The most common ocular finding of the idiopathic thrombocytopenic purpura(ITP) is superficial retinal hemorrhages in both eyes. But the descriptions of new vessel on the optic disc(NVD) associated with ITP are scarcely found in literatures. A 17-year-old girl who managed for ITP complained of visual distrubance of the right eye and floaters of the left eye. On fundoscopy the right eye was failed to examine due to thick vitreous hemorrhage and the left eye showed NVD and preretinal hemorrhage. After panretinal photocoagulation of the left eye, NVD was regressed.

PURPOSE: To evaluate the surgical results and complications in vitrectomy with silicone oil tamponade for the treatment of proliferative diabetic reitnopathy(PDR). METHODS: Vitreous microsurgery with silicone oil tamponade was performed on 21 patients with advanced proliferative diabetic retinopathy. RESULTS: Anatomic attachment was maintained in 19 eyes(90.5%). Functional success with visual acuity 0.02 or better was found in 17 eyes(81.0%). Functional failures were caused by retinal detachment in 2 eyes and glaucoma in 2 eyes. Complications of silicone oil included cataract in 8 of 14 phakic eyes(57.1%), epiretinal proliferation in 7 of 21 eyes(33.3%), retinal detachment in 6 eyes(28.6%), silicone oil in anterior chamber in 3 eyes(14.3%), secondary glaucoma in 2 eyes(9.5%), and emulsification of silicone oil in 2 eyes(9.5%). CONCLUSION: Vitrectomy with silicone oil was highly effective in advanced proliferative diabetic retinopathy and early removal of silicone oil was recommended to reduce the complications of silicone oil.
Anterior Chamber ; Cataract ; Diabetic Retinopathy* ; Glaucoma ; Humans ; Microsurgery ; Retinal Detachment ; Silicone Oils* ; Visual Acuity ; Vitrectomy

The purpose of this study is to investigate that the biological effect of mitomycin C(MMC) on inhibition of cellular proliferation, extracellular synthesis of type_I coolagen, lamini, and study of myofibroblast is derived directly from the primary and recurrent pterygial mesenchymal cell by MMC concentration and duration of exposure time used clinically. Human pterygial mesenchymal cells were exposed for 3 minutes, 5 minutes, and 10 minutes to MMC 0.01%, 0.03%, 0.05%, and DMEM(control). After cells were incubated for 24 hours, [H3] thymidine proliferative assay, immunoassay of type_I collagen and laminin, immunohistochemical and ultrastructual study of -smooth muscle actin were perfromed in vitro. Recurrent pterygal mesenchymal cells were more proliferated and stronger than primary pterygial cells in proliferation and inhibition of cellular proliferation assay. In immunoassay of extracellular matrix, the higher the concentration of MMC and longer the duration of exposure time, the inhibition of laminin are strong. However, there was a little effect of inhibition of synthesis of type-I collagen. Also the results of positive responsed immunohistochemical and ultrastructual finding such as a few pinocytosis, microfilaments, microtendon, and basal lamina like materal by TEM of myofibroblast were revealed. We think that the reccurent pterygial tissue have more effect on inhibition of cellular proliferation and laminin synthesis than primary pterygium. Therefore, reconsideration of MMC concentreation and duration time should be need in case of recurrent tissue, further experimental and clinical research on the myofibroblast and inhibition of type-I collagen also should be need.
Actin Cytoskeleton ; Actins ; Basement Membrane ; Cell Proliferation* ; Collagen* ; Extracellular Matrix ; Humans ; Immunoassay ; Laminin* ; Mitomycin* ; Myofibroblasts ; Pinocytosis ; Pterygium ; Thymidine

