1.The value of colposcopy for early diagnosis of cervical cancer.
Kyung Don BAIK ; Boo Soo HA ; Kyu Sik SIN ; Chul KIM
Korean Journal of Obstetrics and Gynecology 1993;36(7):1815-1821
No abstract available.
Colposcopy*
;
Early Diagnosis*
;
Uterine Cervical Neoplasms*
2.Clinical and pathologic study of dysfunctional uterine bleeding.
Boo Soo HA ; Jong Gi JEUNG ; So Heuy KANG ; Chul KIM ; Chung Hee CHI
Korean Journal of Obstetrics and Gynecology 1993;36(6):847-853
No abstract available.
Female
;
Metrorrhagia*
3.A case of omphalocele and ectopia cordis with diaphragmatic defect.
Young Joo CHOI ; Kyung Don BAIK ; Hong Sup LEE ; Boo Soo HA ; Sang Kap KIM ; Jung Hee CHI
Korean Journal of Obstetrics and Gynecology 1992;35(7):1082-1087
No abstract available.
Ectopia Cordis*
;
Hernia, Umbilical*
4.Total Laparoscopic Hysterectomy (TLH) : A Clinical Review of 300 Cases.
Yeon Ju KIM ; Boo Soo HA ; Beum Deuk LEE ; Jong Keun LEE ; Yong Seuk SON ; Yoon Won CHOUGH
Korean Journal of Obstetrics and Gynecology 2002;45(2):292-297
This clinical study was conducted to survey 300 cases of total laparoscopic hysterctomy (TLH) by the Department of Obstetrics and Gynecology of Boram Hospital in Ulsan, Korea from January, 2000 to June, 2001. TLH has been described in much of the recent literature. We analyzed 300 cases of TLH to evaluate the clinical data such as distribution of age, parity, clinical indication, previous operation history, type of surgery, operation time, weight of uterus, Hb change of post-operation first day and the complications of using this technique. The mean age of patients was 41.3. The mean parity of patients was 2.6. The clinical indications for TLH were myoma (72.3%), adenomyosis (11.3%), PID (5.3%), CIS (4%) and others (5.7%). The most previous operation was bilateral tubal ligation. Others were cesarean section, appendectomy. The most concomitant procedure with TLH was posterior colpoperineorrhaphy. Salpingo-oophorectomy and appendectomy were also carried out concomitantly. The mean operation time was 124 minutes. The mean weight of the uterus was 230 gm. The mean Hb change post-operation on the 1st day was 1.3g/dL. The complications of TLH were bleeding to need blood transfusion, ureteral injury and bladder injury. Thus this technique can be safely performed by skilled laparoscopists for properly selected patients but there is a need for prospective studies for comparision with various laparoscopic hysterctomies.
Adenomyosis
;
Appendectomy
;
Blood Transfusion
;
Cesarean Section
;
Female
;
Gynecology
;
Hemorrhage
;
Humans
;
Hysterectomy*
;
Korea
;
Myoma
;
Obstetrics
;
Parity
;
Pregnancy
;
Sterilization, Tubal
;
Ulsan
;
Ureter
;
Urinary Bladder
;
Uterus
5.Predictive factors of contrast-enhanced ultrasonography for the response to transarterial chemoembolization in hepatocellular carcinoma.
