1.Long-term Survival in Korean Elderly Patients with Symptomatic Severe Aortic Stenosis Who Refused Aortic Valve Replacement
Jin Kyung OH ; Jae Hyeong PARK ; Jin Kyung HWANG ; Chang Hoon LEE ; Jong Seon PARK ; Joong Il PARK ; Hoon Ki PARK ; Jung Sun CHO ; Bong suk SEO ; Seok Woo SEONG ; Byung Joo SUN ; Jae Hwan LEE ; In Whan SEONG
Korean Circulation Journal 2019;49(2):160-169
BACKGROUND AND OBJECTIVES: Aortic valve replacement (AVR) is the treatment of choice in severe symptomatic aortic stenosis (AS) patients. However, a substantial number of elderly patients refuse AVR and treated medically. We investigated their long-term prognosis. METHODS: From January 2005 to December 2016, we analyzed elderly patients with severe symptomatic AS who refused to have AVR. RESULTS: After screening of total 534 patients, we analyzed total 180 severe symptomatic AS patients (78±7 years old, 96 males). Hypertension was the most common cardiovascular risk factor (72%) and the most common symptom was dyspnea (66%). Calculated aortic stenosis area was 0.73±0.20 cm2 and mean left ventricular ejection fraction (LVEF) was 57.8±12.2%. Total 102 patients died during follow-up period (39.1±31.0 months). One-, 3-, and 5-year all-cause mortality rate was 21.1±3.0%, 43.1±3.8%, and 56.5±4.2%, respectively. Of them, 87 died from cardiac causes, and 1-, 3-, and 5-year cardiac mortality rate was 18.0±2.9%, 38.2±3.8%, and 50.7±4.3%, respectively. Their all-cause mortality and cardiac mortality were significantly higher than those of controls. Univariate analysis showed that age, anemia, LVEF, and Log N-terminal pro B-type natriuretic peptide (NT-proBNP) were significant parameters in all-cause mortality (p < 0.001, p=0.001, p=0.039, and p=0.047, respectively) and in cardiac mortality (p < 0.001, p < 0.001, p=0.046, and p=0.026, respectively). Multivariate analysis showed that age and anemia were significant prognostic factors for cardiac and all-cause mortality. CONCLUSIONS: In elderly severe symptomatic AS patients who treated medically, their 1-, 3- and 5-year all-cause mortality rate was 21.1±3.0%, 43.1±3.8%, and 56.5±4.2%, respectively. Age and anemia were significant prognostic factors for cardiac and all-cause mortality.
Aged
;
Anemia
;
Aortic Valve Stenosis
;
Aortic Valve
;
Drug Therapy
;
Dyspnea
;
Follow-Up Studies
;
Humans
;
Hypertension
;
Mass Screening
;
Mortality
;
Multivariate Analysis
;
Natriuretic Peptide, Brain
;
Prognosis
;
Risk Factors
;
Stroke Volume
2.Effectiveness and Safety of Zotarolimus-Eluting Stent (Resolute™ Integrity) in Patients with Diffuse Long Coronary Artery Disease
Keun Ho PARK ; Youngkeun AHN ; Young Youp KOH ; Young Jae KI ; Sung Soo KIM ; Hyun Kuk KIM ; Dong Hyun CHOI ; Young Joon HONG ; Jin Yong HWANG ; Do Hoi KIM ; Jay Young RHEW ; Jae Kean RYU ; Jong Seon PARK ; Tae Ho PARK ; Tae Hyun YANG ; Seok Kyu OH ; Bong Ryeol LEE ; Seung Uk LEE ; Sang Gon LEE ; Kook Jin CHUN ; Jang Hyun CHO ; Kwang Soo CHA ; Jei Keon CHAE ; Seung Ho HUR ; Sun Ho HWANG ; Hun Sik PARK ; Doo Il KIM
Korean Circulation Journal 2019;49(8):709-720
BACKGROUND AND OBJECTIVES: Diffuse long coronary artery disease (DLCAD) still has unfavorable clinical outcomes after successful percutaneous coronary intervention (PCI). Therefore, we aimed to evaluate the effectiveness and safety of Resolute™ zotarolimus-eluting stent (R-ZES; Resolute™ Integrity) for patients with DLCAD. METHODS: From December 2011 to December 2014, 1,011 patients who underwent PCI using R-ZES for CAD with longer than 25 mm lesion were prospectively enrolled from 21 hospitals in Korea. We assessed the clinical outcome of major adverse cardiac events (MACE) defined as the composite of cardiac death, non-fatal myocardial infarction (MI), and clinically-driven target vessel revascularization at 12 months. RESULTS: Mean age was 63.8±10.8 years, 701 (69.3%) patients were male, 572 (87.0%) patients had hypertension, 339 (33.8%) patients had diabetes, 549 (54.3%) patients diagnosed with acute MI and 545 (53.9%) patients had multi-vessel disease (MVD). A total of 1,697 stents were implanted into a total of 1,472 lesions. The mean diameter was 3.07±0.38 mm and the length was 28.27±6.97 mm. Multiple overlapping stents were performed in 205 (13.8%) lesions. A 12-month clinical follow-up was available in 1,004 patients (99.3%). The incidences of MACE and definite stent thrombosis at 12-month were 3.0% and 0.3% respectively. On multivariate Cox-regression analysis, multiple overlapping stents implantation, previous congestive heart failure, MVD, and age ≥75 years were independent predictors of one-year MACE. CONCLUSIONS: Our study shows that R-ZES has an excellent 1-year clinical outcome in Korean patients with DLCAD.
