The author observed one case of typical Linear bassal cell nevus who was 3 year old girl. Since birth, skin lesions reveal a linear band like nodules along the left lateral margin of nose, which are consists of pinhead sized, normal skin colored, pearly and translucent papules. Histopathologically, the preparations showed muItifocal irregular masses of basal type epithelial cells in continuity at pilosebaceous follicles and the cells were oval or spindle shaped and a peripheral palisade arrangement. But comedones and nevus cells were not identified. Diagnosis confirmed by clinical appearance, histopathologically and other clinical study. There were marked improvement by the locaI application of 2% 5-Fluorouracil solution.
Child, Preschool ; Diagnosis ; Epithelial Cells ; Female ; Fluorouracil ; Humans ; Nevus* ; Nose ; Parturition ; Skin

BACKGROUND: Vitiligo is a relatively common acquired depigmentating disorder that affects at least 1 % of the population. The mode of transmission has not been clearly,stablished, but either polygenic or autosomal dominant with incomplete penetrance and variable expresion has been proposed. OBJECTIVE: Our purpose was to evaluate the causative factor, variable clinical features and current teratment of generalized vitiligo patients. METHOD: This clinical in vestigation was made with 225 outpatiens of generalized type vitiligo who had visited the Department of Dermatology, Keirnyung Universitv Hospital from January 1987 till December 1991. Results & CONCLUSION: 1. There were 125 female, (55.5%) and 100 males(44.4%). 2. The mean age of onset was 21.4 years(male . 24.3, female: 19.1). 3. The mean age at the first visit was 27.5 years (male : 28.8, female : 26.5). 4. The mean duration of the disease was 10.7 years(male : 9.9, female : 10.9). 5. The mean interval between onset and visiting was 6.1 years (male : 4.5, female : 7.4). 6. The most common sites of involvernent at the first visit was tie face 11.7% (male : 11.4%, female : 11.8%). 7. The most common precipitating factor was trauma(8.8%). 8. The most common previous treatment was sunlight irradiaion after application of topical oxoralene(33.2%). 9. The most common degree of depigmented lesion was 5-10%(64.4%). 10. The most common occupations of the patients were students mals, and housewife females.
Age of Onset ; Dermatology ; Female ; Humans ; Occupations ; Penetrance ; Precipitating Factors ; Sunlight ; Vitiligo*

Eccrine spiradenoma is a rare benign tumor which is differentiated into the direction of eccrine gland. Neurofibromatosis type-1 is an autosomal dominantly inherited disorder that is characterized by neurofibroma, cafe au lait spots and axillary freckles of the skin. We report a case of a 42-year-old man with a painful, solid nodule on his right arm for 4~5 months. He was diagnosed with neurofibromatosis type-1 in childhood. He has several cafe au lait spots and diffuse freckles on whole body. On microscopy, the tumor was sharply demarcated with encapsulated lobules in the dermis. The lobules consisted of two undifferentiated epithelial cells. There was hyperpigmentation of the basal cell layer in the epidermis without increase in the number of melanocyte. We herein report an unusual case of eccrine spiradenoma in neurofibromatosis type-1 patient.
Adult ; Arm ; Cafe-au-Lait Spots ; Dermis ; Eccrine Glands ; Epidermis ; Epithelial Cells ; Humans ; Hyperpigmentation ; Melanocytes ; Melanosis ; Microscopy ; Neurofibroma ; Neurofibromatoses ; Skin

BACKGROUND: Chronic irritant contact dermatitis, the common occupational dermatitis of the skin, could be caused by repetitive exposure of the skin to irritants. Adaptation of the skin to repeated influence of exogenous irritants is called the hardening. The defining characteristic of hardening phenomenon has been progressively decreasing inflammatory response with prolonged exposure to an irritant. OBJECTIVE: The purpose of this study was to evaluate the induction of hardening phenomenon by the repeated application of various concentrated sodium lauryl sulfate (SLS) solutions. METHODS: Once a day a 0.1%, 0.5%, 2% solution of SLS and distilled water were applied to the volar forearm skin in 15 healthy volunteers for 10 minutes over 3 weeks. After 3 weeks interval of rest, patch tests with 1% solution of SLS were conducted on previously irritated sites for 24 hours. We measured transepidermal water loss (TEWL) and erythema index (E-index) before irritation, during 3 weeks of repeated application. 4 days after the patches test, we measured TEWL and E-index once a day. RESULTS: During 3 weeks of irritation with repeated application of 0.1%, 0.5%, 2% SLS solution, increase of TEWL was accelerated according to concentrations of SLS. In the study of 24-h patch test with 1% SLS solution on previously irritated sites after 3 weeks interval of rest, TEWL on distilled water application site was significantly higher than other sites irritated with SLS solution on D44 and D45. The TEWL values on the site irritated with higher concentration of SLS solution were lower than those with lower concentration of SLS solution. In contrast, there were no significant differences in E-index value during 3 weeks of irritation and after 24-h patch test with 1% SLS solution. CONCLUSION: Hardening could be induced by repeated irritation with SLS solution for 3 weeks. We suggest that hardening could be induced more efficiently with the higher concentration of SLS solution than the lower concentration.
Dermatitis, Contact ; Dermatitis, Occupational ; Erythema ; Forearm ; Irritants ; Organ Preservation Solutions ; Patch Tests ; Skin ; Sodium ; Sodium Dodecyl Sulfate ; Sucrose ; Water

