Objective To observe the efficacy of Zishen Anshen Decoction combined with Compound Zaoren (Ziziphi Spinosae Semen) Capsule on insomnia patients with disharmony between heart-yang and kidney-yin syndrome and its effect on sleep quality index. Methods Seventy insomnia patients were randomly divided into treatment group and control group. Both groups conventionally took estazolam as needed, the treatment group was additionally given Zishen Anshen Decoction (in the afternoon and after dinner) and Compound Zaoren Capsule (before sleep at night) for 14 d. The Pittsburgh sleep quality index (PSQI) score and dosage of estazolam were used as evaluation indexes for the comparison between the two groups. Results PSQI score of daytime function disorder and hypnotics dosage of the treatment group was significantly lower than that of the control group, and the dosages of estazolam were reduced (P<0.05). Conclusion The alternative application of Zishen Anshen Decoction and Compound Zaoren Capsule on insomnia treatment can not only improve daytime function, but also reduce the dosage of benzodiazepine, with better effect than estazolam.