OBJECTIVES: This study aimed to evaluate the clinical efficacy of individual cognitive behavioral therapy (CBT) for Patients with Primary or Secondary Insomnia. METHODS: Participants were recruited from a primary care sleep clinic from January 2008 to June 2009. The study sample included 64 outpatients with primary insomnia (n=30) and secondary insomnia (n=34) according to the criteria of DSM-IV. Participants completed sleep diaries, Dysfunctional Beliefs and Attitudes about Sleep Scale-16 (DBAS), State-Trait Anxiety Inventory (STAI) before CBT and shortly after completion of CBT. CBT was provided in 7 weekly, 40-50-minute individual therapy sessions. RESULTS: Both groups of patients with primary and secondary insomnia showed significant improvement in the DBAS and sleep parameters including sleep onset latency, total sleep time, and sleep efficiency. Repeated-measures ANOVA of the DBAS and sleep parameters showed no significant group-by-time interactions between patients with primary and secondary insomnia, suggesting the efficacy of CBT for patients with secondary insomnia was equivalent to that of CBT for patients with primary insomnia. CONCLUSION: This study suggests that CBT is effective for the management of primary and secondary insomnia in a primary care setting.
Anxiety ; Cognitive Therapy ; Diagnostic and Statistical Manual of Mental Disorders ; Humans ; Outpatients ; Primary Health Care ; Sleep Initiation and Maintenance Disorders

OBJECTIVES: Shift work is a stressful situation. It is important to know the factors associated with the ability to adapt to a shift work schedule. The aim of the present study was to investigate the association between sleep, as well as personality variables, and the resilience of shift work nurses. METHOD: Self-report questionnaires were administered to 95 nurses who worked in one national university hospital. Connor-Davidson resilience scale, hospital anxiety and depression scale, morningness-eveningness scale, Pittsburgh sleep quality index, other sleep-related questionnaires, and Korean defense style questionnaires were used. RESULTS: Age, shift work duration, off-day oversleep, depression, anxiety, adaptive defense style, and self-suppressive defense style were significantly associated with resilience (p < 0.05). Multiple regression analysis showed that age (beta = 0.34, p < 0.05), depression (beta = -0.25, p < 0.05), adaptive defense style (beta = 0.45, p < 0.001), and self-suppressive defense style (beta = -0.19, p < 0.05) significantly predicted the resilience of shift work nurses. Concerning individual defense mechanisms, resignation (beta = -0.20, p < 0.05), sublimation (beta = 0.19, p < 0.05), omnipotence (beta = 0.19, p < 0.05), and humor (beta = 0.20, p < 0.05) significantly predicted the resiliency. CONCLUSION: The findings indicate that a specific defense style and other mechanisms were associated with the resilience of shift work nurses. A future prospective study with more participants could further clarify the relationship between sleep-related variables, as well as personality factors, and resilience of shift work nurses.
Anxiety ; Appointments and Schedules ; Defense Mechanisms ; Depression ; Surveys and Questionnaires ; Sublimation

OBJECTIVE: The pharmacotherapy of bipolar disorder not otherwise specified (BP-NOS) has been insufficiently studied. The aim of this prospective naturalistic study was to explore the effectiveness of lamotrigine adjunctive treatment in patients with BP-NOS. METHODS: Data from 50 patients diagnosed with BP-NOS were analyzed. On the basis of the prospective mood chart methodology, the efficacy of lamotrigine adjunctive treatment was assessed by changes in the mean Clinical Global Impressions-Bipolar Version (CGI-BP) depression scores. A paired t-test was used to test the statistical significance of the changes in CGI-BP depression scores. Repeated-measures analysis of variance (RM ANOVA) with simple effect analysis was performed to explore the sequential changes during a 52-week period. Cohen's d was calculated to measure the magnitude of the treatment effects on the changes in depression severity. Time to lamotrigine discontinuation was also calculated using the Kaplan-Meier estimates. Lamotrigine-associated adverse events were monitored every two weeks. RESULTS: A significant decrease, with a large effect size (Cohen's d=1.6), in the mean CGI-BP depression scores was associated with lamotrigine adjunctive treatment in intent-to-treat analysis (t=8.7, df=49, p<0.001). Twenty-four patients (48.0%) completed 52-week lamotrigine adjunctive treatment. Analysis of the data obtained from those completing the treatment revealed a large effect (Cohen's d=4.0) on improvement in the severity of depression (t=16.8, df=32, p<0.001). Sixty percent of patients achieved remission (n=30), and 64% of patients (n=32) showed some clinical response to lamotrigine adjunctive treatment. The mean time to lamotrigine discontinuation was 31.3+/-3.1 weeks (CI=25.2-37.4). Lamotrigine adjunctive treatment was well tolerated, with no serious rashes reported. CONCLUSION: Lamotrigine seems to be effective in the management of depressive symptoms in BP-NOS. Long-term use of lamotrigine was generally safe and well tolerated. Large-scale controlled trials might be needed to confirm the findings of this naturalistic study.
Bipolar Disorder ; Depression ; Exanthema ; Humans ; Prospective Studies ; Triazines

