1.Expression of p21(waf1/cip1) Protein in Bladder Cancer and its Prognostic Value.
Hwal LEE ; Houng Gyu SOHN ; Dal Bong HA ; Ki Kwon KIM ; Kyung Seop LEE
Korean Journal of Urology 2000;41(7):826-832
No abstract available.
Urinary Bladder Neoplasms*
;
Urinary Bladder*
2.Clinical Study of Atrial Fibrillation.
Bong Kyung KIM ; Ho Bin KIM ; Duk Jae SOHN ; Ki Ik KWON ; Chang Soon KANG ; Un Ho RYOO
Korean Circulation Journal 1985;15(3):497-502
Clinical study was done on 119 patients with atrial fibrillation in the aspect of underlying diseases, particulary. The results were as follow : 1) In the underlying diseases of atrial finbrillation, rheumatic heart disease, hepertension and ischemic heart disease were common, which occupied 27.8%, 22.7% and and 15.1%, respectly. No apparent underlying disease was found in 21.0%, but in the transient atrial fibrillation, no apparent underlying disease in 42.9%. 2) There were no significant correlations between the ventricular rate, amplitude of f wave and underlying diseases of atrial fibrillation. 3) Complications were found in 29.4% of all cases, such as congestive heart failure(22.7%), embolism(6.7%). Otherwise, atrial fibrillation without underying cardiovascular diseases, congestive heart failure was found only(7.7%).
Atrial Fibrillation*
;
Cardiovascular Diseases
;
Estrogens, Conjugated (USP)
;
Heart
;
Heart Failure
;
Humans
;
Myocardial Ischemia
;
Rheumatic Heart Disease
3.Effect of Reperfusion after 20 min Ligation of the Left Coronary Artery in Open-chest Bovine Heart: An Ultrastructural Study.
Ki Min YANG ; Dai Yun CHO ; Dong Suep SOHN ; Jong Wuk LEE ; Bong Jin RAH ; Ho Duk KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1998;31(8):739-748
BACKGROUND: It has been well documented that transient occlusion of the coronary artery causes myocardial ischemia and finally cell death when ischemia is sustained for more than 20 minutes. Extensive studies have revealed that ischemic myocardium cannot recover without reperfusion by adequate restoration of blood flow, however, reperfusion can cause long-lasting cardiac dysfunction and aggravation of structural damage. The author therefore attempted to examine the effect of postischemic reperfusion on myocardial ultrastructure and to determine the rationales for recanalization therapy to salvage ischemic myocardium. MATERIALS AND METHODS: Young Holstein-Friesian cows (130~140 Kg body weight; n=40) of both sexes, maintained with nutritionally balanced diet and under constant conditions, were used. The left anterior descending coronary artery (LAD) was occluded by ligation with 4-0 silk snare for 20 minutes and recanalized by release of the ligation under continuous intravenous drip anesthesia with sodium pentobarbital (0.15 mg/Kg/min). Drill biopsies of the risk area (antero-lateral wall) were performed at just on reperfusion (5 minutes), 1-, 2-, 3-, 6-, 12-hours after recanalization, and at 1-hour assist (only with mechanical respiration and fluid replacement) after 12-hour recanalization. The materials were subdivided into subepicardial and subendocardial tissues. Tissue samples were examined with a transmission electron microscope (Philips EM 300) at the accelerating voltage of 60 KeV. RESULTS: After a 20-minute ligation of the LAD, myocytes showed slight to moderate degree of ultrastructural changes including subsarcolemmal bleb formation, loss of nuclear matrix, clumping of chromatin and margination, mitochondrial destruction, and contracture of sarcomeres. However, microvascular structures were relatively well preserved. After 1-hour reperfusion, nuclear and mitochondrial matrices reappeared and intravascular plugging by polymorphonuclear leukocytes or platelets was observed. However, nucleoli and intramitochondrial granules reappeared within 3 hours of reperfusion and a large number of myocytes were recovered progressively within 6 hours of reperfusion. Recovery was apparent in the subepicardial myocytes and there were no distinct changes in the ultrastructure except narrowed lumen of the microvessels in the later period of reperfusion. CONCLUSIONS: It is likely that the ischemic myocardium could not be salvaged without adequate restoration of coronary flow and that the microvasculature is more resistant to reversible period of ischemia than subendocardium and subepicardium. Therefore, thrombolysis and/or angioplasty may be a rational method of therapy for coronarogenic myocardial ischemia. However, it may take a relatively longer period of time to recover from ischemic insult and reperfusion injury should be considered.
