1.Two cases of congenital sacrococcygeal teratomas.
Dong Hoon KO ; Hyoung Chong LIM ; Bong Seok CHOI ; Young Youn CHOI ; Tai Ju HWANG
Korean Journal of Perinatology 1993;4(4):622-630
No abstract available.
Teratoma*
2.Vitamin D serum levels in children with allergic and vasomotor rhinitis.
Seung Jin LEE ; Bong Hwa KANG ; Bong Seok CHOI
Korean Journal of Pediatrics 2015;58(9):325-329
PURPOSE: In addition to regulating calcium and phosphorus homeostasis and bone metabolism, vitamin D is known as an immune modulator. Recently, there has been increased worldwide interest in the association between low levels of vitamin D and allergic diseases. The purpose of this study was to assess the relationship between serum vitamin D levels and allergic/vasomotor rhinitis (AR/VR) in children. METHODS: This study included 164 patients. The sample included 59 patients with AR, 42 patients with VR, and 63 controls. Their ages ranged from 0 to 16 years. We examined the levels of 25-hydroxyvitamin D, Immunoglobulin E, specific IgE, and eosinophil cationic protein; peripheral blood eosinophil count; and the results of a skin prick test. RESULTS: Serum 25-hydroxyvitamin D levels were 19.0+/-8.5 ng/mL in the AR group, 25.5+/-10.9 ng/mL in the VR group, and 26.9+/-10.7 ng/mL in the control group. After adjustment for body mass index and season at the time of blood sampling, vitamin D levels in the AR group were lower than those of the VR group (P=0.003) and control group (P<0.001). Vitamin D levels were inversely correlated with Immunoglobulin E levels (r=-0.317, P<0.001). AR patients with food allergy or atopic dermatitis did not have lower levels of 25-hydroxyvitamin D than AR patients without these diseases. CONCLUSION: This study demonstrates a possible relationship between vitamin D levels and allergic rhinitis in Korean children.
Body Mass Index
;
Calcium
;
Child*
;
Dermatitis, Atopic
;
Eosinophil Cationic Protein
;
Eosinophils
;
Food Hypersensitivity
;
Homeostasis
;
Humans
;
Immunoglobulin E
;
Immunoglobulins
;
Metabolism
;
Phosphorus
;
Rhinitis
;
Rhinitis, Vasomotor*
;
Seasons
;
Skin
;
Vitamin D*
;
Vitamins*
3.Whole Exome Sequencing of a Patient with Duchenne Muscular Dystrophy.
Bong Seok CHOI ; Su Kyeong HWANG
Journal of the Korean Child Neurology Society 2014;22(1):25-28
Duchenne muscular dystrophy (DMD) is the most common and lethal dystrophy in childhood, caused by mutations in the dystrophin (DMD) gene. Multiplex ligation dependent probe amplification (MLPA) or array comparative genome hybridization (aCGH) is widely used as an initial molecular diagnostic tool. If no deletions or duplications are found in MLPA or aCGH, the samples must be subjected to a second test of direct sequencing. Direct sequencing of the DMD gene, however, is time-consuming, high-cost, and can be inconclusive. Here, we performed whole exome sequencing on a patient with progressive muscle weakness whose MLPA result was negative; the result revealed a rare frame shift mutation. Direct sequencing on the patient's mother showed the same mutation. Whole exome sequencing can be a new diagnostic routine for DMD patients with negative MLPA3.
Comparative Genomic Hybridization
;
Dystrophin
;
Exome*
;
Frameshift Mutation
;
Genetics
;
High-Throughput Nucleotide Sequencing
;
Humans
;
Mothers
;
Multiplex Polymerase Chain Reaction
;
Muscle Weakness
;
Muscular Dystrophy, Duchenne*
;
Pathology, Molecular
4.A Case of Mycosis Fungoides.