Penetrating ocular injuries with retined intraocular foreign bodies(IOFB) may result in significant visual morbidity. Although appropriate use of microsurgical and vitreoretinal surgical techniques can salvage a high percentage of even the most severely traumatized globes with retained IOFB, questions remain about optimal care for these eyes. The authors analysed the results and prognostic factors in 78 cases of penetrating oculr injuries with retained IOFB who were managed at the Pusan National University Hospital from Jan. 1985 to Dec. 1989. The majority of patients were young adult males in their twenties and thirties. The nature of the IOFB was mostly a magnetic property(88.5%), and the causes of injury were hammering in 67.9% of all cases. The majority of the size of IOFB(maximal length) was over 2mm, and most of the IOFB(75.6%) was located at the posterior segment of the eyeball; and the larger the object, the more it was posteriorly located. Success rate of IOFB removal was 91.0%, and 59.0% of all cases were removed through pars plana. Preoperative complications included cataract(48.7%), vitreous hemorrhage(38.5%), and the most common postoperative complication was retinal detachment(10.3%). In our study, better visual result was obtained in cases of better initial visual acuity, smaller size of IOFB, shorter retention time of IOFB in eyeball, and anterior rather than posterior location of the IOFB in the eyeball.
Busan ; Foreign Bodies* ; Humans ; Male ; Postoperative Complications ; Retinaldehyde ; Visual Acuity ; Young Adult

Sixty-four eyes in 65 patients received prophylactic treatment for retinal break and predisposing degeneration. During the follow-up period of 6 months or more, rhegmatogenous retinal detachment occurred in 2 eyes(3.0%). In one aphakic eye, new tear was responsible for the subsequent formation of retinal detachment but in the other eye, retinal detachment resulted from inadequate reaction around the treated retinal tear. One patient with bilateral multiple tears developed new retinal tear without detachment. Except these cases, no intra-or permanent post-operative complications were noticed.
Follow-Up Studies ; Humans ; Retinal Detachment* ; Retinal Perforations ; Retinaldehyde*

Pars plana vitrectomy was performed for 50 eyes of 50 patients with rhegmatogenous retinal detachment, as the primary procedure, and the indications, surgical results, visual outcome, and complications were analyzed. The procedures with vitrectomy included scleral buckling, membrane peeling, intravitreal gas or silicone oil injection, endolaser photocoagulation, or lensectomy. The retina was successfully reattached in 15 (88.2%) of 17 eyes with moderate to severe proliferative vitreoretinopathy (PVR), in 15 (100%) of 15 eyes with posterior retinal breaks, in 6 (75%) of 8 eyes with giant retinal tear, in 8 (100%) of 8 eyes with poor view of the retina and in 2 (100%) of 2 eyes with undetected retinal breaks. Two or more operations were performed in seventeen eyes(34%) and severe PVR (12 eyes, 66.7%) was the most common cause of reoperation. Visual acuity was improved in 30 eyes (60%), unchanged in 8 eyes (16%), and worse in 12 eyes (24%).
Humans ; Light Coagulation ; Membranes ; Reoperation ; Retina ; Retinal Detachment* ; Retinal Perforations ; Retinaldehyde* ; Scleral Buckling ; Silicone Oils ; Visual Acuity ; Vitrectomy* ; Vitreoretinopathy, Proliferative

Transscleral diode laser retinopexy and cryoretinopexy were performed in pigmented rabbits, and light and electron microscopic, and immunohistochemical studies were done. Acute lesions produced by cryoretinopexy showed significant retinal destruction and, in contrast, those produced by transscleral diode laser showed reaction limited to the outer retina and choroid. Chronic lesions by cryoretinopexy showed marked retinal thinning and chorioretinal adhesions. Pigment-laden cells were aggregated at the level of the retinal pigment epithelium, with some having migrated into the sensory retina. The laser lesions showed similar findings but less in size and severity. Acute lesions showed absence of reactivity with all antibodies. While marked expressions of GFAP, vimentin, and S-100 epitopes were seen in chorioretinal scar tissues made with cryoretinopexy, expressions with less intensity were seen with diode retinopexy. Migrating pigment-laden cells were labelled positive for cytokeratins and few cells were positive for anti-macrophage antibody. These results suggest that although transscleral diode laser induce less inner retinal destruction and more localized burns than cryoretinopexy, both forms of treatment produce similar deep retinal Muller cell reaction, as demonstrated by the immunohistochemical studies.
Antibodies ; Burns ; Choroid ; Cicatrix ; Epitopes ; Keratins ; Lasers, Semiconductor* ; Rabbits ; Retina ; Retinal Pigment Epithelium ; Retinaldehyde ; Vimentin

