Objective To observe the clinical effect ofShuganJieyu capsule combined with domperidone on functional dyspepsia (FD).Methods84 FD patients were recruited in this study. The patients were divided into the control group (n=42) and the observation group (n=42). Control group was treated with domperidone, and observation group was treated with combination ofShuganJieyu capsule and domperidone. Both groups were treated for 4 weeks. The gastric volume, gastric gas scores, and gastric emptying rates were detected by the ultrasound and X-ray. The clinical effect and adverse reactions was compared.ResultsThe clinic effective rate of observation group was 90.5% (38/42), and the control group was 76.2% (32/42). After treatment, the gastric volume of 60 min was significantly lower in observation group than that in control group (15.52 ± 3.21 mlvs. 23.54 ± 5.11 ml;t=2.412,P<0.05); the decreasing of gastric gas scores (0.42 ± 0.13vs. 0.64 ± 0.16;t=2.384,P<0.05) and increasing of gastric emptying rate (74.15% ± 11.62%vs. 54.82% ± 10.31%;t=2.324,P<0.05) were significantly higher in observation group than those in control group.ConclusionShugan-Jieyu capsule can improve gastric emptying and gastrointestinal motility, and showed better effect than domperidone alone.