Coronary Artery Disease
;
Coronary Vessels
;
Death
;
Drug-Eluting Stents
;
Follow-Up Studies
;
Heart Failure
;
Humans
;
Hypertension
;
Incidence
;
Korea
;
Male
;
Myocardial Infarction
;
Percutaneous Coronary Intervention
;
Prospective Studies
;
Stents
;
Thrombosis
;
Treatment Outcome
3.Effectiveness and Safety of Zotarolimus-Eluting Stent (Resoluteâ„¢ Integrity) in Patients with Diffuse Long Coronary Artery Disease
Keun Ho PARK ; Youngkeun AHN ; Young Youp KOH ; Young Jae KI ; Sung Soo KIM ; Hyun Kuk KIM ; Dong Hyun CHOI ; Young Joon HONG ; Jin Yong HWANG ; Do Hoi KIM ; Jay Young RHEW ; Jae Kean RYU ; Jong Seon PARK ; Tae Ho PARK ; Tae Hyun YANG ; Seok Kyu OH ; Bong Ryeol LEE ; Seung Uk LEE ; Sang Gon LEE ; Kook Jin CHUN ; Jang Hyun CHO ; Kwang Soo CHA ; Jei Keon CHAE ; Seung Ho HUR ; Sun Ho HWANG ; Hun Sik PARK ; Doo Il KIM
Korean Circulation Journal 2019;49(8):709-720
BACKGROUND AND OBJECTIVES:
Diffuse long coronary artery disease (DLCAD) still has unfavorable clinical outcomes after successful percutaneous coronary intervention (PCI). Therefore, we aimed to evaluate the effectiveness and safety of Resoluteâ„¢ zotarolimus-eluting stent (R-ZES; Resoluteâ„¢ Integrity) for patients with DLCAD.
METHODS:
From December 2011 to December 2014, 1,011 patients who underwent PCI using R-ZES for CAD with longer than 25 mm lesion were prospectively enrolled from 21 hospitals in Korea. We assessed the clinical outcome of major adverse cardiac events (MACE) defined as the composite of cardiac death, non-fatal myocardial infarction (MI), and clinically-driven target vessel revascularization at 12 months.
RESULTS:
Mean age was 63.8±10.8 years, 701 (69.3%) patients were male, 572 (87.0%) patients had hypertension, 339 (33.8%) patients had diabetes, 549 (54.3%) patients diagnosed with acute MI and 545 (53.9%) patients had multi-vessel disease (MVD). A total of 1,697 stents were implanted into a total of 1,472 lesions. The mean diameter was 3.07±0.38 mm and the length was 28.27±6.97 mm. Multiple overlapping stents were performed in 205 (13.8%) lesions. A 12-month clinical follow-up was available in 1,004 patients (99.3%). The incidences of MACE and definite stent thrombosis at 12-month were 3.0% and 0.3% respectively. On multivariate Cox-regression analysis, multiple overlapping stents implantation, previous congestive heart failure, MVD, and age ≥75 years were independent predictors of one-year MACE.
CONCLUSIONS
Our study shows that R-ZES has an excellent 1-year clinical outcome in Korean patients with DLCAD.
4.Long-term Survival in Korean Elderly Patients with Symptomatic Severe Aortic Stenosis Who Refused Aortic Valve Replacement
Jin Kyung OH ; Jae Hyeong PARK ; Jin Kyung HWANG ; Chang Hoon LEE ; Jong Seon PARK ; Joong Il PARK ; Hoon Ki PARK ; Jung Sun CHO ; Bong suk SEO ; Seok Woo SEONG ; Byung Joo SUN ; Jae Hwan LEE ; In Whan SEONG
Korean Circulation Journal 2019;49(2):160-169
BACKGROUND AND OBJECTIVES:
Aortic valve replacement (AVR) is the treatment of choice in severe symptomatic aortic stenosis (AS) patients. However, a substantial number of elderly patients refuse AVR and treated medically. We investigated their long-term prognosis.