Kil Hyo PARK ; Soon Ha KWON ; Yong Sub LEE ; Soung Won JEONG ; Jae Young JANG ; Sae Hwan LEE ; Sang Gyune KIM ; Sang Woo CHA ; Young Seok KIM ; Young Deok CHO ; Hong Soo KIM ; Boo Sung KIM ; Yong Jae KIM
Clinical and Molecular Hepatology 2015;21(2):158-164
BACKGROUND/AIMS: The predictive role of contrast-enhanced ultrasonography (CEUS) before performing transarterial chemoembolization (TACE) has not been determined. We assessed the possible predictive factors of CEUS for the response to TACE. METHODS: Seventeen patients with 18 hepatocellular carcinoma (HCC) underwent TACE. All of the tumors were studied with CEUS before TACE using a second-generation ultrasound contrast agent (SonoVue(R), Bracco, Milan, Italy). The tumor response to TACE was classified with a score between 1 and 4 according to the remaining enhancing-tumor percentage based on modified response evaluation criteria in solid tumors (mRECIST): 1, enhancing tumor <25%; 2, 25%< or =enhancing tumor<50%; 3, 50%< or =enhancing tumor<75%; and 4, enhancing tumor> or =75%). A score of 1 was defined as a "good response" to TACE. The predictive factors for the response to TACE were evaluated during CEUS based on the maximum tumor diameter, initial arterial enhancing time, arterial enhancing duration, intensity of arterial enhancement, presence of a hypoenhanced pattern, and the feeding artery to the tumor. RESULTS: The median tumor size was 3.1 cm. The distribution of tumor response scores after TACE in all tumors was as follows: 1, n=11; 2, n=4; 3, n=2; and 4, n=1. Fifteen tumors showed feeding arteries. The presence of a feeding artery and the tumor size (< or =5 cm) were the predictive factors for a good response (P=0.043 and P=0.047, respectively). CONCLUSIONS: The presence of a feeding artery and a tumor size of less than 5 cm were the predictive factors for a good response of HCC to TACE on CEUS.
Adult
;
Aged
;
Aged, 80 and over
;
Antibiotics, Antineoplastic/administration & dosage
;
Carcinoma, Hepatocellular/pathology/therapy/*ultrasonography
;
Chemoembolization, Therapeutic
;
Contrast Media/*chemistry
;
Doxorubicin/administration & dosage
;
Female
;
Humans
;
Liver Neoplasms/pathology/therapy/*ultrasonography
;
Male
;
Microspheres
;
Middle Aged
;
Tomography, X-Ray Computed
;
Treatment Outcome
6.Practical Effect of Sorafenib Monotherapy on Advanced Hepatocellular Carcinoma and Portal Vein Tumor Thrombosis.
Soung Won JEONG ; Jae Young JANG ; Kwang Yeun SHIM ; Sae Hwan LEE ; Sang Gyune KIM ; Sang Woo CHA ; Young Seok KIM ; Young Deok CHO ; Hong Soo KIM ; Boo Sung KIM ; Kyoung Ha KIM ; Jung Hoon KIM
Gut and Liver 2013;7(6):696-703
BACKGROUND/AIMS: We investigated the effects of sorafenib monotherapy on advanced hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT) in a clinical setting. METHODS: In total, 143 consecutive patients with unresectable HCC were treated with sorafenib. Among these patients, 30 patients with advanced HCC and PVTT (Vp3 or 4) were treated with sorafenib monotherapy. RESULTS: All patients had a performance status of 1 to 2 (Eastern Cooperative Oncology Group 1/2, 20/10) and Child-Pugh class A or B (A/B, 17/13). Eleven patients had modified Union for International Cancer Control stage IVA tumors, whereas 19 had stage IVB tumors. All patients had PVTT (Vp3, 6; Vp4, 24). Following sorafenib monotherapy, three patients (10.0%) had a partial response with PVTT revascularization, and nine (30.0%) had stable disease, with a disease control rate of 33.3%. The median overall survival was 3.1 months (95% confidence interval [CI], 2.70 to 3.50), and the median progression-free survival was 2.0 months (95% CI, 1.96 to 2.05). Fatigue and hand-foot skin reactions were the most troublesome side effects. CONCLUSIONS: A limited proportion of patients with advanced HCC and PVTT exhibited a remarkable outcome after sorafenib monotherapy, although the treatment results in this type of patient is extremely poor. Further studies to predict good responders to personalized therapy are warranted.