Congenital leukemia is a rare disease that develops from birth to 6 weeks of life. Leukemia cutis involves cutaneous infiltration by leukemic cells and is an unusual manifestation of leukemia, and has been documented in 25~30% of patients with congenital leukemia. The authors report a case of congenital leukemia cutis. A newborn male presented with widespread firm dusky red papules and nodules on almost his entire body surface. Skin biopsy specimens confirmed the presence of leukemic infiltrations, and bone marrow cytology was consistent with acute myeloid leukemia of the FAB M5 type.
Biopsy ; Bone Marrow ; Humans ; Infant, Newborn ; Leukemia ; Leukemia, Myeloid, Acute ; Leukemic Infiltration ; Male ; Parturition ; Rare Diseases ; Skin

Foods are recognized as a common cause of urticaria; however, the role of food is considered to be more important in acute not chronic urticaria. Wheat is a basic ingredient found in many common foods. Food allergy to wheat is primarily described in children in the form of atopic dermatitis. It is rare in adults; where it is mainly reported in exercise-induced anaphylaxis. We report a case of wheat dependent exercise-induced anaphylaxis that occurred in a 54-year-old Korean woman.
Anaphylaxis ; Child ; Dermatitis, Atopic ; Female ; Food Hypersensitivity ; Humans ; Middle Aged ; Triticum ; Urticaria

We report here on one patient who suffered from acute myocardial infarction that was due to late stent thrombosis, and this was associated with late stent malapposition very late (21 months) after the deployment of a paclitaxel-eluting stent and shortly after (7 days) the discontinuation of the aspirin therapy. The intravascular ultrasound examination revealed that the late stent thrombosis was accompanied by late stent malapposition. This is a report on late stent thrombosis associated with late stent malapposition after the successful implantation of a paclitaxel-eluting stent (PES).
Aspirin ; Humans ; Myocardial Infarction ; Stents* ; Thrombosis* ; Ultrasonography

PURPOSE: We describe 2 cases of bilateral acute myopia associated with topiramate, a drug that has recently been prescribed for epilepsy or weight reduction. CASE SUMMARY: A 24-year-old woman and a 25-year-old woman, both previously devoid of ocular problems, visited our hospital with blurry vision after taking topiramate for weight reduction. A thorough medical history review and ocular examinations, including a slit lamp examination, were performed. CONCLUSIONS: Slit-lamp examinations revealed forward displacement of the lens-iris diaphragm, which resulted in myopia and anterior chamber shallowing. Discontinuation of topiramate and the administration of cycloplegic agents successfully resolved the symptoms.
Adult ; Anterior Chamber ; Diaphragm ; Displacement (Psychology) ; Epilepsy ; Female ; Fructose ; Humans ; Myopia ; Vision, Ocular ; Weight Loss ; Young Adult

Tofacitinib, a novel Janus kinase inhibitor, may prevent structural damage in rheumatoid arthritis (RA). In this cohort study, we compared radiographic progression of hand joints between 21 RA patients who took tofacitinb for 18 months in a phase IIb and its extension study and 42 patients who took conventional disease modifying antirheumatic drugs (DMARDs), using simple erosion narrowing score. For tofacitinib group, changes before and after the treatment were also compared. The changes of erosion and sum scores were significantly less in tofacitinib than DMARDs group (for erosion, -0.60 +/- 1.83 vs 0.51 +/- 1.77, P = 0.038; for sum, -0.50 +/- 1.72 vs 1.57 +/- 4.13, P = 0.012). Joint space narrowing score (JSN) was also less in tofacitinib group (0.095 +/- 0.58 vs 1.06 +/- 2.60, P = 0.055). In tofacitinib group, yearly rates of both erosion and JSN were significantly decreased after administration of tofacitinib (For erosion, 0.62 +/- 0.93 to -0.14 +/- 0.48, P = 0.009; for JSN, 0.47 +/- 0.64 to 0.03 +/- 0.40, P = 0.032), as was change of sum score (1.09 +/- 1.27 to -0.10 +/- 0.63, P < 0.001). In conclusion, tofacitinib may prevent structural damage caused by RA.
Adult ; Aged ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/*drug therapy/prevention & control/radiography ; Cohort Studies ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Piperidines/*therapeutic use ; Protein Kinase Inhibitors/*therapeutic use ; Pyrimidines/*therapeutic use ; Pyrroles/*therapeutic use ; Severity of Illness Index ; Treatment Outcome

Tofacitinib, a novel Janus kinase inhibitor, may prevent structural damage in rheumatoid arthritis (RA). In this cohort study, we compared radiographic progression of hand joints between 21 RA patients who took tofacitinb for 18 months in a phase IIb and its extension study and 42 patients who took conventional disease modifying antirheumatic drugs (DMARDs), using simple erosion narrowing score. For tofacitinib group, changes before and after the treatment were also compared. The changes of erosion and sum scores were significantly less in tofacitinib than DMARDs group (for erosion, -0.60 +/- 1.83 vs 0.51 +/- 1.77, P = 0.038; for sum, -0.50 +/- 1.72 vs 1.57 +/- 4.13, P = 0.012). Joint space narrowing score (JSN) was also less in tofacitinib group (0.095 +/- 0.58 vs 1.06 +/- 2.60, P = 0.055). In tofacitinib group, yearly rates of both erosion and JSN were significantly decreased after administration of tofacitinib (For erosion, 0.62 +/- 0.93 to -0.14 +/- 0.48, P = 0.009; for JSN, 0.47 +/- 0.64 to 0.03 +/- 0.40, P = 0.032), as was change of sum score (1.09 +/- 1.27 to -0.10 +/- 0.63, P < 0.001). In conclusion, tofacitinib may prevent structural damage caused by RA.
Adult ; Aged ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/*drug therapy/prevention & control/radiography ; Cohort Studies ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Piperidines/*therapeutic use ; Protein Kinase Inhibitors/*therapeutic use ; Pyrimidines/*therapeutic use ; Pyrroles/*therapeutic use ; Severity of Illness Index ; Treatment Outcome