Good sleepers tend to more resilient than poor sleepers. As sleep and resilience may have a bidirectional relationship, it is important to explore the relationship between healthy sleep and resilience. Objectively and subjectively measured sleep quality showed positive association with resiliency. In one study, more resilient adolescents had higher sleep efficiency, less light sleep, more slow-wave sleep, and a smaller number of awakenings after sleep onset. Circadian typology, jetlag and circadian misalignment may be associated with the capacity to deal with adversity. Eveningness, exposure to chronic jetlag and circadian misalignment might be risk factors for development of psychological problems and mental disorders. Additional studies are needed to evaluate whether promoting healthy sleep behaviors results in increased resilience.
Adolescent ; Circadian Rhythm ; Humans ; Jet Lag Syndrome ; Mental Disorders ; Mental Health ; Risk Factors

OBJECTIVE: Bipolar disorder (BD) is characterized by elevated impulsivity, even during periods of remission. Many recovered BD patients have functional impairments, which can lead to poor quality of life (QoL). The aim of this study was to investigate the association between impulsivity and QoL in euthymic BD patients. METHODS: A total of 56 remitted or recovered patients with type I or II BD, diagnosed based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria, were recruited. Psychiatrists administered the Clinical Global Impression (CGI) for BD and the Global Assessment of Functioning (GAF) scales and then interviewed the subjects to assess clinical variables. Patients completed the Barratt Impulsiveness Scale (BIS-11) and the World Health Organization Quality of Life Assessment Instrument-Brief Form (WHOQoL-BREF). Pearson correlations, univariate regression analyses, and multiple linear regression analyses were performed. RESULTS: The BIS-11 total score was significantly correlated with the WHOQoL-BREF total score (r=-0.55, p<0.01) and with the WHOQoL-BREF subscales. After controlling for GAF score and other clinical variables, the BIS-11 total score (beta=-0.43, p=0.001) was independently associated with overall QoL. Additionally, the BIS-11 total score was particularly strongly associated with the physical, psychological, and social domains of the multi-dimensional QoL scale. CONCLUSION: Our results suggest that high impulsivity is related to low QoL in euthymic BD patients. Further studies are needed to examine whether interventions for high impulsivity effectively improve QoL in patients with BD.
Impulsive Behavior ; Bipolar Disorder* ; Diagnostic and Statistical Manual of Mental Disorders ; Humans ; Linear Models ; Psychiatry ; Quality of Life* ; Weights and Measures ; World Health Organization

OBJECTIVE: The current study explored the relationship between the polarity of the first episode and the timing of eventual diagnosis of bipolar I disorder, and associated clinical implications. METHODS: Twelve years of clinical data from the medical records of 258 inpatients meeting DSM-III-R or DSM-IV criteria for bipolar I disorder were analyzed. Subjects were divided into two groups according to the polarity of the first episode: those with depressive polarity (FE-D), and those with manic polarity (FE-M). Comparisons were made between the two groups on variables associated with the timing of diagnosis and related outcomes. RESULTS: In population with bipolar I disorder, a significant longer time lapse from the first major mood episode to the confirmed diagnosis was associated with the FE-D group compared to the FE-M group [5.6 (+/-6.1) vs. 2.5 (+/-5.5) years, p<0.001]. FE-D subjects tended to have prior diagnoses of schizophrenia and major depressive disorder while FE-M subjects tended to have prior diagnoses of bipolar disorder and schizophrenia. A significantly higher rate of suicide attempts was associated with the FE-D group compared to the FE-M group (12.7 vs. 1.7%, p<0.001). CONCLUSION: The results of this study indicate that first-episode depressive polarity is likely to be followed by a considerable delay until an eventual confirmed diagnosis of bipolar I disorder. Given that first-episode depressive patients are particularly vulnerable to unfavorable clinical outcomes such as suicide attempts, a more systematic approach is needed to differentiate bipolar disorder among depressed patients in their early stages.
Bipolar Disorder ; Depressive Disorder, Major ; Diagnostic and Statistical Manual of Mental Disorders ; Humans ; Inpatients ; Medical Records ; Schizophrenia ; Suicide

