No abstract available.
Arteriovenous Malformations ; Embolization, Therapeutic ; Telangiectasia, Hereditary Hemorrhagic

Peroxisome proliferator activated receptors (PPAR)-α is a critical regulator of skin conditions of skin inflammatory disorders, hyper-proliferation, and abnormal differentiation. The new search for PPAR-α activator is required for epidermal differentiation and skin barrier improvement. Citronellic acid was selected for a new PPAR-α ligand through structure-based pharmacophore screening. Citronellic acid is an acyclic monoterpene carboxylic acid found in essential oils of lemongrass and citrus fruits. Citronellic acid enhanced the transactivation activity of PPAR responsive element (PPRE) and cornified envelope (CE) formation, and decreased the expression of inflammatory cytokines and anti-microbial peptides. Citronellic acid also promoted the protein expression of involucrin, as a component of CE and a marker of keratinocyte differentiation, and the synthesis of hyaluronic acid (HA), a moisturizing component. These results indicate that citronellic acid may be a suitable skin treatment for improvement of epidermal barrier function.

Peroxisome proliferator activated receptors (PPAR)-α is a critical regulator of skin conditions of skin inflammatory disorders, hyper-proliferation, and abnormal differentiation. The new search for PPAR-α activator is required for epidermal differentiation and skin barrier improvement. Citronellic acid was selected for a new PPAR-α ligand through structure-based pharmacophore screening. Citronellic acid is an acyclic monoterpene carboxylic acid found in essential oils of lemongrass and citrus fruits. Citronellic acid enhanced the transactivation activity of PPAR responsive element (PPRE) and cornified envelope (CE) formation, and decreased the expression of inflammatory cytokines and anti-microbial peptides. Citronellic acid also promoted the protein expression of involucrin, as a component of CE and a marker of keratinocyte differentiation, and the synthesis of hyaluronic acid (HA), a moisturizing component. These results indicate that citronellic acid may be a suitable skin treatment for improvement of epidermal barrier function.

Peroxisome proliferator activated receptors (PPAR)-α is a critical regulator of skin conditions of skin inflammatory disorders, hyper-proliferation, and abnormal differentiation. The new search for PPAR-α activator is required for epidermal differentiation and skin barrier improvement. Citronellic acid was selected for a new PPAR-α ligand through structure-based pharmacophore screening. Citronellic acid is an acyclic monoterpene carboxylic acid found in essential oils of lemongrass and citrus fruits. Citronellic acid enhanced the transactivation activity of PPAR responsive element (PPRE) and cornified envelope (CE) formation, and decreased the expression of inflammatory cytokines and anti-microbial peptides. Citronellic acid also promoted the protein expression of involucrin, as a component of CE and a marker of keratinocyte differentiation, and the synthesis of hyaluronic acid (HA), a moisturizing component. These results indicate that citronellic acid may be a suitable skin treatment for improvement of epidermal barrier function.

Peroxisome proliferator activated receptors (PPAR)-α is a critical regulator of skin conditions of skin inflammatory disorders, hyper-proliferation, and abnormal differentiation. The new search for PPAR-α activator is required for epidermal differentiation and skin barrier improvement. Citronellic acid was selected for a new PPAR-α ligand through structure-based pharmacophore screening. Citronellic acid is an acyclic monoterpene carboxylic acid found in essential oils of lemongrass and citrus fruits. Citronellic acid enhanced the transactivation activity of PPAR responsive element (PPRE) and cornified envelope (CE) formation, and decreased the expression of inflammatory cytokines and anti-microbial peptides. Citronellic acid also promoted the protein expression of involucrin, as a component of CE and a marker of keratinocyte differentiation, and the synthesis of hyaluronic acid (HA), a moisturizing component. These results indicate that citronellic acid may be a suitable skin treatment for improvement of epidermal barrier function.

Peroxisome proliferator activated receptors (PPAR)-α is a critical regulator of skin conditions of skin inflammatory disorders, hyper-proliferation, and abnormal differentiation. The new search for PPAR-α activator is required for epidermal differentiation and skin barrier improvement. Citronellic acid was selected for a new PPAR-α ligand through structure-based pharmacophore screening. Citronellic acid is an acyclic monoterpene carboxylic acid found in essential oils of lemongrass and citrus fruits. Citronellic acid enhanced the transactivation activity of PPAR responsive element (PPRE) and cornified envelope (CE) formation, and decreased the expression of inflammatory cytokines and anti-microbial peptides. Citronellic acid also promoted the protein expression of involucrin, as a component of CE and a marker of keratinocyte differentiation, and the synthesis of hyaluronic acid (HA), a moisturizing component. These results indicate that citronellic acid may be a suitable skin treatment for improvement of epidermal barrier function.

