1.A Case of Generalized Granuloma Annulare Development in a Psoriasis Patient Treated with Interleukin-12/23 Blockers
Jongwook KIM ; Bongseok JANG ; Yeona KIM ; Sang-Hyeon WON ; Kyung-Nam BAE ; Jungsoo LEE ; Kihyuk SHIN ; Hoonsoo KIM ; Hyunchang KO ; Moon-Bum KIM ; Byungsoo KIM
Korean Journal of Dermatology 2022;60(9):606-610
Granuloma annulare is a relatively common inflammatory skin disease. The etiology is unknown; however, drugs have been considered as one of the predisposing conditions, and a few cases of granuloma annulare related to biologics have been recently reported. A 48-year-old man with a 25-year history of psoriasis visited our dermatological clinic. Ustekinumab was administered for the treatment of psoriasis. After 5 years of ustekinumab therapy, erythematous papules with an annular distribution appeared on his trunk and extremities. Skin biopsy supported the diagnosis of generalized granuloma annulare, and the patient continued to receive ustekinumab with oral methotrexate, cyclosporine, and steroids for 9 months. However, as the skin lesions aggravated, oral steroid treatment was continued, and secukinumab was administered instead of ustekinumab. The skin lesions improved and remained stable with the intermittent administration of oral steroids thereafter.
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