Anesthesia
;
Angioplasty
;
Biopsy
;
Blister
;
Body Weight
;
Cell Death
;
Chromatin
;
Contracture
;
Coronary Vessels*
;
Diet
;
Heart*
;
Infusions, Intravenous
;
Ischemia
;
Ligation*
;
Microvessels
;
Muscle Cells
;
Myocardial Ischemia
;
Myocardium
;
Neutrophils
;
Nuclear Matrix
;
Pentobarbital
;
Reperfusion Injury
;
Reperfusion*
;
Respiration
;
Sarcomeres
;
Silk
;
SNARE Proteins
;
Sodium
4.The Surgical Treatment of Atrial Fibrillation in Patients undergoing Simultaneous Open Heart Surgery.
Chang Ha LEE ; Ki Bong KIM ; Dae Won SOHN ; Joon Ryang RHO
The Korean Journal of Thoracic and Cardiovascular Surgery 1997;30(3):287-292
Atrial fibrillation is one of the most common cardiac arrhythmias requiring treatment. About 60% of patients with mitral valvular disease have atrial fibrillation and one third of the patients with atrial fibrillation may have the past history of thromboembolic events. Between April 1994 and June 1995, 20 patients with organic heart diseases combined with atrial fibrillation underwent open heart surgery including Cox-maze III procedure. There were 6 men and 14 women with an average age of 48 years (range, 31 to 66 years). Nineteen patients had valvular heart diseases and 1 ventricular septal defect (VSD). Mean duration of atrial fibrillation was 36 months (+/-42 months) (range, 1 to 132 months). The past medical history of thromboembolic events was positive in 7 patients (35%) and left atrial thrombi was detected in 9 patients (45%). The concomitant procedures were mitral valve replacement (MVR) and aortic valve replacement (AVR) in 5 patients, MVR in 4, MVR and tricuspid annuloplasty (TAP) in 4, mitral valvuloplasty (MVP) in 3, MVP and TVP in 1, MVP and coronary artery bypass surgery in 1, AVR in 1, and patch closure of VSD in 1. Mean aortic cross-clamping time was 175 minutes (range, 116 to 270 minutes). Atrial fibrillation recurred in 16 patients (80%) during the early postoperative period, however, the recurrent atrial fibrillation converted to regular rhythm at postoperative forty-first day in average. There was no early or late death in this series of 20 patients and postoperative complications were inappropriate tachycardia in 5 patients (25%), low cardiac output syndrome in 3 (15%), aggravated hemiplegia in 1, and acute renal failure in 1. Mean follow-up interval of the patients was 16.5 months (range, 10.5 to 24 months) and all the patients are currently in regular rhythm. Seventeen patients (85%) are in sinus rhythm and 3 (15%) in junctional rhythm. Right atrial contraction was detected in 95% of patients and left atrial contraction in 63% on postoperative transthoracic echocardiogram. The surgical treatment of atrial fibrillation concomitant with open heart surgery is warranted in the recent clinical setting of improved myocardial protection technique, considering the untoward side-effects of atrial fibrillation.
Acute Kidney Injury
;
Aortic Valve
;
Arrhythmias, Cardiac
;
Atrial Fibrillation*
;
Cardiac Output, Low
;
Coronary Artery Bypass
;
Female
;
Follow-Up Studies
;
Heart Diseases
;
Heart Septal Defects, Ventricular
;
Heart Valve Diseases
;
Heart*
;
Hemiplegia
;
Humans
;
Male
;
Mitral Valve
;
Postoperative Complications
;
Postoperative Period
;
Tachycardia
;
Thoracic Surgery*
5.Statistical Observation for Pediatric Inpatients: Second report statistically analyzed for the patients admitted to the pediatric department of 24 hospitals in Korea.
