1.Research and Prospect of Visual Event-Related Potential in Traumatic Brain Injury and Visual Function Evaluation.
Journal of Forensic Medicine 2022;38(4):520-525
Visual event-related potential (ERP) is an electrophysiological technique that objectively reflects the cognitive processing of stimulus from the perspective of detecting and recording neural electrophysiology responses using different paradigms of visual stimuli. Its endogenous components are closely related to advanced psychological activities. This article introduces the characteristics of main endogenous components including visual mismatch negativity (vMMN), N200 and P300, reviews the research progress of visual ERP in the sequelae of brain injury and objective evaluation of visual function, and prospects the application prospect of visual ERP in the field of forensic medicine.
Humans
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Brain Injuries, Traumatic/complications*
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Evoked Potentials
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Brain Injuries
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Forensic Medicine
2.Blast-induced traumatic brain injury: a new trend of blast injury research.
Chinese Journal of Traumatology 2015;18(4):201-203
Blast injury has become the major life- and function-threatening injuries in recent warfares. There is increased research interest in the mental disorders caused by blast-induced traumatic brain injury (bTBI), which has been proved as one of the "signature wounds" in modern battlefield. We reviewed the recent progresses in bTBI-related researches and concluded that the new era of blast injury research has shifted from the traditional physical impairments to cognitive dysfunctional/mental disorders that are proved to be more related to the outcome of combat casualty care.
Animals
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Blast Injuries
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complications
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etiology
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Brain Injuries, Traumatic
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complications
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etiology
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Cognition Disorders
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etiology
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Humans
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Mental Disorders
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etiology
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Research
4.The forensic determination of post-traumatic epilepsy in 21 patients.
Journal of Forensic Medicine 2001;17(1):25-62
UNLABELLED:
To evaluate the forensic determination of post cerebral traumatic epilepsy.
METHODS:
In 21 patients, traumatic history and previous history were analysied combined with the demonstrations of electroencephalogram(EEG), X-ray, CT and MRI.
RESULTS:
Post-traumatic epilepsy, manily in late stage, usually occurred following serious cerebral trauma. The type of traumatic epilepsy was determined by the traumatic location and extent. Abnormal epileptic wave in scalp EEG and 24 h dynamic EEG and medical image examinations were helpful for qualitative analysis.
CONCLUSION
The forensic determination of post traumatic epilepsy must be on the basis of traumatic and previous history combined with EEG, CT and MRI analysis.
Adult
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Brain Injuries/complications*
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Epilepsy, Post-Traumatic/etiology*
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Female
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Forensic Medicine
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Humans
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Male
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Middle Aged
5.Working Memory of Patients with Mild Cognitive Impairment due to Brain Trauma Based on fNIRS.
Fan CHANG ; Hao Zhe LI ; Sheng Yu ZHANG ; Chen CHEN ; Chao LIU ; Hui Yu FAN ; Yan XING ; Qin Ting ZAHNG ; Wei Xiong CAI
Journal of Forensic Medicine 2020;36(1):52-60
Objective To discuss the activation characteristics of the prefrontal cortex of people with mild cognitive impairment (MCI) due to brain trauma during working memory tasks. Methods The psychological experiment design software E-prime was used and N-back paradigm was adopted as working memory task. Functional near-infrared spectroscopy (fNIRS) was used to detect changes in cortical oxygenated hemoglobin concentrations of 22 channels within the prefrontal lobe of 24 people with MCI due to brain trauma (study group) and 27 healthy volunteers (control group) with matching gender and age. Behavioral data, such as the number of keystroke errors and reaction time, were recorded simultaneously. Independent samples t test and non-parametric test were used to compare the mean value of oxygenated hemoglobin concentration change, the number of key errors and the mean value of reaction time of the two groups in each task. Results (1) The differences in the number of errors and reaction time between the two groups in 1-back and 2-back tasks had statistical significance (P<0.05).The main effects of task load and group were both significant (task F=14.11, P=0.001 1; group F=10.39, P=0.001 5). (2) During the 1-back task, the differences in oxygenated hemoglobin concentration changes of the 22 channels between the two groups had no statistical significance (P>0.05). During the 2-back task, the differences in oxygenated hemoglobin concentration changes of the two groups in channel 2, 3, 7, 9, 10, 11, 14, 15, 18, 19, 21 and 22 had statistical significance (P<0.05). (3) In the 1-back task, the left frontal pole and dorsolateral prefrontal area in both groups were activated. In the 2-back task, the activation areas of the control group were the left frontal pole area and the left dorsolateral prefrontal area, while that of the study group almost covered most of the left and right frontal pole areas, which were scattered and the right area was activated, too. Conclusion Patients with MCI due to brain trauma have obvious working memory impairment, and during the 2-back working memory task, the activation of the prefrontal lobe decreased, but the activation range was wider.
