HUANG Yuan-yu's understanding of viscera qi and blood based on the theory of rise and fall of middle qi. He believes that rise and fall of middle qi plays a vital role in the normal operation of the function of organs and blood, so the blood stasis and qi disorder of spleen and stomach can cause the dysfunction of other organs. Therefore, he adopts the method of rising and falling middle qi and four dimensions, which can provide new ideas for clinical treatment of qi and blood stasis syndrome.

Objective:To study the history of migraineurs,and find out the historical features which have higher value in migraine diagnosis and differential diagnosis.Method:250 patients who have primary headache were chosen in this study(include 117 migraineurs),each patient,s history was taked in detail,then each historical feature,s diagnostic value were analysised using statistic method.Results:In all the historical features that we studied pain exacerbated by activity,pain throbbing,disability,phonophobia, nausea,photophobia,pain on oneside,all have high sensitivity and high specificity.Conclusion:Known the sensitivity and specificity of each historical features,can help us to diagnose migraine rapidly and accurately.

442 cases of primary liver carcinoma were admitted to our hospital from August 1975 to June 1983, and confirmed by surgery and pathologic examination. Of these 442 cases, 71 cases (16.8%) were AFP-negative (h magglutination titer 1:10, counter immuno-electrophoresis negative and radio-immuno-assay less than 31ng/ml). The ege of the patients ranged from 15 to 76 years old(average : 46), and the sex ratio between males and females was 4.9 = 1.The pathologic findings were 59 liver cell carcinomas, 10 bile duct cell carcinomas, 2 mixed types and 34(57.6%)pertaining to grade I or I-II, 22(37.3%) grade II-III or III and 3(5.1 %)grade III-IV in differentiation. 31 cases (43.6%) were found to have been combined witn cirrhosis.The most common clinical symptom was hepatodynia and other symptoms were anorexia, s:nse of abdomen distention,fever etc. 10 of the cases were misdiagnosed as caver- nous hemangicma of the liver, diseases of bile ducts and hydatid cyst of the liver before operation.Earlier diagnosis could be made by combining enzyme tcsts(PHI, LDH, rGT, AKP, A1AT etc),B-mode ultrasonography, angiograpby of hepatic artery, liver scanning and clinical symptons together.In addition, an evaluation of enzyme tests, B-mode ultrasonography,liver scanning and angiography of hepatic artery were also discussed as well as the differential diagnosis.

The da Vinci Surgical System has developed and great progress has been made recently in surgery. Despite lack of applications in tumors of head and neck, its advantages, such as minimally invasive procedure and rapid recovery, show great prospects. In this article, we reviewed the surgical method, indication, advantages and prospects of its application in tumors of head and neck.

Objective To study the longitudinal change of Migraine patient′s condition ,quality of life and disability ;analyze the evolution of the relationship between headache frequency ,pain intensity ,medication and treatment efficacy .Methods Continuous registration of migraine patients ,using WHO-DAS Ⅱ to assess the disability ,using MSQ2 .1 to assess the health-related quality of life ,using headache diary to record the patient′s condition .Results Compared the conditions of before and after treatment ,the aver-age level of pain ,acute drug using and headache frequency ,were significantly improved .The three dimensions′scores of MSQ2 .1 were decreased .Conclusion In this study ,significant improvement were found in some of the disability and health-related quality of life .Continuity of treatment has an important role to improve health-related quality of life of patients and reduce disability .

ObjectiveTo evaluate the effects of aerobic exercise, nutrition or both on physical fitness and metabolism in obesity adolescents. Methods94 overweight/obese adolescents (12～16 years old) underwent 10 weeks exercise alone, nutrition intervention alone, and exercise combined with nutrition, respectively. The physical and metabolism index were detected before and after intervention. ResultsThe body mass index (BMI), body fat, body fat% decreased in all the groups. Especially, exercise alone decreased total cholesterol (TC), increased fasting insulin (FINS), insulin resistance (HOMA-IR), and function of β-cells (HOMA-β). Nutrition alone decreased TC, low-density lipoprotein cholesterol (LDL-C). Exercise combined with nutrition decreased TC and LDL-C, increased FINS and HOMA-β. High-density lipoprotein cholesterol (HDL-C) tended to decrease in all the groups. ConclusionThe aerobic exercise and /or nutrition intervention can improve the lipid metabolism, Exercise can improve function of the β-cell of pancreas. But the effects of exercise and/or nutrition on HDL-C and insulin resistance are not satisfactory.

Objective To discuss clinical results of treatment of trimalleolar fractures by minimally invasive surgical osteosynthesis. Methods From January 2002 to Doctober 2005, twenty-eight cases (mean age: 38.7 years) of trimalleolar fracture were treated by minimally invasive surgical osteosynthesis. Their lateral and posterior ankle joints were exposed through the Gatellier-Chastang incision. The sequence of reduction and fixation of ankle fracture was firstly the posterior ankle, then the medial and lateral malleolus, and distal tibiofibular syndesmosis lastly. Postoperatively, all the patients were fixed externally from 3 to 4 weeks with plaster splint. Results Follow-ups of 18 months on average revealed that all the cases healed. The healing time ranging from 2.8 to 4.5 months averaged 3.2 months. According to the Baird-Jackson scoring system, the results were rated as excellent in 16 cases, good in eight cases, moderate in three cases, and poor in one case, with the good-excellent rate being 85.7% . Conclusions The anatomical reduction and firm internal fixation are key factors in treatment of trimalleolar fractures. The minimally invasive surgical osteosynthesis is a good method due to the minimal invasion, a high rate of union, and fewer complications it results in.

BACKGROUND: Some scholars have used finite element analysis to simulate spinal biodynamics. But there are few reports on finite element imitation of lumbar biodynamics system before and after artificial disc replacement. OBJECTIVE: This study aimed to do finite element analysis by establishing new three dimensional finite element models of SB-Chaite Ⅲ lumbar disc replacement. DESIGN, TIME AND SETTING: The observational experiments were performed at the Laboratory of Orthopaedics of Xiangya Hospital of Central South University from December 2003 to August 2004. PARTICIPANT: A healthy male volunteer served as simulation. His T12-S1 underwent continuous CT scanning. There were altogether 264 images with 2 mm in thickness each. Three-dimensional images were reconstructed every 15? in order to obtain the data for three-dimensional model. METHODS: The CT images and human anatomical data were processed by 3DSMAX software to establish three-dimensional L4-5 model of normal Chinese males. MAIN OUTCOME MEASURES: It was transformed to finite element model after processed by SAP2000 software together with SB-Chaite Ⅲ disc prosthesis model. RESULTS: The three-dimensional model and finite element model of lumbar spine were successfully established. The finite element model of SB-Chaite Ⅲ disc replacement in L4-5 spine was established. The total nodes were 2 542, including 1 924 Solid units, 592 Area units and 50 Link units. CONCLUSION: The finite element model of artificial disc replacement can be established by CT scanning, digital processor and computer aided design.

The paper collects patents relevant to hypolipidemic drugs in recent decade based on the Derwent database,reveals the development process of drug research in this field by taking advantage of the patent analysis method,and discusses the change of application quantity for patents over the years,distribution in the hotspot technology field and the main application organizations and their R&D orientations.

Cancer immunotherapy is a new approach to cancer treatment. Dendritic cells, the most potent antigen-presenting cells found in humans, have attracted a lot of researches. However, dendritic cells are insufficient to cross-present self-antigens in-vivo. To improve the dendritic cells' antigen-presenting capabilities and the anti-tumor effect, in vitro preparation of dendritic cell vaccine and combination with pro-apoptotic treatments such as chemotherapy are being used.