We investigated the biological effects and cytotoxicity of the artificial tear formulations and anti-inflammatory agents on the cultured keratocytes of rabbit in vitro by using lactate dehydrogenase (LDH) leakage assay and transmission electron microscopy. In the artificial tear fomualations, the LDH titer of the Tears naturale and Protagent were more increased with time, but the Tears naturale II and Tears naturale free was slowly progressed or has narrow range of LDH increasing. In the anti-inflammatory agent, the LDH titer of the all eye solutions was increased with time, especially Maxidex and Fluorometholone. Non-steroid, Decrol was less than other anti-inflammatory agents in Na+, K+, Cl- electrolyte compositon. Especially, the LDH titer of the artificial tear formulations and anti-inflammatory agents containing the benzalkonium chloride (BAC) or low Na+, K+, Cl- composition was more increased with time. The typical rabbit keratocytes were elongated and had not prominent nuclei. But the higher the titer of LDH, the keratocytes were visible round and swollen, and were injured with the disruption of plasma membrane, vacuole formation in cytoplasm, and damage of nuclei in transmission electron microscopy. As the use of topical drug containing low Na+, K+, Cl- or Benzalkonium chloride should be induced a particulary toxic effect on keratocyte, we should be carefully use these topical eye solutions, especially when the epithelium is denuded.
Anti-Inflammatory Agents* ; Benzalkonium Compounds ; Cell Membrane ; Cytoplasm ; Dexamethasone ; Epithelium ; Fluorometholone ; L-Lactate Dehydrogenase ; Microscopy, Electron, Transmission ; Povidone ; Tears* ; Vacuoles

Trabeculectomy and trabeculotomy are recent development in glaucoma surgery. Results are reported to be better than with standard filtering procedures and complications are few. At the present time trabeculectomy is tbe treatment of choice for patients with simple glaucoma requiring surgery. In the period January, 1975, to March, 1976, 20 trabeculectomies were done in adult glaucoma and combined technique of trabeculectomy and trabeculotomy was done in 6 congenital glaucoma in Busan National University. We tried a modified technique of trabeculectomy, which is; (1) limbal based scleral flap was made of 1/3 in thickness of sclera, (2) 2 knots with 8-0 silk were placed in angle of scleral flap. Success was achieved in 23 eyes (88.4%) of 26 cases and the duration of follow-up ranged from 5 to 18 months. A successful trabeculectomy functions by permitting increased aqueous outflow via several pathways. We suggest that the aqueous may filter externally along the course of the scleral scar or may permeate the thinned outer scleral lamellae, producing a bleb that mayor may not be visible. The complications were hyphema, flat chamber, posterior synechia and retinal hemorrhage.
Adult ; Blister ; Busan ; Cicatrix ; Follow-Up Studies ; Glaucoma* ; Glaucoma, Open-Angle ; Humans ; Hyphema ; Retinal Hemorrhage ; Sclera ; Silk ; Trabeculectomy*

Perfluorocarbon liquids are frequently used intraoperatively in repair of complicated retinal detachments. One complication of their use is prfluorocarbon liquids entering the subretinal space via a retinal break or an iatrogenic retmotomy since these liquids are much heavier than water, We evaluated the response to subretinal perfluorophenanthrene (VitreonR) on the rabbit retina ophthalmoscopically and microscopically. Twenty eight rabbit eyes underwent subretinal injection of 50-100 ml of perfluorophenanthrene via the vitreous space. The same volume of balanced salt solution was injected into control eyes. Eyes were monitored by indirect ophthalmoscopy and examined by light and electron microscopy. Progressive retinal detachments with newly formed retinal breaks in the inferior quadrants developed in 24 of 28 eyes. In the remaining 4 eyes, small retinal bleb, from 0.5 to 3DD size, occurred in inferior peripheral retina. The photoreceptor outer and inner segments were lost and receptor cell nuclei began to deplete within 1-3 days. In addition, marked vacuole formation in the retinal fiber layers as well as in inner and outer nuclear layers were seen. The photoreceptor outer and inner segments had a1most dlsappeared and the number of nuclei in irulei and outer nuclear layers was markedly decreased from 1 to 3 months. The control eyes reattached and healed spontaneously within 3-5 days. Our findings suggest that all subretinal perfluorophenanthrene should be carefully removed from the eyes at the end of the surgery.
Blister ; Cell Nucleus ; Microscopy, Electron ; Ophthalmoscopy ; Retina ; Retinal Detachment ; Retinal Perforations ; Retinaldehyde* ; Vacuoles