Keun Chan SOHN ; Kwang Chan DOH ; Yeun Ki KIM ; Esook OH ; Soon Yong LEE ; Seung Kyu LEE ; Du Bong LEE
Journal of the Korean Pediatric Society 1980;23(5):348-357
This is the clinical statistics concerning the admitted patients observed in the pediatric department of 24 university hospitals and general training hospitals in Korea during the past 3 years from Jan. 1976 to Dec. 1978.All the patients were classified by year and disease according to international classification of disease by W.H.O.(1965 Revision). The results obtained were as follows: 1. Total number of patients during 3 years were 64,864, of which 18,085 were in 1976,22,084 in 1977 and 24,693 in 1978 with about 10% increment every year. 2. Infectious and parasitic disease were the most frequent, 20,737 cases(31.97%) followed by respiratory tract disease,15,917 cases(24.54%) and neonatal disease, 6,388 cases(11.44%) 3. Ten major leading causes of hospitalization were pneumonia(12.7%),diarrheal disease (9.4%), hyperbilirubinemia and postmaturity, upper respiratkory tract infection, immaturity acute bronchitis and bronchiolitis, infectious hepatitis, nephritis,convulsion, and intestinal obstruction in the order of frequency
Bronchiolitis
;
Bronchitis
;
Classification
;
Hepatitis A
;
Hospitalization
;
Hospitals, University
;
Humans
;
Hyperbilirubinemia
;
Inpatients*
;
Intestinal Obstruction
;
Korea*
;
Parasitic Diseases
;
Respiratory System
6.A Case of Mediastinal parathyroid adenoma localized by technetium-99m sestamibi scanning
Bong Yun CHA ; Kwang Woo LEE ; Ho Young SON ; Sung Koo KANG ; Ki Ho SONG ; Sung Hee LEE ; Won Hee HAN ; Hyung Sun SOHN
Journal of Korean Society of Endocrinology 1996;11(2):227-232
We present a patient with primary hyperparathyroidism in whom preoperative Tc-99m sestarnibi scanning cleary demonstrated mediastinal parathyroid adenoma. After resectian of tumor through median sternotomy, he was restored to the normocalcemia. This case suggests that Tc-99m sestamibi scanning may be a useful method in the preoperative localization of mediastinal parathyroid adenoma.
Humans
;
Hyperparathyroidism, Primary
;
Methods
;
Parathyroid Neoplasms
;
Sternotomy
7.Antinociceptive Effect of Botulinum Toxin A in Persistent Muscle Pain Rat Model.
Jin Mok CHAE ; Min Kyun SOHN ; Mi Young LEE ; Ki Seok YOON ; Sheng Huo LEE ; Bong Ok KIM
Journal of the Korean Academy of Rehabilitation Medicine 2008;32(1):1-8
OBJECTIVE: To investigate the effects of botulinum toxin on the mechanical hyperalgesia, electrophysiology and motor functions in the persistent muscle pain rat model. METHOD: A secondary mechanical hyperalgesia in the bilateral hindpaws of Sprague-Dawley rats was produced by the repeated injections of acidic saline into gastrocnemius. Botulinum toxin A (BTX-A(4): 4 U/kg, BTX-A(7): 7 U/kg) was administrated into same muscle 24 hours after a second injection of saline. The mechanical hyperalgesia was measured with withdrawal threshold to von Frey filament. The grade of muscle paralysis was evaluated with electrophysiology and the locomotor performance using inclined plane board. RESULTS: The mechanical hyperalgesia was significantly decreased from 5 days to 2 weeks in BTX-A(7) group in the injected side. The dose-dependent decreased amplitude of compound muscle action potential and reduced prevalence of endplate noise from the first day of botulinum toxin injection lasted for 4 weeks in both gastrocnemius. The maximum angle maintained at initial position on the inclined plane board did not change. CONCLUSION: Local muscular injection of botulinum toxin A reduced ipsilateral hyperalgesia dose-dependently in persistent muscle pain rat model without motor deficit. The antinociceptive mechanism of botulinum toxin might act at a local or peripheral rather than a systemic or central effect due to ineffectiveness of contralateral hyperalgesia. Clinically, botulinum toxin A might be useful for the treatment of local and referred pain of muscle origins.
Action Potentials
;
Animals
;
Botulinum Toxins
;
Electrophysiology
;
Hyperalgesia
;
Muscles
;
Noise
;
Pain, Referred
;
Paralysis
;
Prevalence
;
Rats
;
Rats, Sprague-Dawley
8.The Statistical Observation for Pediatric Inpatients.
Keun Chan SOHN ; Hyung Ki KO ; Ho Woong DOH ; Yeun Ki KIM ; Esook OH ; Soon Yong LEE ; Seung Kyu LEE ; Du Bong LEE
Journal of the Korean Pediatric Society 1980;23(4):261-268
Statistical analysis according to W.H.O. classification for the patients admitted to 11 hospitals during the years of Jan. 1974 to Dec. 1975 was made. The result obtaind were as follows: 1) Total No. of patients were 15,885 2) Infections and parasitic disease were the most frequent, 4655 cases (29.3%) and respiratory tract disease the next, 3,516 cases(22.13%) 3) Major leading causes of hospitalization were pneumonia, 12.5% of all patients, ingectious diarrhea, hyperbilirubinemia and postmaturity, prematurity, upper respiratory tract infection nephritis and bronchiolitis in order of incidence.