OBJECTIVES: We aimed to compare the smoking behaviors in adolescents from monocultural and multicultural families and to evaluate the associations between their smoking behavior and number of suicide attempts. METHODS: The data used in this study was collected from The Tenth Korea Youth Risk Behavior Web-based Survey. The differences in the sociodemographic characteristics between the adolescents in the multicultural and monocultural families were analyzed through the χ2-test, and a logistic regression was conducted to evaluate the relationships between the smoking behavior and number of suicide attempts of the adolescents in multicultural families. The process involved an analysis using a complex sample design. RESULTS: There was significant difference in the weighted rates of the current smoking behavior (13.3% vs. 8.4%, p<0.001), experience of violence (6.8% vs. 2.3%, p<0.001), and number of suicide attempts (5.4% vs. 2.7%, p<0.001) between the adolescents from the multicultural and monocultural families. In both groups, the current smoking behavior was associated with the number of suicide attempts (multicultural families OR=6.5, p=0.005; monocultural families OR=1.5, p<0.001). CONCLUSION: Our results showed that the percentage of current smokers in the adolescents from multicultural families was higher than that in the monocultural families and that current smoking behavior is related to the number of suicide attempts in both groups, after adjustment for age, sex, socioeconomic status, academic achievement, current smoking behavior, depressive mood and experience of violence.
Adolescent* ; Humans ; Korea* ; Logistic Models ; Risk-Taking ; Smoke ; Smoking ; Social Class ; Suicide ; Violence

OBJECTIVE: This study examined the effect of social support on metabolic syndrome (MetS) among elderly population in a city in Korea. METHODS: A total of 352 people all over 60 years of age were analyzed from the data of the Korean Longitudinal Study on Cognitive Aging and Dementia. This study was started in 2010 and is in progress till date. We compared the documented diagnoses of MetS and Medical Outcome Study Social Support Survey at the baseline of the study and two years later. RESULTS: 315 were normal, 37 were developed after two years among subjects without MetS at baseline. When the level of social support was compared at baseline and then at the time of the reassessment two years later, the level had increased in the normal group and the level had not significantly changed for the MetS group. The findings documented at the two year mark indicate that the higher and stronger the level of social support, the lower the risk of developing MetS (odds ratio=0.053, p=0.040). CONCLUSION: The elderly with good social support are noted to be at lower risk in developing MetS as opposed to those with poor social support. It is apparent that adequate social support shows reduced prevalence of MetS among the elderly. Methods to identify strategies in improving social support networks are needed to expand public health resources and to better accommodate the community-based care of the elderly.
Aged* ; Cognitive Aging ; Dementia ; Diagnosis ; Humans ; Korea* ; Longitudinal Studies ; Outcome Assessment (Health Care) ; Prevalence ; Public Health

The aim of this study was to investigate the relationship between metabolic syndrome and suicidal ideation in Korean. This study was based on the 2010 Korean National Health and Nutrition Examination Survey. A questionnaire was used to measure suicidal ideation and physical examination was performed to measure waist circumference, blood pressure, fasting glucose, cholesterol and triglyceride levels. Complex samples logistic regression was performed to estimate the relationship between metabolic syndrome and suicidal ideation among adults and adolescents. Subjects with metabolic syndrome were more likely to have suicidal ideation in adult. There would be essential needs to evaluate suicidal ideation in adult with metabolic syndrome and to follow up suicidal ideation in adolescents with metabolic syndrome.
Adolescent ; Adult ; Blood Pressure ; Cholesterol ; Fasting ; Glucose ; Humans ; Logistic Models ; Nutrition Surveys* ; Physical Examination ; Surveys and Questionnaires ; Suicidal Ideation* ; Triglycerides ; Waist Circumference

OBJECTIVES : The aim of this study was to report the developmental process of the patient mood chart (named the Patient Mood Chart, PMC), and to test its validity and utility. METHODS : One hundred twenty nine subjects with bipolar disorder, as diagnosed using DSM-IV criteria, completed the PMC. A trained clinician administered the Hamilton Depression Rating Scale (HDRS), the Montgomery A sberg Depression Rating Scale (MADRS), the Inventory of Depressive Symptomatology (IDS), the Young Mania Rating Scale (YMRS) and the Global Assessment of Functioning (GAF).Mood ratings on the PMC were compared with clinician-rated measures taken at initial visits and 6- month follow-ups. To examine the utility of the PMC, a patient questionnaire-type survey was done. RESULTS : Depressive symptom ratings on the PMC were highly correlated with the HAMD, MADRS and IDS scores. Manic symptom ratings on the PMC were correlated with the YMRS scores. Similarly, a strong correlation was found between mood chart scores and the GAF scores. Most patients considered the PMC to be useful and helpful. CONCLUSION : These findings support the validity and utility of the PMC. The PMC can be used for prospective assessment of symptom changes, treatment response, and long-term course for subjects with bipolar disorder
Bipolar Disorder ; Depression ; Diagnostic and Statistical Manual of Mental Disorders ; Follow-Up Studies ; Humans