METHODS:
From January 2005 to December 2016, we analyzed elderly patients with severe symptomatic AS who refused to have AVR.
RESULTS:
After screening of total 534 patients, we analyzed total 180 severe symptomatic AS patients (78±7 years old, 96 males). Hypertension was the most common cardiovascular risk factor (72%) and the most common symptom was dyspnea (66%). Calculated aortic stenosis area was 0.73±0.20 cm2 and mean left ventricular ejection fraction (LVEF) was 57.8±12.2%. Total 102 patients died during follow-up period (39.1±31.0 months). One-, 3-, and 5-year all-cause mortality rate was 21.1±3.0%, 43.1±3.8%, and 56.5±4.2%, respectively. Of them, 87 died from cardiac causes, and 1-, 3-, and 5-year cardiac mortality rate was 18.0±2.9%, 38.2±3.8%, and 50.7±4.3%, respectively. Their all-cause mortality and cardiac mortality were significantly higher than those of controls. Univariate analysis showed that age, anemia, LVEF, and Log N-terminal pro B-type natriuretic peptide (NT-proBNP) were significant parameters in all-cause mortality (p < 0.001, p=0.001, p=0.039, and p=0.047, respectively) and in cardiac mortality (p < 0.001, p < 0.001, p=0.046, and p=0.026, respectively). Multivariate analysis showed that age and anemia were significant prognostic factors for cardiac and all-cause mortality.
CONCLUSIONS
In elderly severe symptomatic AS patients who treated medically, their 1-, 3- and 5-year all-cause mortality rate was 21.1±3.0%, 43.1±3.8%, and 56.5±4.2%, respectively. Age and anemia were significant prognostic factors for cardiac and all-cause mortality.
5.Cholangitis Secondary to Food Material Impaction in the Common Bile Duct through a Choledochoduodenal Fistula.
Bong Koo KANG ; Sung Min PARK ; Byung Wook KIM ; Joon Sung KIM ; Ji Hee KIM ; Jeong Seon JI ; Hwang CHOI
Clinical Endoscopy 2015;48(3):265-267
Biliary-enteric communications caused by duodenal ulcers are uncommon, and choledochoduodenal fistula (CDF) is by far the most common type. Usually in this situation, food material does not enter the common bile duct because the duodenal lumen is intact. Here, we report a case in which cholangitis occurred due to food materials impacted through a CDF. Duodenal obstruction secondary to duodenal ulcer prevented food passage into the duodenum in this case. Surgical management was recommended; however, the patient refused surgery because of poor general condition. Consequently, the patient expired with sepsis secondary to ascending cholangitis.
Biliary Fistula
;
Cholangitis*
;
Common Bile Duct*
;
Duodenal Obstruction
;
Duodenal Ulcer
;
Duodenum
;
Fistula*
;
Humans
;
Sepsis
6.Percutaneous transplantation of human umbilical cord-derived mesenchymal stem cells in a dog suspected to have fibrocartilaginous embolic myelopathy.
Wook Hun CHUNG ; Seon Ah PARK ; Jae Hoon LEE ; Dai Jung CHUNG ; Wo Jong YANG ; Eun Hee KANG ; Chi Bong CHOI ; Hwa Seok CHANG ; Dae Hyun KIM ; Soo Han HWANG ; Hoon HAN ; Hwi Yool KIM
Journal of Veterinary Science 2013;14(4):495-497
The use of human umbilical cord blood-derived mesenchymal stem cells for cell transplantation therapy holds great promise for repairing spinal cord injury. Here we report the first clinical trial transplantation of human umbilical cord (hUCB)-derived mesenchymal stem cells (MSCs) into the spinal cord of a dog suspected to have fibrocartilaginous embolic myelopathy (FCEM) and that experienced a loss of deep pain sensation. Locomotor functions improved following transplantation in a dog. Based on our findings, we suggest that transplantation of hUCB-derived MSCs will have beneficial therapeutic effects on FCEM patients lacking deep pain sensation.
