI group were higher compared to the control group (P<0.05). Moreover, the TBI group exhibited significantly lower NoGo-N2 amplitude and lower NoGo-P3 amplitude than the control group. The NoGo-N2 amplitude was larger than the Go-N2 amplitude, and the NoGo-P3 amplitude was larger than the Go-P3 amplitude in both groups (P<0.05). Conclusion Traumatic brain injury could impair impulse control of mild psychiatric impairment patients, and the amplitudes of NoGo-N2 and NoGo-P3 could be important parameters to evaluate the impulse control of patients with mental disorders caused by traumatic brain injury.
Brain Injuries, Traumatic/complications*
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Electroencephalography
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Evoked Potentials
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Female
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Humans
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Inhibition, Psychological
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Male
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Mental Disorders/physiopathology*
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Neuropsychological Tests
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Reaction Time
5.Cellular microparticles and pathophysiology of traumatic brain injury.
Zilong ZHAO ; Yuan ZHOU ; Ye TIAN ; Min LI ; Jing-Fei DONG ; Jianning ZHANG
Protein & Cell 2017;8(11):801-810
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. The finding that cellular microparticles (MPs) generated by injured cells profoundly impact on pathological courses of TBI has paved the way for new diagnostic and therapeutic strategies. MPs are subcellular fragments or organelles that serve as carriers of lipids, adhesive receptors, cytokines, nucleic acids, and tissue-degrading enzymes that are unique to the parental cells. Their sub-micron sizes allow MPs to travel to areas that parental cells are unable to reach to exercise diverse biological functions. In this review, we summarize recent developments in identifying a casual role of MPs in the pathologies of TBI and suggest that MPs serve as a new class of therapeutic targets for the prevention and treatment of TBI and associated systemic complications.
Animals
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Astrocytes
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metabolism
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pathology
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Biological Transport
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Blood Coagulation Factors
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genetics
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metabolism
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Brain
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metabolism
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pathology
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physiopathology
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Brain Injuries, Traumatic
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genetics
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metabolism
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pathology
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physiopathology
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Cell-Derived Microparticles
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chemistry
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metabolism
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pathology
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Cytokines
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blood
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genetics
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Disease Models, Animal
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Disseminated Intravascular Coagulation
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genetics
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metabolism
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pathology
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physiopathology
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Gene Expression Regulation
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Humans
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Microglia
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metabolism
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pathology
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Neurons
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metabolism
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pathology
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Signal Transduction