Brain Injuries, Traumatic/complications*
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Cognitive Dysfunction/etiology*
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Humans
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Memory, Short-Term
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Prefrontal Cortex
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Spectroscopy, Near-Infrared
6.Application of Mismatch Negative in Evaluation of Severity of Mental Disorders due to Traumatic Brain Injury.
Hao Zhe LI ; Lu LIU ; Sheng Yu ZHANG ; Chen CHEN ; Chao LIU ; Hui Yu FAN ; Yan XING ; Jing DAI ; Qin Ting ZHANG ; Wei Xiong CAI
Journal of Forensic Medicine 2019;35(6):695-700
Objective To explore the applied value of mismatch negative (MMN) in evaluation of severity of mental disorders due to traumatic brain injury. Methods Thirty-five patients(case group) that conform to the diagnostic criteria of organic (traumatic brain injury) mental disorder in ICD-10 Classification of Mental and Behavioural Disorders criteria were selected. Twenty-four healthy subjects (normal control group) that matched the case group in terms of gender, age composition ratio and educational level were selected. All subjects were evaluated by Activity of Daily Living Scale (ADL) and Social Disability Screening Schedule (SDSS) and then examined by Event-Related Potential (ERP). A statistical analysis of the data was made by SPSS 22.0 software. Results The 32 patients and 24 normal control subjects completed the study. The scores of ADL and SDSS were significantly higher in the case group than in the normal control group (P<0.05). The latency of Fz, FCz, Cz and Pz in the case group was significantly longer than that in the normal control group (P<0.05). In the case group, the latency of Fz, FCz, Cz and Pz was positively correlated with the scores of ADL and SDSS (P<0.05). The equation can be well fitted with the scores of ADL and SDSS. The latency and amplitude of Fz, FCz, Cz and Pz were used as concomitant variables and whether or not the subjects had mental disorders due to traumatic brain injury as dependent variables. Conclusion The latency of MMN can be used as an indicator in potential evaluation of the severity of mental disorders due to traumatic brain injury, which means that the longer the latency of MMN is, the more severe mental disorders due to traumatic brain injury may be. The combined application of ADL, SDSS and MMN can be an objective indicator in preliminary judgment of mental disorders due to traumatic brain injury.
Activities of Daily Living
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Brain Injuries, Traumatic/complications*
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Disabled Persons
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Evoked Potentials
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Humans
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Mental Disorders/etiology*
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Software
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Trauma Severity Indices
7.Impulse Control and ERP Characteristics of Patients with Mental Disorder Caused by Traumatic Brain Injury.
Hong Fei SONG ; Xi DENG ; Ning YANG ; Bo HAO ; Yu Bo HU ; Yan Wei SHI ; Li XUE ; Hu ZHAO
Journal of Forensic Medicine 2020;36(3):326-332
Objective To explore the impulse control and event-related potential (ERP) characteristics of patients with mental disorders caused by traumatic brain injury (TBI) in forensic psychiatry identification and to provide objective auxiliary indicators for forensic psychiatry identification. Methods Thirty patients (TBI group) with mental disorders caused by traumatic brain injury, who were identified as mild psychiatric impairment by judicial psychiatry, including 24 males and 6 females, as well as the thirty people in the control group participated in the study. All the participants completed Barratt Impulsiveness Scale-11 (BIS-11) and ERP induced by Go/NoGo tasks. BIS-11 and ERP data were collected and analyzed. Results The results of the BIS-11 showed that the total score and subscale scores of the TBI group were higher compared to the control group (P<0.05). Moreover, the TBI group exhibited significantly lower NoGo-N2 amplitude and lower NoGo-P3 amplitude than the control group. The NoGo-N2 amplitude was larger than the Go-N2 amplitude, and the NoGo-P3 amplitude was larger than the Go-P3 amplitude in both groups (P<0.05). Conclusion Traumatic brain injury could impair impulse control of mild psychiatric impairment patients, and the amplitudes of NoGo-N2 and NoGo-P3 could be important parameters to evaluate the impulse control of patients with mental disorders caused by traumatic brain injury.
Brain Injuries, Traumatic/complications*
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Electroencephalography
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Evoked Potentials
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Female
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Humans
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Inhibition, Psychological
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Male
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Mental Disorders/physiopathology*
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Neuropsychological Tests
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Reaction Time
8.An open air research study of blast-induced traumatic brain injury to goats.