Animals
;
Cartilage Diseases/etiology/therapy/*veterinary
;
*Cord Blood Stem Cell Transplantation/veterinary
;
Dog Diseases/etiology/*therapy
;
Dogs
;
Embolism/etiology/therapy/*veterinary
;
Female
;
Humans
;
Mesenchymal Stromal Cells/cytology/*metabolism
;
Spinal Cord Diseases/etiology/therapy/*veterinary
;
Treatment Outcome
7.Temozolomide Salvage Chemotherapy for Recurrent Anaplastic Oligodendroglioma and Oligo-Astrocytoma.
Ho Shin GWAK ; Gi Taek YEE ; Chul Kee PARK ; Jin Wook KIM ; Yong Kil HONG ; Seok Gu KANG ; Jeong Hoon KIM ; Ho Jun SEOL ; Tae Young JUNG ; Jong Hee CHANG ; Heon YOO ; Jeong Hyun HWANG ; Se Hyuk KIM ; Bong Jin PARK ; Sun Chul HWANG ; Min Su KIM ; Seon Hwan KIM ; Eun Young KIM ; Ealmaan KIM ; Hae Yu KIM ; Young Cho KO ; Hwan Jung YUN ; Ji Hye YOUN ; Juyoung KIM ; Byeongil LEE ; Seung Hoon LEE
Journal of Korean Neurosurgical Society 2013;54(6):489-495
OBJECTIVE: To evaluate the efficacy of temozolomide (TMZ) chemotherapy for recurrent anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA). METHODS: A multi-center retrospective trial enrolled seventy-two patients with histologically proven AO/AOA who underwent TMZ chemotherapy for their recurrent tumors from 2006 to 2010. TMZ was administered orally (150 to 200 mg/m2/day) for 5 days per 28 days until unacceptable toxicity occurred or tumor progression was observed. RESULTS: TMZ chemotherapy cycles administered was median 5.3 (range, 1-41). The objective response rate was 24% including 8 cases (11%) of complete response and another 23 patients (32%) were remained as stable disease. Severe side effects (> or =grade 3) occurred only in 9 patients (13%). Progression-free survival (PFS) of all patients was a median 8.0 months (95% confidence interval, 6.0-10.0). The time to recurrence of a year or after was a favorable prognostic factor for PFS (p<0.05). Overall survival (OS) was apparently differed by the patient's histology, as AOA patients survived a median OS of 18.0 months while AO patients did not reach median OS at median follow-up of 11.5 months (range 2.7-65 months). Good performance status of Eastern Cooperative Oncology Group 0 and 1 showed prolonged OS (p<0.01). CONCLUSION: For recurrent AO/AOA after surgery followed by radiation therapy, TMZ could be recommended as a salvage therapy at the estimated efficacy equal to procarbazine, lomustine, and vincristine (PCV) chemotherapy at first relapse. For patients previously treated with PCV, TMZ is a favorable therapeutic option as 2nd line salvage chemotherapy with an acceptable toxicity rate.
Disease-Free Survival
;
Drug Therapy*
;
Follow-Up Studies
;
Humans
;
Lomustine
;
Oligodendroglioma*
;
Procarbazine
;
Recurrence
;
Retrospective Studies
;
Salvage Therapy
;
Vincristine
8.Crohn's Disease Initially Accompanied by Deep Vein Thrombosis and Ulnar Neuropathy without Metronidazole Exposure.
Woohyeon KIM ; Borami KANG ; Byung Wook KIM ; Joon Sung KIM ; Hae Mi LEE ; Eun Joo LIM ; Jong In KIM ; Bong Koo KANG ; Jeong Seon JI ; Bo In LEE ; Hwang CHOI
Gut and Liver 2013;7(2):252-254
Extraintestinal manifestations are not uncommon in Crohn's disease, and a thromboembolic event is a disastrous potential complication. Deep vein thrombosis is the most common manifestation of a thromboembolic event and typically occurs in association with active inflammatory disease. Peripheral neuropathy in Crohn's disease has rarely been reported and is considered an adverse effect of metronidazole therapy. Here, we describe a patient who was initially diagnosed with Crohn's disease complicated with deep vein thrombosis and ulnar neuropathy without metronidazole exposure. The simultaneous occurrence of these complications in the early stage of Crohn's disease has never been reported in the English literature.
Crohn Disease
;
Humans
;
Metronidazole
;
Mononeuropathies
;
Peripheral Nervous System Diseases
;
Ulnar Neuropathies
;
Venous Thrombosis
9.Suppressive Effect of Zinc on the Formation of Colonic Preneoplastic Lesions in the Mouse Fed High Levels of Dietary Iron.
