Korean Ginseng (Panax C.A. Meyer) has survived empirical efficacy as tonic and geriatric agents for several thousands of years in oriental herbal medicine. But there has been numerous controversial reports about its use in aged hypertensive men due to its allegedly hypertensive effects. Therefore, the author conducted the pharmacological studies of Korean Ginseng extracts on the blood pressure and blood lipid metabolism, during development of hypertension, using SHR(Spontaneously Hypertensive Rat), counterpart model of human essential hypertension. The results obtained were as follows: 1. SHR could be grouped, according to their age, as prehypertensive stage(<6th week after birth), labile hypertensive stage(6th 14th week), early established hypertensive stage(14th-20th week), and late established hypertensive stage(>20th week). 2. Plasma renin activity tended to rise steadily, until established hypertensive stage was reached. Thereafter, plasma renin activity tended to decline. 3. The changes of blood pressure due to Ginseng extract, depended on the amount, route and duration of its administration. Low dose of Ginseng tended to increase blood pressure but high dose of Ginseng tended to decrease blood pressure, until 1 week of intraperitonal administration. But prolonged administration of Ginseng extract beyond 1 week, showed delayed hypertensive effect in the intraperitoneal administration but not in oral administration. 4. SHR seemed to have abnormalities in the lipid metabolism. SHR showed lowered level of serum cholesterol and phospholipid, whereas slightly higher level of triglyceride, and showed lower alpha-lipoprotin fraction but higher pre beta-lipoprotein fraction, as compared with NCR.(=Normal Control Rat). 5. When high fat cholesterol salt diet was fed on, it was possible to indece hyperlidemia and increment of hypertension in SHR. but when high fat cholesterol salt diet and Ginseng extract were fed on concomitantly, Ginseng showed significant inhibiting effect on the development of hyperlidemia and hypertension.
Administration, Oral ; Blood Pressure* ; Cholesterol ; Diet ; Herbal Medicine ; Humans ; Hypertension* ; Lipid Metabolism* ; Male ; Panax* ; Plasma ; Rats, Inbred SHR* ; Renin ; Triglycerides

No abstract available.

No abstract available.
Korea*

Two cases of acute digitalis poisoning were presented. The first patient was 20-year-old male with asymptomatic ventricular septal defect (maladie de Roger) who attempted suicide by ingestion of degitalis leaf about 6.0 g (60 tablets). He developed severe epigastric pain and vomiting one hour after ingestion. Syncopal attack was developed once for a few minutes and recovered. Electrocardiogram revealed 2:1 A-V block. By conservative management he was recovered. The second patient was 2-year-old, healthy baby who ingested digoxin about 2.5 mg(10 tablets) by accident. He developed severe vomiting and electrocardiogram revealed 1degrees, 2degreesand 3degrees A-V block in series. He was recovered by conservative management without sequele.
Child, Preschool ; Digitalis* ; Digoxin ; Eating ; Electrocardiography ; Heart Septal Defects, Ventricular ; Humans ; Male ; Poisoning* ; Suicide, Attempted ; Vomiting ; Young Adult

Segmental Spinal Instrumentation(S.S.I.) is more effective means of managing unstable thoraco-lumbar spine fractures than traditional Harrington Rod Instrumentation as an operative procedure which afforded rigid internal fixation with stability and needed minimal external immobilization. Early return to normal activity and successful rehabilitation are facilitated by efficient stabilization with S.S.I. Fifty-nine patients with fractures and fracture-dislocations of thoraco-lumbar spine were treated by Harrington Rod Instrumentation (29 patients) and S.S.I. (30 patients) at this hospital from June 1979 to July 1984. We have analysed the results of these treatment and obtained following conclusions: 1. S.S.I. is more rigid internal fixation than Harrington Rod Instrumentation. a) no or minimal external immobilization b) early ambulation and rehabilitation c) lowered complications 2. There was no significant difference in correction rate, loss of correction, and neurologic recovery between Harrington Rod Instrumentation and S.S.I.
Early Ambulation ; Humans ; Immobilization ; Rehabilitation ; Spine ; Surgical Procedures, Operative