Bronchiolitis
;
Classification
;
Diarrhea
;
Hospitalization
;
Humans
;
Hyperbilirubinemia
;
Incidence
;
Inpatients*
;
Nephritis
;
Parasitic Diseases
;
Pneumonia
;
Respiratory Tract Diseases
;
Respiratory Tract Infections
9.Spatio-Temporal Distribution and Propagation of Temporal Lobe Seizures: Application of Nonlinear Mutual Cross Prediction.
Ki Young JUNG ; Jae Moon KIM ; Yong Man LEE ; Eun Hee SOHN ; Seung Bong HONG ; Cheol Seung YOO ; Sang Hoon YI
Journal of the Korean Neurological Association 2002;20(2):147-152
BACKGROUND: Nonlinear mutual cross prediction (MCP) characterizes dynamic interdependence among nonlinear systems. MCP also reveal relative strength of the coupling between systems, thus provides information about the direc-tion of interdependence. The aim of this study is to apply MCP algorithm to multi-channel EEG and to characterize spatio- temporal pattern of seizure. METHODS: We analyzed MCP of EEG of three medically intractable temporal lobe epilepsy patients, who underwent temporal lobectomy (left 2, right 1). Asymmetry of nonlinear cross predictability between channels was investigated. Five epochs of interictal EEG free from epileptiform discharge(s) and of ictal EEG were analyzed. RESULTS: In interictal period, both frontal and occipital region appeared a weak driving force while awake and this driving force was further weakened during sleep. Before the onset of the seizure (preictal phase), the intensity of driving system became slightly stronger around seizure foci in 3 out of 8 seizures while no significant change was seen on the naked eyes. However this change was dim and not continuous. At the onset of seizure (ictal phase), 5 out of 8 seizures showed strong driving force around seizure foci. Three seizures without significant change initially had strong driving force as synchronous seizure discharges became built-up and spreading to surrounding areas in the middle of seizure. All seizures showed ipsilateral frontotemporal strong driving force and centroparietal response system, which was typical spatio-temporal distribution of MCP. CONCLUSION: MCP analysis may be a useful method for detecting spatio-temporal distribution and propagation pattern in temporal lobe epilepsy.
Electroencephalography
;
Epilepsy, Temporal Lobe
;
Humans
;
Seizures*
;
Temporal Lobe*
10.Percutaneous Intravascular Metallic Stent Placement in Chronic Iliac Artery Stenoses.
Min Jee SOHN ; Kyu Bo SUNG ; Byung Suk SHIN ; Soo Mee LIM ; Bong Soo KIM ; Ho Young SONG ; Tae Won KWON ; Hyun Ki YOON
Journal of the Korean Radiological Society 2001;45(3):255-261
PURPOSE: To determine the long-term patency of percutaneous intravascular metallic stent placement in patients with chronic iliac artery stenosis. MATERIALS AND METHODS: Intravascular metallic stents were placed percutaneously in 41 limbs of 38 patients with chronic iliac artery stenosis who presented with intermittent claudication in 40 limbs and gangrene in the other. Preoperative angiography showed that complete occlusion occurred in one limb, and luminal stenosis of over 50% in 34 and of less than 50% in six. The mean length of stenoses was 3.1 (range, 1 -8) cm, and in all cases the systolic pressure gradient was over 10 (range, 12 -100, mean, 43) mmHg. Stent placement was indicated by failed balloon angioplasty in 35 limbs, primary stenting in five, and restenosis after balloon angioplasty in one. Technical and clinical success were evaluated in terms of immediate results and stent patency over a period of 1 -49 (mean, 19) months (Kaplan-Meier method). RESULTS: Stent placement was successful in all cases in which residual stenosis was less than 10% and systolic pressure gradient less than 2 mmHg. One to three days after the procedure, clinical symptoms had improved in 40 limbs and ABI (n=23) had increased from 0.64 +/-0.20 to 0.92 +/-0.17. Follow-up studies demonstrated patency rates of 94.1% at 6 months, 90.7% at 1 year, 86.6% at 2 years, and 86.6% at 4 years. CONCLUSION: Our results showed that in patients with chronic iliac artery stenosis, percutaneous intravascular metallic stent placement led to patency rates which were similar over a period of between six months and four years.
Angiography
;
Angioplasty, Balloon
;
Blood Pressure
;
Constriction, Pathologic*
;
Extremities
;
Follow-Up Studies
;
Gangrene
;
Humans
;
Iliac Artery*
;
Intermittent Claudication
;
Phenobarbital
;
Stents*