Bong Suk CHOI ; Kee Seok HUH ; Inn Ki CHUN ; Yong Pio KIM
Korean Journal of Dermatology 1981;19(6):897-903
We presented here a case of an 80-year-old male patient who was, confirmed in the typical tumor stage of Mycosis fungoide by skin biopay. Relatively well-defined, brown-colored, round patches were found about 3 years ago on the chest, abdomen and inguinal area. He had received some treatment at several private clinics uder the impression of seborrheic dermatitis, paoriaais and eczematoid dermatitis. However, the skin manifestations were not improved t.ut rarther increased in eize, similarly to tinea corporis. Two months ago, firm nodules and tumors developecl a new on the lesinn sites, assoviated with intense pruritus and ulcerative tendency. We tried radiation therapy, but due to old age the patient chose to discontinurue.
Abdomen
;
Aged, 80 and over
;
Dermatitis
;
Dermatitis, Seborrheic
;
Humans
;
Male
;
Mycosis Fungoides*
;
Pruritus
;
Skin
;
Skin Manifestations
;
Thorax
;
Tinea
;
Ulcer
5.Significance of Renal Resistive Index in Children with Unilateral Ureteral Obstruction.
Bong Seok CHOI ; Ky Hyun CHUNG
Korean Journal of Urology 1997;38(6):595-599
PURPOSE: We assessed the significance of renal resistive index (RI) in the diagnosis of unilateral ureteral obstruction in children. MATERIALS AND METHODS: Duplex Doppler ultrasonography was performed in 4 children with unilateral ureteral obstruction which was proved by excretory urography, diuretic renal scan, and/ or pressure flow study. Renal RI values and RI ratios were calculated. RESULTS: They were 3 males and one female 4 to 26 months old. In all cases, mean RI values of obstructed kidneys were higher than 0.70 which was discriminatory level for obstruction in adults. In contralateral normal kidneys, RI values were widely distributed (0.61 to 0.79). Mean RI values of obstructed kidneys were larger than that of contralateral normal kidneys, and RI ratios were larger than 1.11 in all patients. CONCLUSION: We believe that the comparison of RI value between obstructed and contralateral normal kidney is valuable in the diagnosis of unilateral ureteral obstruction in children, and that RI ratio is also significantly. A prospective study with a larger number of patients is required to confirm this finding.
Adult
;
Child*
;
Child, Preschool
;
Diagnosis
;
Female
;
Humans
;
Kidney
;
Male
;
Ultrasonography, Doppler, Duplex
;
Ureter*
;
Ureteral Obstruction*
;
Urography
6.Analysis of 50 Cases of Renal Injury which Occurred in the Last 6 Years.
Bong Seok CHOI ; Jong Yoon PARK ; Jae Seog HYUN
Korean Journal of Urology 1997;38(5):490-495
In an effort to characterize the trend of renal injury of recent years, we reviewed the charts and x-ray films of 50 patients with renal trauma which occurred in the last 6 years. They were 42 males and 8 females with a mean age of 26.4 years (range: 5 to 66) and most of them are younger generation. The main causes of injury were related to falling down in 21 cases (42%) and traffic accident in 17 cases (34%), followed by stab injury in 7 cases and assault in 5 cases. The severity of renal injury was classified using the renal injury scale which was published by the Organ Injury Scaling (O.I.S.) Committee of the American Association for the Surgery of Trauma (A.A.S.T.) in 1989. According to radiologic and operative findings, they were classified as follows; Grade I, 4 cases; Grade II, 7 cases; Grade III, 12 cases; Grade IV, 23 cases; and Grade V, 4 cases. Of the 50 patients, 39 had gross hematuria and remaining 11 patients had microscopic hematuria. There was no correlation between the degree of hematuria and the severity of renal injury (p=0.098). The major combined other organ injuries were hemoperitoneum in 12 cases, fracture of extremities in 8 cases, liver laceration in 5 cases, hemopneumothorax in 4 cases and intestinal perforation in 2 cases. Surgical treatment was performed in 27 cases (54%) and the remaining 23 cases (46%) which were renal laceration of various degrees without intraperitoneal injuries were managed conservatively.