No abstract available.
Humans ; Hypercholesterolemia*

BACKGROUND: Korea is, known to be an endemic area of viral hepatitis B, and 5-6% of population are carriers. Immunization can reduce the spread of hepatitis B infection. Hower, not all people respond to hepatitis B immunsation. 5-15% of primary vaccinees fail to be immunized. After revaccination, only 37.5 44% of the primary failures elicit antibody response. Recent studies have reported that it is effective to inject a double dose vaccination in immunocompromsed patients. In some country, they recommend that neonate whode mother is HBV carrier shoud receive double dose vaccination. This study documented the results of double dose vaccintion only once to nonrsponders toward the HBV immunzation. METHODS: Healthy nonresponders to Hepatitis B immunization were recuited from Sep. 1995 to Aug. 1996. Subjects with their AST/ALT level over 40, or over 65 years old were excluded. They were received 2ml of plasma-derived vaccine(Hepavax-B) intramuscularly in the deltoid muscle. Anti-HBs antibody testing were performed at 1 to 3 months after vaccintion. RESULTS: 17 healthy nanreponders to Hepatitis B immunization(male 10, female 7) were included. Their mean ages were 47(32 to64), AST/ALT level 20/19(16 to 28/11 to 35), smoking 4.3pys(1 to 7). Seroconversion occured in 13 of them(76.5%). CONCLUSIONS: Nonresponders to Hepatitis B vaccintion respond well to double dose vaccination once.
Aged ; Antibody Formation ; Deltoid Muscle ; Female ; Hepatitis B* ; Hepatitis* ; Humans ; Immunization ; Immunization, Secondary ; Infant, Newborn ; Korea ; Mothers ; Smoke ; Smoking ; Vaccination*

Preoperative diagnosis of an aneurysm of the right coronary sinus of Valsalve with rupture into the right ventricle was made by echocardiography in a patient who also had a small ventricular septal defect. In this case of ruptured sinus of Valsalva aneurysm, the cardinal echocardiographic finding is a defect in the anterior aortic root through which the right coronary cusp appeared to prolapse. After surgical correction the echo from the herniated right coronary cusp of the aortic valve and discontinuity in the echo from anterior aortic wall disappeared.
Aneurysm ; Aneurysm, Ruptured* ; Aortic Valve ; Coronary Sinus ; Diagnosis ; Echocardiography* ; Heart Septal Defects, Ventricular ; Heart Ventricles ; Humans ; Prolapse ; Rupture ; Sinus of Valsalva*

Preoperative diagnosis of an aneurysm of the right coronary sinus of Valsalve with rupture into the right ventricle was made by echocardiography in a patient who also had a small ventricular septal defect. In this case of ruptured sinus of Valsalva aneurysm, the cardinal echocardiographic finding is a defect in the anterior aortic root through which the right coronary cusp appeared to prolapse. After surgical correction the echo from the herniated right coronary cusp of the aortic valve and discontinuity in the echo from anterior aortic wall disappeared.
Aneurysm ; Aneurysm, Ruptured* ; Aortic Valve ; Coronary Sinus ; Diagnosis ; Echocardiography* ; Heart Septal Defects, Ventricular ; Heart Ventricles ; Humans ; Prolapse ; Rupture ; Sinus of Valsalva*

BACKGROUND: The patients visiting the primary care complain of the various symptoms. This symptoms may induce the stress or the reverse. In fact the stress can influence the symptoms and signs. So this study was done for the correlation of the symptoms and signs with stress. METHODS: This study was done about the patients visiting the family medicine department of the one university hospital. We collected the all items that can find in the charts for examining the symptoms and signs, and did the requests pater the patients wrote by themselves. The stress test was Psychosocial well being index to be constructed from the General Health Questionnaire. We tested the study by t-test, anova, chi-square, linear logistic regression. RESULTS: The total study numbers were 351. The stress cut-off point was 63 score. The stress group was consisted of 15 males and 43 females. The meaningful symptoms were headache, dizziness, fatigue, weakness, insomnia, anxiety or depression. The meaningful diagnoses were anxiety or depression, tension headache(p<0.05). The meaningful sociodemographic factors were female, housewife or unemployed, menopause, monthly income below 200 ten thousands won. CONCLUSIONS: It was found that the some symptoms and signs were statistically correlated with stress.
Anxiety ; Depression ; Diagnosis ; Dizziness ; Exercise Test ; Fatigue ; Female ; Headache ; Humans ; Logistic Models ; Male ; Menopause ; Primary Health Care ; Sleep Initiation and Maintenance Disorders ; Surveys and Questionnaires