Adult
;
Aged
;
Aged, 80 and over
;
Anorexia/chemically induced
;
Antineoplastic Agents/adverse effects/*therapeutic use
;
Carcinoma, Hepatocellular/*drug therapy/pathology
;
Diarrhea/chemically induced
;
Disease-Free Survival
;
Fatigue/chemically induced
;
Female
;
Hand-Foot Syndrome/etiology
;
Humans
;
Kaplan-Meier Estimate
;
Liver Neoplasms/*drug therapy/pathology
;
Magnetic Resonance Imaging
;
Male
;
Middle Aged
;
Nausea/chemically induced
;
Neoplasm Invasiveness
;
Niacinamide/adverse effects/*analogs & derivatives/therapeutic use
;
Phenylurea Compounds/adverse effects/*therapeutic use
;
Portal Vein/*pathology
;
Proportional Hazards Models
;
Tomography, Spiral Computed
;
Venous Thrombosis/*drug therapy/pathology
7.Cyclooxygenase-2 and vascular endothelial growth factor in chronic hepatitis, cirrhosis and hepatocellular carcinoma.
Soon Ha KWON ; Soung Won JEONG ; Jae Young JANG ; Ji Eun LEE ; Sae Hwan LEE ; Sang Gyune KIM ; Young Seok KIM ; Young Deok CHO ; Hong Soo KIM ; Boo Sung KIM ; So Young JIN
Clinical and Molecular Hepatology 2012;18(3):287-294
BACKGROUND/AIMS: Cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) are up-regulated in hepatocellular carcinoma (HCC). To investigate the levels of COX-2 and VEGF expression in chronic hepatitis (CH), cirrhosis, and HCC. METHODS: The immunohistochemical expressions of COX-2 and VEGF were evaluated in tissues from patients with CH (n=95), cirrhosis (n=38), low-grade HCC (LG-HCC; n=6), and high-grade HCC (HG-HCC; n=29). RESULTS: The COX-2 expression scores in CH, cirrhosis, LG-HCC, and HG-HCC were 3.3+/-1.9 (mean+/-SD), 4.2+/-1.7, 5.5+/-1.0, and 3.4+/-2.4, respectively (CH vs. cirrhosis, P=0.016; CH vs. LG-HCC, P=0.008; LG-HCC vs. HG-HCC, P=0.004), and the corresponding VEGF expression scores were 0.9+/-0.8, 1.5+/-0.7, 1.8+/-0.9, and 1.6+/-1.1 (CH vs. cirrhosis, P<0.001; CH vs. LG-HCC, P=0.011; LG-HCC vs. HG-HCC, P=0.075). Both factors were correlated with the fibrosis stage in CH and cirrhosis (COX-2: r=0.427, P<0.001; VEGF: r=0.491, P<0.001). There was a significant correlation between COX-2 and VEGF in all of the tissue samples (r=0.648, P<0.001), and between high COX-2 and VEGF expression scores and survival (COX-2: P=0.001; VEGF: P<0.001). CONCLUSIONS: The expressions of both COX-2 and VEGF are significantly higher in cirrhosis and LG-HCC than in CH. High COX-2 and high VEGF expressions are associated with a high survival rate.