Accidents, Traffic
;
Extremities
;
Female
;
Hematuria
;
Hemoperitoneum
;
Hemopneumothorax
;
Humans
;
Intestinal Perforation
;
Kidney
;
Lacerations
;
Liver
;
Male
;
X-Ray Film
7.Paradoxical Responses to Oxybutynin Treatment in Localized Hyperhidrosis: Case Report
Min Sung KIM ; In Ho BAE ; Hoon CHOI ; Chan Ho NA ; Bong Seok SHIN
Korean Journal of Dermatology 2019;57(9):558-559
No abstract available.
Hyperhidrosis
8.Is determining nasal eosinophil count and nasal eosinophil peroxidase concentration clinically useful in children with rhinits?
Korean Journal of Pediatrics 2019;62(9):342-343
No abstract available.
Child
;
Eosinophil Peroxidase
;
Eosinophils
;
Humans
9.The association between asthma and Kawasaki disease
Allergy, Asthma & Respiratory Disease 2019;7(4):173-178
Kawasaki disease (KD) is a systemic vasculitis and the most common cause of acquired heart disease among preschool-aged children. Asthma is one of the most common chronic illness of childhood. There is increasing interest in the potential link between inflammatory diseases and allergic diseases, and there is increasing epidemiologic evidence for an association of KD and allergic disease. In regards to asthma, 9 studies have been reported about its association with KD; 5 of them showed positive associations between these 2 diseases, while 4 of them showed no association. There are some possible underlying mechanisms for this association. The serum IgE levels are found to be increased and there is a Th2-predominant immune response in KD. These are common findings of asthma. Human leukocyte antigen-G/regT cells and SMAD3/transforming growth factor-beta might also be involved in the pathogenesis of both diseases. Asthma may increase susceptibility to KD and tends to lead to immune dysregulation. Clinician's recognition of the increased risks of KD and other asthma-related comorbidities among patients with asthma may enable early identification and intervention. The early identification and management of comorbidities may ultimately reduce the economic and social burden of these chronic conditions.
Asthma
;
Child
;
Chronic Disease
;
Comorbidity
;
Heart Diseases
;
Humans
;
Hypersensitivity
;
Immunoglobulin E
;
Leukocytes
;
Mucocutaneous Lymph Node Syndrome
;
Systemic Vasculitis
10.Two-year Endothalial Changes after Iris Fixed Phakic Intraocular Lens Implantation in Korean.
Woo Seok CHOI ; Bong Joon CHOI ; Jun HER
Journal of the Korean Ophthalmological Society 2008;49(2):230-237
PURPOSE: To investigate quantitative and morphometric endothelial changes in phakic eyes implanted with an iris-fixed phakic intraocular lens in Korean patients. METHODS: We prospectively examined the endothelial cell density (ECD), ECD loss (ECL), coefficient variations (CV), and frequency of Hexagons (6A) in 46 phakic eyes implanted with an iris-fixed phakic intraocular lens. The effect of anterior chamber depth (ACD) and diopter of iris-fixed phakic intraocular lens on ECD was statistically analyzed. RESULTS: Preoperative mean ECD was 2923+/-257 cells/mm2. ECL at postoperative 1, 3, 6, 12, and 24 monthswas 0.71%, 0.88%, 0.70%, 0.64%, and 2.34%. It was significant only in the month 24 results. The mean CV value at the same time was 0.343, 0.342, 0.334, 0.329, 0.326, and 0.338. The change was significant at the 12th month. The mean 6A value at the same time was 58.2%, 57.8%, 59.7%, 59.6%, 60.1%, and 58.8%. There was no significant change in 6A value. Preoperative ACD and diopter of iris-fixed phakic intraocular lens didn't affect the ECD change. CONCLUSIONS: This two-year follow-up study of changes in endothelial cells after implantation iris-fixated phakic intraocular lens showed statistically significant decreases in the cells, which is not very significant considering the physiologic reduction rate of the cells. Thses decreases showed a tendency to be stabilized with recovery of morphological changes. Further long-term follow-up is needed to determine its long-lasting effect.
Anterior Chamber
;
Endothelial Cells
;
Eye
;
Follow-Up Studies
;
Humans
;
Iris
;
Phakic Intraocular Lenses
;
Prospective Studies