Hyunji PARK ; Bong Su KANG ; Dang Young KIM ; Ja Seon YOON ; Jae Hwang JEONG ; Sang Yoon NAM ; Young Won YUN ; Jong Soo KIM ; Beom Jun LEE
Toxicological Research 2012;28(1):39-49
We investigated the effect of zinc on the formation of colonic aberrant crypt foci induced by azoxymethane (AOM) followed by dextran sodium sulfate (DSS) in mice with high iron diet (HFe; 450 ppm iron). Six-week old ICR mice were fed on high iron diets with combination of three different levels of zinc in diets, low-zinc (LZn; 0.01 ppm), medium-zinc (MZn; 0.1 ppm), and high-zinc (HZn; 1 ppm) for 12 weeks. Animals were received weekly intraperitoneal injections of AOM (10 mg/kg B.W. in saline) for 3 weeks followed by 2% DSS (molecular weight 36,000~50,000) in the drinking water for a week. To confirm the iron storage in the body, the hepatic iron concentration has been determine chemically and compared with histological assessment visualized by Prussian blue reaction. Aberrant crypt (AC) and aberrant crypt foci (ACF) were analyzed in the colonic mucosa of mouse fed high dietary iron. Superoxide dismutase (SOD) activity and thiobarbituric acid-reactive substances (TBARS) level were also investigated. Apoptosis in the preneoplastic lesion was determined by terminal deoxynucleotidyl transferase-mediated dUTP nickend labeling (TUNEL). In addition, immunohistochemistry of beta-catenin was also performed on the mucous membrane of colon. The number of large ACF (> or = 4 AC/ACF), which possess greater tumorigenic potential, was significantly lower in MZn and HZn groups compared with LZn group. Cytosolic SOD activity in the liver was significantly higher in HZn group compared with LZn group. Hepatic MDA level was decreased significantly in HZn group compared with MZn and LZn groups. Apoptotic index was significantly higher in HZn group. Taken together, these findings indicate that dietary zinc might exert a protective effect against colonic preneoplastic lesion induced by AOM/DSS in ICR mice with high iron status, and suggest that dietary supplement of zinc might play a role in suppressing colon carcinogenesis in mice.
Aberrant Crypt Foci
;
Animals
;
Apoptosis
;
Azoxymethane
;
beta Catenin
;
Colon
;
Cytosol
;
Dextrans
;
Diet
;
Dietary Supplements
;
Drinking Water
;
Ferrocyanides
;
Immunohistochemistry
;
Injections, Intraperitoneal
;
Iron
;
Iron Overload
;
Iron, Dietary
;
Liver
;
Mice
;
Mice, Inbred ICR
;
Mucous Membrane
;
Prussian Blue Reaction
;
Sodium
;
Sulfates
;
Superoxide Dismutase
;
Zinc
10.The Effect of Co-Administration of Rebamipide on the Expression of Serum Gastrin in Long-term Proton Pump Inhibitor Users: A Prospective Pilot Study.
Eun Joo IM ; Byung Wook KIM ; Joon Sung KIM ; Hae Mi LEE ; Jong In KIM ; Bong Koo KANG ; Jeong Seon JI ; Bo In LEE ; Hwang CHOI
The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2012;12(1):34-37
BACKGROUND/AIMS: In one animal study, co-administration of rebamipide with proton pump inhibitors (PPIs) could suppress hypergastrinemia but there have been no such reports on humans. The aim of this study was to evaluate whether rebamipide could prevent hypergastrinemia in long-term PPI users. MATERIALS AND METHODS: Patients who were diagnosed with reflux esophagitis endoscopically were enrolled in this study. In the control group, lansoprazole 30 mg was administered for 8 weeks and in the rebamipide group, lansoprazole 30 mg with rebamipide 300 mg was administered for 8 weeks. Serum gastrin level was checked before and after administration of the drugs. RESULTS: Thirty patients were enrolled in this study. The control group included 17 patients and the rebamipide group included 13 patients. The gastrin level was elevated in the control group (28.4 pg/mL) compared to the rebamipide group (38.5 pg/mL). However, the gastrin level was decreased in 3 patients in the rebamipide group (23.1%) compared to 2 patients in the control group (11.8%). CONCLUSIONS: Not all patients who are taking PPIs develop hypergastrinemia. Co-administration of rebamipide with PPI does not affect the serum gastrin level.
2-Pyridinylmethylsulfinylbenzimidazoles
;
Alanine
;
Animals
;
Esophagitis, Peptic
;
Gastrins
;
Humans
;
Pilot Projects
;
Prospective Studies
;
Proton Pump Inhibitors
;
Proton Pumps
;
Protons
;
Quinolones

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