PURPOSE: The purpose of this study was to examine mediating effects of pleasurable activities on the relationship between depression and suicidal ideation among the elderly moderated by living arrangement such as those living alone (LA) versus those living with others (LWO). METHODS: This study is a cross-sectional and correlational design using secondary data analysis of the 2017 Korean National Survey on the Elderly (2,416 for the LA group, and 6,106 for the LWO group). Logistic regression analysis was conducted comparing effects of pleasurable activities on suicidal ideation between the two groups. RESULTS: For suicidal ideation, there were significant differences in suicidal ideation by sex, religion, and senior center visits in the LA group, while the LWO group had no significant differences identified. Both groups showed significantly different associations of suicidal ideation by socioeconomic status, gathering, meaningful interaction, and depression. Senior center visits were statistically significant in the LA group, while there was not significant in the LWO group. CONCLUSION: Visiting senior centers can reduce suicidal ideation of the LA group. To prevent suicidal ideation of the elderly living alone, mental health specialists should provide community-cooperative environments to address these issues, especially LA elderly.
Aged ; Depression ; Humans ; Leisure Activities ; Logistic Models ; Mental Health ; Negotiating ; Residence Characteristics ; Senior Centers ; Social Class ; Specialization ; Statistics as Topic ; Suicidal Ideation

A 46-year-old man presented with a progressive headache lasting for 2 weeks. Initial lumbar puncture revealed a pressure of 31 cm H20 and 30 white cells. His symptoms had worsened despite the treatment of intracranial hypertension. Visual field exam showed marked peripheral constriction and the fundus showed marked papilledema. Cytological analysis of cerebrospinal fluid demonstrated positive for metastatic carcinoma. We report a case of a patient with meningeal carcinomatosis who developed isolated intracranial hypertension with papilledema.

Neurological complications following liver transplantation are more common than after other organ transplants. These complications include seizure in about 8% of cases, which is associated with morbidity and mortality. Seizure should be treated immediately, and the process of differential diagnosis has to be performed appropriately in order to avoid permanent neurologic deficit. We herein report a case of status epilepticus after liver transplantation. The status epilepticus was treated promptly and the cause of seizure was assessed. The patient was discharged without any complication.
Diagnosis, Differential ; Humans ; Liver Transplantation* ; Liver* ; Mortality ; Neurologic Manifestations ; Posterior Leukoencephalopathy Syndrome ; Seizures ; Status Epilepticus* ; Transplants

OBJECTIVE: The Valsalva maneuver is recognized as an effective method to dilate the internal jugular vein (IJV). However, this maneuver cannot be performed in many cases, such as children and unconscious patients. The aim of this study was to evaluate the effectiveness of proximal IJV compression, which can easily be performed, regardless of patient cooperation. METHODS: Healthy adult volunteers were recruited from tertiary hospital employees. Basic anatomic and physiologic data were collected. The subjects lay down as if they were undergoing IJV catheter insertion, in the supine position with their necks turned 30 degrees to the left. The main outcome was the cross-sectional area (CSA) of the distal IJV as measured by ultrasound in four stages. The first stage was sham without any maneuver. The second was Valsalva maneuver, the third was digital IJV compression, and the fourth was digital compression accompanied by simultaneous Valsalva maneuver. RESULTS: A total of 41 volunteers were enrolled. Twenty-six (63.41%) were male with an average age of 28.15±2.85 years. Mean height was 170.74±8.66 cm and mean neck circumference was 35.28±3.87 cm. The mean CSA-IJV was 1.06±0.36 cm² without any maneuver. It increased to 1.34±0.45 cm² with Valsalva maneuver (P<0.001), to 1.26±0.41 cm² with digital compression (P<0.001), and to 1.41±0.47 cm² with the two maneuvers combined (P=0.01). CONCLUSION: Digital proximal IJV compression effectively dilates the distal IJV. When performed simultaneously with the Valsalva maneuver, the effect was enhanced.
Adult ; Catheterization ; Catheters ; Child ; Humans ; Jugular Veins* ; Male ; Methods ; Neck ; Patient Compliance ; Supine Position ; Tertiary Care Centers ; Ultrasonography ; Valsalva Maneuver* ; Volunteers