Adult
;
Aged
;
Carcinoma, Hepatocellular/*metabolism/mortality/pathology
;
Cyclooxygenase 2/*metabolism
;
Female
;
Hepatitis, Chronic/*metabolism/mortality/pathology
;
Humans
;
Immunohistochemistry
;
Kaplan-Meier Estimate
;
Liver Cirrhosis/*metabolism/mortality/pathology
;
Liver Neoplasms/*metabolism/mortality/pathology
;
Male
;
Middle Aged
;
Vascular Endothelial Growth Factor A/*metabolism
8.Predictive Value of Interim and End-of-Therapy 18F-FDG PET/CT in Patients with Follicular Lymphoma
Sun Ha BOO ; Joo Hyun O ; Soo Jin KWON ; Ie Ryung YOO ; Sung Hoon KIM ; Gyeong Sin PARK ; Byung Ock CHOI ; Seung Eun JUNG ; Seok Goo CHO
Nuclear Medicine and Molecular Imaging 2019;53(4):263-269
PURPOSE: ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is the standard imaging modality for response evaluation in FDG-avid lymphoma, but the prognostic value is not established in follicular lymphoma (FL). This study investigated the prognostic value of Deauville 5-point scale (D5PS) from paired interim PET/CT (PET(Interim)) and end-of-induction therapy PET/CT (PET(EOI)) in patients with FL.METHODS: FL staging and response assessment PET/CT images from 2013 to 2015 were retrospectively reviewed. PET(Interim) was performed 3 or 4 cycles after chemotherapy and PET(EOI) after 6 or 8 cycles. D5PS scores of 1, 2, and 3 were considered as negative (−), and scores 4 and 5 were considered as positive (+). Statistical analysis was done using Cox regression analysis, Kaplan-Meier survival analysis, and the log-rank test.RESULTS: Thirty-three patients with set of baseline, interim, and end-of-induction therapy PET/CTstudies were included. Ten patients (30.3%) had progression. The median progression-free survival (PFS) was 38.8 months (range 3.5–72.7 months). On PET(Interim), 23 patients were negative and 10 were positive. On PET(EOI) scans, 29 patients were negative, and 4 were positive. On multivariate analysis, PET(EOI)(−) was associated with longer PFS. PET(Interim)(+) and PET(EOI)(+) patients had a significantly shorter PFS than PET(Interim)(−) patients (39.9 months, 95%confidence interval [CI] 23.0–56.9, versus 55.5months, 95%CI 49.7–61.2, p=0.005) and PET(EOI)(−) patients (14.2 months, 95% CI 8.5–19.8, versus 60.5 months, 95% CI 52.1–69.0, p<0.001).CONCLUSION: For patients with FL, PET(Interim) and PET(EOI) response is predictive of PFS, and PET(EOI)(+) is an independent prognostic factor for progression of FL.
Disease-Free Survival
;
Drug Therapy
;
Electrons
;
Fluorodeoxyglucose F18
;
Humans
;
Kaplan-Meier Estimate
;
Lymphoma
;
Lymphoma, Follicular
;
Multivariate Analysis
;
Positron-Emission Tomography
;
Positron-Emission Tomography and Computed Tomography
;
Retrospective Studies
9.Predictive Value of Interim and End-of-Therapy 18F-FDG PET/CT in Patients with Follicular Lymphoma
Sun Ha BOO ; Joo Hyun O ; Soo Jin KWON ; Ie Ryung YOO ; Sung Hoon KIM ; Gyeong Sin PARK ; Byung Ock CHOI ; Seung Eun JUNG ; Seok Goo CHO
Nuclear Medicine and Molecular Imaging 2019;53(4):263-269
PURPOSE:
¹â¸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is the standard imaging modality for response evaluation in FDG-avid lymphoma, but the prognostic value is not established in follicular lymphoma (FL). This study investigated the prognostic value of Deauville 5-point scale (D5PS) from paired interim PET/CT (PET(Interim)) and end-of-induction therapy PET/CT (PET(EOI)) in patients with FL.
METHODS:
FL staging and response assessment PET/CT images from 2013 to 2015 were retrospectively reviewed. PET(Interim) was performed 3 or 4 cycles after chemotherapy and PET(EOI) after 6 or 8 cycles. D5PS scores of 1, 2, and 3 were considered as negative (−), and scores 4 and 5 were considered as positive (+). Statistical analysis was done using Cox regression analysis, Kaplan-Meier survival analysis, and the log-rank test.