Hui-Jun CHEN ; Chuan XU ; Yue LI ; Zhi-Qiang CHEN ; Guan-Hua LI ; Zhao-Xia DUAN ; Xiao-Xia LI ; Jie-Yuan ZHANG ; Zhe WANG ; Hua FENG ; Bing-Cang LI
Chinese Journal of Traumatology 2015;18(5):267-274
PURPOSEWe once reported blast-induced traumatic brain injury (bTBI) in confined space. Here, bTBI was studied again on goats in the open air using 3.0 kg trinitrotoluene.
METHODSThe goats were placed at 2, 4, 6 and 8 m far from explosion center. Trinitrotoluene (TNT) was used as the source of the blast wave and the pressure at each distance was recorded. The systemic physiology, electroencephalogram, serum level of S-100 beta, and neuron specific enolase (NSE) were determined pre and post the exposure. Neuroanatomy and neuropathology were observed 4 h after the exposure.
RESULTSSimple blast waveforms were recorded with parameters of 702.8 kPa-0.442 ms, 148.4 kPa-2.503 ms, 73.9 kPa-3.233 ms, and 41.9 kPa-5.898 ms at 2, 4, 6 and 8 m respectively. Encephalic blast overpressure was on the first time recorded in the literature by us at 104.2 kPa-0.60 ms at 2 m, where mortality and burn rate were 44% and 44%. Gross examination showed that bTBI was mainly manifested as congestive expansion of blood vessels and subarachnoid hemorrhage, which had a total incidence of 25% and 19% in 36 goats. Microscopical observation found that the main pathohistological changes were enlarged perivascular space (21/36, 58%), small hemorrhages (9/36, 25%), vascular dilatation and congestion (8/36, 22%), and less subarachnoid hemorrhage (2/36, 6%). After explosion, serum levels of S-100b and NSE were elevated, and EEG changed into slow frequency with declined amplitude. The results indicated that severity and incidence of bTBI is related to the intensity of blast overpressure.
CONCLUSIONBlast wave can pass through the skull to directly injure brain tissue.
Animals ; Blast Injuries ; complications ; Brain ; pathology ; Brain Injuries, Traumatic ; etiology ; pathology ; Electroencephalography ; Goats ; Male ; Phosphopyruvate Hydratase ; blood ; S100 Calcium Binding Protein beta Subunit ; blood
9.The significance of contribution degree of hurting factors in mental injury and the research progress.
Yu-Bing TANG ; Bei-Ling GAO ; Xiao-Lin LIU ; Ling-Li ZHANG
Journal of Forensic Medicine 2011;27(4):295-299
In forensic psychiatric evaluation, experts frequently need to assess the contribution degree of hurting factors to the victims. The contribution degree reflects the extent of hurt caused by the injurer and is the quantitative index of the responsibility which should be undertaken by the injurer. It is also important evidence for the judgement. Presently, there is no accepted and practicable quantitative tool to reflect the objective contribution degree. This article reviews domestic and international researches on the contribution degree of hurting factors in mental injury, including the concept, connotation, related assessment methods, problems in assessment and its future study trend.
Age Factors
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Brain Injuries/complications*
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Expert Testimony
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Forensic Psychiatry
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Humans
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Injury Severity Score
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Mental Disorders/psychology*
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Psychology, Social
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Sex Factors
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Stress Disorders, Post-Traumatic/psychology*
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Wounds and Injuries/complications*
10.Clinical analysis of 36 cases of sinus-straddling hematoma after craniocerebral injury.
Shan-lang YIN ; Shan-cheng CHEN ; Yang ZHENG ; Ze-liang YE
Journal of Southern Medical University 2006;26(1):130-1p following 130
OBJECTIVETo investigate the relation between sinus-straddling hematoma (SSH) and venous sinus injury and explore the approaches for surgical management.
METHODSThirty-six cases of stride sinus hematoma were reviewed to observe the incidence rate of sinus injury complicated with (SSH) and explore its surgical management.
RESULTSThe incidence rate of venous sinus injury following (SSH) was 80.56% (29/36), and appropriate surgical management yielded good therapeutic effect in these patients.
CONCLUSIONIntracranial stride sinus hematoma is often accompanied by venous sinus injury, and adequate preoperative risk evaluation may improve the success rate of the operation.
Adolescent ; Adult ; Brain Injuries ; complications ; China ; epidemiology ; Cranial Sinuses ; injuries ; Female ; Hematoma ; epidemiology ; etiology ; Humans ; Incidence ; Intracranial Hemorrhage, Traumatic ; epidemiology ; etiology ; Male ; Middle Aged