RESULTS:
Thirty-three patients with set of baseline, interim, and end-of-induction therapy PET/CTstudies were included. Ten patients (30.3%) had progression. The median progression-free survival (PFS) was 38.8 months (range 3.5–72.7 months). On PET(Interim), 23 patients were negative and 10 were positive. On PET(EOI) scans, 29 patients were negative, and 4 were positive. On multivariate analysis, PET(EOI)(−) was associated with longer PFS. PET(Interim)(+) and PET(EOI)(+) patients had a significantly shorter PFS than PET(Interim)(−) patients (39.9 months, 95%confidence interval [CI] 23.0–56.9, versus 55.5months, 95%CI 49.7–61.2, p=0.005) and PET(EOI)(−) patients (14.2 months, 95% CI 8.5–19.8, versus 60.5 months, 95% CI 52.1–69.0, p<0.001).
CONCLUSION
For patients with FL, PET(Interim) and PET(EOI) response is predictive of PFS, and PET(EOI)(+) is an independent prognostic factor for progression of FL.
10.The Relationship between the Causative Allergens of Allergic Diseases and Environments in Korea Over a 8-Year-Period: Based on Skin Prick Test from 2006 to 2015.
Chan Soon PARK ; Boo Young KIM ; Soo Whan KIM ; Joo Hyung LEE ; Soo Kweon KOO ; Kyung Su KIM ; Seon Tae KIM ; Yong Dae KIM ; Jeong Hong KIM ; Jin Kook KIM ; Chang Hoon KIM ; Hyun Jun KIM ; Hyo Yeol KIM ; Ki Sang RHA ; Hwan Jung ROH ; Dong Joon PARK ; Seung Heon SHIN ; Sang Chul LIM ; Jae Hoon LEE ; Heung Man LEE ; Heung Gu LEE ; Young Ha KIM ; Jin Hee CHO
Journal of Rhinology 2018;25(2):91-98
BACKGROUND AND OBJECTIVES: The present study evaluated the results of skin prick test using 55 allergens at 20 centers in the Republic of Korea in 2006, 2010, and 2014–2015. The aim was to assess changes in the positive rate of allergens according to temporal, regional, and environmental factors. MATERIALS AND METHODS: In total, 20 hospitals were selected based on the population distribution in the Republic of Korea. A skin prick test panel comprising 55 aeroallergens was distributed to 18 hospitals for this prospective study. The 2006 and 2010 skin prick test results were collected and analyzed retrospectively from 20 hospitals, while the 2014/2015 skin prick test results (from June 2014 to May 2015) were collected prospectively from 18 hospitals. RESULTS: A total of 14,897 SPT test results were analyzed: 4,319 in 2006, 7,431 in 2010, and 1,852 in 2014/2015. The overall rate of skin prick test positivity to more than two allergens was significantly higher in males than females. The positive rates of alder pollens and birch, oak and ragweed pollen positivity were increased in older patients. Several positive rates were increased according to the temperature in spring. The positive rates for beech pollen, birch pollen, hazel pollen, oak pollen, Tyrophagus putrescentiae, mugwort, cat, Acarus siro, Lepidoglyphus destructor and Tyrophagus putrescentiae were significantly increased, while those of Cult rye pollen and dandelion were significantly decreased over the three test periods. The overall positive rate for allergens in Jeju province varied significantly from Seoul and other cities. CONCLUSION: Change in the positive rate of multiple aeroallergens was evaluated in the Republic of Korea over time. Our findings can be used to recommend aeroallergens suitable for inclusion in skin prick test panels in the Republic of Korea and will facilitate further investigation of changes in the patterns of allergic diseases.
Allergens*
;
Alnus
;
Ambrosia
;
Animals
;
Artemisia
;
Betula
;
Cats
;
Demography
;
Fagus
;
Female
;
Humans
;
Korea*
;
Male
;
Mites
;
Pollen
;
Prospective Studies
;
Republic of Korea
;
Retrospective Studies
;
Secale
;
Seoul
;
Skin*
;
Taraxacum